J L Pepin

Summary

Affiliation: CHU de Grenoble
Country: France

Publications

  1. ncbi request reprint Overdrive atrial pacing does not improve obstructive sleep apnoea syndrome
    J L Pepin
    Sleep Laboratory, Joseph Fourier University, Grenoble, France
    Eur Respir J 25:343-7. 2005
  2. pmc Comorbidities and mortality in hypercapnic obese under domiciliary noninvasive ventilation
    Jean Christian Borel
    INSERM U 1042, HP2 Laboratory, Universite Joseph Fourier, Faculte de Medecine, Grenoble, France
    PLoS ONE 8:e52006. 2013
  3. pmc Endothelial dysfunction and specific inflammation in obesity hypoventilation syndrome
    Jean Christian Borel
    INSERM ERI17, Laboratoire HP2, Universite Joseph Fourier, Faculte de Medecine, Grenoble, France
    PLoS ONE 4:e6733. 2009
  4. pmc Polysomnography in stable COPD under non-invasive ventilation to reduce patient-ventilator asynchrony and morning breathlessness
    Dan Adler
    Division of Pulmonary Diseases, Geneva University Hospitals, Rue Gabrielle Perret Gentil 4, 1211, Geneva 14, Switzerland
    Sleep Breath 16:1081-90. 2012
  5. doi request reprint A critical review of peripheral arterial tone and pulse transit time as indirect diagnostic methods for detecting sleep disordered breathing and characterizing sleep structure
    Jean Louis Pepin
    Rehabilitation and Physiology Department, Grenoble University Hospital, France
    Curr Opin Pulm Med 15:550-8. 2009
  6. doi request reprint The upper airway resistance syndrome
    J L Pepin
    Sleep Laboratory, EFCR, Grenoble University Hospital, Grenoble, France
    Respiration 83:559-66. 2012
  7. doi request reprint Noninvasive ventilation in mild obesity hypoventilation syndrome: a randomized controlled trial
    Jean Christian Borel
    Laboratoire EFCR, CHU de Grenoble, Grenoble Cedex 09, France
    Chest 141:692-702. 2012
  8. ncbi request reprint [Alveolar hypoventilation during sleep and domiciliary assisted ventilation]
    J L Pepin
    Département de Médecine Aiguë Spécialisée, CHU, Grenoble, France
    Rev Mal Respir 22:113-25. 2005
  9. ncbi request reprint [Periodic respiration and central sleep apnea syndrome in subjects with congestive heart disease]
    J L Pepin
    Laboratoire du Sommeil et Département de Médecine Aiguë Spécialisée, CHU de Grenoble
    Rev Mal Respir 21:S49-55. 2004
  10. ncbi request reprint [Influence of CPAP in inflammation and nasal obstruction]
    J L Pepin
    Laboratoire du Sommeil, Laboratoire HP2, Inserm ESPRI 0017, Universite Joseph Fourier, 621, av Centrale, 38400 Saint Martin d Hères
    Rev Mal Respir 23:7S137-7S139. 2006

Collaborators

Detail Information

Publications49

  1. ncbi request reprint Overdrive atrial pacing does not improve obstructive sleep apnoea syndrome
    J L Pepin
    Sleep Laboratory, Joseph Fourier University, Grenoble, France
    Eur Respir J 25:343-7. 2005
    ..Overdrive pacing changed none of the respiratory indices, or sleep fragmentation or sleep structure parameters. In conclusion, atrial overdrive pacing has no significant effect on obstructive sleep apnoea...
  2. pmc Comorbidities and mortality in hypercapnic obese under domiciliary noninvasive ventilation
    Jean Christian Borel
    INSERM U 1042, HP2 Laboratory, Universite Joseph Fourier, Faculte de Medecine, Grenoble, France
    PLoS ONE 8:e52006. 2013
    ..The impacts of comorbidities, medications and NIV compliance on survival of these patients remain largely unexplored...
  3. pmc Endothelial dysfunction and specific inflammation in obesity hypoventilation syndrome
    Jean Christian Borel
    INSERM ERI17, Laboratoire HP2, Universite Joseph Fourier, Faculte de Medecine, Grenoble, France
    PLoS ONE 4:e6733. 2009
    ..Obesity hypoventilation syndrome (OHS) is associated with increased cardiovascular morbidity. What moderate chronic hypoventilation adds to obesity on systemic inflammation and endothelial dysfunction remains unknown...
  4. pmc Polysomnography in stable COPD under non-invasive ventilation to reduce patient-ventilator asynchrony and morning breathlessness
    Dan Adler
    Division of Pulmonary Diseases, Geneva University Hospitals, Rue Gabrielle Perret Gentil 4, 1211, Geneva 14, Switzerland
    Sleep Breath 16:1081-90. 2012
    ..We hypothesised that in these patients, progressive hyperinflation, resulting from inappropriate ventilator settings, leads to patient-ventilator asynchrony (PVA) with a high rate of unrewarded inspiratory efforts and morning discomfort...
  5. doi request reprint A critical review of peripheral arterial tone and pulse transit time as indirect diagnostic methods for detecting sleep disordered breathing and characterizing sleep structure
    Jean Louis Pepin
    Rehabilitation and Physiology Department, Grenoble University Hospital, France
    Curr Opin Pulm Med 15:550-8. 2009
    ....
  6. doi request reprint The upper airway resistance syndrome
    J L Pepin
    Sleep Laboratory, EFCR, Grenoble University Hospital, Grenoble, France
    Respiration 83:559-66. 2012
    ..In this review, the authors attempt to describe the specific characteristics of UARS that are relevant for both clinicians and researchers...
  7. doi request reprint Noninvasive ventilation in mild obesity hypoventilation syndrome: a randomized controlled trial
    Jean Christian Borel
    Laboratoire EFCR, CHU de Grenoble, Grenoble Cedex 09, France
    Chest 141:692-702. 2012
    ....
  8. ncbi request reprint [Alveolar hypoventilation during sleep and domiciliary assisted ventilation]
    J L Pepin
    Département de Médecine Aiguë Spécialisée, CHU, Grenoble, France
    Rev Mal Respir 22:113-25. 2005
    ..An alveolar hypoventilation physiologically occurs during sleep and more specifically during REM sleep...
  9. ncbi request reprint [Periodic respiration and central sleep apnea syndrome in subjects with congestive heart disease]
    J L Pepin
    Laboratoire du Sommeil et Département de Médecine Aiguë Spécialisée, CHU de Grenoble
    Rev Mal Respir 21:S49-55. 2004
  10. ncbi request reprint [Influence of CPAP in inflammation and nasal obstruction]
    J L Pepin
    Laboratoire du Sommeil, Laboratoire HP2, Inserm ESPRI 0017, Universite Joseph Fourier, 621, av Centrale, 38400 Saint Martin d Hères
    Rev Mal Respir 23:7S137-7S139. 2006
  11. ncbi request reprint [Resistance syndrome of the upper airways: a separate entity of sleep apnea syndrome?]
    J L Pepin
    EFCR, Laboratoire du Sommeil, Centre Hospitalier Universitaire, BP 217, 38043 Grenoble Cedex 9 Laboratoire HP2, INSERM ERI 0017
    Rev Mal Respir 23:7S44-7S47. 2006
  12. ncbi request reprint Pulse transit time improves detection of sleep respiratory events and microarousals in children
    Jean Louis Pepin
    Department of Pediatrics and Respiratory Medicine, Intensive Care Unit and Sleep Laboratory, University Hospital, Grenoble, France
    Chest 127:722-30. 2005
    ..To evaluate the additional information provided by pulse transit time (PTT), a noninvasive tool, when using during polysomnography for the diagnosis of sleep breathing disorders in a pediatric population...
  13. doi request reprint Prevalence of residual excessive sleepiness in CPAP-treated sleep apnoea patients: the French multicentre study
    J L Pepin
    HP2 Laboratory Hypoxia Pathophysiology, INSERM ERI 0017, EA 3745 Joseph Fourier University, Grenoble, France
    Eur Respir J 33:1062-7. 2009
    ..As 230,000 obstructive sleep apnoea patients are currently treated in France by continuous positive airway pressure, more than 13,800 of them might suffer from residual excessive sleepiness...
  14. doi request reprint Pressure reduction during exhalation in sleep apnea patients treated by continuous positive airway pressure
    Jean Louis Pepin
    HP2 Laboratory, Institut National de la Sante et de la Recherche Medicale, Equipe Région INSERM 17, Grenoble University Hospital, Grenoble, France
    Chest 136:490-7. 2009
    ....
  15. ncbi request reprint [Tools available for the diagnosis of obstructive sleep apnea syndrome. Measurements for the evaluation of therapeutic efficacy]
    J L Pepin
    Departement de Medecine, CHU de Grenoble, 38043 Grenoble
    Rev Stomatol Chir Maxillofac 103:151-7. 2002
    ..It should also include simplified methods or complete polysomnography to obtain a precise measurement of residual respiratory events and sleep pattern after treatment...
  16. ncbi request reprint [Pathophysiology of cardiovascular risk in sleep apnea syndrome (SAS)]
    J L Pepin
    Département de Médecine aiguë spécialisée et Laboratoire de Neurophysiopathologie du sommeil et de l épilepsie Pr Lévy, CHU, Grenoble, France
    Rev Neurol (Paris) 158:785-97. 2002
    ..Very recently, epidemiological studies suggested that continuous positive pressure ventilation in SAS patients can reduce the cardiovascular risk...
  17. doi request reprint Comparison of continuous positive airway pressure and valsartan in hypertensive patients with sleep apnea
    Jean Louis Pepin
    Rehabilitation and Physiology Department, Grenoble University Hospital, Grenoble, France
    Am J Respir Crit Care Med 182:954-60. 2010
    ..CPAP treatment has never been compared with antihypertensive medications in an RCT...
  18. doi request reprint Sleep apnea diagnosis using an ECG Holter device including a nasal pressure (NP) recording: validation of visual and automatic analysis of nasal pressure versus full polysomnography
    Jean Louis Pepin
    Cardiology Department, EFCR et Laboratoire du sommeil, Pôle Rééducation Physiologie, CHU de Grenoble, BP 217X 38043 Grenoble Cedex 09, France
    Sleep Med 10:651-6. 2009
    ..New simplified techniques for diagnosing sleep apnea should be specially tailored for easy use in cardiologic practice...
  19. ncbi request reprint Differentiating obstructive and central sleep respiratory events through pulse transit time
    J Argod
    Department of Respiratory Medicine and Sleep Laboratory, University Hospital, Grenoble, France
    Am J Respir Crit Care Med 158:1778-83. 1998
    ..8%). PTT has shown a high sensitivity and specificity in differentiating obstructive and central respiratory events, and may become the reference noninvasive tool for this purpose...
  20. doi request reprint 14 nights of intermittent hypoxia elevate daytime blood pressure and sympathetic activity in healthy humans
    R Tamisier
    Sleep Laboratory and EFCR, Dept of Rehabilitation and Physiology, University Hospital, Grenoble, France
    Eur Respir J 37:119-28. 2011
    ..These mechanisms may reflect those underlying the blood pressure elevation associated with OSAS...
  21. doi request reprint Leukotriene B4: early mediator of atherosclerosis in obstructive sleep apnoea?
    B Lefebvre
    INSERM, ERI7, Centre Hospitalier Universitaire, Hopital A Michallon, BP 217, 38043 Grenoble Cedex 9, France
    Eur Respir J 32:113-20. 2008
    ..Leukotriene B(4) production is increased in obstructive sleep apnoea in relation to oxygen desaturation. Leukotriene B(4) could promote early vascular remodelling in moderate-to-severe hypoxic obstructive sleep apnoea patients...
  22. ncbi request reprint [Surgery and obstructive sleep apnea syndrome: indications and precautions]
    G Bettega
    Service de Chirurgie Maxillo faciale, CHU de Grenoble, B P 217, 38043 Grenoble
    Rev Stomatol Chir Maxillofac 103:181-7. 2002
    ..A considerable effort must be made in this domain...
  23. ncbi request reprint Critical analysis of the results of surgery in the treatment of snoring, upper airway resistance syndrome (UARS), and obstructive sleep apnea (OSA)
    J L Pepin
    Department of Respiratory Medicine, University Hospital, Grenoble, France
    Sleep 19:S90-100. 1996
    ....
  24. ncbi request reprint Management of simple snoring, upper airway resistance syndrome, and moderate sleep apnea syndrome
    P Levy
    Sleep and Respiration Unit, Grenoble University Hospital, France
    Sleep 19:S101-10. 1996
    ..However, these conditions are likely to be particularly appropriate for randomized trials comparing different modalities of treatment that may be the only way to validate these treatment strategies...
  25. ncbi request reprint Cognitive executive dysfunction in patients with obstructive sleep apnea syndrome (OSAS) after CPAP treatment
    B Naegele
    CNRS GDR 978, Department of Clinical and Biological Neurosciences, CHU, Grenoble, France
    Sleep 21:392-7. 1998
    ..In conclusion, short-term memory impairment was persistent in OSAS patients despite CPAP treatment for 4-6 months...
  26. doi request reprint [Management of central sleep apnea]
    I Boutin
    Laboratoire du sommeil et EFCR, Pôle Rééducation et Physiologie, CHU de Grenoble, BP 217, 38043 Grenoble Cedex 09, France
    Rev Pneumol Clin 65:261-72. 2009
    ..Ventilatory supports used for treating central sleep apnea are non-invasive ventilation and servo-assisted ventilation in hypercapnic and hypocapnic patients respectively...
  27. doi request reprint Intermittent hypoxia and sleep-disordered breathing: current concepts and perspectives
    P Levy
    Pathophysiology Laboratory, Grenoble University, Grenoble, France
    Eur Respir J 32:1082-95. 2008
    ..Overall, chronic intermittent hypoxia appears to have specific genomic effects that differ notably from continuous hypoxia. Further research is required to fully elucidate the molecular and cellular mechanisms...
  28. ncbi request reprint [Lateral cephalometric radiography of the upper airways for evaluation of surgical treatment of obstructive sleep apnea syndrome]
    J Teitelbaum
    Service de chirurgie maxillofaciale, CHU de Grenoble, BP 217, 38043 Grenoble Cedex 09, France
    Rev Stomatol Chir Maxillofac 108:13-20. 2007
    ..We studied the prognostic value of this exploration in terms of therapeutic outcome in surgically treated patients...
  29. ncbi request reprint Driving ability in sleep apnoea patients before and after CPAP treatment: evaluation on a road safety platform
    S Mazza
    HP2 laboratory hypoxia, pathophysiology INSERM ERI 0017, Joseph Fourier University, Grenoble, France
    Eur Respir J 28:1020-8. 2006
    ..This stresses the importance of evaluating attentional parameters in apnoeic patients and of offering continuous positive airway pressure treatment even to non-sleepy subjects...
  30. doi request reprint The impact of obstructive sleep apnea on homocysteine and carotid remodeling in metabolic syndrome
    D Monneret
    Inserm U1042 HP2 Laboratory Hypoxia and Pathophysiology, Joseph Fourier University, Grenoble, France
    Respir Physiol Neurobiol 180:298-304. 2012
    ..We conclude that homocysteine level was higher in MetS when associated with OSA and proportional to OSA severity. In this context, vascular remodeling appeared more severe and mediated by oxidative stress...
  31. doi request reprint Left ventricular diastolic dysfunction is linked to severity of obstructive sleep apnoea
    J P Baguet
    Dept of Cardiology, Functional Explorations Unit, University Hospital, France
    Eur Respir J 36:1323-9. 2010
    ..91) were associated with left ventricular diastolic dysfunction. Our findings demonstrate that left ventricular diastolic dysfunction frequently occurs in patients with OSA and that it is related to the severity of oxygen desaturation...
  32. pmc A new model of chronic intermittent hypoxia in humans: effect on ventilation, sleep, and blood pressure
    R Tamisier
    Laboratoire du sommeil et EFCR, Pôle Rééducation et Physiologie, CHU A Michallon, Grenoble, B P 217, 38043 Grenoble Cedex 9, France
    J Appl Physiol (1985) 107:17-24. 2009
    ..3 to 74 +/- 1.7 mmHg). We propose this model as a new technique to study the cardiovascular and metabolic consequences of CIH in human volunteers...
  33. doi request reprint Hypertension and obstructive sleep apnoea syndrome: current perspectives
    J P Baguet
    Department of Cardiology, University Hospital, Grenoble, France
    J Hum Hypertens 23:431-43. 2009
    ..Optimal treatment for HT associated with OSAS has not been evidenced. Antihypertensive drugs do not change the respiratory parameters during OSAS...
  34. ncbi request reprint Is sleep apnea syndrome in the elderly a specific entity?
    P Levy
    Secteur Sommeil et Respiration, Service de Pneumologie, Grenoble, France
    Sleep 19:S29-38. 1996
    ..Further studies are needed to determine whether or not the associated morbidity is different in the elderly; these studies could lead to different diagnosis strategies and therapeutic approaches...
  35. pmc A simple procedure for measuring pharyngeal sensitivity: a contribution to the diagnosis of sleep apnoea
    M Dematteis
    Laboratoire HP2 INSERM ESPRI EA3745, Centre Hospitalier Universitaire, Grenoble Cedex, France
    Thorax 60:418-26. 2005
    ..The accuracy of a simple new procedure to measure pharyngeal sensitivity and to diagnose sleep disordered breathing (SDB) was investigated...
  36. ncbi request reprint [Cardiovascular consequences of obstructive sleep apnea syndrome]
    J P Baguet
    Service de Cardiologie et hypertension artérielle, CHU de Grenoble, BP 217, 38043 Grenoble Cedex 09, France
    Rev Med Interne 24:530-7. 2003
    ..This article is an update of past and current data on the relationship between obstructive sleep apnea syndrome and cardiovascular diseases...
  37. ncbi request reprint Increased lipid peroxidation in patients with pulmonary hypertension
    J L Cracowski
    Laboratoire de Pharmacologie, and Département de Médecine Aiguë Spécialisée, Grenoble University Hospital, Grenoble, France
    Am J Respir Crit Care Med 164:1038-42. 2001
    ..Furthermore, iPF(2alpha)-III levels inversely correlate to pulmonary vasoreactivity. These observations are consistent with the hypothesis that free radical generation is involved in PHT pathogenesis...
  38. ncbi request reprint [Clinical protocols for therapy of obstructive sleep apnea syndrome: the role of the stomatologist]
    G Bettega
    Service de Chirurgie Maxillo faciale, CHU de Grenoble, BP 217, 38043 Grenoble
    Rev Stomatol Chir Maxillofac 103:188-9. 2002
  39. ncbi request reprint [Nyctohemeral variations in intraocular pressure]
    J P Romanet
    Service d Ophtalmologie, CHU de Grenoble, BP 217, 38043 Grenoble Cedex 9, France
    J Fr Ophtalmol 27:2S19-2S26. 2004
    ..Lowering IOP is still the only option that is available for treating patients with glaucoma. Variations encountered in the individual's nyctohemeral IOP pattern must be taken into consideration to provide the most effective treatment...
  40. pmc Non-arteritic anterior ischaemic optic neuropathy is nearly systematically associated with obstructive sleep apnoea
    K Palombi
    Department of Ophthalmology, University Hospital, Grenoble, France
    Br J Ophthalmol 90:879-82. 2006
    ..To evaluate newly diagnosed non-arteritic anterior ischaemic optic neuropathy (NAION) patients for the existence of an associated sleep apnoea syndrome...
  41. ncbi request reprint [Obstructive sleep apnea syndrome]
    N Chouri-Pontarollo
    Laboratoire du sommeil et EFCR, Département de Médecine Aiguë Spécialisée, CHU de Grenoble
    Presse Med 34:1533-40. 2005
    ..Prosthetic management is an alternative to CPAP in cases of moderate sleep apnea with or without retrognathism in normal-weight patients. The effectiveness of surgery has not been proven, and it is indicated only in exceptional cases...
  42. doi request reprint Respiratory muscle endurance training in obese patients
    J C Villiot-Danger
    HP2 Laboratory, INSERM ERI17, Joseph Fourier University, Grenoble, France
    Int J Obes (Lond) 35:692-9. 2011
    ..We evaluated the effect of respiratory muscle endurance training (RMET) on respiratory muscle capacities, symptoms and exercise capacity in obese patients...
  43. doi request reprint [Obstructive sleep-apnoea syndrome in adult and its perioperative management]
    J F Payen
    Pôle d Anesthésie Réanimation, Hopital Michallon, CHU de Grenoble, BP 217, 38043 Grenoble Cedex 09, France
    Ann Fr Anesth Reanim 29:787-92. 2010
    ..Alternatives to opioids should be promoted for postoperative pain control...
  44. ncbi request reprint [Imaging in obstructive sleep apnea syndrome]
    G Ferretti
    Service Central de Radiologie et Imagerie Médicale Centre Hospitalier Universitaire, Grenoble BP 217 F 38043 Grenoble, France
    Rev Neurol (Paris) 157:S78-81. 2001
    ....
  45. ncbi request reprint [Cardiovascular morbidity associated with obstructive sleep apnea syndrome]
    M Destors
    Laboratoire HP2, Université Grenoble Alpes, 38000 Grenoble, France Laboratoire Inserm U1042, 38000 Grenoble, France Clinique de pneumologie, CHU de Grenoble, 38000 Grenoble, France Electronic address
    Rev Mal Respir 31:375-85. 2014
    ..The obstructive sleep apnoea syndrome (OSAS) had become a major public health concern in modern society due to its high prevalence but, above all, to its associated morbidity, especially cardiovascular...
  46. ncbi request reprint [Can mandibular advancement prosthesis be used in the treatment of sleep apnea syndrome? Arguments against]
    J L Pepin
    Service d Explorations Fonctionnelles Respiratoires, CHU de Grenoble, La Tronche, France
    Rev Mal Respir 21:213-4. 2004
  47. ncbi request reprint Deficits of cognitive executive functions in patients with sleep apnea syndrome
    B Naegele
    Department of Clinical and Biological Neurosciences, CHU, Grenoble, France
    Sleep 18:43-52. 1995
    ....
  48. ncbi request reprint Identification of quality of life concerns of patients with obstructive sleep apnoea at the time of initiation of continuous positive airway pressure: a discourse analysis
    D Veale
    Sleep Laboratory, CHU Grenoble, Centre Pneumologie, Henri Bazire, France
    Qual Life Res 11:389-99. 2002
    ..Thus many worries and concerns of patients remain hidden. Treatment by nasal continuous positive airway pressure (CPAP) can be imposing for the individual. An analysis of the freely expressed concerns of such patients is required...
  49. ncbi request reprint Effect of autonomic blockade on heart rate and blood pressure in sleep apnea syndrome
    B Januel
    Laboratoire du Sommeil, INSERM CJF 89 09, Hopital A Beclere, Clamart, France
    Blood Press 4:226-31. 1995
    ..9 +/- 1.9 bpm) and at RB (75.9 +/- 1.9 vs 81.6 +/- 1.8). With A, the rise in HR at end-apnea (P3) suggests a vagal hyperactivity during this phase which is blunted at resumption when HR is unchanged.(ABSTRACT TRUNCATED AT 250 WORDS)..