Jean Francois Mosnier

Summary

Affiliation: CHU de Nantes
Country: France

Publications

  1. doi request reprint N-cadherin serves as diagnostic biomarker in intrahepatic and perihilar cholangiocarcinomas
    Jean Francois Mosnier
    Universite de Nantes, Faculté de Médecine de Nantes, EA Biometadys, Nantes, France
    Mod Pathol 22:182-90. 2009
  2. doi request reprint In situ evidence of involvement of Schwann cells in ulcerative colitis: autocrine and paracrine signaling by A disintegrin and metalloprotease-17-mediated tumor necrosis factor alpha production
    Jean Francois Mosnier
    Universite de Nantes, Faculte de Medecine, EA Biometadys, Nantes, France
    Hum Pathol 40:1159-67. 2009
  3. doi request reprint ADAM15 to α5β1 integrin switch in colon carcinoma cells: a late event in cancer progression associated with tumor dedifferentiation and poor prognosis
    Claire Toquet
    EA4273 Biometadys, Nantes F 44035, France
    Int J Cancer 130:278-87. 2012
  4. ncbi request reprint Up-regulated expression of ADAM17 in human colon carcinoma: co-expression with EGFR in neoplastic and endothelial cells
    Frédérique Blanchot-Jossic
    INSERM U539, Faculté de Médecine de Nantes, France
    J Pathol 207:156-63. 2005
  5. ncbi request reprint Low expression of ORF4, a dominant negative variant of peroxisome proliferator-activated receptor gamma, in colorectal adenocarcinoma
    Delphine Bouancheau
    INSERM U539, IFR26, Faculte de Medecine, F 44035 Nantes, France
    Oncol Rep 18:489-95. 2007
  6. ncbi request reprint ADAM15 upregulation and interaction with multiple binding partners in inflammatory bowel disease
    Jean Francois Mosnier
    INSERM, U539, Nantes, France
    Lab Invest 86:1064-73. 2006
  7. doi request reprint Delineation of the infrequent mosaicism of KRAS mutational status in metastatic colorectal adenocarcinomas
    Céline Bossard
    Universite de Nantes, Faculté de Médecine de Nantes, EA 4273 Biometadys, Nantes, France
    J Clin Pathol 65:466-9. 2012
  8. doi request reprint Loss of interleukin-10 or transforming growth factor β signaling in the human colon initiates a T-helper 1 response via distinct pathways
    Anne Jarry
    EA 4273 Biometadys, Universite de Nantes, Faculte de Medecine, Nantes, France
    Gastroenterology 141:1887-96.e1-2. 2011
  9. ncbi request reprint Involvement of the serrated neoplasia pathway in inflammatory bowel disease-related colorectal oncogenesis
    Céline Bossard
    INSERM U539, Faculte de Medecine, 1 rue Gaston Veil, 44035 Nantes cedex 1, France
    Oncol Rep 18:1093-7. 2007
  10. pmc Differential roles of Hath1, MUC2 and P27Kip1 in relation with gamma-secretase inhibition in human colonic carcinomas: a translational study
    Frédérique Souazé
    EA Biometadys, Universite de Nantes, Nantes, France
    PLoS ONE 8:e55904. 2013

Collaborators

Detail Information

Publications13

  1. doi request reprint N-cadherin serves as diagnostic biomarker in intrahepatic and perihilar cholangiocarcinomas
    Jean Francois Mosnier
    Universite de Nantes, Faculté de Médecine de Nantes, EA Biometadys, Nantes, France
    Mod Pathol 22:182-90. 2009
    ..In combination with cytokeratin 7 and Hep Par1, N-cadherin is a reliable tool for the histopathological diagnosis of primary hepatic tumors...
  2. doi request reprint In situ evidence of involvement of Schwann cells in ulcerative colitis: autocrine and paracrine signaling by A disintegrin and metalloprotease-17-mediated tumor necrosis factor alpha production
    Jean Francois Mosnier
    Universite de Nantes, Faculte de Medecine, EA Biometadys, Nantes, France
    Hum Pathol 40:1159-67. 2009
    ..Tumor necrosis factor alpha is thus likely to stimulate Schwann cell proliferation through an autocrine/paracrine mechanism...
  3. doi request reprint ADAM15 to α5β1 integrin switch in colon carcinoma cells: a late event in cancer progression associated with tumor dedifferentiation and poor prognosis
    Claire Toquet
    EA4273 Biometadys, Nantes F 44035, France
    Int J Cancer 130:278-87. 2012
    ..Finally this profile that includes characteristic of epithelial to mesenchymal transition is a late progression event of colon cancer with a poor prognosis...
  4. ncbi request reprint Up-regulated expression of ADAM17 in human colon carcinoma: co-expression with EGFR in neoplastic and endothelial cells
    Frédérique Blanchot-Jossic
    INSERM U539, Faculté de Médecine de Nantes, France
    J Pathol 207:156-63. 2005
    ..Its co-expression with EGFR, in both neoplastic and endothelial cells, suggests a role for ADAM17 in tumour growth and angiogenesis...
  5. ncbi request reprint Low expression of ORF4, a dominant negative variant of peroxisome proliferator-activated receptor gamma, in colorectal adenocarcinoma
    Delphine Bouancheau
    INSERM U539, IFR26, Faculte de Medecine, F 44035 Nantes, France
    Oncol Rep 18:489-95. 2007
    ..We conclude that ORF4 expression is a general phenomenon, and that its low level should not affect the efficiency of selective PPARgamma modulators in colon cancer treatment...
  6. ncbi request reprint ADAM15 upregulation and interaction with multiple binding partners in inflammatory bowel disease
    Jean Francois Mosnier
    INSERM, U539, Nantes, France
    Lab Invest 86:1064-73. 2006
    ..In addition, the spatial relationships with its binding partners suggest a role for ADAM15 in the differentiation of regenerative colonic mucosa as well as in leukocyte transmigration across epithelial and endothelial barriers...
  7. doi request reprint Delineation of the infrequent mosaicism of KRAS mutational status in metastatic colorectal adenocarcinomas
    Céline Bossard
    Universite de Nantes, Faculté de Médecine de Nantes, EA 4273 Biometadys, Nantes, France
    J Clin Pathol 65:466-9. 2012
    ..Finally, the KRAS status varied among different areas of the same metastatic focus. This study defines the concept of KRAS mosaicism that affects a minority of mCRCs...
  8. doi request reprint Loss of interleukin-10 or transforming growth factor β signaling in the human colon initiates a T-helper 1 response via distinct pathways
    Anne Jarry
    EA 4273 Biometadys, Universite de Nantes, Faculte de Medecine, Nantes, France
    Gastroenterology 141:1887-96.e1-2. 2011
    ..We studied conversion of human mucosal innate immune cells into inflammatory cells and the initiation of a Th1 cell response following loss of IL-10 or TGF-β signaling...
  9. ncbi request reprint Involvement of the serrated neoplasia pathway in inflammatory bowel disease-related colorectal oncogenesis
    Céline Bossard
    INSERM U539, Faculte de Medecine, 1 rue Gaston Veil, 44035 Nantes cedex 1, France
    Oncol Rep 18:1093-7. 2007
    ..e. the appearance of the BRAF mutation as early as the hyperplastic polyp stage followed by MSI at the carcinoma stage. We therefore identified the serrated neoplasia pathway in IBD-related colorectal oncogenesis...
  10. pmc Differential roles of Hath1, MUC2 and P27Kip1 in relation with gamma-secretase inhibition in human colonic carcinomas: a translational study
    Frédérique Souazé
    EA Biometadys, Universite de Nantes, Nantes, France
    PLoS ONE 8:e55904. 2013
    ..Interestingly, the response patterns of primary tumors to DBZ fitted with the hierarchical model of divergent signalling derived from our findings on cell lines...
  11. ncbi request reprint TACE inhibition amplifies TNF-alpha-mediated colonic epithelial barrier disruption
    Thomas Freour
    INSERM U539, Faculte de Medecine, F 44035 Nantes, France
    Int J Mol Med 23:41-8. 2009
    ..TIMP3 could thus play a major role in inflammatory conditions by creating an autocrine effect leading to amplified epithelial barrier hyperpermeability...
  12. ncbi request reprint V gamma 9V delta 2 T cell response to colon carcinoma cells
    Murielle Corvaisier
    Institut National de la Sante et de la Recherche Medicale INSERM, Unite 601, Nantes, France
    J Immunol 175:5481-8. 2005
    ..Therefore, this study provides a strong rationale for the use of Vgamma9Vdelta2 T cell agonists in immunotherapies targeting colon tumors...
  13. ncbi request reprint Down-regulation of the monocarboxylate transporter 1 is involved in butyrate deficiency during intestinal inflammation
    Ronan Thibault
    UMR 1280 Physiologie des Adaptations Nutritionnelles, INRA, Universite de Nantes, Nantes, France
    Gastroenterology 133:1916-27. 2007
    ..Butyrate uptake by colonocytes involves the monocarboxylate transporter (MCT) 1. We aimed to investigate the role of MCT1 in butyrate oxidation deficiency during colonic inflammation...