Fr Mégraud

Summary

Affiliation: CHU de Bordeaux
Country: France

Publications

  1. doi request reprint Helicobacter pylori resistance to antibiotics in Europe and its relationship to antibiotic consumption
    Francis Megraud
    INSERM U853, Bordeaux, France
    Gut 62:34-42. 2013
  2. pmc Evaluation of the positive predictive value of a rapid Immunochromatographic test to detect Campylobacter in stools
    Pauline Floch
    Universite de Bordeaux, French National Reference Center for Campylobacters, 33076, Bordeaux, France
    Gut Pathog 4:17. 2012
  3. pmc Geographic distribution of methyltransferases of Helicobacter pylori: evidence of human host population isolation and migration
    Filipa F Vale
    Engineering Faculty, Portuguese Catholic University, Estrada Octávio Pato, 2635 631 Rio de Mouro, Portugal
    BMC Microbiol 9:193. 2009
  4. pmc Allelic diversity and phylogeny of homB, a novel co-virulence marker of Helicobacter pylori
    Monica Oleastro
    Departamento de Doenças Infecciosas, Instituto Nacional Saúde Dr Ricardo Jorge, Av Padre Cruz, 1649 016 Lisboa, Portugal
    BMC Microbiol 9:248. 2009
  5. pmc First multi-locus sequence typing scheme for Arcobacter spp
    William G Miller
    Produce Safety and Microbiology Research Unit, Agricultural Research Service, US Department of Agriculture, Albany, CA 94710, USA
    BMC Microbiol 9:196. 2009
  6. pmc From array-based hybridization of Helicobacter pylori isolates to the complete genome sequence of an isolate associated with MALT lymphoma
    Jean Michel Thiberge
    Institut Pasteur, Unité postulante de Pathogenèse de Helicobacter, Paris, France
    BMC Genomics 11:368. 2010
  7. pmc Ancestral European roots of Helicobacter pylori in India
    S Manjulata Devi
    Pathogen Evolution Group, Centre for DNA Fingerprinting and Diagnostics, Hyderabad, India
    BMC Genomics 8:184. 2007
  8. ncbi request reprint Impact of Helicobacter pylori virulence on the outcome of gastroduodenal diseases: lessons from the microbiologist
    F Megraud
    Laboratoire de Bacteriologie, Hopital Pellegrin, Bordeaux, France
    Dig Dis 19:99-103. 2001
  9. pmc Disease association with two Helicobacter pylori duplicate outer membrane protein genes, homB and homA
    Monica Oleastro
    INSERM U853, 33076 Bordeaux, France
    Gut Pathog 1:12. 2009
  10. ncbi request reprint Resistance of Helicobacter pylori to antibiotics and its impact on treatment options
    F Megraud
    Laboratoire de Bacteriologie, Hopital Pellegrin, Bordeaux, France
    Drug Resist Updat 4:178-86. 2001

Detail Information

Publications91

  1. doi request reprint Helicobacter pylori resistance to antibiotics in Europe and its relationship to antibiotic consumption
    Francis Megraud
    INSERM U853, Bordeaux, France
    Gut 62:34-42. 2013
    ..A study was conducted to assess prospectively the antibacterial resistance rates of H pylori in Europe and to study the link between outpatient antibiotic use and resistance levels in different countries...
  2. pmc Evaluation of the positive predictive value of a rapid Immunochromatographic test to detect Campylobacter in stools
    Pauline Floch
    Universite de Bordeaux, French National Reference Center for Campylobacters, 33076, Bordeaux, France
    Gut Pathog 4:17. 2012
    ..The PPV was 80.6%. We conclude that ICT is a good method to screen Campylobacter positive stools but because of its lack of specificity the positive stools must be tested by another method...
  3. pmc Geographic distribution of methyltransferases of Helicobacter pylori: evidence of human host population isolation and migration
    Filipa F Vale
    Engineering Faculty, Portuguese Catholic University, Estrada Octávio Pato, 2635 631 Rio de Mouro, Portugal
    BMC Microbiol 9:193. 2009
    ..To evaluate if R-M systems are an adequate tool to determine the geographic distribution of H. pylori strains, we typed 221 strains from Africa, America, Asia, and Europe, and evaluated the expression of different 29 methyltransferases...
  4. pmc Allelic diversity and phylogeny of homB, a novel co-virulence marker of Helicobacter pylori
    Monica Oleastro
    Departamento de Doenças Infecciosas, Instituto Nacional Saúde Dr Ricardo Jorge, Av Padre Cruz, 1649 016 Lisboa, Portugal
    BMC Microbiol 9:248. 2009
    ..This study investigated the distribution of homB and homA genes in 455 H. pylori strains from East Asian and Western countries, and carried out sequence comparison and phylogenetic analyses...
  5. pmc First multi-locus sequence typing scheme for Arcobacter spp
    William G Miller
    Produce Safety and Microbiology Research Unit, Agricultural Research Service, US Department of Agriculture, Albany, CA 94710, USA
    BMC Microbiol 9:196. 2009
    ..Here, we describe the first Arcobacter multilocus sequence typing (MLST) method for A. butzleri, A. cryaerophilus, A. skirrowii, A. cibarius and A. thereius...
  6. pmc From array-based hybridization of Helicobacter pylori isolates to the complete genome sequence of an isolate associated with MALT lymphoma
    Jean Michel Thiberge
    Institut Pasteur, Unité postulante de Pathogenèse de Helicobacter, Paris, France
    BMC Genomics 11:368. 2010
    ..To determine whether certain combinations of genetic markers can be used to predict the clinical source of the infection, we analyzed well documented and geographically homogenous clinical isolates using a comparative genomics approach...
  7. pmc Ancestral European roots of Helicobacter pylori in India
    S Manjulata Devi
    Pathogen Evolution Group, Centre for DNA Fingerprinting and Diagnostics, Hyderabad, India
    BMC Genomics 8:184. 2007
    ..pylori. We tried to address these issues through mapping genetic origins of present day H. pylori in India and their genomic comparison with hundreds of isolates from different geographic regions...
  8. ncbi request reprint Impact of Helicobacter pylori virulence on the outcome of gastroduodenal diseases: lessons from the microbiologist
    F Megraud
    Laboratoire de Bacteriologie, Hopital Pellegrin, Bordeaux, France
    Dig Dis 19:99-103. 2001
    ..pylori strains. Indeed, both are often found simultaneously, but it may well be that the combination of the two, with specific adherence properties, increases even more the pathogenicity of the strains...
  9. pmc Disease association with two Helicobacter pylori duplicate outer membrane protein genes, homB and homA
    Monica Oleastro
    INSERM U853, 33076 Bordeaux, France
    Gut Pathog 1:12. 2009
    ..CONCLUSION: The global results suggest that homB and homA contribute to the determination of clinical outcome...
  10. ncbi request reprint Resistance of Helicobacter pylori to antibiotics and its impact on treatment options
    F Megraud
    Laboratoire de Bacteriologie, Hopital Pellegrin, Bordeaux, France
    Drug Resist Updat 4:178-86. 2001
    ..The situation for the rare cases of amoxicillin resistance is not fully determined. The impact of resistance on the clinical outcome is dramatic for clarithromycin while it only decreases the success by 20% for metronidazole...
  11. ncbi request reprint Basis for the management of drug-resistant Helicobacter pylori infection
    Francis Megraud
    Laboratoire de Bacteriologie, Universite Victor Segalen Bordeaux 2, Bordeaux, France
    Drugs 64:1893-904. 2004
    ..pylori infection, a practical limitation is the availability of the drugs in certain countries. Furthermore, the progressive increase in drug resistance warrants the need for new antibacterials in the near future...
  12. ncbi request reprint Helicobacter pylori resistance to antibiotics: prevalence, mechanism, detection. What's new?
    Francis Megraud
    Laboratoire de Bacteriologie, Universite Victor Segalen Bordeaux 2, Hopital Pellegrin, Place Amelie Raba Leon, 33076 Bordeaux Cedex, France
    Can J Gastroenterol 17:49B-52B. 2003
    ....
  13. pmc H pylori antibiotic resistance: prevalence, importance, and advances in testing
    F Megraud
    Laboratoire de Bacteriologie, Hopital Pellegrin, Place Amelie Raba Leon, 33076 Bordeaux Cedex, France
    Gut 53:1374-84. 2004
  14. ncbi request reprint [Helicobacter pylori, gastric inflammation and its consequences]
    Fr Mégraud
    Laboratoire de Bacteriologie, Hopital Pellegrin, Place Amelie Raba Leon, F33076 Bordeaux Cedex
    Ann Pharm Fr 61:282-7. 2003
    ..The maximum risk to develop a gastric cancer occurs for subjects harboring certain alleles of the interleukin 1B and H. pylori strains with the cag pathogenicity island...
  15. ncbi request reprint [When and how does Helicobacter pylori infection occur?]
    Francis Megraud
    Centre national de référence des Campylobacters et Helicobacters, Laboratoire de Bacteriologie, Universite Victor Segalen Bordeaux 2, Bordeaux
    Gastroenterol Clin Biol 27:374-9. 2003
    ..To the contrary, in developed countries, factors for a fecal-oral transmission seems to have disappeared, which is in agreement with a currently rare transmission rate, and probably essentially via the oral-oral route...
  16. pmc Helicobacter pylori and antibiotic resistance
    Francis Megraud
    Laboratoire de Bacteriologie, CHU Pellegrin, 33076 Bordeaux Cedex, France
    Gut 56:1502. 2007
  17. ncbi request reprint Helicobacter pylori and gastric cancer prevention is possible
    Francis Megraud
    Universite Victor Segalen Bordeaux 2, National Reference Center for Campylobacters and Helicobacters, Laboratoire de Bacteriologie, Universite Victor Segalen Bordeaux 2, 33076 Bordeaux Cedex, France
    Cancer Detect Prev 28:392-8. 2004
    ..pylori are now stronger than before, given the availability of simple and accurate diagnostic tests (serology) and treatment follow-up (urea breath test), as well as a 7-day treatment which is usually sufficient for eradication...
  18. ncbi request reprint Evolution of Helicobacter pylori research as observed through the workshops of the European Helicobacter Study Group
    Francis Megraud
    INSERM U853, F33076 Bordeaux, France, and Université Victor Segalen Bordeaux 2, F33076 Bordeaux, France
    Helicobacter 12:1-5. 2007
    ..Some landmarks have been highlighted. These data constitute an important source of information with regard to the evolution of Helicobacter pylori research over these 20 years...
  19. doi request reprint [Helicobacter pylori: bacteriological aspects, diagnostic methods, and susceptibility to antibiotics]
    Francis Megraud
    INSERM U853, F 33076 Bordeaux cedex, France
    Presse Med 37:507-12. 2008
    ..Macrolide susceptibility testing by culture or molecular methods is now necessary before prescribing clarithromycin, because of the high prevalence of this resistance...
  20. pmc Helicobacter pylori detection and antimicrobial susceptibility testing
    Francis Megraud
    INSERM U853, and Université Victor Segalen Bordeaux 2, and Laboratoire de Bacteriologie, Hopital Pellegrin, Place Amelie Raba Leon, 33076 Bordeaux Cedex, France
    Clin Microbiol Rev 20:280-322. 2007
    ..The aim of this article is to review the current status of these methods and their application, highlighting the important progress which has been made in the past decade. Both invasive and noninvasive techniques will be reviewed...
  21. ncbi request reprint Review article: the treatment of refractory Helicobacter pylori infection
    F Megraud
    Laboratoire de Bacteriologie, Universite Victor Segalen Bordeaux, Bordeaux, France
    Aliment Pharmacol Ther 17:1333-43. 2003
    ..However, the best approach remains the prevention of refractory H. pylori infection and, for this purpose, antimicrobial susceptibility testing before first-line therapy is important and should be encouraged...
  22. doi request reprint [Helicobacter pylori infection: Review and practice]
    Francis Megraud
    INSERM U853, Centre national de référence des Campylobacters et Helicobacters, Universite Victor Segalen Bordeaux 2, 33076 Bordeaux, France
    Presse Med 39:815-22. 2010
    ..The rising rate of treatment failure following increasing resistance to clarithromycin has generated new protocols of antibiotic therapy. A policy for gastric cancer prevention by eradication ofH. pylori is currently being debated...
  23. ncbi request reprint Review article: have we found the source of Helicobacter pylori?
    F Megraud
    Laboratoire de Bacteriologie, Universite Victor Segalen Bordeaux 2, Bordeaux, France
    Aliment Pharmacol Ther 14:7-12. 2000
    ..pylori in vomitus and in faeces in the event of diarrhoea...
  24. ncbi request reprint Strategies to treat patients with antibiotic resistant Helicobacter pylori
    F Megraud
    Laboratoire de Bacteriologie, Hopital Pellegrin, Place Amelie Raba Leon, 33076 Bordeaux Cedex, France
    Int J Antimicrob Agents 16:507-9. 2000
    ..The only therapy without clarithomycin and metronidazole includes rifabutin and amoxicillin. Dual therapies with amoxicillin and a proton pump inhibitor at high dose can also be used...
  25. ncbi request reprint A humble bacterium sweeps this year's Nobel Prize
    Francis Megraud
    INSERM ERI 10, Laboratoire de Bacteriologie, Universite Victor Segalen Bordeaux 2, Bordeaux, France
    Cell 123:975-6. 2005
  26. doi request reprint Evaluation of the clinical significance of homB, a novel candidate marker of Helicobacter pylori strains associated with peptic ulcer disease
    Monica Oleastro
    Departamento de Doenças Infecciosas, Instituto Nacional Saúde Dr Ricardo Jorge, Lisbon, Portugal
    J Infect Dis 198:1379-87. 2008
    ..homB codes for a putative Helicobacter pylori outer membrane protein and has previously been associated with peptic ulcer disease (PUD) in children...
  27. pmc DPO multiplex PCR as an alternative to culture and susceptibility testing to detect Helicobacter pylori and its resistance to clarithromycin
    Philippe Lehours
    Universite de Bordeaux, Centre National de Référence des Campylobacters et des Hélicobacters, 146 rue Leo Saignat, 33000 Bordeaux, France
    BMC Gastroenterol 11:112. 2011
    ..pylori ACE detection designed to detect H. pylori and two types of point mutations causing clarithromycin resistance in H. pylori...
  28. ncbi request reprint Comparison of non-invasive tests to detect Helicobacter pylori infection in children and adolescents: results of a multicenter European study
    Francis Megraud
    Universite Victor Segalen Bordeaux 2, 33076 Bordeaux, France
    J Pediatr 146:198-203. 2005
    ..To compare the current non-invasive tests for Helicobacter pylori infection in children and adolescents...
  29. pmc cagA Status and eradication treatment outcome of anti-Helicobacter pylori triple therapies in patients with nonulcer dyspepsia
    N Broutet
    Laboratoire de Bacteriologie, Universite Victor Segalen Bordeaux 2, Bordeaux, France
    J Clin Microbiol 39:1319-22. 2001
    ..However, the type of histological lesions which it causes in the gastric mucosa may be implicated. Regardless of the mechanism involved, cagA status is a good predictive marker of eradication outcome...
  30. doi request reprint Gastric carcinogenesis and Helicobacter pylori infection
    Christine Varon
    INSERM U853, Universite Victor Segalen, Bordeaux, France
    Methods Mol Biol 511:237-65. 2009
    ..On the host side, tissue microarray, immunohistochemistry and chromogenic in situ hybridization (CISH) are described...
  31. ncbi request reprint Ranitidine bismuth citrate can help to overcome Helicobacter pylori resistance to clarithromycin in vivo
    F Megraud
    Laboratoire de Bacteriologie, Hopital Pellegrin, Bordeaux, France
    Helicobacter 5:222-6. 2000
    ..Helicobacter pylori eradication usually fails when clarithromycin is used against resistant strains...
  32. ncbi request reprint Resistance of Helicobacter pylori to antibiotics: the main limitation of current proton-pump inhibitor triple therapy
    F Megraud
    Laboratoire de Bacteriologie, Hopital Pellegrin, Bordeaux, France
    Eur J Gastroenterol Hepatol 11:S35-7; discussion S43-5. 1999
    ..The addition of omeprazole improved the efficacy of metronidazole-clarithromycin dual therapy. The best way to prevent resistance is to obtain the highest possible eradication rate...
  33. ncbi request reprint Second-line treatment for failure to eradicate Helicobacter pylori: a randomized trial comparing four treatment strategies
    H Lamouliatte
    Service des Maladies de l Appareil digestif, Hôpital St André, Bordeaux, France
    Aliment Pharmacol Ther 18:791-7. 2003
    ..To compare the efficacy of different regimens in patients in whom previous Helicobacter pylori eradication therapy has failed...
  34. pmc Association of Helicobacter species with hepatitis C cirrhosis with or without hepatocellular carcinoma
    M Rocha
    Universite Victor Segalen Bordeaux 2, Laboratoire de Bacteriologie, Bat 2B RDC Zone Nord, 33076 Bordeaux Cedex, France
    Gut 54:396-401. 2005
    ..A retrospective cross sectional study was performed in order to explore the association between Helicobacter species and HCV associated liver diseases...
  35. ncbi request reprint Detection of Helicobacter pylori DNA in human feces by PCR: DNA stability and removal of inhibitors
    L Monteiro
    , , Bordeaux, France
    J Microbiol Methods 45:89-94. 2001
    ..In conclusion, this study confirms that H. pylori DNA degrades with time in stools. A diet free of plant material or a special DNA preparation can be used to remove inhibitors and to allow the detection of H. pylori...
  36. pmc Antimicrobial susceptibility testing of Helicobacter pylori in a large multicenter trial: the MACH 2 study
    F Megraud
    Laboratoire de Bacteriologie, Hopital Pellegrin, Bordeaux, France
    Antimicrob Agents Chemother 43:2747-52. 1999
    ..Mutations (A2142G and 2143G) were found in all strains tested except one. This study stresses the importance of performing susceptibility tests in clinical trials in order to explain the results of different treatments...
  37. ncbi request reprint Should we eradicate Helicobacter pylori before prescribing an NSAID? Result of a placebo-controlled study
    T Schaeverbeke
    Service de Rhumatologie, Hopital Pellegrin, Bordeaux Cedex, France
    Am J Gastroenterol 100:2637-43. 2005
    ..pylori eradication on these symptoms...
  38. ncbi request reprint Evaluation of the performance of the Helico Blot 2.1 as a tool to investigate the virulence properties of Helicobacter pylori
    L Monteiro
    Laboratoire de Bacteriologie, Universite Victor Segalen Bordeaux 2, France
    Clin Microbiol Infect 8:676-9. 2002
    ..1 kit. Considering the results obtained by PCR, Helico Blot 2.1 presented sensitivity, specificity, and positive and negative predictive values for CagA status of 97.4%, 87.7%, 80.9% and 98.5%, respectively...
  39. ncbi request reprint Effects of Helicobacter pylori infection on gut appetite peptide (leptin, ghrelin) expression in elderly inpatients
    Nathalie Salles
    INSERM ERI 10, Laboratoire de Bacteriologie, Universite Victor Segalen Bordeaux 2, Bat 2B RDC Zone Nord, 33076 Bordeaux Cedex, France
    J Gerontol A Biol Sci Med Sci 61:1144-50. 2006
    ..34; p = .018). The negative association between ghrelin and H. pylori infection may be related to a higher prevalence of atrophy and raises the possibility that H. pylori may be contributing to undernutrition in some older people...
  40. ncbi request reprint Current management of Helicobacter pylori infections in the elderly
    Nathalie Salles
    Pôle de Gérontologie Clinique, Hopital Xavier Arnozan, CHU Bordeaux, 33604 Pessac, France
    Expert Rev Anti Infect Ther 5:845-56. 2007
    ..Low compliance is the main factor related to treatment failure in this population...
  41. ncbi request reprint Clinical, histological and molecular follow-up of 60 patients with gastric marginal zone lymphoma of mucosa-associated lymphoid tissue
    Antoine de Mascarel
    Department of Pathology, University Victor Segalen Bordeaux 2, Hopital Haut Leveque, 33604 Pessac Cedex, France
    Virchows Arch 446:219-24. 2005
    ..The presence of monoclonal B cells at both infiltrated and normal sites may therefore identify patients with a longer delay to achieve complete response, suggesting that molecular dissemination may require therapeutic intensification...
  42. pmc Nitazoxanide, a potential drug for eradication of Helicobacter pylori with no cross-resistance to metronidazole
    F Megraud
    Laboratoire de Bacteriologie, Hopital Pellegrin, 33076 Bordeaux Cedex, France
    Antimicrob Agents Chemother 42:2836-40. 1998
    ..It is therefore a good candidate to be included in treatment regimens aimed at the eradication of H. pylori...
  43. doi request reprint Association between entero-hepatic Helicobacter species and Crohn's disease: a prospective cross-sectional study
    D Laharie
    INSERM, U853, Bordeaux, Univ Bordeaux 2, Bordeaux, France
    Aliment Pharmacol Ther 30:283-93. 2009
    ..Aim To look for an association between CD and the presence of EHH DNA in intestinal biopsies...
  44. pmc Evaluation of performances of three DNA enzyme immunoassays for detection of Helicobacter pylori PCR products from biopsy specimens
    L Monteiro
    Laboratoire de Bacteriologie, Universite de Bordeaux 2, France
    J Clin Microbiol 35:2931-6. 1997
    ..The detection of PCR products by colorimetric hybridization increases the sensitivity up to 100-fold compared to that with gel electrophoresis. The results are rapid (4 h) and easy to interpret and can be automated...
  45. ncbi request reprint What is the role of serology in assessing Helicobacter pylori eradication?
    B Bergey
    Laboratoire de Bacteriologie, Universite Victor Segalen Bordeaux 2, Bordeaux, France
    Aliment Pharmacol Ther 18:635-9. 2003
    ..To assess the decline in Helicobacter pylori antibodies after eradication of infection...
  46. doi request reprint Diagnosis of Helicobacter pylori infection
    Lurdes Monteiro
    Departamento de Doenças Infecciosas, Instituto Nacional Saúde Dr Ricardo Jorge, Lisbon, Portugal
    Helicobacter 14:8-14. 2009
    ..pylori and its clarithromycin resistance, either by polymerase chain reaction or fluorescent in-situ hybridization. For the first time, there was a report on a possible interest of magnetic resonance spectroscopy...
  47. pmc Pepsinogen A, pepsinogen C, and gastrin as markers of atrophic chronic gastritis in European dyspeptics
    N Broutet
    Unité d Epidémiologie des Maladies Digestives, Universite Victor Segalen Bordeaux, Cedex, France
    Br J Cancer 88:1239-47. 2003
    ..7, with sensitivity 77.1% and specificity 87.4%. The results suggested that only the PGA/PGC ratio can be considered as a biomarker for precancerous lesions of the stomach, and may be useful as a screening test...
  48. ncbi request reprint Risk factors for failure of Helicobacter pylori therapy--results of an individual data analysis of 2751 patients
    N Broutet
    Unité d Epidémiologie des Maladies Digestives, Laboratoire de Bacteriologie, Universite Victor Segalen Bordeaux 2, 146 rue Leo Saignat, 33076 Bordeaux Cedex, France
    Aliment Pharmacol Ther 17:99-109. 2003
    ..To study risk factors for failure of Helicobacter pylori eradication treatment...
  49. ncbi request reprint Investigation of an outbreak due to Alcaligenes xylosoxydans subspecies xylosoxydans by random amplified polymorphic DNA analysis
    P Lehours
    Laboratoire de Bacteriologie, Hopital Pellegrin, Bordeaux, France
    Eur J Clin Microbiol Infect Dis 21:108-13. 2002
    ..RAPD analysis proved to be more discriminant than biotyping or antibiotyping in this context and identified the common source of the outbreak...
  50. ncbi request reprint Comparison of tests for assessment of Helicobacter pylori eradication: results of a multi-centre study using centralized facility testing
    F Megraud
    Laboratoire de Bacteriologie, Hopital Pellegrin, Bordeaux, France
    Eur J Gastroenterol Hepatol 12:629-33. 2000
    ..The accuracy of diagnostic tests to assess Helicobacter pylori eradication has rarely been performed...
  51. pmc Identification of a genetic marker of Helicobacter pylori strains involved in gastric extranodal marginal zone B cell lymphoma of the MALT-type
    P Lehours
    Laboratoire de Bacteriologie, Universite Victor Segalen Bordeaux 2, Bordeaux, France
    Gut 53:931-7. 2004
    ..Currently, no bacterial factor has been associated with the development of this disease. Our aim was to identify genes associated with lymphoma development...
  52. ncbi request reprint Long-term effects of Helicobacter pylori eradication on gastric antral mucosa in duodenal ulcer patients
    F Zerbib
    Department of Gastroenterology, Saint Andre Hospital, Bordeaux, France
    Eur J Gastroenterol Hepatol 12:719-25. 2000
    ..The aim of this study was to assess the consequences of prolonged Helicobacter pylori eradication on gastric antral mucosa in duodenal ulcer patients...
  53. doi request reprint Modulation of lymphocyte proliferation induced by gastric MALT lymphoma-associated Helicobacter pylori strains
    Jonathan Ferrand
    INSERM U853, Bordeaux, F 33076 France, and Université Victor Segalen Bordeaux 2, Bordeaux, F33076, France
    Helicobacter 13:167-73. 2008
    ..Our aim was to characterize the effects of mucosa-associated lymphoid tissue (MALT) associated H. pylori strains on lymphocyte proliferation...
  54. pmc Identification of markers for Helicobacter pylori strains isolated from children with peptic ulcer disease by suppressive subtractive hybridization
    Monica Oleastro
    Unidade Helicobacter Campylobacter, Centro de Bacteriologia, Instituto Nacional Saúde Dr Ricardo Jorge, Av Padre Cruz 1649 016 Lisbon, Portugal
    Infect Immun 74:4064-74. 2006
    ..pylori...
  55. ncbi request reprint Lewis antigen expression and other pathogenic factors in the presence of atrophic chronic gastritis in a European population
    Nathalie Broutet
    Unité d Epidémiologie des Maladies Digestives, Laboratoire de Bacteriologie, Universite Victor Segalen Bordeaux 2, Bordeaux, France
    J Infect Dis 185:503-12. 2002
    ..7%). Among patients with ACG, 54% of their isolates were from cluster s1m1/cagA(+)/Le(x)+/Le(y)+, which was associated with the presence of ACG (odds ratio, 7.4; 95% confidence interval, 1.5-37.0)...
  56. pmc Evaluation of the association of nine Helicobacter pylori virulence factors with strains involved in low-grade gastric mucosa-associated lymphoid tissue lymphoma
    Philippe Lehours
    Laboratoire de Bacteriologie, Universite Victor Segalen Bordeaux 2, Bordeaux, France
    Infect Immun 72:880-8. 2004
    ..Our data confirmed that H. pylori virulence factors are correlated with one another. If the involvement of H. pylori in MALT lymphoma is well established, the pathomechanism by which gastric lymphoma occurs remains to be identified...
  57. pmc Is there a link between the lipopolysaccharide of Helicobacter pylori gastric MALT lymphoma associated strains and lymphoma pathogenesis?
    Philippe Lehours
    INSERM, U853, Bordeaux, France
    PLoS ONE 4:e7297. 2009
    ..In conclusion, cagPAI (-) MALT strains have a particular Lewis antigen profile which could represent an adaptive mechanism to the host response or participate in MALT lymphomagenesis...
  58. ncbi request reprint Primary Lung Small B-Cell Lymphoma versus Lymphoid Hyperplasia: Evaluation of Diagnostic Criteria in 26 Cases
    Hugues Begueret
    Department of Pathology and Molecular Biology, Universite de Bordeaux, Bordeaux, France
    Am J Surg Pathol 26:76-81. 2002
    ..4% of the mucosa-associated lymphoid tissue-type lymphoma specimens. Investigation of H. pylori by polymerase chain reaction detection was negative, even for the two cases associated with H. pylori gastritis...
  59. pmc Clinical relevance and diversity of two homologous genes encoding glycosyltransferases in Helicobacter pylori
    Monica Oleastro
    Departamento de Doenças Infecciosas, Instituto Nacional Saúde Dr Ricardo Jorge, Lisbon, Portugal
    J Clin Microbiol 48:2885-91. 2010
    ..Overall, the results of this study suggest that the jhp0562 gene is of great clinical relevance, being a useful comarker for severe H. pylori-related disease and contributing to host adaptation...
  60. doi request reprint Study of Helicobacter pullorum proinflammatory properties on human epithelial cells in vitro
    C Varon
    INSERM U853, Bordeaux, France
    Gut 58:629-35. 2009
    ..The aim of the present study was to determine whether H pullorum exerts a direct effect on human intestinal epithelial cells in vitro and to characterise the bacterial mechanisms and the signalling pathways involved...
  61. ncbi request reprint Diagnosis of Helicobacter pylori infection: noninvasive methods compared to invasive methods and evaluation of two new tests
    L Monteiro
    , , Bordeaux 2, France
    Am J Gastroenterol 96:353-8. 2001
    ..The noninvasive tests are accurate for the diagnosis of H. pylori infection. Helicoblot 2.1 performed as well as the best ELISA kit. The HpSA is a promising direct noninvasive test that can be applied easily to evaluate H. pylori status...
  62. pmc Evaluation of moxalactam with the BD phoenix system for detection of methicillin resistance in coagulase-negative staphylococci
    H Pupin
    CHU de Bordeaux, Hopital Pellegrin, Laboratoire de Bacteriologie, Place Amelie Raba Leon, 33076 Bordeaux, France
    J Clin Microbiol 45:2005-8. 2007
    ..For strains other than Staphylococcus saprophyticus, a moxalactam MIC >16 microg/ml was indicative of methicillin resistance...
  63. pmc Helicobacter pylori: bacterial factors and interaction with the epithelial cells
    F Megraud
    Laboratoire de Bacteriologie, Hopital Pellegrin, Bordeaux, France
    Yale J Biol Med 69:35-7. 1996
    ..pylori. This long-standing infection gives us a very good model of interaction between a bacterium and its host. We will review the direct and indirect effects of H. pylori...
  64. ncbi request reprint [Epidemiology, acquisition and transmission of Helicobacter pylori]
    F Megraud
    Centre national de référence des Campylobacters et Helicobacters, Hopital Pellegrin, Bordeaux
    Rev Prat 50:1414-7. 2000
    ..Transmission most likely occurs between humans by an oro-oral or a gastro-oral transmission. Faeco-oral transmission, either direct or via the environment, is possible but seems to be rare in France...
  65. ncbi request reprint Helicobacter pylori infection in patients consulting gastroenterologists in France: prevalence is linked to gender and region of residence
    N Broutet
    Laboratoire de Bacteriologie, Universite Victor Segalen Bordeaux 2, France
    Eur J Gastroenterol Hepatol 13:677-84. 2001
    ....
  66. pmc Composition and gene expression of the cag pathogenicity island in Helicobacter pylori strains isolated from gastric carcinoma and gastritis patients in Costa Rica
    A Occhialini
    , , 33076 Bordeaux, France
    Infect Immun 69:1902-8. 2001
    ..The virB10 homolog gene was the sole gene studied to be significantly expressed more often in cancer strains than in gastritis strains (P = 0.03)...
  67. pmc Natural history of Helicobacter hepaticus infection in conventional A/J mice, with special reference to liver involvement
    Philippe Avenaud
    Laboratoire de Bacteriologie, Universite Victor Segalen Bordeaux 2, France
    Infect Immun 71:3667-72. 2003
    ..The evolution towards hepatocarcinoma is not always the endpoint and may depend on the bacterial strain and on the environmental conditions...
  68. ncbi request reprint Detection of mutations associated with macrolide resistance in thermophilic Campylobacter spp. by real-time PCR
    Sylvie Vacher
    Centre National de Référence des Helicobacters et Campylobacters, Laboratoire de Bacteriologie, Hopital Pellegrin, Bordeaux, France
    Microb Drug Resist 11:40-7. 2005
    ..1%). This assay is more sensitive and more rapid than other PCR assays, the entire procedure taking less than 2 hr...
  69. ncbi request reprint [Helicobacter pylori infection as a cause of extra-digestive diseases: myth or reality?]
    Frédérique Richy
    Centre national de référence des Campylobacters et Helicobacters, Laboratoire de Bacteriologie, Universite de Bordeaux 2, 33076 Bordeaux Cedex
    Gastroenterol Clin Biol 27:459-66. 2003
    ..pylori infection and the pathogenic processes of these extra-digestive diseases...
  70. doi request reprint CTX-M-producing Escherichia coli in a maternity ward: a likely community importation and evidence of mother-to-neonate transmission
    Veronique Dubois
    UMR 5234, CNRS, 33076 Bordeaux, France
    J Antimicrob Chemother 65:1368-71. 2010
    ....
  71. ncbi request reprint Genetic diversity of the HpyC1I restriction modification system in Helicobacter pylori
    Philippe Lehours
    INSERM U853, 33076 Bordeaux Cedex, France
    Res Microbiol 158:265-71. 2007
    ....
  72. ncbi request reprint Nucleotide sequence of the gyrA gene of Arcobacter species and characterization of human ciprofloxacin-resistant clinical isolates
    Khalil Abdelbaqi
    Universite Victor Segalen Bordeaux 2, Centre national de référence des Campylobacters et Helicobacters, Laboratoire de Bacteriologie, Bordeaux, France
    FEMS Immunol Med Microbiol 49:337-45. 2007
    ..In addition, a Thr-->Ile mutation at amino acid 85 in the quinolone resistance-determining region was associated with ciprofloxacin resistance for two A. butzleri and one A. cryaerophilus ciprofloxacin-resistant strains...
  73. pmc Development of a real-time fluorescence resonance energy transfer PCR to detect arcobacter species
    Khalil Abdelbaqi
    Universite Victor Segalen Bordeaux 2, Centre National de Référence des Helicobacters et Campylobacters, F33076 Bordeaux, France
    J Clin Microbiol 45:3015-21. 2007
    ..The assay is economical since only one biprobe is used and multiple Arcobacter species are identified in a single test...
  74. ncbi request reprint Helicobacter pylori infection and gastric MALT lymphoma
    P Lehours
    INSERM ERI 10, Centre National de Réfrénce des Campylobacters et Hélicobacters Laboratoire de Bactériologie, CHU Pellegrin, Bordeaux, France
    Rocz Akad Med Bialymst 50:54-61. 2005
    ..pylori infection towards lymphoma is exceptional. Host susceptibility factors and environmental factors predisposing a patient to lymphoma have not yet been determined. The bacterial factors are currently being identified...
  75. pmc Complex polysaccharides as PCR inhibitors in feces: Helicobacter pylori model
    L Monteiro
    Laboratoire de Bacteriologie, Universite de Bordeaux 2, France
    J Clin Microbiol 35:995-8. 1997
    ..Inhibitors, separated on an Ultrogel AcA44 column, were characterized. Inhibitors in feces are complex polysaccharides possibly originating from vegetable material in the diet...
  76. pmc New methods for detection of campylobacters in stool samples in comparison to culture
    Emilie Bessède
    C H U de Bordeaux, Hopital Pellegrin, Laboratoire de Bacteriologie, 33076 Bordeaux Cedex, France
    J Clin Microbiol 49:941-4. 2011
    ..The striking feature of this study is the low sensitivity of culture, in the range of 60%, in contrast to immunoenzymatic and molecular tests...
  77. pmc The rtxA toxin gene of Kingella kingae: a pertinent target for molecular diagnosis of osteoarticular infections
    Philippe Lehours
    CHU de Bordeaux, Hopital Pellegrin, Laboratoire de Bacteriologie, Bordeaux, France
    J Clin Microbiol 49:1245-50. 2011
    ..The results obtained demonstrate that these assays are accurate for the diagnosis of Kingella kingae infection...
  78. pmc First report of septic arthritis caused by Klebsiella oxytoca
    Armelle Menard
    Laboratoire de Bacteriologie, Hôpital Pellegrin et Hôpital des Enfants, CHU Bordeaux, France
    J Clin Microbiol 48:3021-3. 2010
    ..Despite an initial antibiotic treatment failure, a second treatment led to a cure of the infection with no joint sequelae...
  79. ncbi request reprint Identification of strain-specific genes located outside the plasticity zone in nine clinical isolates of Helicobacter pylori
    Grettel Chanto
    Laboratoire de Bacteriologie, Université Victor Segalen Bordeaux 2 and Hôpital Pellegrin, Place Amelie Raba Leon, 33076 Bordeaux Cedex, France
    Microbiology 148:3671-80. 2002
    ..Of these six genes, five were putative genes and one was an orthologue of a gene encoding a transposase in Thermotoga maritima. However, no association with disease was found for these genes...
  80. ncbi request reprint Evaluation of the homologous recombination in Helicobacter pylori
    Slovénie Pyndiah
    INSERM ESPRI 2004, Laboratoire de Bacteriologie, UniversitéVictor Segalen Bordeaux 2, 33076 Bordeaux Cedex, France
    Helicobacter 10:185-92. 2005
    ..Most strategies for direct mutagenesis of Helicobacter pylori primarily involve genomic DNA cloning which is a time-consuming and expensive technique...
  81. ncbi request reprint Effect of rebamipide on the colonic barrier in interleukin-10-deficient mice
    David Laharie
    INSERM ERI 10, Universite Victor Segalen, Bordeaux, France
    Dig Dis Sci 52:84-92. 2007
    ..These properties could be helpful in the management of some inflammatory bowel diseases...
  82. pmc A variable gene in a conserved region of the Helicobacter pylori genome: isotopic gene replacement or rapid evolution?
    Armelle Menard
    INSERM U853, Laboratoire de Bacteriologie, Universite Victor Segalen Bordeaux 2, 146 rue Leo Saignat, F 33076 Bordeaux cedex, France
    DNA Res 15:163-8. 2008
    ..The CDSs identified in the present study could be used as strain specific markers...
  83. ncbi request reprint Development of a real-time fluorescence resonance energy transfer PCR to identify the main pathogenic Campylobacter spp
    A Menard
    Laboratoire de Bacteriologie, Universite Victor Segalen Bordeaux 2, France
    Clin Microbiol Infect 11:281-7. 2005
    ..10% of isolates. It was concluded that the FRET assays were rapid, reliable, reproducible and relatively cost-efficient, as they require only one biprobe and can be performed directly on boiled isolates...
  84. ncbi request reprint Development of a real-time PCR for the identification of Bordetella pertussis and Bordetella parapertussis
    A Menard
    Laboratoire de Bacteriologie, Bordeaux, France
    Clin Microbiol Infect 13:419-23. 2007
    ..The new assay was sensitive and specific, and can be implemented easily using any real-time PCR apparatus...
  85. ncbi request reprint Detecting Helicobacter pylori infection in hospitalized frail older patients: the challenge
    Nathalie Salles-Montaudon
    Department of Geriatrics, Hopital Xavier Arnozan, Pessac, France
    J Am Geriatr Soc 50:1674-80. 2002
    ..The aim of our study was to evaluate the prevalence of the infection in this population using five H. pylori diagnostic tests...
  86. pmc The cag pathogenicity island of Helicobacter pylori is disrupted in the majority of patient isolates from different human populations
    Farhana Kauser
    Pathogen Evolution Group, Center for DNA Fingerprinting and Diagnostics, Hyderabad 500 076, India
    J Clin Microbiol 42:5302-8. 2004
    ..Analysis of the cag-PAI genotypes with a different biogeoclimatic history will contribute to our understanding of the pathogen-host interaction in health and disease...
  87. ncbi request reprint Update on fluoroquinolone resistance in Helicobacter pylori: new mutations leading to resistance and first description of a gyrA polymorphism associated with hypersusceptibility
    Vincent Cattoir
    Laboratoire de bactériologie virologie hygiène, Centre Hospitalier, Universitaire Henri Mondor, Assistance Publique Hopitaux de Paris, Universite Paris XII, Creteil, France
    Int J Antimicrob Agents 29:389-96. 2007
    ..The high rate of quinolone resistance in H. pylori requires the use/implication of a 'test and treat' strategy that can confidently rely on QRDR gyrA sequencing...
  88. ncbi request reprint Eradication therapy for Helicobacter pylori
    Nimish Vakil
    Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA
    Gastroenterology 133:985-1001. 2007
    ..In this article, we discuss the epidemiology and cellular mechanisms that result in antimicrobial resistance, the results of current eradication therapies, and new approaches to the management of Helicobacter pylori infection...
  89. doi request reprint A comparison of antimicrobial usage in human and veterinary medicine in France from 1999 to 2005
    Gérard Moulin
    AFSSA ANMV French Agency for Veterinary Medicinal Products, Fougeres, France
    J Antimicrob Chemother 62:617-25. 2008
    ..The antimicrobials allowed and amounts sold in veterinary and human medicine in France were compared to see if the same antimicrobial drugs are used in veterinary and human medicine, and to the same extent...
  90. ncbi request reprint Bioinformatic analysis of Helicobacter pylori XGPRTase: a potential therapeutic target
    Megan Duckworth
    School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales, Australia
    Helicobacter 11:287-95. 2006
    ..The aims of this work were to investigate the structure of H. pylori XGPRTase and to compare the key features of the enzyme to other phosphoribosyltransferases employing computational, modelling, and bioinformatic tools...
  91. pmc Fatal relapse of a purulent pleurisy caused by Campylobacter fetus subsp. fetus
    Jean Winoc Decousser
    Department of Biology, Centre Hospitalier de Dourdan, 91415 Dourdan, France
    J Clin Microbiol 45:2334-6. 2007
    ..Bacteremia has been well described, but pleurisy remains very uncommon. We report the recurrent isolation of a C. fetus subsp. fetus strain during two episodes of pleural effusion with a fatal outcome...