Research Topics
Species | Paul-Michel MertesSummaryAffiliation: CHU de Nancy Country: France Publications
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Detail Information
Publications
Anaphylaxis to dyes during the perioperative period: reports of 14 clinical casesPaul Michel Mertes
Service d Anesthesie Reanimation, Hopital Central, Centre Hospitalier Universitaire de Nancy, Nancy, France
J Allergy Clin Immunol 122:348-52. 2008..Vital dyes are widely used for lymphatic mapping and sentinel lymph node biopsy in patients with malignant tumors, and reports of anaphylactic reactions are becoming more frequent...
Hypersensitivity reactions in the anesthesia setting/allergic reactions to anestheticsPaul M Mertes
CHU de Nancy, Service d Anesthésie Réanimation Chirurgicale, INSERM U 911 Groupe Choc, Hopital Central, Nancy, France
Curr Opin Allergy Clin Immunol 12:361-8. 2012..Immediate hypersensitivity reactions are an important cause for mortality and morbidity in anesthesia. The present review considers reports covering epidemiology, diagnosis, and treatment of these reactions...
[Cardiac complications of acute brain injury]P M Mertes
Service d Anesthesie Reanimation, CHU de Nancy, Hopital Central, 29, avenue de Lattre de Tassigny, 54035 Nancy Cedex, France
Ann Fr Anesth Reanim 31:e91-6. 2012..This report summarizes the main data available regarding the cardiovascular consequences of brain death, traumatic brain injury, stroke and epilepsy...
Hypersensitivity reactions during anesthesia. Results from the ninth French survey (2005-2007)S W Dong
INSERM U 911, Groupe CHOC, Hopital Central, Nancy, France
Minerva Anestesiol 78:868-78. 2012..We report the results of the ninth consecutive survey of hypersensitivity reactions observed during anesthesia in France. This report will be used as an epidemiologic reference prior to this intervention...
The ethical and legal aspects of palliative sedation in severely brain-injured patients: a French perspectiveAntoine Baumann
Departement d Anesthesie Reanimation, Hopital Central, Centre Hospitalier Universitaire de Nancy, France
Philos Ethics Humanit Med 6:4. 2011....
An optimized protocol for microarray validation by quantitative PCR using amplified amino allyl labeled RNACéline Jeanty
Laboratory of Cardiovascular Research, Centre de Recherche Public Santé, Luxembourg
BMC Genomics 11:542. 2010..To test this possibility, we used an ongoing study of our laboratory aiming at identifying new biomarkers of graft rejection by the transcriptomic analysis of blood cells from brain-dead organ donors...
Anaphylaxis during anesthesia in France: an 8-year national surveyPaul Michel Mertes
Service d Anesthésie Réanimation Chirurgicale, Hopital Central, CHU de Nancy, INSERM U911 Groupe Choc, Nancy, France
J Allergy Clin Immunol 128:366-73. 2011..More attention should be paid to rare serious adverse events such as anaphylaxis to increase the safety of anesthesia...
Hypersensitivity reactions to blood components: document issued by the allergy committee of the French medicines and healthcare products regulatory agencyP M Mertes
Service d Anesthesie Reanimation, INSERM U961, Hopital Central, CHU, Nancy, France
J Investig Allergol Clin Immunol 21:171-8. 2011....
Perioperative anaphylaxisP M Mertes
Service d Anesthésie Réanimation Chirurgicale, CHU de Nancy, Hopital Central, 29 Avenue de Lattre de Tassigny, 54035 Nancy Cedex, France
Med Clin North Am 94:761-89, xi. 2010..Treatment consists of rapid volume expansion and epinephrine administration titrated to symptom severity...
Perioperative anaphylaxisP M Mertes
Service d Anesthésie Réanimation Chirurgicale, CHU de Nancy, Hopital Central, 29 Avenue de Lattre de Tassigny, Nancy Cedex 54035, France
Immunol Allergy Clin North Am 29:429-51. 2009..Diagnosis relies on tryptase measurements at the time of the reaction and skin tests and specific IgE or basophil activation assays...
Hypersensitivity reactions to neuromuscular blocking agentsP M Mertes
Departement d Anesthesie Reanimation, CHU de Nancy, Hopital Central, 29 Avenue de Lattre de Tassigny, 54035 Nancy Cedex, France
Curr Pharm Des 14:2809-25. 2008....
Skin reactions to intradermal neuromuscular blocking agent injections: a randomized multicenter trial in healthy volunteersPaul Michel Mertes
Department of Anesthesiology, Service d Anesthesie Reanimation, Hopital Central, Centre Hospitalier Universitaire de Nancy, Unité Inserm 684, Faculte de Medecine de Nancy, France
Anesthesiology 107:245-52. 2007..Numerous reports confirm the performance of intradermal tests for the diagnosis of anaphylaxis during anesthesia; however, there is controversy over their diagnostic value regarding the newer neuromuscular blocking agents (NMBAs)...
Reversal of rocuronium-induced (1.2 mg/kg) profound neuromuscular block by sugammadex: a multicenter, dose-finding and safety studyHans D de Boer
Department of Anesthesiology, Radboud University Medical Center Nijmegen, The Netherlands
Anesthesiology 107:239-44. 2007..This study investigated the efficacy and safety of sugammadex in reversing rocuronium-induced profound neuromuscular blockade at 5 min in American Society of Anesthesiologists physical status I and II patients...
Adverse reactions to neuromuscular blocking agentsPaul Michel Mertes
Departement d Anesthesie Reanimation, CHU de Nancy, Hopital Central, 29 Avenue de Lattre de Tassigny, 54035 Nancy Cedex, France
Curr Allergy Asthma Rep 4:7-16. 2004..effects have been described, such as the succinylcholine-triggered cytotoxic effects on muscle cells, but these are responsible for characteristic clinical symptoms, which are usually easy to distinguish from anaphylactic reactions..
Allergy and anaphylaxis in anaesthesiaP M Mertes
Departement of Anesthesia and Resuscitation, CHU, Hopital Central, Nancy, France
Minerva Anestesiol 70:285-91. 2004..They represent an incentive for further development of allergo-anaesthesiology clinical networks to provide expert advice for anaesthetists and allergologists...
[Anaphylactic and anaphylactoid reactions occurring during anaesthesia in France. Seventh epidemiologic survey (January 2001-December 2002)]P M Mertes
Service d Anesthésie Réanimation Chirurgicale, Hopital Central, Nancy, France
Ann Fr Anesth Reanim 23:1133-43. 2004....
Anaphylactic and anaphylactoid reactions occurring during anesthesia in France in 1999-2000Paul Michel Mertes
Department of Anesthesiology, Hopital Central, Centre Hospitalier Universitaire de Nancy, France
Anesthesiology 99:536-45. 2003..Anaphylactic and anaphylactoid reactions occurring during anesthesia remain a major cause of concern for anesthesiologists. The authors report the results of a 2-yr survey of such reactions observed during anesthesia in France...
Reducing the risk of anaphylaxis during anaesthesia: guidelines for clinical practiceP M Mertes
Service d Anesthésie Réanimation Chirurgicale, Nancy, France
J Investig Allergol Clin Immunol 15:91-101. 2005..This paper presents the main extracts of these recommendations with the most relevant clinical implications...
Successful use of terlipressin in post-cardiac arrest resuscitation after an epinephrine-resistant anaphylactic shock to suxamethoniumNicolas Rocq
, Centre Hospitalier Universitaire, Nancy, France
Anesthesiology 107:166-7. 2007
[Cerebral microdialysis as a clinical tool]G Audibert
Departement d Anesthesie Reanimation, Hopital Central, CHU de Nancy, 54000 Nancy, France
Ann Fr Anesth Reanim 25:741-7. 2006..Moreover, it permits the assessment of metabolic changes after therapeutic interventions. Finally, some markers (like lactate/pyruvate ratio) are related to outcome, especially after traumatic brain injury...
[Subarachnoid haemorrhage: epidemiology, genomic, clinical presentation]G Audibert
Service d Anesthesie Reanimation, Hopital Central, CHU de Nancy, 29, Avenue du Marechal de Lattre de Tassigny, 54000 Nancy, France
Ann Fr Anesth Reanim 26:943-7. 2007..For example, in the future, this approach could help to identify patients who are at high risk to develop vasospasm after SAH...
[Anaesthetic management of the patient with acute intracranial hypertension]G Audibert
Departement d Anesthesie Reanimation, Hopital Central, CHU de Nancy, 54000 Nancy, France
Ann Fr Anesth Reanim 24:492-501. 2005..If a long-lasting (several hours) extracranial surgery is necessary, ICP should be monitored and treatment of ICH should have been instituted before...
[Postoperative pain management on surgical wards in one university hospital: short- and medium-term effects of a quality assurance program]C Cornet
Service d Anesthesie Reanimation, Hopital Central, 29, Avenue du Marechal de Lattre de Tassigny, Co n o 34, 54035 Nancy Cedex, France
Ann Fr Anesth Reanim 26:292-8. 2007..Evaluation of the short- and medium-term impact of a postoperative pain management quality assurance programme in a university hospital...
[Monitoring of cerebral oxygenation with SvjO(2) or PtiO(2)]L M Joly
Departement d Anesthesie Reanimation, CHU de Rouen, Hopital Charles Nicolle, rue de Germont, 76031 Rouen, France
Ann Fr Anesth Reanim 25:748-54. 2006..Nor SvjO(2), nor PtiO(2) monitoring have at present been demonstrated to be associated with a clinical benefit, and their use should be restricted to scientific research...
[Unilateral spinal anaesthesia in elderly patient for hip trauma: a pilot study]M Khatouf
, , 29, , 54035 Nancy Cedex, France
Ann Fr Anesth Reanim 24:249-54. 2005..CONCLUSION: Hypobaric unilateral spinal anaesthesia is a simple technique, produces satisfactory operative conditions and induces very little haemodynamic change in the elderly population...
[Evaluation of the off-site preanaesthetic consult in Lorraine]M Rollin
, , CHU de Nancy 29, , CO no 34, 54035 Nancy Cedex, France
Ann Fr Anesth Reanim 25:927-34. 2006..CONCLUSION: Off Site preanaesthetic consult may have real benefits in terms of, patient satisfaction, comfort and cost-effectiveness. In the Lorraine region, a majority of anaesthetists has experience with this practice...
C-reactive protein induces pro- and anti-inflammatory effects, including activation of the liver X receptor alpha, on human monocytesDidier Hanriot
INSERM, U684, Nancy, France
Thromb Haemost 99:558-69. 2008..Among these novel anti-inflammatory effects, we show clearly that CRP activates the LXRalpha pathway...
[Value of skin tests for the choice of a neuromuscular blocking agent after an anaphylactic reaction]P Dewachter
Service d Anesthésie Réanimation Chirurgicale, CHU Hôpital Central, 29 Avenue du Marechal de Lattre de Tassigny, 54035 Nancy Cedex, France
Ann Fr Anesth Reanim 24:543-6. 2005..The authors underline the value of a detailed allergological assessment to identify the pathophysiologic mechanism, the culprit drug and to propose a safer alternate drug that might be used...
[Analysis of the criteria that contribute to the decision to harvest the heart in brain-dead organ donors]C Boudaa
, , CO no 34, 54035 Nancy, France
Ann Fr Anesth Reanim 22:765-72. 2003..These results should be an incentive to conceive a score that could allow a more formal decision process for heart harvesting...
Preventing complications of central venous catheterizationPascale Dewachter
N Engl J Med 348:2684-6; author reply 2684-6. 2003
