Affiliation: CHU de Grenoble
Maurin M, Hammer L, Gestin B, Timsit J, Rogeaux O, Delavena F, et al
. Quantitative real-time PCR tests for diagnostic and prognostic purposes in cases of legionellosis. Clin Microbiol Infect. 2010;16:379-84 pubmed publisher
..High bacterial loads in LRT samples at hospital admission were significantly associated with higher Fine classes, the need for hospitalization in an intensive care unit and for prolonged hospitalization...
Maurin M. Real-time PCR as a diagnostic tool for bacterial diseases. Expert Rev Mol Diagn. 2012;12:731-54 pubmed publisher
..Finally, an approach combining the detection of pathogens, their mechanisms of antibiotic resistance, their virulence factors and bacterial load in clinical samples could lead to profound changes in the care of these infected patients. ..
Caspar Y, Jeanty M, Blu J, Burchak O, Le Pihive E, Maigre L, et al
. Novel synthetic bis-indolic derivatives with antistaphylococcal activity, including against MRSA and VISA strains. J Antimicrob Chemother. 2015;70:1727-37 pubmed publisher
..We have synthesized and characterized novel bis-indole derivatives as promising candidates for the development of new antistaphylococcal treatments, with preserved activity against MDR S. aureus strains. ..
Courtois N, Caspar Y, Maurin M. Phenotypic and genetic resistance traits of Pseudomonas aeruginosa strains infecting cystic fibrosis patients: A French cohort study. Int J Antimicrob Agents. 2018;52:358-364 pubmed publisher
..No genes coding for ESBLs or carbapenemases were detected, but monitoring of the emergence of such resistance genes in CF patients is warranted owing to their ability to rapidly spread by horizontal gene transfer. ..
Maurin M, Gyuranecz M. Tularaemia: clinical aspects in Europe. Lancet Infect Dis. 2016;16:113-124 pubmed publisher
Roch N, Epaulard O, Pelloux I, Pavese P, Brion J, Raoult D, et al
. African tick bite fever in elderly patients: 8 cases in French tourists returning from South Africa. Clin Infect Dis. 2008;47:e28-35 pubmed publisher
..Most cases reported in the literature occurred in middle-aged, otherwise-healthy persons and corresponded to benign diseases. The course of African tick bite fever in elderly people is less well documented...
Sutera V, Hoarau G, Renesto P, Caspar Y, Maurin M. In vitro and in vivo evaluation of fluoroquinolone resistance associated with DNA gyrase mutations in Francisella tularensis, including in tularaemia patients with treatment failure. Int J Antimicrob Agents. 2017;50:377-383 pubmed publisher
..Further phenotypic and genetic resistance traits should be explored to explain the poor clinical response to FQ treatment in such tularaemia patients. ..
Yanes H, Hennebique A, Pelloux I, Boisset S, Bicout D, Caspar Y, et al
. Evaluation of In-House and Commercial Serological Tests for Diagnosis of Human Tularemia. J Clin Microbiol. 2018;56: pubmed publisher
..In conclusion, the Serion ELISAs are useful as screening tests for tularemia diagnosis, but additional confirmatory tests (such as MAT and IFA) are needed, especially in areas of low endemicity. ..