P Levy

Summary

Affiliation: CHU de Grenoble
Country: France

Publications

  1. doi request reprint Sleep, sleep-disordered breathing and metabolic consequences
    P Levy
    INSERM ERI 17, HP2 Laboratory, Joseph Fourier University and Sleep Laboratory, EFCR, Pôle Rééducation et Physiologie, CHU Grenoble, Grenoble, France
    Eur Respir J 34:243-60. 2009
  2. ncbi request reprint [Surviving sleep: when the heart and brain are damaged by apnea]
    Patrick Levy
    Exploration fonctionnelle cardio respiratoire et Laboratoire du sommeil Pôl de locomotion rééducation et physiologie CHU de Grenoble 38043 Grenoble cédex
    Bull Acad Natl Med 195:1611-28; discussion 1628-34. 2011
  3. ncbi request reprint Sleep deprivation, sleep apnea and cardiovascular diseases
    Patrick Levy
    INSERM U 1042, Hypoxia PathoPhysiology Laboratory, Joseph Fourier University, Grenoble, France
    Front Biosci (Elite Ed) 4:2007-21. 2012
  4. ncbi request reprint [Obstructive sleep apnea syndrome]
    Patrick Levy
    Laboratoire du sommeil et d explorations fonctionnelles cardiorespiratoires, Pôle Rééducation et Physiologie, CHU Grenoble, 38043 Grenoble Cedex 09
    Rev Prat 57:1569-80. 2007
  5. doi request reprint Intermittent hypoxia and sleep-disordered breathing: current concepts and perspectives
    P Levy
    Pathophysiology Laboratory, Grenoble University, Grenoble, France
    Eur Respir J 32:1082-95. 2008
  6. ncbi request reprint Should all sleep apnoea patients be treated? Yes
    Patrick Levy
    Department of Respiratory Medicine and Sleep Laboratory, PRETA Laboratory TIMC UMR CNRS 5525, University Hospital, Grenoble, France
    Sleep Med Rev 6:17-26; discussion 27. 2002
  7. doi request reprint Obstructive sleep apnea and atherosclerosis
    Patrick Levy
    HP2 Laboratory, INSERM ERI17, Joseph Fourier University, Grenoble, France
    Prog Cardiovasc Dis 51:400-10. 2009
  8. ncbi request reprint Cognitive executive dysfunction in patients with obstructive sleep apnea syndrome (OSAS) after CPAP treatment
    B Naegele
    CNRS GDR 978, Department of Clinical and Biological Neurosciences, CHU, Grenoble, France
    Sleep 21:392-7. 1998
  9. doi request reprint Prevalence of residual excessive sleepiness in CPAP-treated sleep apnoea patients: the French multicentre study
    J L Pepin
    HP2 Laboratory Hypoxia Pathophysiology, INSERM ERI 0017, EA 3745 Joseph Fourier University, Grenoble, France
    Eur Respir J 33:1062-7. 2009
  10. doi request reprint 14 nights of intermittent hypoxia elevate daytime blood pressure and sympathetic activity in healthy humans
    R Tamisier
    Sleep Laboratory and EFCR, Dept of Rehabilitation and Physiology, University Hospital, Grenoble, France
    Eur Respir J 37:119-28. 2011

Collaborators

Detail Information

Publications34

  1. doi request reprint Sleep, sleep-disordered breathing and metabolic consequences
    P Levy
    INSERM ERI 17, HP2 Laboratory, Joseph Fourier University and Sleep Laboratory, EFCR, Pôle Rééducation et Physiologie, CHU Grenoble, Grenoble, France
    Eur Respir J 34:243-60. 2009
    ..Molecular and cellular mechanisms are currently being investigated...
  2. ncbi request reprint [Surviving sleep: when the heart and brain are damaged by apnea]
    Patrick Levy
    Exploration fonctionnelle cardio respiratoire et Laboratoire du sommeil Pôl de locomotion rééducation et physiologie CHU de Grenoble 38043 Grenoble cédex
    Bull Acad Natl Med 195:1611-28; discussion 1628-34. 2011
    ..Continuous positive airway pressure (CPAP) has been the first-line treatment for the last 30 years, and partly prevents the excess cardiovascular morbidity and mortality...
  3. ncbi request reprint Sleep deprivation, sleep apnea and cardiovascular diseases
    Patrick Levy
    INSERM U 1042, Hypoxia PathoPhysiology Laboratory, Joseph Fourier University, Grenoble, France
    Front Biosci (Elite Ed) 4:2007-21. 2012
    ..Whether treating sleep apnea enables the reversal of chronic cardiovascular and metabolic consequences of OSA, remains to be studied in adequately designed studies, particularly in comparison with usual treatment strategies...
  4. ncbi request reprint [Obstructive sleep apnea syndrome]
    Patrick Levy
    Laboratoire du sommeil et d explorations fonctionnelles cardiorespiratoires, Pôle Rééducation et Physiologie, CHU Grenoble, 38043 Grenoble Cedex 09
    Rev Prat 57:1569-80. 2007
    ..Surgical treatment remains poorly efficient and is of limited use in OSA. Lastly, pharmacological developments are currently being evaluated regarding symptoms such as sleepiness or comorbidities...
  5. doi request reprint Intermittent hypoxia and sleep-disordered breathing: current concepts and perspectives
    P Levy
    Pathophysiology Laboratory, Grenoble University, Grenoble, France
    Eur Respir J 32:1082-95. 2008
    ..Overall, chronic intermittent hypoxia appears to have specific genomic effects that differ notably from continuous hypoxia. Further research is required to fully elucidate the molecular and cellular mechanisms...
  6. ncbi request reprint Should all sleep apnoea patients be treated? Yes
    Patrick Levy
    Department of Respiratory Medicine and Sleep Laboratory, PRETA Laboratory TIMC UMR CNRS 5525, University Hospital, Grenoble, France
    Sleep Med Rev 6:17-26; discussion 27. 2002
    ..Moreover, there is increasing evidence that the cardiovascular risk has to be taken into account when deciding on treatment, even in asymptomatic patients. All this evidence put together suggests early treatment in OSA...
  7. doi request reprint Obstructive sleep apnea and atherosclerosis
    Patrick Levy
    HP2 Laboratory, INSERM ERI17, Joseph Fourier University, Grenoble, France
    Prog Cardiovasc Dis 51:400-10. 2009
    ..Further studies are needed to identify at-risk subjects prone to develop vascular changes because OSA treatment may either be initiated earlier or combined with specific drug treatments...
  8. ncbi request reprint Cognitive executive dysfunction in patients with obstructive sleep apnea syndrome (OSAS) after CPAP treatment
    B Naegele
    CNRS GDR 978, Department of Clinical and Biological Neurosciences, CHU, Grenoble, France
    Sleep 21:392-7. 1998
    ..In conclusion, short-term memory impairment was persistent in OSAS patients despite CPAP treatment for 4-6 months...
  9. doi request reprint Prevalence of residual excessive sleepiness in CPAP-treated sleep apnoea patients: the French multicentre study
    J L Pepin
    HP2 Laboratory Hypoxia Pathophysiology, INSERM ERI 0017, EA 3745 Joseph Fourier University, Grenoble, France
    Eur Respir J 33:1062-7. 2009
    ..As 230,000 obstructive sleep apnoea patients are currently treated in France by continuous positive airway pressure, more than 13,800 of them might suffer from residual excessive sleepiness...
  10. doi request reprint 14 nights of intermittent hypoxia elevate daytime blood pressure and sympathetic activity in healthy humans
    R Tamisier
    Sleep Laboratory and EFCR, Dept of Rehabilitation and Physiology, University Hospital, Grenoble, France
    Eur Respir J 37:119-28. 2011
    ..These mechanisms may reflect those underlying the blood pressure elevation associated with OSAS...
  11. ncbi request reprint Differentiating obstructive and central sleep respiratory events through pulse transit time
    J Argod
    Department of Respiratory Medicine and Sleep Laboratory, University Hospital, Grenoble, France
    Am J Respir Crit Care Med 158:1778-83. 1998
    ..8%). PTT has shown a high sensitivity and specificity in differentiating obstructive and central respiratory events, and may become the reference noninvasive tool for this purpose...
  12. doi request reprint The upper airway resistance syndrome
    J L Pepin
    Sleep Laboratory, EFCR, Grenoble University Hospital, Grenoble, France
    Respiration 83:559-66. 2012
    ..In this review, the authors attempt to describe the specific characteristics of UARS that are relevant for both clinicians and researchers...
  13. ncbi request reprint Exhaled nitric oxide in single and repetitive prolonged exercise
    S Verges
    HP2 Laboratory, Department of Medicine, Joseph Fourier University, La Tronche, France
    J Sports Sci 24:1157-63. 2006
    ..However, repetitive exercises (at least every 24 h) allow complete NO recovery from one session to another. The implication of such a decrease in NO availability within the lung remains to be clarified...
  14. doi request reprint The impact of obstructive sleep apnea on homocysteine and carotid remodeling in metabolic syndrome
    D Monneret
    Inserm U1042 HP2 Laboratory Hypoxia and Pathophysiology, Joseph Fourier University, Grenoble, France
    Respir Physiol Neurobiol 180:298-304. 2012
    ..We conclude that homocysteine level was higher in MetS when associated with OSA and proportional to OSA severity. In this context, vascular remodeling appeared more severe and mediated by oxidative stress...
  15. doi request reprint [Management of central sleep apnea]
    I Boutin
    Laboratoire du sommeil et EFCR, Pôle Rééducation et Physiologie, CHU de Grenoble, BP 217, 38043 Grenoble Cedex 09, France
    Rev Pneumol Clin 65:261-72. 2009
    ..Ventilatory supports used for treating central sleep apnea are non-invasive ventilation and servo-assisted ventilation in hypercapnic and hypocapnic patients respectively...
  16. pmc A new model of chronic intermittent hypoxia in humans: effect on ventilation, sleep, and blood pressure
    R Tamisier
    Laboratoire du sommeil et EFCR, Pôle Rééducation et Physiologie, CHU A Michallon, Grenoble, B P 217, 38043 Grenoble Cedex 9, France
    J Appl Physiol (1985) 107:17-24. 2009
    ..3 to 74 +/- 1.7 mmHg). We propose this model as a new technique to study the cardiovascular and metabolic consequences of CIH in human volunteers...
  17. ncbi request reprint Deficits of cognitive executive functions in patients with sleep apnea syndrome
    B Naegele
    Department of Clinical and Biological Neurosciences, CHU, Grenoble, France
    Sleep 18:43-52. 1995
    ....
  18. pmc Non-arteritic anterior ischaemic optic neuropathy is nearly systematically associated with obstructive sleep apnoea
    K Palombi
    Department of Ophthalmology, University Hospital, Grenoble, France
    Br J Ophthalmol 90:879-82. 2006
    ..To evaluate newly diagnosed non-arteritic anterior ischaemic optic neuropathy (NAION) patients for the existence of an associated sleep apnoea syndrome...
  19. ncbi request reprint Driving ability in sleep apnoea patients before and after CPAP treatment: evaluation on a road safety platform
    S Mazza
    HP2 laboratory hypoxia, pathophysiology INSERM ERI 0017, Joseph Fourier University, Grenoble, France
    Eur Respir J 28:1020-8. 2006
    ..This stresses the importance of evaluating attentional parameters in apnoeic patients and of offering continuous positive airway pressure treatment even to non-sleepy subjects...
  20. doi request reprint Time-dependent effect of acute hypoxia on corticospinal excitability in healthy humans
    T Rupp
    HP2 Laboratory, Joseph Fourier University and CHU Grenoble, Grenoble, France
    J Neurophysiol 108:1270-7. 2012
    ..The impact of these cortical changes on physical or psychomotor performances needs to be elucidated to better understand the cerebral effects of hypoxemia...
  21. ncbi request reprint Critical analysis of the results of surgery in the treatment of snoring, upper airway resistance syndrome (UARS), and obstructive sleep apnea (OSA)
    J L Pepin
    Department of Respiratory Medicine, University Hospital, Grenoble, France
    Sleep 19:S90-100. 1996
    ....
  22. doi request reprint Can crossover and maximal fat oxidation rate points be used equally for ergocycling and walking/running on a track?
    M Mendelson
    Joseph Fourier University, Hypoxia Physiopathology laboratory, 38000 Grenoble, France
    Diabetes Metab 38:264-70. 2012
    ....
  23. doi request reprint [Obstructive sleep-apnoea syndrome in adult and its perioperative management]
    J F Payen
    Pôle d Anesthésie Réanimation, Hopital Michallon, CHU de Grenoble, BP 217, 38043 Grenoble Cedex 09, France
    Ann Fr Anesth Reanim 29:787-92. 2010
    ..Alternatives to opioids should be promoted for postoperative pain control...
  24. ncbi request reprint [Cardiovascular consequences of obstructive sleep apnea syndrome]
    J P Baguet
    Service de Cardiologie et hypertension artérielle, CHU de Grenoble, BP 217, 38043 Grenoble Cedex 09, France
    Rev Med Interne 24:530-7. 2003
    ..This article is an update of past and current data on the relationship between obstructive sleep apnea syndrome and cardiovascular diseases...
  25. ncbi request reprint [Imaging in obstructive sleep apnea syndrome]
    G Ferretti
    Service Central de Radiologie et Imagerie Médicale Centre Hospitalier Universitaire, Grenoble BP 217 F 38043 Grenoble, France
    Rev Neurol (Paris) 157:S78-81. 2001
    ....
  26. ncbi request reprint [Resistance syndrome of the upper airways: a separate entity of sleep apnea syndrome?]
    J L Pepin
    EFCR, Laboratoire du Sommeil, Centre Hospitalier Universitaire, BP 217, 38043 Grenoble Cedex 9 Laboratoire HP2, INSERM ERI 0017
    Rev Mal Respir 23:7S44-7S47. 2006
  27. ncbi request reprint [Influence of CPAP in inflammation and nasal obstruction]
    J L Pepin
    Laboratoire du Sommeil, Laboratoire HP2, Inserm ESPRI 0017, Universite Joseph Fourier, 621, av Centrale, 38400 Saint Martin d Hères
    Rev Mal Respir 23:7S137-7S139. 2006
  28. ncbi request reprint [Tools available for the diagnosis of obstructive sleep apnea syndrome. Measurements for the evaluation of therapeutic efficacy]
    J L Pepin
    Departement de Medecine, CHU de Grenoble, 38043 Grenoble
    Rev Stomatol Chir Maxillofac 103:151-7. 2002
    ..It should also include simplified methods or complete polysomnography to obtain a precise measurement of residual respiratory events and sleep pattern after treatment...
  29. ncbi request reprint Overdrive atrial pacing does not improve obstructive sleep apnoea syndrome
    J L Pepin
    Sleep Laboratory, Joseph Fourier University, Grenoble, France
    Eur Respir J 25:343-7. 2005
    ..Overdrive pacing changed none of the respiratory indices, or sleep fragmentation or sleep structure parameters. In conclusion, atrial overdrive pacing has no significant effect on obstructive sleep apnoea...
  30. ncbi request reprint Is sleep apnea syndrome in the elderly a specific entity?
    P Levy
    Secteur Sommeil et Respiration, Service de Pneumologie, Grenoble, France
    Sleep 19:S29-38. 1996
    ..Further studies are needed to determine whether or not the associated morbidity is different in the elderly; these studies could lead to different diagnosis strategies and therapeutic approaches...
  31. doi request reprint Left ventricular diastolic dysfunction is linked to severity of obstructive sleep apnoea
    J P Baguet
    Dept of Cardiology, Functional Explorations Unit, University Hospital, France
    Eur Respir J 36:1323-9. 2010
    ..91) were associated with left ventricular diastolic dysfunction. Our findings demonstrate that left ventricular diastolic dysfunction frequently occurs in patients with OSA and that it is related to the severity of oxygen desaturation...
  32. ncbi request reprint [Pathophysiology of cardiovascular risk in sleep apnea syndrome (SAS)]
    J L Pepin
    Département de Médecine aiguë spécialisée et Laboratoire de Neurophysiopathologie du sommeil et de l épilepsie Pr Lévy, CHU, Grenoble, France
    Rev Neurol (Paris) 158:785-97. 2002
    ..Very recently, epidemiological studies suggested that continuous positive pressure ventilation in SAS patients can reduce the cardiovascular risk...
  33. ncbi request reprint [Alveolar hypoventilation during sleep and domiciliary assisted ventilation]
    J L Pepin
    Département de Médecine Aiguë Spécialisée, CHU, Grenoble, France
    Rev Mal Respir 22:113-25. 2005
    ..An alveolar hypoventilation physiologically occurs during sleep and more specifically during REM sleep...
  34. ncbi request reprint Identification of quality of life concerns of patients with obstructive sleep apnoea at the time of initiation of continuous positive airway pressure: a discourse analysis
    D Veale
    Sleep Laboratory, CHU Grenoble, Centre Pneumologie, Henri Bazire, France
    Qual Life Res 11:389-99. 2002
    ..Thus many worries and concerns of patients remain hidden. Treatment by nasal continuous positive airway pressure (CPAP) can be imposing for the individual. An analysis of the freely expressed concerns of such patients is required...