D Leroux

Summary

Affiliation: CHU de Grenoble
Country: France

Publications

  1. ncbi request reprint CD4(+), CD56(+) DC2 acute leukemia is characterized by recurrent clonal chromosomal changes affecting 6 major targets: a study of 21 cases by the Groupe Français de Cytogénétique Hématologique
    Dominique Leroux
    Laboratoire d hématologie cellulaire et moléculaire, Centre Hospitalier Universitaire CHU Michallon, Grenoble, France
    Blood 99:4154-9. 2002
  2. ncbi request reprint [Genetic changes in chronic lymphocytic leukemia]
    D Leroux
    Laboratoire d hématologie cellulaire et moléculaire, Département de Biologie et Pathologie de la Cellule, Centre Hospitalier Universitaire de Grenoble, BP217, 38043 Grenoble 9, France
    Pathol Biol (Paris) 51:366-74. 2003
  3. ncbi request reprint [CDKN2A gene mutation and loss of p16 protein activity in a patient on levodopa presenting sporadic multiple primary melanoma]
    I Templier
    Dermatologie, Département Pluridisciplinaire de Médecine, CHU Albert Michallon, BP 217, 38043 Grenoble Cedex 9
    Ann Dermatol Venereol 133:777-80. 2006
  4. ncbi request reprint Novel evidence of a role for chromosome 1 pericentric heterochromatin in the pathogenesis of B-cell lymphoma and multiple myeloma
    P Le Baccon
    The Lymphoma Research Group, Institut Albert Bonniot, , Grenoble, France
    Genes Chromosomes Cancer 32:250-64. 2001
  5. ncbi request reprint Human herpesvirus 8 and Epstein Barr-virus in a cutaneous B-cell lymphoma and a malignant cell line established from the blood of an AIDS patient
    P Morand
    Laboratoire de Virologie Médicale Moléculaire RHAP, Grenoble, France
    Leuk Lymphoma 35:379-87. 1999
  6. ncbi request reprint Composite splenic marginal zone lymphoma and mantle cell lymphoma arising from 2 independent B-cell clones
    Christine Lefebvre
    INSERM, E353, F 38000 Grenoble, France
    Hum Pathol 38:660-7. 2007
  7. ncbi request reprint Differences in nuclear positioning of 1q12 pericentric heterochromatin in normal and tumor B lymphocytes with 1q rearrangements
    Leila Barki-Celli
    Lymphoma Research Group, INSERM E353, Institut Albert Bonniot Faculté de Médecine, Universite Joseph Fourier Grenoble 1, Domaine de la Merci, La Tronche Cedex, France
    Genes Chromosomes Cancer 43:339-49. 2005
  8. ncbi request reprint Further cytogenetic characterization of multiple myeloma confirms that 14q32 translocations are a very rare event in hyperdiploid cases
    Nicole Véronique Smadja
    Cytogenetic Research Laboratory, Hopital Saint Antoine, AP HP, Paris, France
    Genes Chromosomes Cancer 38:234-9. 2003
  9. ncbi request reprint CD4+ CD56+ lineage negative malignancies: a new entity developed from malignant early plasmacytoid dendritic cells
    Marie Christine Jacob
    EFS Rhone Alpes, Dept of Cellular Immunology, Grenoble, France
    Haematologica 88:941-55. 2003
  10. ncbi request reprint Impairment of death-inducing signalling complex formation in CD95-resistant human primary lymphoma B cells
    Alicia Lajmanovich
    The Research Group on Lymphoma, INSERM, EMI 353, Albert Bonniot Institute, La Tronche, France
    Br J Haematol 124:746-53. 2004

Collaborators

  • L Chaperot
  • Christine Lefebvre
  • Marie Joelle Mozziconacci
  • Virginie Eclache
  • Herve Avet-Loiseau
  • P Morand
  • Jean Feuillard
  • I Templier
  • Jean Marc Limacher
  • Nicole Véronique Smadja
  • Jean Yves Cahn
  • Jean Claude Bensa
  • Jean Jacques Sotto
  • Thierry Bonnefoix
  • Jian Qing Mi
  • Olivier Manches
  • Joel Plumas
  • Marie Christine Jacob
  • F Lesueur
  • Leila Barki-Celli
  • Alicia Lajmanovich
  • Jean Charles Renversez
  • Pascal Perron
  • Mary Callanan
  • Jean Paul Molens
  • P Le Baccon
  • Laurence Venat
  • Eve Maubec
  • Monique Baccard
  • Pascal Pujol
  • Pierre Vabres
  • Laetitia Huiart
  • Sophie Giraud
  • Jean Pierre Fricker
  • Delphine Kerob
  • G Durand
  • Liliane Demange
  • J Bombled
  • Bruno Sassolas
  • B Bressac-de Paillerets
  • Bertrand Bachollet
  • Julie de Quatrebarbes
  • Florent Grange
  • F Boitier
  • Jean Francois Dore
  • Jean François Cuny
  • A Chompret
  • G M Lenoir
  • Ewa Wierzbicka
  • Andrew Green
  • M Barrois
  • Laurence Olivier-Faivre
  • Jacqueline Chevrant-Breton
  • Marc Frenay
  • Paul Gesta
  • Michele Delaunay
  • Karine Marrou
  • Pascal Joly
  • Dominique Stoppa-Lyonnet
  • M de Lichy
  • Stephane Dalle
  • Jean Marie Bonnetblanc
  • Sandrine Mansard
  • Christine Lasset
  • Philippe Gorry
  • Michel Longy
  • Helene Zattara
  • Christine Mateus
  • M F Avril
  • Olivier Caron
  • Luc Thomas
  • Marion Gauthier-Villars
  • Nicolas Janin
  • Tanguy Martin-Denavit
  • Vincent Orlandini
  • Valerie Bonadona
  • Pascaline Berthet
  • Patrice N Marche
  • Sebastien Weisbuch
  • Jin Wang
  • Claire Vourc'h
  • Gwenael Nadeau
  • Yves Usson
  • Saadi Khochbin
  • Patricia Le Baccon
  • Marie Anne Pasquier
  • Magdalena Irisarri
  • Pascal Mossuz
  • Francoise Valensi
  • Marie Christine Bene

Detail Information

Publications15

  1. ncbi request reprint CD4(+), CD56(+) DC2 acute leukemia is characterized by recurrent clonal chromosomal changes affecting 6 major targets: a study of 21 cases by the Groupe Français de Cytogénétique Hématologique
    Dominique Leroux
    Laboratoire d hématologie cellulaire et moléculaire, Centre Hospitalier Universitaire CHU Michallon, Grenoble, France
    Blood 99:4154-9. 2002
    ..In conclusion, the present study documents for the first time the existence of a characteristic cytogenetic profile for this novel disease entity...
  2. ncbi request reprint [Genetic changes in chronic lymphocytic leukemia]
    D Leroux
    Laboratoire d hématologie cellulaire et moléculaire, Département de Biologie et Pathologie de la Cellule, Centre Hospitalier Universitaire de Grenoble, BP217, 38043 Grenoble 9, France
    Pathol Biol (Paris) 51:366-74. 2003
    ..Genetic analyses as well as the first transcriptome studies of CLL reveal 1) a common mechanism of transformation and/or cell of origin, 2) the existence of at least two prognostic subgroups based on Ig mutational status...
  3. ncbi request reprint [CDKN2A gene mutation and loss of p16 protein activity in a patient on levodopa presenting sporadic multiple primary melanoma]
    I Templier
    Dermatologie, Département Pluridisciplinaire de Médecine, CHU Albert Michallon, BP 217, 38043 Grenoble Cedex 9
    Ann Dermatol Venereol 133:777-80. 2006
    ..Cutaneous melanoma is a complex disease involving genetic and environmental factors. Levodopa has been incriminated in the development and/or progression of melanoma...
  4. ncbi request reprint Novel evidence of a role for chromosome 1 pericentric heterochromatin in the pathogenesis of B-cell lymphoma and multiple myeloma
    P Le Baccon
    The Lymphoma Research Group, Institut Albert Bonniot, , Grenoble, France
    Genes Chromosomes Cancer 32:250-64. 2001
    ..This study provides the first evidence of involvement of 1q12 constitutive heterochromatin in the pathogenesis of NHL and MM and indicates proximal 1q21 to be of specific pathological significance in NHL...
  5. ncbi request reprint Human herpesvirus 8 and Epstein Barr-virus in a cutaneous B-cell lymphoma and a malignant cell line established from the blood of an AIDS patient
    P Morand
    Laboratoire de Virologie Médicale Moléculaire RHAP, Grenoble, France
    Leuk Lymphoma 35:379-87. 1999
    ....
  6. ncbi request reprint Composite splenic marginal zone lymphoma and mantle cell lymphoma arising from 2 independent B-cell clones
    Christine Lefebvre
    INSERM, E353, F 38000 Grenoble, France
    Hum Pathol 38:660-7. 2007
    ..This case highlights the importance of a multidisciplinary approach and tissue diagnosis in these complex situations...
  7. ncbi request reprint Differences in nuclear positioning of 1q12 pericentric heterochromatin in normal and tumor B lymphocytes with 1q rearrangements
    Leila Barki-Celli
    Lymphoma Research Group, INSERM E353, Institut Albert Bonniot Faculté de Médecine, Universite Joseph Fourier Grenoble 1, Domaine de la Merci, La Tronche Cedex, France
    Genes Chromosomes Cancer 43:339-49. 2005
    ..Taken together, these results point to the 1q12HcD having a specific, nonrandom, and regulated peripheral organization in B lymphocytes. This organization is significantly disrupted in lymphoma cells harboring 1q rearrangements...
  8. ncbi request reprint Further cytogenetic characterization of multiple myeloma confirms that 14q32 translocations are a very rare event in hyperdiploid cases
    Nicole Véronique Smadja
    Cytogenetic Research Laboratory, Hopital Saint Antoine, AP HP, Paris, France
    Genes Chromosomes Cancer 38:234-9. 2003
    ..0001) and that cryptic t(4;14)(p16;q32) is strongly associated with hypodiploid karyotypes (P<0.01). Through the use of this reliable assay, only 42% of MM had 14q32t...
  9. ncbi request reprint CD4+ CD56+ lineage negative malignancies: a new entity developed from malignant early plasmacytoid dendritic cells
    Marie Christine Jacob
    EFS Rhone Alpes, Dept of Cellular Immunology, Grenoble, France
    Haematologica 88:941-55. 2003
    ..The clinico-biological features of this neoplasm were moreover recently summarized from a large series of 23 patients...
  10. ncbi request reprint Impairment of death-inducing signalling complex formation in CD95-resistant human primary lymphoma B cells
    Alicia Lajmanovich
    The Research Group on Lymphoma, INSERM, EMI 353, Albert Bonniot Institute, La Tronche, France
    Br J Haematol 124:746-53. 2004
    ..In contrast, DISC formation was observed in CD95-resistant non-tumoural (NT) B cells. Therefore, we propose that the absence of DISC formation in primary lymphoma B cells may contribute to protect these cells from CD95-induced apoptosis...
  11. ncbi request reprint Differentiation of anti-tumour cytotoxic T lymphocytes from autologous peripheral blood lymphocytes in non-Hodgkin's lymphomas
    Laurence Chaperot
    R and D Laboratory, EFS Rhone Alpes, La Tronche, France
    Br J Haematol 119:425-31. 2002
    ..The source of patient T cells used for the generation of anti-tumour CTL should be based on the results obtained with peripheral blood lymphocytes and TIL...
  12. ncbi request reprint Development of autologous cytotoxic CD4+ T clones in a human model of B-cell non-Hodgkin follicular lymphoma
    Jian Qing Mi
    Institut National de la Santé et de la Recherche Médicale Inserm E353, Lymphoma Research Group Molecular Bases of Tumor Progression, Universite Joseph Fourier, La Tronche, France
    Br J Haematol 135:324-35. 2006
    ..Such lymphoma models would provide a useful tool for in vivo expansion and the adoptive transfer of selected CD4(+) cytotoxic cells in immunotherapeutic strategies...
  13. ncbi request reprint In vitro mechanisms of action of rituximab on primary non-Hodgkin lymphomas
    Olivier Manches
    Department of Research and Development, EFS Rhone Alpes, and Research Group on Lymphoma, Albert Bonniot Institute, La Tronche, France
    Blood 101:949-54. 2003
    ..Poor sensitivity to CDC in vitro might predict a poor clinical response, whereas high sensitivity to CDC would only indicate a likelihood of response to rituximab treatment...
  14. ncbi request reprint Terminal plasmocytoid differentiation of malignant B cells induced by autotumor-reactive CD4(+) T cells in one case of splenic marginal zone B-cell lymphoma
    Thierry Bonnefoix
    Blood 99:388-91. 2002
  15. pmc The contribution of large genomic deletions at the CDKN2A locus to the burden of familial melanoma
    F Lesueur
    Groupe Mélanome, Institut Gustave Roussy, FRE2939 CNRS Université Paris Sud, Villejuif, France
    Br J Cancer 99:364-70. 2008
    ..1% of total mutations in this series (1 of 48), confirming that they explain a very small proportion of CMM susceptibility. In addition, we excluded a new gene on 9p21, KLHL9, as being a major CMM gene...