Serge Halimi

Summary

Affiliation: CHU de Grenoble
Country: France

Publications

  1. doi request reprint [Management of type 2 diabetes: new or previous agents, how to choose?]
    Serge Halimi
    CHU de Grenoble, Pôle Digestif DUNE, Service de Diabétologie Endocrinologie Nutrition, 38043 Grenoble Cedex, France
    Presse Med 42:861-70. 2013
  2. doi request reprint Therapeutic management of orally treated type 2 diabetic patients, by French general practitioners in 2010: the DIAttitude Study
    S Halimi
    CHU Grenoble Clinique Diabétologie Nutrition Pôle DigiDUNE University Hospital Grenoble University Joseph Fourier, 38043 Grenoble, France
    Diabetes Metab 38:S36-46. 2012
  3. ncbi request reprint Effect on compliance, acceptability of blood glucose self-monitoring and HbA(1c) of a self-monitoring system developed according to patient's wishes. The ACCORD study
    S Halimi
    Service Endocrinologie Diabétologie Nutrition, CHU de Grenoble, 38043 Grenoble Cedex, France
    Diabetes Metab 27:681-7. 2001
  4. ncbi request reprint [Clinical case: beliefs, Ramadan and diabetes mellitus]
    S Halimi
    Service d endocrinologie, Diabetologie, Nutrition CHU de Grenoble, F 38043 Grenoble Cedex
    Ann Endocrinol (Paris) 65:S68-73. 2004
  5. ncbi request reprint [Primary cardiorenal prevention in patients with type-2 diabetes. The Roadmap study]
    S Halimi
    Secteur diabétologie nutrition, Dune Département uro néphro endocrinologie, CHU de Grenoble
    Presse Med 34:1300-2. 2005
  6. ncbi request reprint [The glitazones]
    S Halimi
    Département d urologie, Nephrologie et Endocrinologie, UF diabétologie 11 A, Centre Hospitalier Universitaire de Grenoble, BP 217, 38043 Grenoble Cedex 09, France
    Rev Med Interne 26:54-7. 2005
  7. ncbi request reprint [Insulin in acute coronary syndromes]
    S Halimi
    CHU de Grenoble, Departement Urologie, Nephrologie, Endocrinologie, UF diabétologie
    Arch Mal Coeur Vaiss 97:63-70. 2004
  8. ncbi request reprint [Coming clinical recommendations: where will the glitazones fit in?]
    S Halimi
    Service d endocrinologie, Diabetologie, Nutrition, CHU de Grenoble, F 38043 Grenoble Cedex, France
    Ann Endocrinol (Paris) 66:1S59-70. 2005
  9. ncbi request reprint [New treatment strategies for type-2 diabetes?]
    S Halimi
    Secteur diabétologie nutrition, Dune Département uro néphro endocrinologie, CHU de Grenoble
    Presse Med 34:1287-92. 2005
  10. ncbi request reprint Efficacy of biphasic insulin aspart in patients with type 2 diabetes
    Serge Halimi
    Department d Urologie, Nephrologie et Endocrinologie, Centre Hospitalier Universitaire de Grenoble, Grenoble, France
    Clin Ther 27:S57-74. 2005

Detail Information

Publications47

  1. doi request reprint [Management of type 2 diabetes: new or previous agents, how to choose?]
    Serge Halimi
    CHU de Grenoble, Pôle Digestif DUNE, Service de Diabétologie Endocrinologie Nutrition, 38043 Grenoble Cedex, France
    Presse Med 42:861-70. 2013
    ..Finally, we must reconsider every treatment after a maximum of 6 months of use, if the results are deemed inadequate substitute rather than adding drugs...
  2. doi request reprint Therapeutic management of orally treated type 2 diabetic patients, by French general practitioners in 2010: the DIAttitude Study
    S Halimi
    CHU Grenoble Clinique Diabétologie Nutrition Pôle DigiDUNE University Hospital Grenoble University Joseph Fourier, 38043 Grenoble, France
    Diabetes Metab 38:S36-46. 2012
    ..To describe the behaviour of French general practitioners (GP) regarding intensification of hypoglycaemic agents in orally treated type 2 diabetic (T2D) patients, according to their HbA(1c) level...
  3. ncbi request reprint Effect on compliance, acceptability of blood glucose self-monitoring and HbA(1c) of a self-monitoring system developed according to patient's wishes. The ACCORD study
    S Halimi
    Service Endocrinologie Diabétologie Nutrition, CHU de Grenoble, 38043 Grenoble Cedex, France
    Diabetes Metab 27:681-7. 2001
    ..Self-monitoring of blood glucose (SMBG) generates hope when introduced, however several studies questioned its efficacy and many diabetics judge it too constraining...
  4. ncbi request reprint [Clinical case: beliefs, Ramadan and diabetes mellitus]
    S Halimi
    Service d endocrinologie, Diabetologie, Nutrition CHU de Grenoble, F 38043 Grenoble Cedex
    Ann Endocrinol (Paris) 65:S68-73. 2004
    ..This, should be avoided through an appropriate patient's education, all along the Year, not only through the healthcare team, but involving patient's family and friends too, as well as the community and religious Authorities...
  5. ncbi request reprint [Primary cardiorenal prevention in patients with type-2 diabetes. The Roadmap study]
    S Halimi
    Secteur diabétologie nutrition, Dune Département uro néphro endocrinologie, CHU de Grenoble
    Presse Med 34:1300-2. 2005
    ..Follow-up of this placebo-controlled study will last for 5 years. Conducted in 200 European centers, its results are expected for 2012...
  6. ncbi request reprint [The glitazones]
    S Halimi
    Département d urologie, Nephrologie et Endocrinologie, UF diabétologie 11 A, Centre Hospitalier Universitaire de Grenoble, BP 217, 38043 Grenoble Cedex 09, France
    Rev Med Interne 26:54-7. 2005
    ..For decades we used sulfonylureas, metformin and alpha glucosidases inhibitors. However these drugs have no effect on muscle insulin resistance, high levels of free fatty acids, lipotoxicity and progressive pancreatic beta-cell loss...
  7. ncbi request reprint [Insulin in acute coronary syndromes]
    S Halimi
    CHU de Grenoble, Departement Urologie, Nephrologie, Endocrinologie, UF diabétologie
    Arch Mal Coeur Vaiss 97:63-70. 2004
    ..Very few centres use the GIK protocol in non-diabetics in acute coronary syndromes with a risk of loss of benefit for these patients. Therapeutic protocols which can be used by paramedical personnel should be developed...
  8. ncbi request reprint [Coming clinical recommendations: where will the glitazones fit in?]
    S Halimi
    Service d endocrinologie, Diabetologie, Nutrition, CHU de Grenoble, F 38043 Grenoble Cedex, France
    Ann Endocrinol (Paris) 66:1S59-70. 2005
    ..This review, presents and discuss these various points, and the questions they generate, which have to be answer to update the therapeutic recommendations for type 2 diabetes...
  9. ncbi request reprint [New treatment strategies for type-2 diabetes?]
    S Halimi
    Secteur diabétologie nutrition, Dune Département uro néphro endocrinologie, CHU de Grenoble
    Presse Med 34:1287-92. 2005
    ..Patient education is fundamental. The establishment of care networks for these patients seems to us to be the best tool for meeting the objectives of these guidelines...
  10. ncbi request reprint Efficacy of biphasic insulin aspart in patients with type 2 diabetes
    Serge Halimi
    Department d Urologie, Nephrologie et Endocrinologie, Centre Hospitalier Universitaire de Grenoble, Grenoble, France
    Clin Ther 27:S57-74. 2005
    ..It would be expected that these pharmacokinetic improvements would enhance clinical performance. However, the efficacy of BIAsp 30 compared with other common treatment regimens has not yet been systematically reviewed...
  11. ncbi request reprint [Diabetes in 2005]
    Serge Halimi
    Département DUNE Département d Uro Néphro Endocrinologie, CHU de Grenoble, 11A, BP217X Grenoble 09, France
    Nephrol Ther 2:S2-7. 2006
    ..The availability of new drugs and the high evidence based Levels of several trials confirm the lawfulness of these approaches...
  12. doi request reprint DPP-4 inhibitors and GLP-1 analogues: for whom? Which place for incretins in the management of type 2 diabetic patients?
    S Halimi
    Department of Endocrinology Diabetology Nutrition, University Hospital Grenoble, F 38043 Grenoble, France
    Diabetes Metab 34:S91-5. 2008
    ..Their efficacy, safety and their cost vs. older strategies, will be really evaluated by physicians in the real daily practice and by large and long term systematic surveys, as recently shown in other therapeutic fields...
  13. doi request reprint [New therapies for type 2 diabetes: what place for incretin-based agents and rimonabant compared to the previous ones?]
    S Halimi
    Service de Diabétologie Endocrinologie Nutrition, CHU de Grenoble, 38043 Grenoble Cedex, France
    Rev Med Interne 29:881-90. 2008
    ..Several studies support the use of DPP-4 inhibitors in combination with Met as a promising second line treatment...
  14. ncbi request reprint [Towards new recommendations for the treatment of type 2 diabetes? An expert's point of view]
    Serge Halimi
    Service de diabétologie nutrition endocrinologie, Pôle DigiDUNE, CHU de Grenoble, 38043 Grenoble Cedex
    Rev Prat 60:504-9. 2010
    ..Thereby, recommendations cannot enter so many details and strategies. The need for continuing medical education and the referral to diabetologist more often is becoming essential...
  15. doi request reprint Acute consequences of hypoglycaemia in diabetic patients
    S Halimi
    Clinique d Endocrinologie Diabétologie Nutrition, Pôle DigiDUNE, CHU Grenoble, BP217X, Grenoble, France
    Diabetes Metab 36:S75-83. 2010
    ....
  16. ncbi request reprint Efficacy and safety of acarbose add-on therapy in the treatment of overweight patients with Type 2 diabetes inadequately controlled with metformin: a double-blind, placebo-controlled study
    S Halimi
    CHU de Grenoble, Endocrinology Diabetology Nutrition, 38043 Grenoble, Cedex, France
    Diabetes Res Clin Pract 50:49-56. 2000
    ..The results indicate that acarbose has potential clinical utility for improving glycaemic control in overweight patients with Type 2 diabetes inadequately controlled with metformin...
  17. ncbi request reprint One-year efficacy and safety of Web-based follow-up using cellular phone in type 1 diabetic patients under insulin pump therapy: the PumpNet study
    P Y Benhamou
    Department of Endocrinology, Grenoble University Hospital, BP 217 X, 38043 Grenoble Cedex 09, France
    Diabetes Metab 33:220-6. 2007
    ....
  18. pmc Combination treatment in the management of type 2 diabetes: focus on vildagliptin and metformin as a single tablet
    Serge Halimi
    University Hospital of Grenoble College of Medicine, Diabetes and Endocrine department, Grenoble, France
    Vasc Health Risk Manag 4:481-92. 2008
    ..Therefore, by specifically combining these agents in a single tablet, there is considerable potential to achieve better blood glucose control and to improve compliance to therapy...
  19. ncbi request reprint [Therapeutic strategies for type 2 diabetes]
    Serge Halimi
    Service d endocrinologie, Diabetologie, nutrition Centre hospitalier universitaire de Grenoble B P 217 38043 Grenoble
    Rev Prat 53:1079-85. 2003
    ..New strategies now in the process of being elaborated suggest to treat type 2 diabetes much earlier and with much more ambitious glycaemic objectives...
  20. ncbi request reprint Comparison of the effects of zinc alone and zinc associated with selenium and vitamin E on insulin sensitivity and oxidative stress in high-fructose-fed rats
    Patrice Faure
    Laboratoire HP2, Hypoxie Physio Pathologie Respiratoire et Cardiovasculaire, INSERM ERI 0017, Faculte de Medecine Pharmacie, BP 217, 38043 Grenoble Cedex 9, France
    J Trace Elem Med Biol 21:113-9. 2007
    ....
  21. ncbi request reprint Huge progression of diabetes prevalence and incidence among dialysed patients in mainland France and overseas French territories. A second national survey six years apart. (UREMIDIAB 2 study)
    S Halimi
    CHU de Grenoble, France
    Diabetes Metab 25:507-12. 1999
    ....
  22. ncbi request reprint [Type 2 diabetes mellitus: Which place for thiazolidinediones in the therapeutic strategy?]
    S Halimi
    Service Endocrinologie, Diabetologie, Nutrition CHU de Grenoble, Grenoble, France
    Diabetes Metab 27:287-93. 2001
    ..However the frequency of adverse events must be evaluated in a large use, beyond phase II and III, after the withdrawal of the first TZD introduced on the market (troglitazone)...
  23. ncbi request reprint [Self-monitoring of blood glucose in type 2 diabetic patients. What could we propose according to their treatment?]
    S Halimi
    Service Endocrinologie Diabétologie Nutrition, CHU de Grenoble, Universite J Fourier, 38043 Grenoble Cedex, France
    Diabetes Metab 29:S26-30. 2003
    ..These programs must be evaluated by randomized controlled trials...
  24. ncbi request reprint Prediction of cardiovascular events in clinically selected high-risk NIDDM patients. Prognostic value of exercise stress test and thallium-201 single-photon emission computed tomography
    G Vanzetto
    Department of Cardiology, University Hospital, Grenoble, France
    Diabetes Care 22:19-26. 1999
    ..We evaluated the prognostic value of an exercise stress test and thallium-201 scintigraphy for the prediction of cardiac events in selected high-risk NIDDM patients...
  25. ncbi request reprint [Is a new therapeutic class justified in the treatment of type 2 diabetes?]
    S Halimi
    Service d Endocrinologie Diabétologie Nutrition, CHU de Grenoble, F 38043 Grenoble Cedex, France
    Ann Endocrinol (Paris) 63:1S7-11. 2002
    ..The association of metformin (or a sulfonylurea) and a thiazolidinedione should permit to obtain early a better glycaemic control without the hypoglycaemic risk associated with intensive therapy at an early stage of type 2 diabetes...
  26. ncbi request reprint Predictive value of silent myocardial ischemia for cardiac events in diabetic patients: influence of age in a French multicenter study
    Paul Valensi
    Department of Endocrinology Diabetology Nutrition, Jean Verdier Hospital, Bondy Cedex, France
    Diabetes Care 28:2722-7. 2005
    ..The aim of the study was to examine the predictive value of SMI for cardiac events in a multicenter cohort and to determine whether this value is higher in patients with a particular clinical profile...
  27. ncbi request reprint Impairment of the antioxidant properties of serum albumin in patients with diabetes: protective effects of metformin
    Patrice Faure
    laboratoire d étude de la physiopatologie de l hypoxie HP2, Département de Biologie Intégrée, CHU, Hopital A Michallon, INSERM, ERI0017, 38042 Grenoble, France
    Clin Sci (Lond) 114:251-6. 2008
    ..Moreover, a significant protection of albumin was found in patients with T2DM treated with MET...
  28. ncbi request reprint Effects of a myocardial ischaemia-guided therapeutic program on survival and incidence of coronary events in asymptomatic patients with diabetes: the ARCADIA study
    G Vanzetto
    Department of Cardiology, University Hospital of Grenoble, France
    Diabetes Metab 33:459-65. 2007
    ....
  29. ncbi request reprint [Study of a detection strategy for silent ischemia in diabetic patients: 18 month follow-up of the ARCADIA register]
    G Vanzetto
    Clinique de Cardiologie, CHU de Grenoble, BP 217 38043 Grenoble Cedex 9
    Arch Mal Coeur Vaiss 100:845-52. 2007
    ..Low risk patients (Group 3, n=276) underwent no specific management...
  30. doi request reprint A prospective study of quality of life in 77 type 1 diabetic patients 12 months after a hospital therapeutic educational programme
    I Debaty
    Department of Endocrinology, Grenoble University Hospital, Grenoble, France
    Diabetes Metab 34:507-13. 2008
    ..However, the majority of studies are focused on biomedical or behavioural markers only. We performed a prospective study to assess QOL in adult type 1 diabetic patients for one year following a hospital educational programme...
  31. doi request reprint Plasma 15-F2t isoprostane concentrations are increased during acute fructose loading in type 2 diabetes
    P Faure
    INSERM, ERI17, laboratoire d étude de la physiopatologie de l hypoxie HP2, Département de Biologie Intégrée, Hopital Albert Michallon, CHU de Grenoble, 38042 Grenoble, France
    Diabetes Metab 34:148-54. 2008
    ....
  32. doi request reprint Basal insulin dose in 40 type 1 diabetic patients remains stable 1 year after educational training in flexible insulin therapy
    P Y Benhamou
    Department of Endocrinology, Pôle DigiDUNE, Grenoble University Hospital, Joseph Fourier University, BP 217X, 38043 Grenoble, France
    Diabetes Metab 36:369-74. 2010
    ..As our hypothesis was that BID changes over time, the primary objective of the present study was to determine the changes in BID 1 year after a therapeutic educational programme on FIT...
  33. ncbi request reprint [Malignant carotid paraganglioma. A case report]
    Ch Righini
    Service ORL, CHU de Grenoble, 38043 Grenoble
    Ann Otolaryngol Chir Cervicofac 120:103-8. 2003
    ..In this case scintigraphy can provide the diagnosis. Malignant forms are more frequent in case of functional paraganglioma, more particularly in case of dopamine secretion...
  34. doi request reprint Role of vildagliptin in managing type 2 diabetes mellitus in the elderly
    S Halimi
    University Hospital of Grenoble, Grenoble, France
    Curr Med Res Opin 26:1647-56. 2010
    ..The objective of this review is to provide an overview of the challenges in managing T2DM in the elderly, with an emphasis on prevention of hypoglycaemia and the role of the DPP-4 inhibitor vildagliptin in this patient population...
  35. pmc The severity of nocturnal hypoxia but not abdominal adiposity is associated with insulin resistance in non-obese men with sleep apnea
    Anne Laure Borel
    Endocrinology Department, University Hospital, Grenoble, France Institut National de la Santé et de la Recherche Médicale INSERM U1042, Grenoble, France HP2 laboratory, University Grenoble Alpes, Grenoble, France
    PLoS ONE 8:e71000. 2013
    ..Beyond obesity, sleep apnea syndrome is frequently associated with excess abdominal adiposity that could contribute to the deteriorated cardiometabolic risk profile of apneic patients...
  36. ncbi request reprint Role of ACE inhibitors in patients with diabetes mellitus
    D J Cordonnier
    Service de Nephrologie, Centre Hospitalier Universitaire de Grenoble, France
    Drugs 61:1883-92. 2001
    ..Finally, there are a growing number of arguments favouring the use of ACE inhibitors very early in patients with diabetes mellitus...
  37. pmc Matrix metalloproteinases and diabetic foot ulcers: the ratio of MMP-1 to TIMP-1 is a predictor of wound healing
    M Muller
    Department of Nephrology and Endocrinology, University Hospital, Grenoble, France
    Diabet Med 25:419-26. 2008
    ..In diabetic foot ulcers there is an excess of MMPs and a decrease of the tissue inhibitors of MMPs (TIMPs). This imbalance is probably one cause of impaired healing. However, little is known about changes in MMPs during wound healing...
  38. ncbi request reprint Effect of low-dose perindopril/indapamide on albuminuria in diabetes: preterax in albuminuria regression: PREMIER
    Carl Erik Mogensen
    Medical Department M, Aarhus Komunehospital, Aarhus University Hospital, 8000 Aarhus, Denmark
    Hypertension 41:1063-71. 2003
    ..A BP-independent effect of the combination may increase renal protection...
  39. ncbi request reprint Postprandial glucose and its role in type 2 diabetes
    Jaime Davidson
    Hormones (Athens) 5:1 p following 217. 2006
  40. pmc Assessment of insulin resistance in fructose-fed rats with 125I-6-deoxy-6-iodo-D-glucose, a new tracer of glucose transport
    Pascale Perret
    INSERM, E340, 38000 Grenoble, France
    Eur J Nucl Med Mol Imaging 34:734-44. 2007
    ..The purpose of this study was to assess variations in glucose transport in rats using (125)I-6-deoxy-6-iodo-D-glucose (6DIG), a new tracer of glucose transport proposed as an imaging tool to assess insulin resistance in vivo...
  41. ncbi request reprint [Diabetes, a worldwide disease]
    Serge Halimi
    Département diabète urologie néphrologie endocrinologie, Hopital Nord, CHU, 38043 Grenoble Cedex 9
    Presse Med 33:Sp37-40. 2004
  42. ncbi request reprint Urinary leukotriene E4 excretion is increased in type 1 diabetic patients: a quantification by liquid chromatography-tandem mass spectrometry
    Gaëlle Hardy
    Laboratory of Pharmacology, Laboratory HP2 INSERM ESPRI EA3745, University of Medicine, F 38706 La Tronche Cedex, France
    Prostaglandins Other Lipid Mediat 78:291-9. 2005
    ..The aim of this study was to evaluate (1) the urinary excretion of leukotriene E4 (LTE4) in type 1 diabetic subjects and healthy volunteers and (2) the influence of glycemic control attested by HbA(1C) on LTE4 excretion...
  43. ncbi request reprint [Interview with professor Serge Halimi]
    Serge Halimi
    Nephrol Ther 2:S206-9. 2006
  44. ncbi request reprint [Measuring microalbuminuria in patients with diabetes: plea for harmonization]
    Serge Halimi
    Presse Med 35:1109-10. 2006
  45. ncbi request reprint In vivo assessment of cardiac insulin resistance by nuclear probes using an iodinated tracer of glucose transport
    Arnaud Briat
    INSERM, E0340, Radiopharmaceutiques Biocliniques, Grenoble 38000, France
    Eur J Nucl Med Mol Imaging 34:1756-64. 2007
    ..This study is the first step towards the development of a technique of insulin resistance measurement in humans with a new tracer of glucose transport, [(123)I]6-deoxy-6-iodo-D-glucose (6DIG)...
  46. ncbi request reprint Characterization of free radical defense system in high glucose cultured HeLa-tat cells: consequences for glucose-induced cytotoxicity
    Sophie Bouvard
    Laboratoire de Biochimie, Faculte de Medecine, Universite Joseph Fourier, 38000 Grenoble, France
    Free Radic Res 36:1017-22. 2002
    ..As a consequence of tat tranfection Mn-SOD activity was 50% lower in HeLa-tat cells in comparison to HeLa-wild cells. This work emphasizes the importance of the antioxidant system in the glucose induced cytotoxicity...
  47. ncbi request reprint Zinc protects HeLa-tat cells against free radical cytotoxicity induced by glucose
    Patrice Faure
    Laboratoire HP2, Faculte de Medecine, Universite Joseph Fourier, 38000 Grenoble, France
    J Trace Elem Med Biol 18:269-76. 2005
    ..These results suggest that the glucose oxidation and its subsequent effects on the cells can be prevented by a biological antioxidant such as zinc...