Jean Louis Gueant

Summary

Affiliation: CHU de Nancy
Country: France

Publications

  1. ncbi request reprint IgE-mediated hypersensitivity to cephalosporins
    Jean Louis Gueant
    INSERM U 724, Laboratoire de Pathologie Cellulaire et Moléculaire en Nutrition and Department of Clinical Biochemistry, University Hospital Center of Nancy and Medical Faculty, University Henry Poincaré, 54500, Nancy, France
    Curr Pharm Des 12:3335-45. 2006
  2. pmc Environmental influence on the worldwide prevalence of a 776C->G variant in the transcobalamin gene (TCN2)
    Jean Louis Gueant
    INSERM U 724, Cellular and Molecular Pathology in Nutrition, Faculte de Medecine, University Henry Poincaré of Nancy, Vandoeuvre les Nancy, France
    J Med Genet 44:363-7. 2007
  3. ncbi request reprint Vitamin B12 is a strong determinant of low methionine synthase activity and DNA hypomethylation in gastrectomized rats
    Laurent Brunaud
    Cellular and Molecular Pathology in Nutrition, EMI, INSERM 0014, URM IFREMER 20, CHU Nancy Brabois, Vandoeuvre les Nancy, Nancy, France
    Digestion 68:133-40. 2003
  4. ncbi request reprint Association of MTRRA66G polymorphism (but not of MTHFR C677T and A1298C, MTRA2756G, TCN C776G) with homocysteine and coronary artery disease in the French population
    Rosa Maria Guéant-Rodriguez
    INSERM U 724, Laboratory of Cellular and Molecular Pathology in Nutrition, Faculty of Medicine, Vandoeuvre les Nancy Cedex, France
    Thromb Haemost 94:510-5. 2005
  5. ncbi request reprint Low frequency of mutated methylenetetrahydrofolate reductase 677C-->T and 1298A-->C genetics single nucleotide polymorphisms (SNPs) in Sub-Saharan populations
    Charles E Adjalla
    Laboratory of Cellular and Molecular Pathology in Nutrition, INSERM 00 14, Faculty of Medicine, Vandoeuvre les Nancy, France
    Clin Chem Lab Med 41:1028-32. 2003
  6. ncbi request reprint Prevalence of methylenetetrahydrofolate reductase 677T and 1298C alleles and folate status: a comparative study in Mexican, West African, and European populations
    Rosa Maria Guéant-Rodriguez
    INSERM U 724, Cellular and Molecular Pathology in Nutrition, Faculte de Medecine, University Henry Poincaré of Nancy, Vandoeuvre les Nancy, France
    Am J Clin Nutr 83:701-7. 2006
  7. doi request reprint Methyl deficient diet aggravates experimental colitis in rats
    Min Chen
    Inserm U954, Medical Faculty and CHU of Nancy, Nancy Universite, Nancy, France
    J Cell Mol Med 15:2486-97. 2011
  8. ncbi request reprint Mild neonatal hypoxia exacerbates the effects of vitamin-deficient diet on homocysteine metabolism in rats
    Sébastien Blaise
    INSERM U 724, Université H Poincaré, 54505 Vandoeuvre les Nancy, France
    Pediatr Res 57:777-82. 2005
  9. pmc Non-injurious neonatal hypoxia confers resistance to brain senescence in aged male rats
    Nicolas Martin
    Inserm U954, Vandoeuvre les Nancy, France
    PLoS ONE 7:e48828. 2012
  10. doi request reprint Homocysteinylation of neuronal proteins contributes to folate deficiency-associated alterations of differentiation, vesicular transport, and plasticity in hippocampal neuronal cells
    Nassila Akchiche
    Inserm U954, Faculte de Medecine, 9 Avenue de la Forêt de Haye, F 54500 Vandoeuvre les Nancy, France
    FASEB J 26:3980-92. 2012

Collaborators

Detail Information

Publications56

  1. ncbi request reprint IgE-mediated hypersensitivity to cephalosporins
    Jean Louis Gueant
    INSERM U 724, Laboratoire de Pathologie Cellulaire et Moléculaire en Nutrition and Department of Clinical Biochemistry, University Hospital Center of Nancy and Medical Faculty, University Henry Poincaré, 54500, Nancy, France
    Curr Pharm Des 12:3335-45. 2006
    ..In assessing the selectivity of the response, negative results in skin testing with cephalosporins other than the responsible one appear to be a reliable indicator of tolerability...
  2. pmc Environmental influence on the worldwide prevalence of a 776C->G variant in the transcobalamin gene (TCN2)
    Jean Louis Gueant
    INSERM U 724, Cellular and Molecular Pathology in Nutrition, Faculte de Medecine, University Henry Poincaré of Nancy, Vandoeuvre les Nancy, France
    J Med Genet 44:363-7. 2007
    ..A 776C-->G variant (dbSNP ID: rs1801198) in the transcobalamin gene (TCN2; MIM# 275350) decreases the cellular and plasma concentration of transcobalamin and thereby influences the cellular availability of vitamin B(12)...
  3. ncbi request reprint Vitamin B12 is a strong determinant of low methionine synthase activity and DNA hypomethylation in gastrectomized rats
    Laurent Brunaud
    Cellular and Molecular Pathology in Nutrition, EMI, INSERM 0014, URM IFREMER 20, CHU Nancy Brabois, Vandoeuvre les Nancy, Nancy, France
    Digestion 68:133-40. 2003
    ..The aim of this study was to assess the respective influence of folate and vitamin B12 deficiency on MTR transcription and activity, and on DNA methylation...
  4. ncbi request reprint Association of MTRRA66G polymorphism (but not of MTHFR C677T and A1298C, MTRA2756G, TCN C776G) with homocysteine and coronary artery disease in the French population
    Rosa Maria Guéant-Rodriguez
    INSERM U 724, Laboratory of Cellular and Molecular Pathology in Nutrition, Faculty of Medicine, Vandoeuvre les Nancy Cedex, France
    Thromb Haemost 94:510-5. 2005
    ..5 (95% CI: 1.5-13.1, P = 0.0051). In conclusion, in contrast to North Europe studies, MTRRAA genotype is a genetic determinant of moderate hyperhomocysteinemia associated with CAD in a French population without vitamin fortification...
  5. ncbi request reprint Low frequency of mutated methylenetetrahydrofolate reductase 677C-->T and 1298A-->C genetics single nucleotide polymorphisms (SNPs) in Sub-Saharan populations
    Charles E Adjalla
    Laboratory of Cellular and Molecular Pathology in Nutrition, INSERM 00 14, Faculty of Medicine, Vandoeuvre les Nancy, France
    Clin Chem Lab Med 41:1028-32. 2003
    ..The 677TT low frequency may be related to the high effect of this mutation on homocysteine metabolism in the environmental conditions of this African region...
  6. ncbi request reprint Prevalence of methylenetetrahydrofolate reductase 677T and 1298C alleles and folate status: a comparative study in Mexican, West African, and European populations
    Rosa Maria Guéant-Rodriguez
    INSERM U 724, Cellular and Molecular Pathology in Nutrition, Faculte de Medecine, University Henry Poincaré of Nancy, Vandoeuvre les Nancy, France
    Am J Clin Nutr 83:701-7. 2006
    ..Distribution of MTHFR 1298A-->C is less well known. It has been hypothesized that 677T frequency could result in part from gene-nutrient interactions...
  7. doi request reprint Methyl deficient diet aggravates experimental colitis in rats
    Min Chen
    Inserm U954, Medical Faculty and CHU of Nancy, Nancy Universite, Nancy, France
    J Cell Mol Med 15:2486-97. 2011
    ..These findings suggest paying attention to vitamin B12 and folate deficits, frequently reported in IBD patients...
  8. ncbi request reprint Mild neonatal hypoxia exacerbates the effects of vitamin-deficient diet on homocysteine metabolism in rats
    Sébastien Blaise
    INSERM U 724, Université H Poincaré, 54505 Vandoeuvre les Nancy, France
    Pediatr Res 57:777-82. 2005
    ..It could therefore potentiate the well-known adverse effects of hyperhomocysteinemia...
  9. pmc Non-injurious neonatal hypoxia confers resistance to brain senescence in aged male rats
    Nicolas Martin
    Inserm U954, Vandoeuvre les Nancy, France
    PLoS ONE 7:e48828. 2012
    ..Thus, early non-injurious hypoxia may trigger beneficial long term effects conferring higher resistance to senescence in aged male rats, with a better preservation of cognitive functions...
  10. doi request reprint Homocysteinylation of neuronal proteins contributes to folate deficiency-associated alterations of differentiation, vesicular transport, and plasticity in hippocampal neuronal cells
    Nassila Akchiche
    Inserm U954, Faculte de Medecine, 9 Avenue de la Forêt de Haye, F 54500 Vandoeuvre les Nancy, France
    FASEB J 26:3980-92. 2012
    ..Prominent homocysteinylation of key neuronal proteins and subsequent aggregation certainly constitute major adverse effects of folate deficiency, affecting normal development with possible long-lasting consequences...
  11. doi request reprint Fumonisin FB1 treatment acts synergistically with methyl donor deficiency during rat pregnancy to produce alterations of H3- and H4-histone methylation patterns in fetuses
    Hélène Pellanda
    INSERM U954 Nutrition, Genetics, and Environmental Risk Exposure, Faculte de Medecine, Nancy Universite, Vandoeuvre les Nancy, France
    Mol Nutr Food Res 56:976-85. 2012
    ..Methyl-deficient diet (MDD) and fumonisin FB1 are risk factors for neural tube defects and cancers. Evidence indicates that FB1 impairs folate metabolism...
  12. ncbi request reprint Genetic determinants of folate and vitamin B12 metabolism: a common pathway in neural tube defect and Down syndrome?
    Jean Louis Gueant
    INSERM 00 14, Laboratory of Cellular and Molecular Pathology in Nutrition, Faculty of Medicine Nancy, Vandoeuvre les Nancy, France
    Clin Chem Lab Med 41:1473-7. 2003
    ..The distinct data produced in different geographical areas may be explained by differences in the nutritional environment and genetic characteristics of the populations...
  13. ncbi request reprint High prevalence of hyperhomocysteinemia related to folate deficiency and the 677C-->T mutation of the gene encoding methylenetetrahydrofolate reductase in coastal West Africa
    Emile K Amouzou
    Laboratory of Cellular and Molecular Pathology in Nutrition, EMI INSERM 00 14, Vandoeuvre les Nancy, France
    Am J Clin Nutr 79:619-24. 2004
    ..Moderate hyperhomocysteinemia is a risk for neural tube defect and neurodegenerative and vascular diseases and has nutritional, metabolic, and genetic determinants. Its prevalence in sub-Saharan Africa remains unknown...
  14. ncbi request reprint Effects of vitamin B12 and folate deficiencies on DNA methylation and carcinogenesis in rat liver
    Laurent Brunaud
    Laboratory of Cell and Molecular Pathology in Nutrition, INSERM EMI 0014 Medical Faculty, University of Nancy I, Vandoeuvre les Nancy, France
    Clin Chem Lab Med 41:1012-9. 2003
    ..In contrast, the effect of vitamin B12 withdrawal, in addition to choline, methionine and folate, induced hepatocellular carcinoma in less than 5% of rats...
  15. doi request reprint Methyl donor deficiency impairs fatty acid oxidation through PGC-1α hypomethylation and decreased ER-α, ERR-α, and HNF-4α in the rat liver
    Shabnam Pooya
    Inserm U954, Medical Faculty and CHU of Nancy, Nancy University, Nancy, France
    J Hepatol 57:344-51. 2012
    ..Methyl donor deficiency produces liver steatosis and predisposes to metabolic syndrome. Whether impaired fatty acid oxidation contributes to this steatosis remains unknown...
  16. doi request reprint Plasma soluble triggering receptor expressed on myeloid cells-1 in Crohn's disease
    Vincent Billioud
    Inserm U954, Université Henri Poincaré 1, Vandoeuvre les Nancy, France
    Dig Liver Dis 44:466-70. 2012
    ..No definite conclusions can be drawn from available data on the accuracy of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) to assess disease activity in Crohn's disease...
  17. doi request reprint Differentiation and neural integration of hippocampal neuronal progenitors: signaling pathways sequentially involved
    Nassila Akchiche
    Inserm U954, Vandoeuvre les Nancy, F 54500, France
    Hippocampus 20:949-61. 2010
    ..Finally, when seeded on rat hippocampal primary cultured neurons, a significant number of differentiated H19-7 cells were able to survive and to develop cell-cell communication...
  18. ncbi request reprint Homocysteine increases methionine synthase mRNA level in Caco-2 cells
    Sandrine Ortiou
    Laboratoire de Pathologie Cellulaire et Moleculaire en Nutrition, Equipe INSERM 0014, Faculte de Medecine, Vandoeuvre les Nancy, France
    Cell Physiol Biochem 14:407-14. 2004
    ..Methionine synthase (MTR) synthesizes methionine from homocysteine, using cobalamin as a cofactor and 5-methyltetrahydrofolate as a cosubstrate...
  19. doi request reprint Helicobacter pylori serologic status has no influence on the association between fucosyltransferase 2 polymorphism (FUT2 461 G->A) and vitamin B-12 in Europe and West Africa
    Abderrahim Oussalah
    INSERM U, Cellular and Molecular Pathology in Nutrition, Henri Poincaré University Nancy, Vandoeuvre les Nancy, France
    Am J Clin Nutr 95:514-21. 2012
    ..Genomewide association studies have shown a relation between plasma vitamin B-12 concentration and the 461G→A polymorphism of fucosyltransferase 2 (FUT2), a gene associated with susceptibility to Helicobacter pylori infection...
  20. doi request reprint Homocysteine is a determinant of ApoA-I and both are associated with ankle brachial index, in an ambulatory elderly population
    Rosa Maria Guéant-Rodriguez
    Inserm U954, Medical Faculty and CHU of Nancy, University Henri Poincare, Nancy, France
    Atherosclerosis 214:480-5. 2011
    ..We aimed therefore to evaluate whether homocysteine and its nutritional determinants, folate and vitamin B12 are associated with ABI by influencing HDL metabolism, in an ambulatory elderly population...
  21. doi request reprint Conditioning-like brief neonatal hypoxia improves cognitive function and brain tissue properties with marked gender dimorphism in adult rats
    Nicolas Martin
    Inserm U954, Nancy Universite, Faculte de Medecine, Nancy, France
    Semin Perinatol 34:193-200. 2010
    ..Therefore, it is proposed that brief neonatal hypoxia may exert long-term beneficial effects through neurogenesis stimulation...
  22. doi request reprint A splicing variant leads to complete loss of function of betaine-homocysteine methyltransferase (BHMT) gene in hepatocellular carcinoma
    Hélène Pellanda
    INSERM U954 Nutrition, Genetics, and Environmental Risk Exposure, Faculte de Medecine, Nancy Universite, 9 Avenue de Forêt de Haye, 54500 Vandoeuvre Nancy, France
    Int J Biochem Cell Biol 44:385-92. 2012
    ..Whether this abnormal transcription of BHMT is part or consequence of liver carcinogenesis should deserve further investigations...
  23. ncbi request reprint Association of MTRR 66A>G polymorphism with superoxide dismutase and disease activity in patients with Crohn's disease
    Laurent Peyrin-Biroulet
    INSERM, U724, Laboratory of Cellular and Molecular Pathology in Nutrition, Faculty of Medicine, Vandoeuvre les Nancy, France
    Am J Gastroenterol 103:399-406. 2008
    ..The aim of this study was to evaluate the association of nutritional (folate, vitamin B12) and genetic (MTHFR, MTR, MTRR, TCN) determinants of homocysteine metabolism and of superoxide dismutase with Crohn's disease (CD)...
  24. doi request reprint Submucosal plexitis as a predictor of postoperative surgical recurrence in Crohn's disease
    Aude Bressenot
    Inserm U954, Genetic Nutrition and Exposure to Environmental Risks NGERE, Henri Poincare University, Vandoeuvre les Nancy, France
    Inflamm Bowel Dis 19:1654-61. 2013
    ..We assessed the value of both submucosal and myenteric plexitis for predicting postoperative surgical recurrence in CD...
  25. ncbi request reprint Hyperhomocysteinemia is related to a decreased blood level of vitamin B12 in the second and third trimester of normal pregnancy
    Celine Chery
    Laboratoire de Pathologie Cellulaire et Moleculaire en Nutrition, Equipe INSERM 00 14, Universite Henri Poincare, Nancy, France
    Clin Chem Lab Med 40:1105-8. 2002
    ..Subclinical deficiency of vitamin B12 should be further investigated in pregnant women who remain on inadequate diet...
  26. doi request reprint Association of IL1B polymorphism with left ventricular systolic dysfunction: a relation with the release of interleukin-1β in stress condition
    Rosa Maria Guéant-Rodriguez
    Nutrition, Genetics and Environment, Inserm U954, Faculty of Medicine, Vandoeuvre les Nancy, Nancy, France
    Pharmacogenet Genomics 21:579-86. 2011
    ....
  27. ncbi request reprint Familial pernicious anaemia with hyperhomocysteinaemia in recurrent early pregnancy loss
    Jean Louis Gueant
    INSERM 0014, University Hospital of Nancy, Vandoeuvre les Nancy, France
    Thromb Haemost 92:1147-9. 2004
  28. pmc Gestational vitamin B deficiency leads to homocysteine-associated brain apoptosis and alters neurobehavioral development in rats
    Sébastien A Blaise
    INSERM U 724, Faculte de Medecine, 9 Avenue de la Forêt de Haye, B P 184, 54500 Vandoeuvre les Nancy, France
    Am J Pathol 170:667-79. 2007
    ....
  29. pmc Luminal expression of cubilin is impaired in Imerslund-Grasbeck syndrome with compound AMN mutations in intron 3 and exon 7
    Fares Namour
    Faculte de Medecine, INSERM U954 Nutrition, Genetics, and Environmental Risk Exposure, Vandoeuvre les Nancy, France
    Haematologica 96:1715-9. 2011
    ..Heterozygous carriers for c.742T and c.208-2G had no pathological signs. These results indicate that amnionless is essential for the correct luminal expression of cubilin in humans...
  30. pmc Vitamin B12 deficiency reduces proliferation and promotes differentiation of neuroblastoma cells and up-regulates PP2A, proNGF, and TACE
    Shyue Fang Battaglia-Hsu
    Institut National de la Santé et de la Recherche Médicale U954, Faculte de Medecine, Nancy Universite, F 54505 Vandoeuvre les Nancy, France
    Proc Natl Acad Sci U S A 106:21930-5. 2009
    ....
  31. doi request reprint Folate and fetal programming: a play in epigenomics?
    Jean Louis Gueant
    Institut National de la Santé et de la Recherche Médicale INSERM Unité 954, Department of Nutrition Genetics Environmental Risk Exposure, University of Lorraine and University Hospital of Nancy, Vandoeuvre les Nancy, France
    Trends Endocrinol Metab 24:279-89. 2013
    ..Deciphering these mechanisms will help understanding the discordances between experimental models and population studies of folate deficiency and supplementation...
  32. doi request reprint Genetic predictors of inflammation in the risk of occupational asthma in young apprentices
    Dovi Stéphanie Acouetey
    Nutrition, Genetics and Environment, Inserm U954, Faculty of Medecine, Vandoeuvre les Nancy, France
    Ann Allergy Asthma Immunol 110:423-428.e5. 2013
    ..The influence of genetic predictors of inflammation and atopy on occupational asthma in apprentices is not known...
  33. ncbi request reprint Gene-gene interactions of IL13 and IL4RA variants in immediate allergic reactions to betalactam antibiotics
    Rosa Maria Guéant-Rodriguez
    INSERM U 724, Faculte de Medecine, University of Nancy Henri Poincaré and Department of Clinical Chemistry, Nutrition and Metabolism, University Hospital, Nancy Vandoeuvre, France
    Pharmacogenet Genomics 16:713-9. 2006
    ..We aimed to evaluate the association between immediate allergic reactions to betalactams and the polymorphisms of IL13 (R130Q and -1055C>T variants) and IL4RA (I50V, S478P, and Q551R variants)...
  34. doi request reprint Colorectal cancer in inflammatory bowel diseases: a population-based study (1976-2008)
    Laurent Peyrin-Biroulet
    INSERM, U954 and Department of Hepato Gastroenterology, University Hospital of Nancy, Université Henri Poincaré 1, Vandoeuvre les Nancy, France
    Inflamm Bowel Dis 18:2247-51. 2012
    ..Few data are available on the incidence, characteristics, treatment, and prognosis of inflammatory bowel disease (IBD)-associated colorectal cancer (CRC) in population-based cohorts...
  35. doi request reprint Molecular and cellular effects of vitamin B12 in brain, myocardium and liver through its role as co-factor of methionine synthase
    Jean Louis Gueant
    Inserm U954, Department of Nutrition Genetics Environmental Risk Exposure, University of Lorraine and University Hospital of Nancy, Vandoeuvre les Nancy, France
    Biochimie 95:1033-40. 2013
    ..Some but not all of these effects reflect the upstream role of vitamin B12 in SAM synthesis...
  36. ncbi request reprint Mice deficient in cystathionine beta synthase display altered homocysteine remethylation pathway
    Jean Marc Alberto
    INSERM U724, Faculte de Medecine, Vandoeuvre les Nancy, France
    Mol Genet Metab 91:396-8. 2007
    ..We showed that CBS deficiency in mice reduced hepatic methionine synthase and betaine-homocysteine methyltransferase activities, whereas 5,10-methylene tetrahydrofolate reductase activity was increased...
  37. doi request reprint Urinary tract infections in hospitalized inflammatory bowel disease patients: a 10-year experience
    Laurent Peyrin-Biroulet
    INSERM, U954 and Department of Hepato Gastroenterology, University Hospital of Nancy, Vandoeuvre les Nancy, France
    Inflamm Bowel Dis 18:697-702. 2012
    ..Cystitis is the most common genitourinary complication in Crohn's disease (CD). We assessed the prevalence of and risk factors for urinary tract infections (UTI) in inflammatory bowel diseases (IBD)...
  38. doi request reprint Evaluation of neonatal BH4 loading test in neonates screened for hyperphenylalaninemia
    Francois Feillet
    Reference Centre for Inborn Errors of Metabolism, Department of Pediatry, CHU of Nancy, Allee du Morvan, Vandoeuvre les Nancy, 54500, France
    Early Hum Dev 84:561-7. 2008
    ..The outcome in phenylketonuria is related to the early diagnosis and management due to neonatal screening...
  39. doi request reprint Evidence of cataplerosis in a patient with neonatal classical galactosemia presenting as citrin deficiency
    Francois Feillet
    Centre de Référence des Maladies Héréditaires du Métabolisme et Inserm U724, CHU et Faculté de Médecine de Nancy, France
    J Hepatol 48:517-22. 2008
    ..Our case clearly shows that cataplerosis could play a role in the pathophysiology of the neonatal liver disease observed in classical galactosemia...
  40. ncbi request reprint Constitutive nitric oxide synthase inhibition combined with histamine and serotonin receptor blockade improves the initial ovalbumin-induced arterial hypotension but decreases the survival time in brown norway rats anaphylactic shock
    Abdelouahab Bellou
    Experimental Nephrology Laboratory, Vandoeuvre les Nancy, 54505, France
    Shock 19:71-8. 2003
    ..Thus, the combined blockade of vasodilator mediators (histamine, serotonin, and nitric oxide) slowed the MABP drop in anaphylactic shock, but did not improve survival. More studies are needed to understand these discordant effects...
  41. doi request reprint Methylenetetrahydrofolate reductase 677 T allele protects against persistent HBV infection in West Africa
    Jean Pierre Bronowicki
    INSERM U724, Cellular and Molecular Pathology in Nutrition, Faculte de Medecine, University Henri Poincaré of Nancy, Vandoeuvre les Nancy, France
    J Hepatol 48:532-9. 2008
    ..We evaluated the association of determinants of homocysteine metabolism with the outcome of HBV infection...
  42. ncbi request reprint Purification and cloning of two high molecular mass isoforms of peanut seed oleosin encoded by cDNAs of equal sizes
    Laurent Pons
    Laboratoire de Pathologie Cellulaire et Moleculaire en Nutrition, INSERM EMI 0014, Faculte de Medecine, Universite Henri Poincare Nancy 1, BP 184, 54505 Vandaeuvre lès Nancy Cedex, France
    Plant Physiol Biochem 43:659-68. 2005
    ..Oligomers reflect the natural ability of oleosins to strongly interact with each other via not only their central domains but also their N- and C-terminal domains...
  43. ncbi request reprint Serum concentrations of sex hormone binding globulin are elevated in kwashiorkor and anorexia nervosa but not in marasmus
    Nathalie Pascal
    Laboratoire de Pathologie Cellulaire et Moleculaire en Nutrition, EMI INSERM 0014 et URM IFREMER 20, Faculte de Medecine, Vandoeuvre, France
    Am J Clin Nutr 76:239-44. 2002
    ..Customary blood protein markers for malnutrition are of limited value in the diagnosis of protein-energy malnutrition or anorexia nervosa in children and in the follow-up to refeeding in such children...
  44. ncbi request reprint Influence of preconditioning-like hypoxia on the liver of developing methyl-deficient rats
    Sébastien A Blaise
    INSERM U724, Faculte de Medecine, 9 ave de la forêt de Haye, BP 184, F 54500 Vandoeuvre les Nancy, France
    Am J Physiol Endocrinol Metab 293:E1492-502. 2007
    ....
  45. ncbi request reprint Lack of association between microsatellite instability and benign adrenal tumors
    Fares Namour
    Department of Biochemistry, CHU Nancy Brabois, INSERM U724, Allee du Morvan, 54511, Vandoeuvre les Nancy, France
    World J Surg 30:1240-6. 2006
    ..The genetic mechanisms underlying the formation of these tumors include somatic mutations in susceptibility genes, especially in the familial forms, and allelic loss, especially in chromosome 1...
  46. ncbi request reprint Hypersensitivity reactions to iodinated contrast media
    Rosa Maria Guéant-Rodriguez
    INSERM U 724, Laboratory of Cellular and Molecular Pathology in Nutrition, Faculty of Medicine, B P 184 54505 Vandoeuvre les Nancy Cedex, France
    Curr Pharm Des 12:3359-72. 2006
    ..This paper summarizes the current state of the art and addresses the research that is still needed on the pathogenic mechanisms, diagnosis, and prevention of ICM-induced hypersensitivity reactions...
  47. doi request reprint Interaction between methionine synthase isoforms and MMACHC: characterization in cblG-variant, cblG and cblC inherited causes of megaloblastic anaemia
    Ma atem B Fofou-Caillierez
    Inserm U954 Nutrition Genetics Environmental Risk Exposure and Reference Centre of Inborn Metabolism Diseases, Medical Faculty of Nancy University and University Hospital Centre, Nancy, France
    Hum Mol Genet 22:4591-601. 2013
    ..Our data suggest that the interaction of MS with MMACHC may play a role in the regulation of the cellular processing of Cbls that is required for Cbl cofactor synthesis. ..
  48. ncbi request reprint Inhibition by TNF-alpha and IL-4 of cationic lipid mediated gene transfer in cystic fibrosis tracheal gland cells
    Sonia Bastonero
    Laboratoire de Pathologie Cellulaire et Moleculaire en Nutrition, INSERM U724, Faculte de Medecine, BP 184, 54505 Vandoeuvre les Nancy, France
    J Gene Med 7:1439-49. 2005
    ..This gene is mutated in the lethal monogenic disease cystic fibrosis (CF). Clinical trials in which the human CFTR cDNA was delivered to the respiratory epithelia of CF patients have resulted in weak and transient gene expression...
  49. doi request reprint Microscopic features for initial diagnosis and disease activity evaluation in inflammatory bowel disease
    Aude Bressenot
    Inserm U954, Medical Faculty and CHU of Nancy, Nancy Universite, Nancy, France
    Inflamm Bowel Dis 19:1745-52. 2013
    ..The aim of this review was to summarize microscopic features of inflammatory bowel disease for initial diagnosis and evaluation of disease activity in both CD and UC...
  50. pmc Early incidence of occupational asthma among young bakers, pastry-makers and hairdressers: design of a retrospective cohort study
    Thomas Rémen
    Institut National de la santé et de la Recherche Médicale U 954, School of Medicine, Nancy, France
    BMC Public Health 10:206. 2010
    ....
  51. doi request reprint Life-threatening methylenetetrahydrofolate reductase (MTHFR) deficiency with extremely early onset: characterization of two novel mutations in compound heterozygous patients
    Thierry Forges
    INSERM U954 Nutrition, Genetics, and Environmental Risk Exposure, Faculte de Medecine, 9 Avenue de la Forêt de Haye, Vandoeuvre les Nancy, France
    Mol Genet Metab 100:143-8. 2010
    ..Characterization of the relatives further allows for preventive measure to limit the risks of chronic hyperhomocysteinemia...
  52. ncbi request reprint Cobalamin potentiates vinblastine cytotoxicity through downregulation of mdr-1 gene expression in HepG2 cells
    Véronique Marguerite
    Laboratoire de Pathologie Cellulaire et Moleculaire en Nutrition, Faculte de Medecine, University Henry Poincaré, Vandoeuvre les Nancy, Cedex, France
    Cell Physiol Biochem 20:967-76. 2007
    ..We here used HepG2 cells to determine the role of the methionine cycle (through the use of the Methionine-Synthase (MS) cofactor, cobalamin) on mdr-1 gene expression...
  53. doi request reprint Ovarian tissue cryopreservation and subsequent spontaneous pregnancies in a patient with classic galactosemia
    Thierry Forges
    Inserm U954, Nutrition, Genetics, and Environmental Risk Exposure, Nancy University Medical School, and Department of Pediatrics and Clinical Genetics, University Hospital of Nancy, Vandoeuvre les Nancy, France
    Fertil Steril 95:290.e1-3. 2011
    ..To report two consecutive spontaneous pregnancies in a compound heterozygous patient with classic galactosemia and a heterozygous partner, 6 years after ovarian tissue cryopreservation...
  54. ncbi request reprint Evidence for a functional genetic polymorphism of the human retinoic acid-metabolizing enzyme CYP26A1, an enzyme that may be involved in spina bifida
    Emmanuel Rat
    Equipe d accueil EA2679, Faculte de Medecine, Lille Cedex, France
    Birth Defects Res A Clin Mol Teratol 76:491-8. 2006
    ..As RA is a critical regulator of gene expression during embryonic development, the imbalance between the synthesis and degradation of RA during embryogenesis could contribute to malformations and developmental defects...
  55. doi request reprint Ocular symptoms are not predictive of ophthalmologic inflammation in inflammatory bowel disease
    Véronique Cloché
    Department of Ophthalmology, Nancy University Hospital, Vandoeuvre les Nancy, France
    Dig Liver Dis 45:195-9. 2013
    ..Ocular manifestations are frequent in patients with inflammatory bowel disease...
  56. pmc Anchoring secreted proteins in endoplasmic reticulum by plant oleosin: the example of vitamin B12 cellular sequestration by transcobalamin
    Laurent Pons
    Inserm U954, Faculte de Medecine, Nancy Universite, Vandoeuvre les Nancy, France
    PLoS ONE 4:e6325. 2009
    ..This was achieved by the overexpression of transcobalamin inside cells through anchoring to oleosin...