Philippe Gosse

..We compared a number of common criteria in hypertensive patients by taking as references left ventricular mass (LVM) measured by echocardiography and prediction of incident CVE...

..Study of the PROOF cohort supplied further information by analysis of subjects of identical age using a method that eliminates the immediate influence of blood pressure on pulse wave velocity...

..This indice of arterial stiffness has been shown to be linked to future cardiovascular (CV) events, independently of 24 h BP. However this interval may be abnormally prolonged in case of left bundle branch blocks (LBBB)...

..This study shows a significant proportion of hypertensive patients, whether treated or not, with high ambulatory blood pressure, especially in those with hyperglycemia who have a higher risk of complications...

..We wanted to study this relationship in a population of newly recognized hypertensive subjects with preserved renal function using another method to assess arterial stiffness and to see whether it was independent of 24-h BP...

..The objective of this longitudinal study was to examine the relationship between arterial stiffness assessed by this method and the occurrence of cardiovascular complications in a cohort of initially untreated hypertensive patients...

..Further high-quality studies are needed to define how LVH predicts cardiovascular risk, which agents are most effective at eliciting LVH regression and how such reversal can affect cardiovascular outcome...

..45 ng/ml/h, supine aldosteronaemia >417 pmol/l, and erect aldosterone/renin >1180...

..A priori, this method of reading has the potential of decreasing measurement variability...

..Within this class of anti-hypertensive agents, pharmacological differences may mean that some agents afford greater cardioprotection than others...

..Physicians involved in the management of hypertensive patients should be aware of its value in order to assist patients in their care...

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..The cohort of the Prognostic Indicator of Cardiovascular and Cerebrovascular Events study is a representative population of 65-year-old individuals in which this relation can be examined...

..The existence of diabetes appeared to have a negative influence on this improvement. Furthermore, an increase in arterial stiffness may be a factor of resistance to the action of antihypertensive medication...

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..This supposition is being tested in the ONgoing Telmisartan Alone and in combination with Ramipril Global Endpoint Trial (ONTARGET) programme...

..Several recent studies, essentially cross-sectional, point to a role for an increase in arterial stiffness and its corollary, the increased pulse pressure (PP), in barotrauma of the renal glomerulus...

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..To assess the consequences of malignant hypertension and its evolution with antihypertensive treatment...

..Because this link was observed during follow-up, it is possible that increased arterial stiffness favors the increase in the PR interval with age...

..Such a trial, the LIVE study, gave us the opportunity to examine the influence of the mode of reading of the echo tracings on results and to underline the value of two initial recordings performed at entry...

..73 vs 0.58, p < 0.01). In multivariate analysis, the variable showing the higher correlation to LVM is 24 h SBP in males, weight in females. For a similar increase in BP, males hypertensive show a higher increase in LVM than females...

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..In conclusion: determination of QKD(100-60) to assess arterial stiffness gives stable results over 1 year in patients with systemic sclerosis...

..Our findings indicate the value of aggressive blockade of alpha-1 receptors in preparation for surgery of phaeochromocytoma...

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..We compared telmisartan, an angiotensin II receptor blocker with a trough-to-peak ratio >90%, with ramipril, an angiotensin-converting enzyme inhibitor with a trough-to-peak ratio of around 50%...

..This study was designed to examine the relationship between QKD and QKD(100-60) on heart rate and systolic function of the left ventricle, the two parameters governing the pre-ejection time which is part of the QKD interval...

..The concentric character of the LVH of the hypertensive patient was thus linked to the reduction in arterial distensibility...

..To compare the efficacy of indapamide sustained release (SR) 1.5 mg and enalapril 20 mg at reducing left ventricular mass index (LVMI) in hypertensive patients with left ventricular hypertrophy (LVH)...

..Left ventricular hypertrophy (LVH) is a marker of cardiovascular risk. However, the progression of the risk as a function of the course of the LVH has only been the subject of few studies...

..The ERAMS study addressed the value of arterial stiffness in predicting the severity of systemic sclerosis...

..Standard deviation of differences for QKD100-60 was 12 ms, the coefficient of variation 6% and the coefficient of repeatibility 24 ms. So QKD100-60 shows a good reproducibility in the same range that 24 h blood pressure means...

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..Distensibility is the ability of large elastic arteries to increase in diameter from diastole to systole. Pulse wave velocity (PWV) is one of the ways to measure this parameter. Several techniques, including QKd, are able to measure PWV...

..Results are presented for each 10 years age group (mean +/- SD)...

..The aim was to block the alpha(1) adrenergic receptors before any acute catecholamine release, to prevent any severe rise in blood pressure...

..It fulfils most of the conditions of a substitute criterion. However, the relationship between its reduction with treatment and the reduction of risk, independently of the change in blood pressure, remains to be shown...

..This effectively eliminates the influence of height, which reflects the length of the arterial segment under investigation...

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..A marked abrupt daily elevation in blood pressure on arising, then maintained for a certain time, could contribute to the development of left ventricular hypertrophy and may constitute a trigger for cardiovascular complications...

..A possible explanation lies in the different effects of the treatments on BPc. We propose a new noninvasive method for the automatic measurement of BPc based on the QKD interval, an arterial stiffness marker...

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..It provides further support for a genetic anomaly in this condition. Our case also indicates the interest of laparoscopy for the surgical treatment of adrenal pheochromocytoma, even in bilateral tumors...

..The intensive research into this problem, further stimulated by the encouraging results of the HYCAR study, should help define the role and value of echocardiography in the future management of hypertension...

..014). CONCLUSIONS: Magnitude of gray level cyclic variation of IVS can be studied easily with this new semi-automatic software, is altered in hypertensives and correlated with parameters of systolic function...

..Although aptitude for resumption of work is usually evaluated after myocardial infarction, the return home often entails significant daily obligations whose cardiovascular implications are poorly described and may well be underestimated...

..This study confirms the value of using everyday activities for programming rate responsive pacemakers, the limitations of automatic adjustment and the need for personalized programming...

..The PICXEL study compared the efficacy of a strategy based on first-line combination with perindopril/indapamide versus monotherapy with enalapril in reducing left ventricular hypertrophy (LVH) in hypertensive patients...

..To compare the efficacy and safety of once-daily telmisartan and ramipril on blood pressure (BP) reductions during the last 6 h of the dosing interval...

..CONCLUSIONS: Objective sleep quality as assessed by wrist actigraphy is not significantly altered by ambulatory blood pressure monitoring, whereas subjective sleep quality is adversely affected in good sleepers...

..Ambulatory blood pressure (BP) is more sensitive than office BP and is highly correlated with the left ventricular mass (LVM) of hypertensive patients with left ventricular hypertrophy (LVH)...

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