Victor de Ledinghen

Summary

Affiliation: CHU de Bordeaux
Country: France

Publications

  1. doi request reprint Transient elastography for the diagnosis of liver fibrosis
    Victor de Ledinghen
    Centre d Investigation de la Fibrose hépatique, Hopital Haut Leveque, 33604 Pessac Cedex, France
    Expert Rev Med Devices 7:811-23. 2010
  2. doi request reprint Non-invasive tests for fibrosis and liver stiffness predict 5-year survival of patients chronically infected with hepatitis B virus
    V de Ledinghen
    Centre d Investigation de la Fibrose hépatique, Hopital Haut Leveque, CHU Bordeaux, Pessac, France
    Aliment Pharmacol Ther 37:979-88. 2013
  3. doi request reprint Non-invasive diagnosis of liver steatosis using controlled attenuation parameter (CAP) and transient elastography
    Victor de Ledinghen
    Service d Hepato Gastroenterologie, Hopital Haut Leveque, CHU Bordeaux, Pessac, France
    Liver Int 32:911-8. 2012
  4. doi request reprint Screening for liver fibrosis by using FibroScan(®) and FibroTest in patients with diabetes
    Victor de Ledinghen
    Service d Hepato Gastroenterologie, Hopital Haut Leveque, Pessac, France
    Dig Liver Dis 44:413-8. 2012
  5. doi request reprint Diagnosis of liver fibrosis and cirrhosis using liver stiffness measurement: comparison between M and XL probe of FibroScan®
    Victor de Ledinghen
    Centre d Investigation de la Fibrose hépatique, Centre Hospitalier Universitaire CHU de Bordeaux, Hopital Haut Leveque, France
    J Hepatol 56:833-9. 2012
  6. pmc Diagnostic value of biochemical markers (NashTest) for the prediction of non alcoholo steato hepatitis in patients with non-alcoholic fatty liver disease
    Thierry Poynard
    Hepato Gastroenterology, AP HP Groupe Hospitalier Pitié Salpétrière, Paris, France
    BMC Gastroenterol 6:34. 2006
  7. pmc Diagnostic value of biochemical markers (FibroTest-FibroSURE) for the prediction of liver fibrosis in patients with non-alcoholic fatty liver disease
    Vlad Ratziu
    Hepato Gastroenterology, AP HP Groupe Hospitalier Pitié Salpétrière, Paris, France
    BMC Gastroenterol 6:6. 2006
  8. doi request reprint Liver fibrosis on account of chronic hepatitis C is more severe in HIV-positive than HIV-negative patients despite antiretroviral therapy
    V de Ledinghen
    Centre d Investigation de la Fibrose hépatique, Hopital Haut Leveque, CHU Bordeaux, Pessac, France
    J Viral Hepat 15:427-33. 2008
  9. ncbi request reprint Diagnostic and predictive factors of significant liver fibrosis and minimal lesions in patients with persistent unexplained elevated transaminases. A prospective multicenter study
    Victor de Ledinghen
    Service d Hepato Gastroenterologie, Hopital du Haut leveque, Pessac, France
    J Hepatol 45:592-9. 2006
  10. ncbi request reprint Outbreak of hepatitis C virus infection during sclerotherapy of varicose veins: long-term follow-up of 196 patients (4535 patient-years)
    Victor de Ledinghen
    Service d Hepato Gastroenterologie, Hopital Haut Leveque, Pessac, France
    J Hepatol 46:19-25. 2007

Detail Information

Publications48

  1. doi request reprint Transient elastography for the diagnosis of liver fibrosis
    Victor de Ledinghen
    Centre d Investigation de la Fibrose hépatique, Hopital Haut Leveque, 33604 Pessac Cedex, France
    Expert Rev Med Devices 7:811-23. 2010
    ..FibroScan evaluates liver stiffness, which is related to fibrosis, but also inflammation and portal hypertension. Therefore, FibroScan values have to be interpreted according to clinical, biological and morphological data...
  2. doi request reprint Non-invasive tests for fibrosis and liver stiffness predict 5-year survival of patients chronically infected with hepatitis B virus
    V de Ledinghen
    Centre d Investigation de la Fibrose hépatique, Hopital Haut Leveque, CHU Bordeaux, Pessac, France
    Aliment Pharmacol Ther 37:979-88. 2013
    ..However, in patients chronically infected with hepatitis B virus (HBV), only the association between liver stiffness and the risk of hepatocellular carcinoma has been published...
  3. doi request reprint Non-invasive diagnosis of liver steatosis using controlled attenuation parameter (CAP) and transient elastography
    Victor de Ledinghen
    Service d Hepato Gastroenterologie, Hopital Haut Leveque, CHU Bordeaux, Pessac, France
    Liver Int 32:911-8. 2012
    ..The aim of this study was to prospectively evaluate the performance of CAP for the diagnosis of steatosis in patients with chronic liver disease...
  4. doi request reprint Screening for liver fibrosis by using FibroScan(®) and FibroTest in patients with diabetes
    Victor de Ledinghen
    Service d Hepato Gastroenterologie, Hopital Haut Leveque, Pessac, France
    Dig Liver Dis 44:413-8. 2012
    ..Patients with diabetes are at risk for nonalcoholic fatty liver disease leading to cirrhosis. Existing guidelines do not advocate screening for liver related complications amongst persons with diabetes...
  5. doi request reprint Diagnosis of liver fibrosis and cirrhosis using liver stiffness measurement: comparison between M and XL probe of FibroScan®
    Victor de Ledinghen
    Centre d Investigation de la Fibrose hépatique, Centre Hospitalier Universitaire CHU de Bordeaux, Hopital Haut Leveque, France
    J Hepatol 56:833-9. 2012
    ..The aim of this study was to evaluate the accuracy of liver stiffness measurement using M and XL probes of Fibroscan® for the diagnosis of fibrosis and cirrhosis in a large cohort of patients...
  6. pmc Diagnostic value of biochemical markers (NashTest) for the prediction of non alcoholo steato hepatitis in patients with non-alcoholic fatty liver disease
    Thierry Poynard
    Hepato Gastroenterology, AP HP Groupe Hospitalier Pitié Salpétrière, Paris, France
    BMC Gastroenterol 6:34. 2006
    ..The aim was to develop and validate a new biomarker of non alcoholic steato hepatitis (NASH) the NashTest (NT) in patients with NAFLD...
  7. pmc Diagnostic value of biochemical markers (FibroTest-FibroSURE) for the prediction of liver fibrosis in patients with non-alcoholic fatty liver disease
    Vlad Ratziu
    Hepato Gastroenterology, AP HP Groupe Hospitalier Pitié Salpétrière, Paris, France
    BMC Gastroenterol 6:6. 2006
    ..The aim of this study was to determine the diagnostic utility of non-invasive markers of fibrosis, validated in chronic viral hepatitis and alcoholic liver disease (FibroTest, FT), in patients with NAFLD...
  8. doi request reprint Liver fibrosis on account of chronic hepatitis C is more severe in HIV-positive than HIV-negative patients despite antiretroviral therapy
    V de Ledinghen
    Centre d Investigation de la Fibrose hépatique, Hopital Haut Leveque, CHU Bordeaux, Pessac, France
    J Viral Hepat 15:427-33. 2008
    ..HIV/HCV-coinfected patients have more advanced liver fibrosis than HCV-monoinfected patients despite the immunologic benefit of HAART...
  9. ncbi request reprint Diagnostic and predictive factors of significant liver fibrosis and minimal lesions in patients with persistent unexplained elevated transaminases. A prospective multicenter study
    Victor de Ledinghen
    Service d Hepato Gastroenterologie, Hopital du Haut leveque, Pessac, France
    J Hepatol 45:592-9. 2006
    ..The aim of this prospective study was to identify diagnosis and clinical and biological factors associated with significant (bridging) fibrosis and minimal lesions of the liver in patients with persistent unexplained elevated ALT levels...
  10. ncbi request reprint Outbreak of hepatitis C virus infection during sclerotherapy of varicose veins: long-term follow-up of 196 patients (4535 patient-years)
    Victor de Ledinghen
    Service d Hepato Gastroenterologie, Hopital Haut Leveque, Pessac, France
    J Hepatol 46:19-25. 2007
    ....
  11. doi request reprint [Non-invasive evaluation of liver fibrosis in hepatitis C]
    V de Ledinghen
    Centre d Investigation de la Fibrose hépatique, CHU Bordeaux, Hopital du Haut leveque, 1, Avenue de Magellan, 33604 Pessac, France
    Gastroenterol Clin Biol 32:S90-5. 2008
    ..However, their performances are excellent for the diagnosis of severe fibrosis or cirrhosis compared to moderate fibrosis...
  12. ncbi request reprint Liver stiffness measurement in children using FibroScan: feasibility study and comparison with Fibrotest, aspartate transaminase to platelets ratio index, and liver biopsy
    Victor de Ledinghen
    INSERM, Universite Victor Segalen Bordeaux 2, Bordeaux, France
    J Pediatr Gastroenterol Nutr 45:443-50. 2007
    ....
  13. doi request reprint Feasibility of liver transient elastography with FibroScan using a new probe for obese patients
    Victor de Ledinghen
    Service d Hepato Gastroenterologie, Hopital Haut Leveque, Pessac, France
    Liver Int 30:1043-8. 2010
    ..The aim of this prospective study was to assess the feasibility of LSM when using a new XL probe on patients with a body mass index (BMI) > or =30 kg/m(2)...
  14. ncbi request reprint Detection of nodules in liver cirrhosis: spiral computed tomography or magnetic resonance imaging? A prospective study of 88 nodules in 34 patients
    Victor de Ledinghen
    Unite de Transplantation Hepatique, Hopital Pellegrin, Bordeaux, France
    Eur J Gastroenterol Hepatol 14:159-65. 2002
    ..However, tumour size is always a restricting factor for these two techniques, which are unable to detect small HCC in more than 60% of cases...
  15. ncbi request reprint [Should we do a liver puncture biopsy in patients with chronic "unexplained" cytolyses?]
    Victor de Ledinghen
    Service d Hepato Gastroenterologie, Hopital du Haut leveque, 33604 Pessac Cedex, France
    Gastroenterol Clin Biol 26:724-7. 2002
  16. doi request reprint Transient elastography (FibroScan)
    V de Ledinghen
    Centre d Investigation de la Fibrose hépatique, Hopital Haut Leveque, Pessac, France INSERM U889, Universite Victor Segalen, Bordeaux, France
    Gastroenterol Clin Biol 32:58-67. 2008
    ..Therefore, FibroScan values have to be interpreted according to clinical, biological and morphological data...
  17. ncbi request reprint Should a liver biopsy be done in patients with subclinical chronically elevated transaminases?
    Victor de Ledinghen
    Service d Hepato Gastroenterologie, Centre Hospitalier Universitaire, Hopital du Haut leveque, Pessac, France
    Eur J Gastroenterol Hepatol 16:879-83. 2004
    ..Since the risk of F > or = 2 fibrosis is significantly increased in patients with AST > N and/or ALT > 2N, liver biopsy should be performed only in patients with AST > N or ALT > 2N...
  18. ncbi request reprint Daily or three times a week interferon alfa-2b in combination with ribavirin or interferon alone for the treatment of patients with chronic hepatitis C
    Victor de Ledinghen
    Service d Hepato Gastroenterologie, Centre Hospitalier Universitaire, Pessac, France
    J Hepatol 36:672-80. 2002
    ..We compared the efficacy and safety of daily interferon alfa-2b in combination with ribavirin with those of interferon alfa-2b three times a week alone or in combination with ribavirin...
  19. ncbi request reprint Epidemiological and phylogenetic evidence for patient-to-patient hepatitis C virus transmission during sclerotherapy of varicose veins
    Victor de Ledinghen
    Services d Hépato gastroentérologie, Centre Hospitalier Universitaire, Bordeaux, France
    J Med Virol 76:279-84. 2005
    ..The method by which infection was likely to have been transmitted was probably the use of a single vial for multiple patients. This study provides strong evidence that sclerotherapy of varicose veins is a risk factor for HCV infection...
  20. doi request reprint Early detection in routine clinical practice of cirrhosis and oesophageal varices in chronic hepatitis C: comparison of transient elastography (FibroScan) with standard laboratory tests and non-invasive scores
    Laurent Castera
    Service d Hepato Gastroenterologie, Hopital Haut Leveque, Centre Hospitalier Universitaire CHU de Bordeaux, Pessac, France
    J Hepatol 50:59-68. 2009
    ....
  21. doi request reprint Noninvasive tests for fibrosis and liver stiffness predict 5-year outcomes of patients with chronic hepatitis C
    Julien Vergniol
    Centre d Investigation de la Fibrose hépatique, Hopital Haut Leveque, CHU Bordeaux, Pessac, France
    Gastroenterology 140:1970-9, 1979.e1-3. 2011
    ..We evaluated the abilities of liver stiffness, results from noninvasive tests for fibrosis, and liver biopsy analyses to predict overall survival or survival without liver-related death with a 5-year period...
  22. ncbi request reprint Prospective comparison of transient elastography, Fibrotest, APRI, and liver biopsy for the assessment of fibrosis in chronic hepatitis C
    Laurent Castera
    Service d Hepato Gastroenterologie, Hopital Haut Leveque, C H U Bordeaux, Pessac, France
    Gastroenterology 128:343-50. 2005
    ....
  23. doi request reprint Assessment of liver fibrosis using transient elastography in patients with alcoholic liver disease
    Pierre Nahon
    AP HP, Service d Hepato Gastroenterologie, Hopital Jean Verdier, Avenue du 14 Juillet, 93143 Bondy, France
    J Hepatol 49:1062-8. 2008
    ..The aim of this study was to assess the accuracy of liver stiffness measurement (LSM) for the diagnosis of extensive fibrosis and cirrhosis in patients with alcoholic liver disease (ALD)...
  24. doi request reprint Usefulness of noninvasive tests in nodular regenerative hyperplasia of the liver
    David Laharie
    INSERM U853, Universite Victor Segalen Bordeaux 2, France
    Eur J Gastroenterol Hepatol 22:487-93. 2010
    ..The only way to diagnose nodular regenerative hyperplasia (NRH) is liver biopsy...
  25. doi request reprint Validation and comparison of simple noninvasive indexes for predicting liver fibrosis in HIV-HCV-coinfected patients: ANRS CO3 Aquitaine cohort
    Marc Arthur Loko
    INSERM, U593, Bordeaux, France
    Am J Gastroenterol 103:1973-80. 2008
    ..Although an increasing number of noninvasive fibrosis markers are available in HCV-monoinfected patients, data on the performance of these tests in HIV-HCV-coinfected patients are lacking...
  26. doi request reprint Prospective comparison of two algorithms combining non-invasive methods for staging liver fibrosis in chronic hepatitis C
    Laurent Castera
    Service d Hepato Gastroenterologie, Hopital Haut Leveque, Centre Hospitalier Universitaire C H U de Bordeaux, Pessac, France
    J Hepatol 52:191-8. 2010
    ..The aim of this prospective study was to compare the performance of these two algorithms for diagnosing significant fibrosis and cirrhosis in 302 CHC patients...
  27. ncbi request reprint Daily or three times per week interferon alpha-2b in combination with ribavirin or interferon alone for the treatment of patients with chronic hepatitis C not responding to previous interferon alone
    Victor de Ledinghen
    Service d Hepato Gastroenterologie, Centre Hospitalier Universitaire, Hopital du Haut leveque, 33604 Pessac Cedex, France
    J Hepatol 36:819-26. 2002
    ....
  28. doi request reprint A new combination of blood test and fibroscan for accurate non-invasive diagnosis of liver fibrosis stages in chronic hepatitis C
    Jérôme Boursier
    Service d Hepato Gastroenterologie, CHU, Angers, France
    Am J Gastroenterol 106:1255-63. 2011
    ..Our aim was to develop a new and more accurate fibrosis stage classification by using new scores combining non-invasive fibrosis tests...
  29. ncbi request reprint Psychological impact of chronic hepatitis C: comparison with other stressful life events and chronic diseases
    Laurent Castera
    Service d Hepato Gastroenterologie, Centre Hospitalier Universitaire de Bordeaux, Hopital Haut Leveque, Avenue Magellan, 33604 Pessac, France
    World J Gastroenterol 12:1545-50. 2006
    ..To examine the psychological impact of chronic hepatitis C (CHC) diagnosis in a large cohort of CHC patients as compared with other stressful life events and chronic diseases carrying a risk of life-threatening complications...
  30. ncbi request reprint Prevalence and factors associated with failure of liver stiffness measurement using FibroScan in a prospective study of 2114 examinations
    Juliette Foucher
    Service d Hepato Gastroenterologie, Centre d Investigation de la Fibrose hépatique, Hopital Haut Leveque, Pessac, France
    Eur J Gastroenterol Hepatol 18:411-2. 2006
    ..Other non-invasive methods such as biochemical methods or liver biopsy could therefore be used only in patients with failure of FibroScan examination...
  31. doi request reprint [Transient elastography (FibroScan): a new tool in hepatology]
    Julien Vergniol
    Centre d Investigation de la Fibrose hépatique, Service d Hepato gastro enterologie, Hopital Haut Leveque, F 33604 PESSAC, France
    Presse Med 38:1516-25. 2009
    ..Liver stiffness is strongly correlated with the severity of portal hypertension and of cirrhosis...
  32. ncbi request reprint [Natural history of hepatitis C virus infection]
    Victor de Ledinghen
    Service d Hepato Gastroenterologie, Hopital du Haut leveque, 33604 Pessac
    Gastroenterol Clin Biol 26:B9-22. 2002
  33. pmc Hepatic Steatosis, Carbohydrate Intake, and Food Quotient in Patients with NAFLD
    Concepcion Gonzalez
    Pôle Hépatogastroentérologie, endocrinologie et nutrition, CHU de Bordeaux, Avenue de Magellan, 33600 Pessac, France
    Int J Endocrinol 2013:428542. 2013
    ..Hepatic steatosis was related to the energy and carbohydrate intakes in our patients; the role of dietary carbohydrates was detectable in the range of usual carbohydrate intake: 32% to 58% calories...
  34. pmc Meta-analyses of FibroTest diagnostic value in chronic liver disease
    Thierry Poynard
    Service d Hepato Gastroenterologie, Groupe Hospitalier Pitie Salpetriere, Universite Paris VI, CNRS ESA 8067 Paris, France
    BMC Gastroenterol 7:40. 2007
    ....
  35. ncbi request reprint Predictive value of early HCV RNA quantitation for sustained response in nonresponders receiving daily interferon and ribavirin therapy
    Pascale Trimoulet
    Laboratoire de Virologie, Centre Hospitalier Universitaire, Hopital Pellegrin, Bordeaux Cedex, France
    J Med Virol 72:46-51. 2004
    ..Nonresponse can be predicted as early as week 4 or week 12 in nonresponders treated with daily IFN and ribavirin...
  36. doi request reprint Pitfalls of liver stiffness measurement: a 5-year prospective study of 13,369 examinations
    Laurent Castera
    Services d Hépato gastroentérologie, Centre Hospitalo Universitaire de Bordeaux, Hopital Haut Leveque, Avenue Magellan, 33604 Pessac, France
    Hepatology 51:828-35. 2010
    ..These results emphasize the need for adequate operator training and for technological improvements in specific patient subpopulations...
  37. ncbi request reprint Paroxysmal nocturnal hemoglobinuria and Budd-Chiari syndrome: therapeutic challenge with bone marrow transplantation, transjugular intrahepatic portosystemic shunt, and vena cava stent
    Julien Vergniol
    Service d Hepato Gastroenterologie, Hôpital Saint André, CHU Bordeaux, France
    Eur J Gastroenterol Hepatol 17:453-6. 2005
    ..This case report confirms that TIPS is a good treatment for BCS, but stenosis of inferior vena cava can occur after such a treatment...
  38. ncbi request reprint Psychosocial factors associated with perceived disease severity in patients with chronic hepatitis C: relationship with information sources and attentional coping styles
    Aymery Constant
    Laboratoire de Psychologie de la Santé EA 3662, Universite Victor Segalen Bordeaux 2, France
    Psychosomatics 46:25-33. 2005
    ..These results suggest that information processing and psychological features play a key role in the way patients with chronic hepatitis C perceive their disease...
  39. doi request reprint Optimization and robustness of blood tests for liver fibrosis and cirrhosis
    Paul Cales
    Service d Hepato Gastroenterologie, CHU, Angers, France
    Clin Biochem 43:1315-22. 2010
    ..To optimize the performance and feasibility of fibrosis blood tests and evaluate their robustness...
  40. doi request reprint Gastric variceal bleeding uncovering a rare association of CREST syndrome, primary biliary cirrhosis, nodular regenerative hyperplasia and pulmonary hypertension
    Etienne Riviere
    Service d Hepato Gastroenterologie, Hopital du Haut leveque, 33604 Pessac Cedex, France
    Eur J Gastroenterol Hepatol 22:1145-8. 2010
    ..This case shows the association of PBC and NRH with porto pulmonary hypertension in CREST syndrome...
  41. ncbi request reprint Diagnosis of hepatic fibrosis and cirrhosis by transient elastography in HIV/hepatitis C virus-coinfected patients
    Victor de Ledinghen
    Service d Hepato Gastroenterologie, Hopital Haut Leveque, Bordeaux, France
    J Acquir Immune Defic Syndr 41:175-9. 2006
    ....
  42. doi request reprint [Managing comorbidities in hepatology: toward a more holistic medicine]
    Patrice Couzigou
    Service Hépato gastroentérologie, Hopital du Haut leveque, F 33604 PESSAC, France
    Presse Med 37:1274-80. 2008
    ..In this more holistic approach, the physician treats a person with liver disease, rather than just a diseased liver...
  43. ncbi request reprint Hepatitis B virus genotypes: a retrospective survey in Southwestern France, 1999-2004
    Pascale Trimoulet
    Laboratoire de virologie Hôpital Pellegrin, 33076 Bordeaux Cedex
    Gastroenterol Clin Biol 31:1088-94. 2007
    ..To determine the prevalence of HBV genotypes in Southwestern France and the association between HBV genotypes and patients characteristics...
  44. doi request reprint [Brief intervention about alcohol use]
    Patrice Couzigou
    Service d Hepato gastro enterologie, Hôpital Haut Lévêque Pessac, F 33600 Bordeaux, France
    Presse Med 38:1126-33. 2009
    ..This efficacy has been demonstrated for a duration of at least 4 years. Given that evidence also supports the behavioral changes, these findings should be taken into account by healthcare providers...
  45. ncbi request reprint Lamivudine therapy of chronic hepatitis B in three groups of patients: non transplanted patients, liver recipients, and kidney recipients
    Evelyne Schvoerer
    Laboratoire de Virologie, Universite Victor Segalen, Bordeaux, France
    Gastroenterol Clin Biol 26:62-6. 2002
    ..As conflicting results have been observed by some authors in liver recipients, the aim of the study was to evaluate lamivudine therapy in 3 groups of patients with chronic hepatitis B: non-transplanted patients, liver and kidney recipients...
  46. ncbi request reprint Effects of Helicobacter pylori infection on gut appetite peptide (leptin, ghrelin) expression in elderly inpatients
    Nathalie Salles
    INSERM ERI 10, Laboratoire de Bacteriologie, Universite Victor Segalen Bordeaux 2, Bat 2B RDC Zone Nord, 33076 Bordeaux Cedex, France
    J Gerontol A Biol Sci Med Sci 61:1144-50. 2006
    ..34; p = .018). The negative association between ghrelin and H. pylori infection may be related to a higher prevalence of atrophy and raises the possibility that H. pylori may be contributing to undernutrition in some older people...
  47. ncbi request reprint Subsequent resection of locally advanced pancreatic carcinoma after chemoradiotherapy
    Xavier Adhoute
    Service d Hepato Gastroenterologie, Hopital Haut Leveque, CHU de Bordeaux
    Gastroenterol Clin Biol 30:224-30. 2006
    ..The aim of this study was to evaluate the possibility of subsequent resection of locally advanced pancreatic adenocarcinoma after chemotherapy and external-beam radiotherapy...
  48. ncbi request reprint [Treatment of hepatorenal syndrome]
    Victor de Ledinghen
    Service d Hepato Gastroenterologie, Hopital du Haut leveque, 33604 Pessac
    Gastroenterol Clin Biol 28:B130-7. 2004