L Castera

Summary

Affiliation: CHU de Bordeaux
Country: France

Publications

  1. pmc Meta-analyses of FibroTest diagnostic value in chronic liver disease
    Thierry Poynard
    Service d Hepato Gastroenterologie, Groupe Hospitalier Pitie Salpetriere, Universite Paris VI, CNRS ESA 8067 Paris, France
    BMC Gastroenterol 7:40. 2007
  2. doi request reprint Assessing liver fibrosis
    Laurent Castera
    Service d Hepato Gastroenterologie, CHU Bordeaux, Hopital Haut Leveque, Avenue Magellan, 33604 Pessac, France
    Expert Rev Gastroenterol Hepatol 2:541-52. 2008
  3. ncbi request reprint Steatosis, insulin resistance and fibrosis progression in chronic hepatitis C
    L Castera
    Department of Hepatology and Gastroenterology, CHU Bordeaux, Hopital Haut Leveque, Pessac, France
    Minerva Gastroenterol Dietol 52:125-34. 2006
  4. doi request reprint Early detection in routine clinical practice of cirrhosis and oesophageal varices in chronic hepatitis C: comparison of transient elastography (FibroScan) with standard laboratory tests and non-invasive scores
    Laurent Castera
    Service d Hepato Gastroenterologie, Hopital Haut Leveque, Centre Hospitalier Universitaire CHU de Bordeaux, Pessac, France
    J Hepatol 50:59-68. 2009
  5. ncbi request reprint Psychological impact of chronic hepatitis C: comparison with other stressful life events and chronic diseases
    Laurent Castera
    Service d Hepato Gastroenterologie, Centre Hospitalier Universitaire de Bordeaux, Hopital Haut Leveque, Avenue Magellan, 33604 Pessac, France
    World J Gastroenterol 12:1545-50. 2006
  6. doi request reprint Transient elastography and other noninvasive tests to assess hepatic fibrosis in patients with viral hepatitis
    Laurent Castera
    Department of Hepatology, Hôpital St André and Haut Lévêque, Bordeaux University Hospital, Bordeaux, France
    J Viral Hepat 16:300-14. 2009
  7. ncbi request reprint Lifestyle changes and beliefs regarding disease severity in patients with chronic hepatitis C
    L Castera
    Service d Hepato Gastroenterologie, Hopital Haut Leveque, Pessac, France
    J Viral Hepat 13:482-8. 2006
  8. ncbi request reprint Impact on adherence and sustained virological response of psychiatric side effects during peginterferon and ribavirin therapy for chronic hepatitis C
    L Castera
    Service d Hepato Gastroenterologie, C H U Bordeaux, Hopital Haut Leveque, Avenue Magellan, 33604 Pessac, France
    Aliment Pharmacol Ther 24:1223-30. 2006
  9. doi request reprint Non-invasive evaluation of liver fibrosis using transient elastography
    Laurent Castera
    Departments of Hepatology, Hospital Saint André and Haut Lévêque, University Hospital of Bordeaux, Avenue Magellan, Pessac, France
    J Hepatol 48:835-47. 2008
  10. ncbi request reprint [Use of elastometry (FibroScan) for the non-invasive staging of liver fibrosis]
    Laurent Castera
    Service d Hepato Gastroenterologie, Hôpital Saint André, CHU de Bordeaux, France
    Gastroenterol Clin Biol 31:524-30; quiz 500, 531-2. 2007

Detail Information

Publications51

  1. pmc Meta-analyses of FibroTest diagnostic value in chronic liver disease
    Thierry Poynard
    Service d Hepato Gastroenterologie, Groupe Hospitalier Pitie Salpetriere, Universite Paris VI, CNRS ESA 8067 Paris, France
    BMC Gastroenterol 7:40. 2007
    ....
  2. doi request reprint Assessing liver fibrosis
    Laurent Castera
    Service d Hepato Gastroenterologie, CHU Bordeaux, Hopital Haut Leveque, Avenue Magellan, 33604 Pessac, France
    Expert Rev Gastroenterol Hepatol 2:541-52. 2008
    ..This review is aimed at discussing the advantages and limits of these methods and the perspectives for their rationale for use in clinical practice...
  3. ncbi request reprint Steatosis, insulin resistance and fibrosis progression in chronic hepatitis C
    L Castera
    Department of Hepatology and Gastroenterology, CHU Bordeaux, Hopital Haut Leveque, Pessac, France
    Minerva Gastroenterol Dietol 52:125-34. 2006
    ..This review is aimed at describing the current knowledge of steatosis, insulin resistance and fibrosis progression in chronic hepatitis C...
  4. doi request reprint Early detection in routine clinical practice of cirrhosis and oesophageal varices in chronic hepatitis C: comparison of transient elastography (FibroScan) with standard laboratory tests and non-invasive scores
    Laurent Castera
    Service d Hepato Gastroenterologie, Hopital Haut Leveque, Centre Hospitalier Universitaire CHU de Bordeaux, Pessac, France
    J Hepatol 50:59-68. 2009
    ....
  5. ncbi request reprint Psychological impact of chronic hepatitis C: comparison with other stressful life events and chronic diseases
    Laurent Castera
    Service d Hepato Gastroenterologie, Centre Hospitalier Universitaire de Bordeaux, Hopital Haut Leveque, Avenue Magellan, 33604 Pessac, France
    World J Gastroenterol 12:1545-50. 2006
    ..To examine the psychological impact of chronic hepatitis C (CHC) diagnosis in a large cohort of CHC patients as compared with other stressful life events and chronic diseases carrying a risk of life-threatening complications...
  6. doi request reprint Transient elastography and other noninvasive tests to assess hepatic fibrosis in patients with viral hepatitis
    Laurent Castera
    Department of Hepatology, Hôpital St André and Haut Lévêque, Bordeaux University Hospital, Bordeaux, France
    J Viral Hepat 16:300-14. 2009
    ..Transient elastography also appears to be an excellent tool for early detection of cirrhosis and may have prognostic value in this setting. Guidelines are now awaited for the use of noninvasive methods in clinical practice...
  7. ncbi request reprint Lifestyle changes and beliefs regarding disease severity in patients with chronic hepatitis C
    L Castera
    Service d Hepato Gastroenterologie, Hopital Haut Leveque, Pessac, France
    J Viral Hepat 13:482-8. 2006
    ..01-1.08, P < 0.006). Our results show the considerable impact of CHC diagnosis on patients' lifestyle. They emphasize the need for improving CHC patient counselling in order to avoid unnecessary sex life and dietary intake changes...
  8. ncbi request reprint Impact on adherence and sustained virological response of psychiatric side effects during peginterferon and ribavirin therapy for chronic hepatitis C
    L Castera
    Service d Hepato Gastroenterologie, C H U Bordeaux, Hopital Haut Leveque, Avenue Magellan, 33604 Pessac, France
    Aliment Pharmacol Ther 24:1223-30. 2006
    ..The psychiatric side effects of interferon, often responsible for dose reduction or treatment discontinuation, represent a major limitation in the treatment of chronic hepatitis C (CHC)...
  9. doi request reprint Non-invasive evaluation of liver fibrosis using transient elastography
    Laurent Castera
    Departments of Hepatology, Hospital Saint André and Haut Lévêque, University Hospital of Bordeaux, Avenue Magellan, Pessac, France
    J Hepatol 48:835-47. 2008
    ..Guidelines are needed for the use of TE in clinical practice...
  10. ncbi request reprint [Use of elastometry (FibroScan) for the non-invasive staging of liver fibrosis]
    Laurent Castera
    Service d Hepato Gastroenterologie, Hôpital Saint André, CHU de Bordeaux, France
    Gastroenterol Clin Biol 31:524-30; quiz 500, 531-2. 2007
  11. ncbi request reprint Hepatic steatosis in HIV-HCV coinfected patients in France: comparison with HCV monoinfected patients matched for body mass index and HCV genotype
    L Castera
    Department of Hepatology, Hopital Haut Leveque, Centre Hospitalier Universitaire Bordeaux, Pessac, France
    Aliment Pharmacol Ther 26:1489-98. 2007
    ..Significance of steatosis in HIV-HCV coinfection remains controversial...
  12. doi request reprint Non-invasive diagnosis of steatosis and fibrosis
    L Castera
    Département d Hépatologie, Hôpital Saint André and Haut Lévêque, CHU Bordeaux, Bordeaux, France
    Diabetes Metab 34:674-9. 2008
    ..This review discusses the advantages and limitations of these different methods in clinical practice...
  13. pmc Effect of antiviral treatment on evolution of liver steatosis in patients with chronic hepatitis C: indirect evidence of a role of hepatitis C virus genotype 3 in steatosis
    L Castera
    Department of Virology EA 3489, Centre Hospitalier Universitaire Henri Mondor, Assistance Publique Hopitaux de Paris, Universite Paris XII, Creteil, France
    Gut 53:420-4. 2004
    ..To investigate this hypothesis, we studied the relationship between steatosis evolution and HCV clearance after antiviral treatment in patients with chronic hepatitis C and paired liver biopsies...
  14. ncbi request reprint [Psychiatric disorders during treatment of chronic hepatitis C]
    Laurent Castera
    Service d Hepato Gastroenterologie, Hopital Haut Leveque, Pessac
    Gastroenterol Clin Biol 29:123-33. 2005
  15. pmc Worsening of steatosis is an independent factor of fibrosis progression in untreated patients with chronic hepatitis C and paired liver biopsies
    L Castera
    Department of Virology EA 3489, Centre Hospitalier Universitaire Henri Mondor, Universite Paris XII, Creteil, France
    Gut 52:288-92. 2003
    ..The aim of the present study was to evaluate in patients with CHC and paired liver biopsies the relationship between the evolution of steatosis and that of fibrosis between the two biopsies...
  16. doi request reprint Prospective comparison of two algorithms combining non-invasive methods for staging liver fibrosis in chronic hepatitis C
    Laurent Castera
    Service d Hepato Gastroenterologie, Hopital Haut Leveque, Centre Hospitalier Universitaire C H U de Bordeaux, Pessac, France
    J Hepatol 52:191-8. 2010
    ..The aim of this prospective study was to compare the performance of these two algorithms for diagnosing significant fibrosis and cirrhosis in 302 CHC patients...
  17. doi request reprint How to assess liver fibrosis in chronic hepatitis C: serum markers or transient elastography vs. liver biopsy?
    Laurent Castera
    Department of Hepatology, Hôpital St André and Haut Lévêque, Bordeaux University Hospital, Bordeaux, France
    Liver Int 31:13-7. 2011
    ..The aim of this review is to discuss the advantages and limitations of liver biopsy and non-invasive methods and the perspectives for their use in clinical practice...
  18. doi request reprint Pitfalls of liver stiffness measurement: a 5-year prospective study of 13,369 examinations
    Laurent Castera
    Services d Hépato gastroentérologie, Centre Hospitalo Universitaire de Bordeaux, Hopital Haut Leveque, Avenue Magellan, 33604 Pessac, France
    Hepatology 51:828-35. 2010
    ..These results emphasize the need for adequate operator training and for technological improvements in specific patient subpopulations...
  19. doi request reprint Changes of non-invasive markers and FibroScan values during HCV treatment
    J Vergniol
    Centre d Investigation de la Fibrose hépatique, Hopital Haut Leveque, CHU Bordeaux, Pessac, France
    J Viral Hepat 16:132-40. 2009
    ..Further studies are needed to compare these non-invasive methods with liver biopsy. These non-invasive methods, and especially FibroScan, should be useful for assessing treatment efficacy in clinical trials of new drugs...
  20. doi request reprint Transient elastography and biomarkers for liver fibrosis assessment and follow-up of inactive hepatitis B carriers
    L Castera
    Hopital Haut Leveque, Centre Hospitalier Universitaire Bordeaux, Pessac, France
    Aliment Pharmacol Ther 33:455-65. 2011
    ..Non invasive methods for fibrosis evaluation remain to be validated longitudinally in hepatitis B...
  21. pmc Diagnosis of cirrhosis by transient elastography (FibroScan): a prospective study
    J Foucher
    Service d Hepato Gastroenterologie, Hopital Haut Leveque, Avenue Magellan, 33604 Pessac, France
    Gut 55:403-8. 2006
    ..5 kPa. However, the clinical relevance of these values is unknown. The aim of this prospective study was to evaluate the accuracy of liver stiffness measurement for the detection of cirrhosis in patients with chronic liver disease...
  22. doi request reprint Impact of ribavirin plasma level on sustained virological response in patients treated with pegylated interferon and ribavirin for chronic hepatitis C
    D Breilh
    Laboratoire de Pharmacocinétique et de Pharmacie Clinique EA2968, Universite Victor Segalen Bordeaux 2, Bordeaux, France
    Aliment Pharmacol Ther 30:487-94. 2009
    ..The main goal of therapy in hepatitis C virus (HCV) infection is to achieve a sustained virological response (SVR). However, the impact of the pharmacological properties of ribavirin on the SVR has not been fully investigated...
  23. doi request reprint Liver stiffness diminishes with antiviral response in chronic hepatitis C
    C Hezode
    Department of Hepatology and Gastroenterology, Hopital Henri Mondor, Universite Paris Est, Creteil, France INSERM U955, Creteil, France
    Aliment Pharmacol Ther 34:656-63. 2011
    ..Transient elastography measures liver stiffness, which correlates with the hepatic fibrosis stage and has excellent accuracy for the diagnosis of cirrhosis in patients with chronic hepatitis C...
  24. ncbi request reprint Peginterferon alpha-2b plus ribavirin for treatment of chronic hepatitis C with severe fibrosis: a multicentre randomized controlled trial comparing two doses of peginterferon alpha-2b
    A Abergel
    Service d Hepato Gastroenterologie, Hotel Dieu, Clermont Ferrand, France
    J Viral Hepat 13:811-20. 2006
    ....
  25. doi request reprint Validation and comparison of simple noninvasive indexes for predicting liver fibrosis in HIV-HCV-coinfected patients: ANRS CO3 Aquitaine cohort
    Marc Arthur Loko
    INSERM, U593, Bordeaux, France
    Am J Gastroenterol 103:1973-80. 2008
    ..Although an increasing number of noninvasive fibrosis markers are available in HCV-monoinfected patients, data on the performance of these tests in HIV-HCV-coinfected patients are lacking...
  26. doi request reprint Liver fibrosis on account of chronic hepatitis C is more severe in HIV-positive than HIV-negative patients despite antiretroviral therapy
    V de Ledinghen
    Centre d Investigation de la Fibrose hépatique, Hopital Haut Leveque, CHU Bordeaux, Pessac, France
    J Viral Hepat 15:427-33. 2008
    ..HIV/HCV-coinfected patients have more advanced liver fibrosis than HCV-monoinfected patients despite the immunologic benefit of HAART...
  27. ncbi request reprint Diagnosis of liver fibrosis by transient elastography (FibroScan) and non-invasive methods in Crohn's disease patients treated with methotrexate
    D Laharie
    Gastroenterology and Hepatology Unit, Haut Leveque Hospital, Pessac, France
    Aliment Pharmacol Ther 23:1621-8. 2006
    ..Transient elastography (FibroScan, Echosens, Paris, France) is a new non-invasive rapid, allowing assessment of liver fibrosis by measurement of liver stiffness...
  28. ncbi request reprint Diagnosis of liver fibrosis using FibroScan and other noninvasive methods in patients with hemochromatosis: a prospective study
    X Adhoute
    Service d Hepatogastroenterologie, Centre d Investigation de la Fibrose hépatique, Hopital Haut Leveque, 33604 Pessac Cedex, France
    Gastroenterol Clin Biol 32:180-7. 2008
    ..Transient elastography (FibroScan) is a new noninvasive, rapid, reproducible bedside method, allowing assessment of liver fibrosis by measuring liver rigidity...
  29. doi request reprint [Managing comorbidities in hepatology: toward a more holistic medicine]
    Patrice Couzigou
    Service Hépato gastroentérologie, Hopital du Haut leveque, F 33604 PESSAC, France
    Presse Med 37:1274-80. 2008
    ..In this more holistic approach, the physician treats a person with liver disease, rather than just a diseased liver...
  30. ncbi request reprint Hepatitis B virus genotypes: a retrospective survey in Southwestern France, 1999-2004
    Pascale Trimoulet
    Laboratoire de virologie Hôpital Pellegrin, 33076 Bordeaux Cedex
    Gastroenterol Clin Biol 31:1088-94. 2007
    ..To determine the prevalence of HBV genotypes in Southwestern France and the association between HBV genotypes and patients characteristics...
  31. doi request reprint [Brief intervention about alcohol use]
    Patrice Couzigou
    Service d Hepato gastro enterologie, Hôpital Haut Lévêque Pessac, F 33600 Bordeaux, France
    Presse Med 38:1126-33. 2009
    ..This efficacy has been demonstrated for a duration of at least 4 years. Given that evidence also supports the behavioral changes, these findings should be taken into account by healthcare providers...
  32. ncbi request reprint Outbreak of hepatitis C virus infection during sclerotherapy of varicose veins: long-term follow-up of 196 patients (4535 patient-years)
    Victor de Ledinghen
    Service d Hepato Gastroenterologie, Hopital Haut Leveque, Pessac, France
    J Hepatol 46:19-25. 2007
    ....
  33. ncbi request reprint Prevalence of and factors associated with hepatic steatosis in patients coinfected with hepatitis C virus and HIV: Agence Nationale pour la Recherche contre le SIDA et les hépatites virales CO3 Aquitaine Cohort
    Didier Neau
    Fédération des Maladies Infectieuses et Tropicales, Centre Hospitalo Universitaire, Hopital Pellegrin, Bordeaux, France
    J Acquir Immune Defic Syndr 45:168-73. 2007
    ..The prevalence and factors associated with hepatic steatosis are not well defined in HCV-HIV-coinfected patients...
  34. ncbi request reprint Liver stiffness measurement in children using FibroScan: feasibility study and comparison with Fibrotest, aspartate transaminase to platelets ratio index, and liver biopsy
    Victor de Ledinghen
    INSERM, Universite Victor Segalen Bordeaux 2, Bordeaux, France
    J Pediatr Gastroenterol Nutr 45:443-50. 2007
    ....
  35. ncbi request reprint [Hepatitis C virus screening in drug users in an addiction out-patient unit]
    Veronique Grando-Lemaire
    Service d Hepato Gastroenterologie, Hopital Jean Verdier, Assistance Publique Hopitaux de Paris, 93143 Bondy Cedex, France
    Gastroenterol Clin Biol 26:1091-6. 2002
    ..To investigate the feasibility and efficacy of hepatitis C virus screening in drug users in an addiction out-patient unit...
  36. pmc Noninvasive diagnosis of liver fibrosis in patients with chronic hepatitis C
    Laurent Castera
    Department of Hepatology and Gastroenterology, C H U Bordeaux, Hopital Haut Leveque, Pessac, France
    MedGenMed 7:39. 2005
  37. ncbi request reprint Antiviral action of ribavirin in chronic hepatitis C
    Jean Michel Pawlotsky
    Department of Virology, INSERM U635, Hopital Henri Mondor, Universite Paris XII, Creteil, France
    Gastroenterology 126:703-14. 2004
    ..Our aim was to assess the antiviral action of ribavirin on hepatitis C virus (HCV) as a function of ribavirin pharmacokinetics and to evaluate the influence of this antiviral effect on IFN-alpha efficacy...
  38. ncbi request reprint [Hepatitis C virus genotype 4: epidemiology and treatment]
    Laurent Castera
    Service d Hepato Gastroenterologie, Hopital Haut Leveque, 33604 Pessac
    Gastroenterol Clin Biol 27:596-604. 2003
  39. ncbi request reprint Hepatitis C virus-induced hepatocellular steatosis
    Laurent Castera
    Department of Hepatology and Gastroenterology, Centre Hospitalier Universitaire, Bordeaux, France
    Am J Gastroenterol 100:711-5. 2005
    ..This review discusses current knowledge of HCV-induced steatosis and its relation to chronic HCV-associated liver disease...
  40. ncbi request reprint [Steasis and hepatitis C]
    Christophe Hezode
    Service d hépatologie et de gastroentérologie, Hopital Henri Mondor, 51, Avenue du Marechal de Lattre de Tassigny, 94010 Creteil
    Gastroenterol Clin Biol 27:1091-5. 2003
  41. ncbi request reprint The MTHFR 677C > T polymorphism is associated with an increased risk of hepatocellular carcinoma in patients with alcoholic cirrhosis
    Raphael Saffroy
    Service de Biochimie et Biologie Moléculaire, Cedex, France
    Carcinogenesis 25:1443-8. 2004
    ..02). The relative risk for HCC in subjects with alcoholic cirrhosis and the CC genotype was 2.03. These results suggest that the MTHFR CC genotype increases the risk to develop HCC in patients who consume a high alcohol diet...
  42. ncbi request reprint Psychosocial factors associated with perceived disease severity in patients with chronic hepatitis C: relationship with information sources and attentional coping styles
    Aymery Constant
    Laboratoire de Psychologie de la Santé EA 3662, Universite Victor Segalen Bordeaux 2, France
    Psychosomatics 46:25-33. 2005
    ..These results suggest that information processing and psychological features play a key role in the way patients with chronic hepatitis C perceive their disease...
  43. ncbi request reprint FibroScan and FibroTest to assess liver fibrosis in HCV with normal aminotransferases
    Laurent Castera
    Hepatology 43:373-4; author reply 375-6. 2006
  44. ncbi request reprint [Liver biopsy in management of chronic liver diseases: "EASL monothematic conference highlights"]
    Jean Francois Cadranel
    Services d Hépato Gastroentérologie et de Diabétologie, Centre Hospitalier Laennec, Creil
    Gastroenterol Clin Biol 30:121-3. 2006
  45. ncbi request reprint Accuracy of liver stiffness measurement for the diagnosis of cirrhosis in patients with chronic liver diseases
    Nathalie Ganne-Carrie
    Hépato Gastroentérologie, Hopital Jean Verdier, Bondy, France UPRES EA3409, Universite Paris 13, Bobigny, France
    Hepatology 44:1511-7. 2006
    ..6 kPa. False-negatives are mainly attributable to inactive or macronodular cirrhosis...
  46. ncbi request reprint Standardization of ROC curve areas for diagnostic evaluation of liver fibrosis markers based on prevalences of fibrosis stages
    Thierry Poynard
    Assistance Publique Hôpitaux de Paris Groupe Hospitalier Pitié Salpêtrière, Paris, France
    Clin Chem 53:1615-22. 2007
    ..The aim of this study was to assess the relationships between the AUC and the prevalence of each fibrosis stage and to elaborate simple methods of standardization...
  47. ncbi request reprint HEPACOM: multicenter, observational prospective study of outcome and monitoring of HCV positive antiviral-naïve patients managed in the French health care system
    Helene Agostini
    Seillans Conseils, Paris
    Gastroenterol Clin Biol 31:1074-80. 2007
    ..To study management practices in the French health care system for antiviral-naïve patients with chronic hepatitis C virus (HCV) infection...
  48. ncbi request reprint Evolving practices of non-invasive markers of liver fibrosis in patients with chronic hepatitis C in France: time for new guidelines?
    Laurent Castera
    J Hepatol 46:528-9; author reply 529-30. 2007
  49. ncbi request reprint Mood alterations during interferon-alfa therapy in patients with chronic hepatitis C: evidence for an overlap between manic/hypomanic and depressive symptoms
    Aymery Constant
    Department of Health Psychology EA 3662, University of Bordeaux 2, France
    J Clin Psychiatry 66:1050-7. 2005
    ..However, irritability, anger/hostility, and manic/hypomanic episodes have also been reported, suggesting that these symptoms are important features of IFN-alfa-induced neuropsychiatric side effects...
  50. ncbi request reprint Hepatitis B vaccination in HIV-infected patients: a survey of physicians and patients participating in the Aquitaine cohort
    Maria Winnock
    INSERM U593 ISPED, Universite Victor Segalen Bordeaux 2
    Gastroenterol Clin Biol 30:189-95. 2006
    ..In France, HIV-infected (HIV+) patients are frequently coinfected with hepatitis B virus (HBV) or at risk for this infection. Physicians and their patients should be more committed to HBV prevention than the average population...
  51. ncbi request reprint Partial splenic embolization in patients with cirrhosis: efficacy, tolerance and long-term outcome in 32 patients
    Gisèle N'kontchou
    Department of Hepato Gastroenterology, Hopital Jean Verdier, Bondy Cedex, France
    Eur J Gastroenterol Hepatol 17:179-84. 2005
    ..We provide a retrospective review of results and the tolerance of all PSE procedures in patients with cirrhosis in our department...