Research Topics
| L CasteraSummaryAffiliation: CHU de Bordeaux Country: France Publications
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Detail Information
Publications
Meta-analyses of FibroTest diagnostic value in chronic liver diseaseThierry Poynard
Service d Hepato Gastroenterologie, Groupe Hospitalier Pitie Salpetriere, Universite Paris VI, CNRS ESA 8067 Paris, France
BMC Gastroenterol 7:40. 2007....
Steatosis, insulin resistance and fibrosis progression in chronic hepatitis CL Castera
Department of Hepatology and Gastroenterology, CHU Bordeaux, Hopital Haut Leveque, Pessac, France
Minerva Gastroenterol Dietol 52:125-34. 2006..This review is aimed at describing the current knowledge of steatosis, insulin resistance and fibrosis progression in chronic hepatitis C...
Early detection in routine clinical practice of cirrhosis and oesophageal varices in chronic hepatitis C: comparison of transient elastography (FibroScan) with standard laboratory tests and non-invasive scoresLaurent Castera
Service d Hepato Gastroenterologie, Hopital Haut Leveque, Centre Hospitalier Universitaire CHU de Bordeaux, Pessac, France
J Hepatol 50:59-68. 2009....- Psychological impact of chronic hepatitis C: comparison with other stressful life events and chronic diseasesLaurent Castera
Service d Hepato Gastroenterologie, Centre Hospitalier Universitaire de Bordeaux, Hopital Haut Leveque, Avenue Magellan, 33604 Pessac, France
World J Gastroenterol 12:1545-50. 2006..To examine the psychological impact of chronic hepatitis C (CHC) diagnosis in a large cohort of CHC patients as compared with other stressful life events and chronic diseases carrying a risk of life-threatening complications... - Transient elastography and other noninvasive tests to assess hepatic fibrosis in patients with viral hepatitisLaurent Castera
Department of Hepatology, Hôpital St André and Haut Lévêque, Bordeaux University Hospital, Bordeaux, France
J Viral Hepat 16:300-14. 2009..Transient elastography also appears to be an excellent tool for early detection of cirrhosis and may have prognostic value in this setting. Guidelines are now awaited for the use of noninvasive methods in clinical practice... - Lifestyle changes and beliefs regarding disease severity in patients with chronic hepatitis CL Castera
Service d Hepato Gastroenterologie, Hopital Haut Leveque, Pessac, France
J Viral Hepat 13:482-8. 2006..01-1.08, P < 0.006). Our results show the considerable impact of CHC diagnosis on patients' lifestyle. They emphasize the need for improving CHC patient counselling in order to avoid unnecessary sex life and dietary intake changes... - Impact on adherence and sustained virological response of psychiatric side effects during peginterferon and ribavirin therapy for chronic hepatitis CL Castera
Service d Hepato Gastroenterologie, C H U Bordeaux, Hopital Haut Leveque, Avenue Magellan, 33604 Pessac, France
Aliment Pharmacol Ther 24:1223-30. 2006..The psychiatric side effects of interferon, often responsible for dose reduction or treatment discontinuation, represent a major limitation in the treatment of chronic hepatitis C (CHC)... - Non-invasive evaluation of liver fibrosis using transient elastographyLaurent Castera
Departments of Hepatology, Hospital Saint André and Haut Lévêque, University Hospital of Bordeaux, Avenue Magellan, Pessac, France
J Hepatol 48:835-47. 2008..Guidelines are needed for the use of TE in clinical practice... - [Use of elastometry (FibroScan) for the non-invasive staging of liver fibrosis]Laurent Castera
, , CHU de Bordeaux, France
Gastroenterol Clin Biol 31:524-30; quiz 500, 531-2. 2007 - Hepatic steatosis in HIV-HCV coinfected patients in France: comparison with HCV monoinfected patients matched for body mass index and HCV genotypeL Castera
Department of Hepatology, Hopital Haut Leveque, Centre Hospitalier Universitaire Bordeaux, Pessac, France
Aliment Pharmacol Ther 26:1489-98. 2007..Significance of steatosis in HIV-HCV coinfection remains controversial... - Assessing liver fibrosisLaurent Castera
Service d Hepato Gastroenterologie, CHU Bordeaux, Hopital Haut Leveque, Avenue Magellan, 33604 Pessac, France
Expert Rev Gastroenterol Hepatol 2:541-52. 2008..This review is aimed at discussing the advantages and limits of these methods and the perspectives for their rationale for use in clinical practice... - Non-invasive diagnosis of steatosis and fibrosisL Castera
Département d Hépatologie, Hôpital Saint André and Haut Lévêque, CHU Bordeaux, Bordeaux, France
Diabetes Metab 34:674-9. 2008..This review discusses the advantages and limitations of these different methods in clinical practice... - How to assess liver fibrosis in chronic hepatitis C: serum markers or transient elastography vs. liver biopsy?Laurent Castera
Department of Hepatology, Hôpital St André and Haut Lévêque, Bordeaux University Hospital, Bordeaux, France
Liver Int 31:13-7. 2011..The aim of this review is to discuss the advantages and limitations of liver biopsy and non-invasive methods and the perspectives for their use in clinical practice... 
Effect of antiviral treatment on evolution of liver steatosis in patients with chronic hepatitis C: indirect evidence of a role of hepatitis C virus genotype 3 in steatosisL Castera
Department of Virology EA 3489, Centre Hospitalier Universitaire Henri Mondor, Assistance Publique Hopitaux de Paris, Universite Paris XII, Creteil, France
Gut 53:420-4. 2004..To investigate this hypothesis, we studied the relationship between steatosis evolution and HCV clearance after antiviral treatment in patients with chronic hepatitis C and paired liver biopsies...- Pitfalls of liver stiffness measurement: a 5-year prospective study of 13,369 examinationsLaurent Castera
Services d Hépato gastroentérologie, Centre Hospitalo Universitaire de Bordeaux, Hopital Haut Leveque, Avenue Magellan, 33604 Pessac, France
Hepatology 51:828-35. 2010..These results emphasize the need for adequate operator training and for technological improvements in specific patient subpopulations... - Prospective comparison of two algorithms combining non-invasive methods for staging liver fibrosis in chronic hepatitis CLaurent Castera
Service d Hepato Gastroenterologie, Hopital Haut Leveque, Centre Hospitalier Universitaire C H U de Bordeaux, Pessac, France
J Hepatol 52:191-8. 2010..The aim of this prospective study was to compare the performance of these two algorithms for diagnosing significant fibrosis and cirrhosis in 302 CHC patients... - Worsening of steatosis is an independent factor of fibrosis progression in untreated patients with chronic hepatitis C and paired liver biopsiesL Castera
Department of Virology EA 3489, Centre Hospitalier Universitaire Henri Mondor, Universite Paris XII, Creteil, France
Gut 52:288-92. 2003..The aim of the present study was to evaluate in patients with CHC and paired liver biopsies the relationship between the evolution of steatosis and that of fibrosis between the two biopsies... - [Psychiatric disorders during treatment of chronic hepatitis C]Laurent Castera
Service d Hepato Gastroenterologie, Hopital Haut Leveque, Pessac
Gastroenterol Clin Biol 29:123-33. 2005 - Changes of non-invasive markers and FibroScan values during HCV treatmentJ Vergniol
Centre d Investigation de la Fibrose hépatique, Hopital Haut Leveque, CHU Bordeaux, Pessac, France
J Viral Hepat 16:132-40. 2009..Further studies are needed to compare these non-invasive methods with liver biopsy. These non-invasive methods, and especially FibroScan, should be useful for assessing treatment efficacy in clinical trials of new drugs... - Transient elastography and biomarkers for liver fibrosis assessment and follow-up of inactive hepatitis B carriersL Castera
Hopital Haut Leveque, Centre Hospitalier Universitaire Bordeaux, Pessac, France
Aliment Pharmacol Ther 33:455-65. 2011..Non invasive methods for fibrosis evaluation remain to be validated longitudinally in hepatitis B... - Impact of ribavirin plasma level on sustained virological response in patients treated with pegylated interferon and ribavirin for chronic hepatitis CD Breilh
Laboratoire de Pharmacocinétique et de Pharmacie Clinique EA2968, Universite Victor Segalen Bordeaux 2, Bordeaux, France
Aliment Pharmacol Ther 30:487-94. 2009..The main goal of therapy in hepatitis C virus (HCV) infection is to achieve a sustained virological response (SVR). However, the impact of the pharmacological properties of ribavirin on the SVR has not been fully investigated... - Liver stiffness diminishes with antiviral response in chronic hepatitis CC Hezode
Department of Hepatology and Gastroenterology, Hopital Henri Mondor, Universite Paris Est, Creteil, France INSERM U955, Creteil, France
Aliment Pharmacol Ther 34:656-63. 2011..Transient elastography measures liver stiffness, which correlates with the hepatic fibrosis stage and has excellent accuracy for the diagnosis of cirrhosis in patients with chronic hepatitis C... - Peginterferon alpha-2b plus ribavirin for treatment of chronic hepatitis C with severe fibrosis: a multicentre randomized controlled trial comparing two doses of peginterferon alpha-2bA Abergel
Service d Hepato Gastroenterologie, Hotel Dieu, Clermont Ferrand, France
J Viral Hepat 13:811-20. 2006.... - Liver fibrosis on account of chronic hepatitis C is more severe in HIV-positive than HIV-negative patients despite antiretroviral therapyV de Ledinghen
Centre d Investigation de la Fibrose hépatique, Hopital Haut Leveque, CHU Bordeaux, Pessac, France
J Viral Hepat 15:427-33. 2008..HIV/HCV-coinfected patients have more advanced liver fibrosis than HCV-monoinfected patients despite the immunologic benefit of HAART... - Diagnosis of liver fibrosis using FibroScan and other noninvasive methods in patients with hemochromatosis: a prospective studyX Adhoute
Service d Hepatogastroenterologie, Centre d Investigation de la Fibrose hépatique, Hopital Haut Leveque, 33604 Pessac Cedex, France
Gastroenterol Clin Biol 32:180-7. 2008..Transient elastography (FibroScan) is a new noninvasive, rapid, reproducible bedside method, allowing assessment of liver fibrosis by measuring liver rigidity... - Validation and comparison of simple noninvasive indexes for predicting liver fibrosis in HIV-HCV-coinfected patients: ANRS CO3 Aquitaine cohortMarc Arthur Loko
INSERM, U593, Bordeaux, France
Am J Gastroenterol 103:1973-80. 2008..Although an increasing number of noninvasive fibrosis markers are available in HCV-monoinfected patients, data on the performance of these tests in HIV-HCV-coinfected patients are lacking... - [Managing comorbidities in hepatology: toward a more holistic medicine]Patrice Couzigou
Service Hépato gastroentérologie, Hopital du Haut leveque, F 33604 PESSAC, France
Presse Med 37:1274-80. 2008..In this more holistic approach, the physician treats a person with liver disease, rather than just a diseased liver... - Hepatitis B virus genotypes: a retrospective survey in Southwestern France, 1999-2004Pascale Trimoulet
Laboratoire de virologie Hôpital Pellegrin, 33076 Bordeaux Cedex
Gastroenterol Clin Biol 31:1088-94. 2007..To determine the prevalence of HBV genotypes in Southwestern France and the association between HBV genotypes and patients characteristics... - [Brief intervention about alcohol use]Patrice Couzigou
Service d Hepato gastro enterologie, Hôpital Haut Lévêque Pessac, F 33600 Bordeaux, France
Presse Med 38:1126-33. 2009..This efficacy has been demonstrated for a duration of at least 4 years. Given that evidence also supports the behavioral changes, these findings should be taken into account by healthcare providers... - Liver stiffness measurement in children using FibroScan: feasibility study and comparison with Fibrotest, aspartate transaminase to platelets ratio index, and liver biopsyVictor de Ledinghen
INSERM, Universite Victor Segalen Bordeaux 2, Bordeaux, France
J Pediatr Gastroenterol Nutr 45:443-50. 2007.... - Outbreak of hepatitis C virus infection during sclerotherapy of varicose veins: long-term follow-up of 196 patients (4535 patient-years)Victor de Ledinghen
Service d Hepato Gastroenterologie, Hopital Haut Leveque, Pessac, France
J Hepatol 46:19-25. 2007.... - Prevalence of and factors associated with hepatic steatosis in patients coinfected with hepatitis C virus and HIV: Agence Nationale pour la Recherche contre le SIDA et les hépatites virales CO3 Aquitaine CohortDidier Neau
Fédération des Maladies Infectieuses et Tropicales, Centre Hospitalo Universitaire, Hopital Pellegrin, Bordeaux, France
J Acquir Immune Defic Syndr 45:168-73. 2007..The prevalence and factors associated with hepatic steatosis are not well defined in HCV-HIV-coinfected patients... - [Hepatitis C virus screening in drug users in an addiction out-patient unit]Veronique Grando-Lemaire
Service d Hepato Gastroenterologie, Hopital Jean Verdier, Assistance Publique Hopitaux de Paris, 93143 Bondy Cedex, France
Gastroenterol Clin Biol 26:1091-6. 2002..To investigate the feasibility and efficacy of hepatitis C virus screening in drug users in an addiction out-patient unit... - Antiviral action of ribavirin in chronic hepatitis CJean Michel Pawlotsky
Department of Virology, INSERM U635, Hopital Henri Mondor, Universite Paris XII, Creteil, France
Gastroenterology 126:703-14. 2004..Our aim was to assess the antiviral action of ribavirin on hepatitis C virus (HCV) as a function of ribavirin pharmacokinetics and to evaluate the influence of this antiviral effect on IFN-alpha efficacy... - [Hepatitis C virus genotype 4: epidemiology and treatment]Laurent Castera
, , 33604 Pessac
Gastroenterol Clin Biol 27:596-604. 2003 - Noninvasive diagnosis of liver fibrosis in patients with chronic hepatitis CLaurent Castera
Department of Hepatology and Gastroenterology, C.H.U. Bordeaux, , Pessac, France
MedGenMed 7:39. 2005 - Hepatitis C virus-induced hepatocellular steatosisLaurent Castera
Department of Hepatology and Gastroenterology, Centre Hospitalier Universitaire, Bordeaux, France
Am J Gastroenterol 100:711-5. 2005..This review discusses current knowledge of HCV-induced steatosis and its relation to chronic HCV-associated liver disease... - [Steasis and hepatitis C]Christophe Hezode
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Gastroenterol Clin Biol 27:1091-5. 2003 - The MTHFR 677C > T polymorphism is associated with an increased risk of hepatocellular carcinoma in patients with alcoholic cirrhosisRaphael Saffroy
Service de Biochimie et Biologie Moléculaire, Cedex, France
Carcinogenesis 25:1443-8. 2004..02). The relative risk for HCC in subjects with alcoholic cirrhosis and the CC genotype was 2.03. These results suggest that the MTHFR CC genotype increases the risk to develop HCC in patients who consume a high alcohol diet... - Psychosocial factors associated with perceived disease severity in patients with chronic hepatitis C: relationship with information sources and attentional coping stylesAymery Constant
Laboratoire de Psychologie de la Santé EA 3662, Universite Victor Segalen Bordeaux 2, France
Psychosomatics 46:25-33. 2005..These results suggest that information processing and psychological features play a key role in the way patients with chronic hepatitis C perceive their disease... - FibroScan and FibroTest to assess liver fibrosis in HCV with normal aminotransferasesLaurent Castera
Hepatology 43:373-4; author reply 375-6. 2006 - [Liver biopsy in management of chronic liver diseases: "EASL monothematic conference highlights"]Jean Francois Cadranel
Services d Hépato Gastroentérologie et de Diabétologie, Centre Hospitalier Laennec, Creil
Gastroenterol Clin Biol 30:121-3. 2006 - Accuracy of liver stiffness measurement for the diagnosis of cirrhosis in patients with chronic liver diseasesNathalie Ganne-Carrie
Hépato Gastroentérologie, Hopital Jean Verdier, Bondy, France UPRES EA3409, Universite Paris 13, Bobigny, France
Hepatology 44:1511-7. 2006..6 kPa. False-negatives are mainly attributable to inactive or macronodular cirrhosis... - Evolving practices of non-invasive markers of liver fibrosis in patients with chronic hepatitis C in France: time for new guidelines?Laurent Castera
J Hepatol 46:528-9; author reply 529-30. 2007 - Standardization of ROC curve areas for diagnostic evaluation of liver fibrosis markers based on prevalences of fibrosis stagesThierry Poynard
Assistance Publique Hôpitaux de Paris Groupe Hospitalier Pitié Salpêtrière, Paris, France
Clin Chem 53:1615-22. 2007..The aim of this study was to assess the relationships between the AUC and the prevalence of each fibrosis stage and to elaborate simple methods of standardization... - HEPACOM: multicenter, observational prospective study of outcome and monitoring of HCV positive antiviral-naïve patients managed in the French health care systemHelene Agostini
Seillans Conseils, Paris
Gastroenterol Clin Biol 31:1074-80. 2007..To study management practices in the French health care system for antiviral-naïve patients with chronic hepatitis C virus (HCV) infection... - Mood alterations during interferon-alfa therapy in patients with chronic hepatitis C: evidence for an overlap between manic/hypomanic and depressive symptomsAymery Constant
Department of Health Psychology EA 3662, University of Bordeaux 2, France
J Clin Psychiatry 66:1050-7. 2005..The impact of such findings on therapeutic management should be investigated... - Hepatitis B vaccination in HIV-infected patients: a survey of physicians and patients participating in the Aquitaine cohortMaria Winnock
INSERM U593 ISPED, Universite Victor Segalen Bordeaux 2
Gastroenterol Clin Biol 30:189-95. 2006..In France, HIV-infected (HIV+) patients are frequently coinfected with hepatitis B virus (HBV) or at risk for this infection. Physicians and their patients should be more committed to HBV prevention than the average population... - Partial splenic embolization in patients with cirrhosis: efficacy, tolerance and long-term outcome in 32 patientsGisèle N'kontchou
Department of Hepato Gastroenterology, Hopital Jean Verdier, Bondy Cedex, France
Eur J Gastroenterol Hepatol 17:179-84. 2005..We provide a retrospective review of results and the tolerance of all PSE procedures in patients with cirrhosis in our department...