Ibrahim Yakoub-Agha

Summary

Affiliation: CHRU de Lille
Country: France

Publications

  1. doi Impact of azacitidine before allogeneic stem-cell transplantation for myelodysplastic syndromes: a study by the Société Française de Greffe de Moelle et de Thérapie-Cellulaire and the Groupe-Francophone des Myélodysplasies
    Gandhi Damaj
    Centre Hospitalier Universitaire Sud, Amiens, France
    J Clin Oncol 30:4533-40. 2012
  2. doi Low-dose vs. high-dose thalidomide for advanced multiple myeloma: a prospective trial from the Intergroupe Francophone du Myélome
    Ibrahim Yakoub-Agha
    Service des Maladies du Sang, CHU, Lille, France
    Eur J Haematol 88:249-59. 2012
  3. doi Immune reconstitution following myeloablative allogeneic hematopoietic stem cell transplantation: the impact of expanding CD28negative CD8+ T cells on relapse
    Ibrahim Yakoub-Agha
    Service des Maladies du Sang, UAM allogreffes de CSH, CHU, Lille, France
    Biol Blood Marrow Transplant 15:496-504. 2009
  4. ncbi Comparative analysis of naïve and memory CD4+ and CD8+ T-cell subsets in bone marrow and G-CSF-mobilized peripheral blood stem cell allografts: impact of donor characteristics
    Ibrahim Yakoub-Agha
    Service des Maladies du Sang, CHU, Lille, France
    Exp Hematol 35:861-71. 2007
  5. ncbi A high proportion of donor CD4+ T cells expressing the lymph node-homing chemokine receptor CCR7 increases incidence and severity of acute graft-versus-host disease in patients undergoing allogeneic stem cell transplantation for hematological malignancy
    I Yakoub-Agha
    Service des Maladies du Sang, UAM allogreffes de CSH, Hopital Huriez, CHRU de Lille, Lille Cedex, France
    Leukemia 20:1557-65. 2006
  6. ncbi Dexamethasone-based regimens versus melphalan-prednisone for elderly multiple myeloma patients ineligible for high-dose therapy
    Thierry Facon
    Service des Maladies du Sang, Hopital Huriez, CHU de Lille, Rue Michel Polonovski, 59037 Lille, France
    Blood 107:1292-8. 2006
  7. ncbi Enteral feeding and early outcomes of patients undergoing allogeneic stem cell transplantation following myeloablative conditioning
    David Seguy
    Service de Nutrition, CHU, Lille, France
    Transplantation 82:835-9. 2006
  8. doi Better outcome of patients undergoing enteral tube feeding after myeloablative conditioning for allogeneic stem cell transplantation
    David Seguy
    Unité Mobile de Soutien Nutritionnel, Univ Lille Nord de France, Lille, France
    Transplantation 94:287-94. 2012
  9. ncbi Plasma cell growth fraction using Ki-67 antigen expression identifies a subgroup of multiple myeloma patients displaying short survival within the ISS stage I
    Thomas Gastinne
    Service d Hematologie Clinique, CHU, Nantes, France
    Eur J Haematol 79:297-304. 2007
  10. doi Imatinib mesylate as salvage therapy for refractory sclerotic chronic graft-versus-host disease
    Leonardo Magro
    Service des Maladies du Sang, Centre Hospitalier Regional Universitaire de Lille, Lille Cedex, France
    Blood 114:719-22. 2009

Collaborators

Detail Information

Publications30

  1. doi Impact of azacitidine before allogeneic stem-cell transplantation for myelodysplastic syndromes: a study by the Société Française de Greffe de Moelle et de Thérapie-Cellulaire and the Groupe-Francophone des Myélodysplasies
    Gandhi Damaj
    Centre Hospitalier Universitaire Sud, Amiens, France
    J Clin Oncol 30:4533-40. 2012
    ..To investigate the impact of prior-to-transplantation azacitidine (AZA) on patient outcome after allogeneic stem-cell transplantation (alloSCT) for myelodysplastic syndrome (MDS)...
  2. doi Low-dose vs. high-dose thalidomide for advanced multiple myeloma: a prospective trial from the Intergroupe Francophone du Myélome
    Ibrahim Yakoub-Agha
    Service des Maladies du Sang, CHU, Lille, France
    Eur J Haematol 88:249-59. 2012
    ..Collectively, low-dose thalidomide 100 mg/day has significant activity in advanced myeloma with an improved safety profile and can be a good salvage therapy in combination with dexamethasone...
  3. doi Immune reconstitution following myeloablative allogeneic hematopoietic stem cell transplantation: the impact of expanding CD28negative CD8+ T cells on relapse
    Ibrahim Yakoub-Agha
    Service des Maladies du Sang, UAM allogreffes de CSH, CHU, Lille, France
    Biol Blood Marrow Transplant 15:496-504. 2009
    ....
  4. ncbi Comparative analysis of naïve and memory CD4+ and CD8+ T-cell subsets in bone marrow and G-CSF-mobilized peripheral blood stem cell allografts: impact of donor characteristics
    Ibrahim Yakoub-Agha
    Service des Maladies du Sang, CHU, Lille, France
    Exp Hematol 35:861-71. 2007
    ....
  5. ncbi A high proportion of donor CD4+ T cells expressing the lymph node-homing chemokine receptor CCR7 increases incidence and severity of acute graft-versus-host disease in patients undergoing allogeneic stem cell transplantation for hematological malignancy
    I Yakoub-Agha
    Service des Maladies du Sang, UAM allogreffes de CSH, Hopital Huriez, CHRU de Lille, Lille Cedex, France
    Leukemia 20:1557-65. 2006
    ..Determination of the percentage of CD4+CCR7+ T cells in the graft provides a predictive indicator of acute GVHD. Partial depletion of this subset may reduce the risk of acute GVHD while preserving immunotherapeutic effects...
  6. ncbi Dexamethasone-based regimens versus melphalan-prednisone for elderly multiple myeloma patients ineligible for high-dose therapy
    Thierry Facon
    Service des Maladies du Sang, Hopital Huriez, CHU de Lille, Rue Michel Polonovski, 59037 Lille, France
    Blood 107:1292-8. 2006
    ..These results might be useful in the context of future combinations with innovative drugs...
  7. ncbi Enteral feeding and early outcomes of patients undergoing allogeneic stem cell transplantation following myeloablative conditioning
    David Seguy
    Service de Nutrition, CHU, Lille, France
    Transplantation 82:835-9. 2006
    ..3. Enteral nutrition is a safe and effective method for feeding allo-SCT patients. A randomized trial is warranted to confirm its advantage on early patient outcome...
  8. doi Better outcome of patients undergoing enteral tube feeding after myeloablative conditioning for allogeneic stem cell transplantation
    David Seguy
    Unité Mobile de Soutien Nutritionnel, Univ Lille Nord de France, Lille, France
    Transplantation 94:287-94. 2012
    ..The purpose was to determine whether EN improves early outcome after MAC allo-SCT...
  9. ncbi Plasma cell growth fraction using Ki-67 antigen expression identifies a subgroup of multiple myeloma patients displaying short survival within the ISS stage I
    Thomas Gastinne
    Service d Hematologie Clinique, CHU, Nantes, France
    Eur J Haematol 79:297-304. 2007
    ..In this series, we demonstrated that a proliferation marker provides clear-cut additional survival prognostic information to b2m into the ISS model...
  10. doi Imatinib mesylate as salvage therapy for refractory sclerotic chronic graft-versus-host disease
    Leonardo Magro
    Service des Maladies du Sang, Centre Hospitalier Regional Universitaire de Lille, Lille Cedex, France
    Blood 114:719-22. 2009
    ..Despite its limited size, this cohort suggests some beneficial activity of imatinib in sclerotic chronic graft-versus-host disease, warranting further prospective investigations...
  11. ncbi Total soluble HLA class I and soluble HLA-G in multiple myeloma and monoclonal gammopathy of undetermined significance
    Xavier Leleu
    Service d Hematologie, Lille, France
    Clin Cancer Res 11:7297-303. 2005
    ..0001). HLA-Is is a new marker of multiple myeloma tumor load and provides additional survival prognostic information to beta2-microglobulin...
  12. ncbi Melphalan and prednisone plus thalidomide versus melphalan and prednisone alone or reduced-intensity autologous stem cell transplantation in elderly patients with multiple myeloma (IFM 99-06): a randomised trial
    Thierry Facon
    Service d Hematologie, Centre Hospitalier Universitaire, Lille, France
    Lancet 370:1209-18. 2007
    ..We assessed whether the addition of thalidomide to this combination, or reduced-intensity stem cell transplantation, would improve survival...
  13. doi Early human herpesvirus type 6 reactivation after allogeneic stem cell transplantation: a large-scale clinical study
    Remy Dulery
    Hospital Huriez, Division of Hematology, CHU, Lille, France
    Biol Blood Marrow Transplant 18:1080-9. 2012
    ..Careful monitoring of HHV6 by PCR is warranted during the early posttransplantation period...
  14. ncbi Impact of Small Bowel Exploration Using Video-Capsule Endoscopy in the Management of Acute Gastrointestinal Graft-versus-Host Disease
    Ibrahim Yakoub-Agha
    Service des Maladies du Sang, UAM d Allogreffes de Cellule Souches Hématopoïétiques, CHRU de Lille, F 59037 Lille, France
    Transplantation 78:1697-701. 2004
    ..The purpose of this study was to evaluate the impact of the global diagnostic approach on the outcome of patients suspected of having acute (a) gastrointestinal (GI) graft-versus-host disease (GVHD)...
  15. ncbi Outcome of patients less than 55 years of age with high-risk acute leukemia who did not have an human leukocyte antigen-identical related donor: a long-term study of 97 consecutive patients
    Jerome Cornillon
    Service de Maladies du Sang, CHRU, Lille, France
    Leuk Lymphoma 46:841-9. 2005
    ..For patients who achieve remission and for whom UDS fails, auto-SCT may prove to be a good approach. For patients who fail to enter into remission, intensive salvage chemotherapy has a very limited effect...
  16. ncbi Thalidomide in patients with advanced multiple myeloma: a study of 83 patients--report of the Intergroupe Francophone du Myélome (IFM)
    Ibrahim Yakoub-Agha
    Service des Maladies du Sang, and the laboratoire de biostatistique CERIM, CHRU, Lille, France
    Hematol J 3:185-92. 2002
    ..To evaluate treatment by thalidomide and identify predictive factors of survival, event free survival and response among patients with advanced multiple myeloma treated with thalidomide as single agent therapy...
  17. ncbi An 18-case outbreak of drug-resistant Pseudomonas aeruginosa bacteriemia in hematology patients
    Jean Baptiste Micol
    Service des Maladies du Sang, CHRU, Lille, France
    Haematologica 91:1134-8. 2006
    ..Colistin was useful even in highly resistant strains and the efficacy of antibacterial therapy was similar (57%)in bacteriemia due to strains only susceptible to colistin...
  18. doi [IMiDs in hematology]
    Mathieu Wemeau
    CHRU, Hopital Huriez, Lille Cedex, France
    Bull Cancer 98:879-87. 2011
    ..A third component has been developed, the pomalidomide, which may be more effective in certain indications. Here we present an overview of IMiDs in hematology, including mechanisms of action and known significant side effects...
  19. ncbi Naïve subset develops the most important alloreactive response among human CD4+ T lymphocytes in human leukocyte antigen-identical related setting
    Mathilde Cherel
    EA2686, Universite Lille 2, Lille, France Institut d Immunologie, CHRU Lille, Lille Cedex, France
    Eur J Haematol 92:491-6. 2014
    ..These in vitro results in line with what we have observed in clinical studies and may also lend support to approaches of partial selective T-cell depletion for GVHD prevention. ..
  20. ncbi Antithymocyte globulin before allogeneic stem cell transplantation for progressive myelodysplastic syndrome: a study from the French Society of Bone Marrow Transplantation and Cellular Therapy
    Remy Dulery
    Department of Hematology and Bone Marrow Transplantation, CHRU Lille, Lille, France
    Biol Blood Marrow Transplant 20:646-54. 2014
    ..In conclusion, the addition of ATG to allo-SCT conditioning did not increase the incidence of relapse of patients with progressive MDS. The incidence of acute GVHD was decreased without compromising outcomes...
  21. doi Long-term follow-up results of IFM99-03 and IFM99-04 trials comparing nonmyeloablative allotransplantation with autologous transplantation in high-risk de novo multiple myeloma
    Philippe Moreau
    Blood 112:3914-5. 2008
  22. doi Graft-versus-lymphoma effect for aggressive T-cell lymphomas in adults: a study by the Société Francaise de Greffe de Moëlle et de Thérapie Cellulaire
    Steven Le Gouill
    Hematology Department, University Hospital, Hotel Dieu, Nantes, France
    J Clin Oncol 26:2264-71. 2008
    ..Aggressive T-cell lymphomas (ATCLs) represent 10% to 15% of non-Hodgkin's lymphomas (NHLs) in adults. ATCLs show a worse prognosis than B-cell lymphomas...
  23. doi Predictive factors for outcomes after reduced intensity conditioning hematopoietic stem cell transplantation for hematological malignancies: a 10-year retrospective analysis from the Société Française de Greffe de Moelle et de Thérapie Cellulaire
    Mauricette Michallet
    Service d Hematologie, Hopital Edouard Herriot, Lyon, France
    Exp Hematol 36:535-44. 2008
    ..In conclusion, this study highlights the major impact on RIC HSCT outcome of disease status before transplantation, ATG dose and ABO incompatibility...
  24. ncbi Efficacy of a low dose of thalidomide in advanced multiple myeloma
    Xavier Leleu
    Blood 100:1519-20. 2002
  25. ncbi Genetic abnormalities and survival in multiple myeloma: the experience of the Intergroupe Francophone du Myélome
    Herve Avet-Loiseau
    INSERM Unité 601, Laboratoire d Hematologie, Institut de Biologie, 9 quai Moncousu, 44093 Nantes, France
    Blood 109:3489-95. 2007
    ..In myeloma, the genomic aberrations t(4;14) and del(17p), together with beta2-microglobulin level, are important independent predictors of survival. These findings have implications for the design of risk-adapted treatment strategies...
  26. ncbi Allogeneic marrow stem-cell transplantation from human leukocyte antigen-identical siblings versus human leukocyte antigen-allelic-matched unrelated donors (10/10) in patients with standard-risk hematologic malignancy: a prospective study from the French
    Ibrahim Yakoub-Agha
    Agence de la biomedecine, St Denis, France
    J Clin Oncol 24:5695-702. 2006
    ....
  27. ncbi Prospective comparison of autologous stem cell transplantation followed by dose-reduced allograft (IFM99-03 trial) with tandem autologous stem cell transplantation (IFM99-04 trial) in high-risk de novo multiple myeloma
    Frederic Garban
    Hematology Department, University Hospital Hotel Dieu, Place Ricordeau, 44093 Nantes Cedex 01, France
    Blood 107:3474-80. 2006
    ..2 vs 35 months; P = .07). In patients with high-risk de novo MM, the combination of ASCT followed by dose-reduced allogeneic transplantation was not superior to tandem dose-intensified, melphalan-based ASCT...
  28. ncbi Inolimomab in steroid-refractory acute graft-versus-host disease following allogeneic hematopoietic stem cell transplantation: retrospective analysis and comparison with other interleukin-2 receptor antibodies
    Jacques Olivier Bay
    Unité de Transplantation Médullaire, Centre Jean Perrin, Clermont Ferrand, France
    Transplantation 80:782-8. 2005
    ..The use of monoclonal antibodies against interleukin-2 receptor (IL-2R)-alpha chains could be an effective treatment of acute graft-versus-host disease (GvHD). Experimental model and clinical studies have reported various results...
  29. ncbi Tandem autologous stem cell transplantation in high-risk de novo multiple myeloma: final results of the prospective and randomized IFM 99-04 protocol
    Philippe Moreau
    Hematology Department, University Hospital Hotel Dieu, Place Alexis Ricordeau, 44093 Nantes Cedex 01, France
    Blood 107:397-403. 2006
    ..39). In high-risk patients the dose intensity of melphalan at 420 mg/m2 led to encouraging results, but the addition of anti-IL-6 monoclonal antibody to the second conditioning regimen did not improve either OS nor EFS...
  30. ncbi Quantification by magnetic resonance imaging and liver consequences of post-transfusional iron overload alone in long term survivors after allogeneic hematopoietic stem cell transplantation (HSCT)
    Christian Rose
    Service d Hematologie, Groupe Hospitalier de l Institut CatholiqueService of Hemotherapy and Hemostasis, Hospital Clinic, Barcelona, Spain
    Haematologica 92:850-3. 2007
    ..009). But occurrence of liver dysfunction was not significant. Magnitude of iron overload correlates closely to the number of RBCs and is quantified by MRI. Impact on liver dysfunction is moderate in absence of co-morbidity...