J L Wemeau

..Antithyroid drugs, surgery and radioactive iodine, are useful for the traditional forms of hyperthyroidism. But the choice of the therapy and the procedures for the follow-up has now a more rational background...

..Primary prevention of this lethal disease may consist of adequate treatment of differentiated thyroid cancers and goiters in elderly...

..It is usually temporary, regressing with a few days or weeks after iodine withdrawal. Nevertheless, some patients require transient hormone replacement therapy...

..Lack of MCT8 transport of T(3) in neurons could explain the neurological phenotype...

..Surprisingly, it significantly reduced proptosis, one of the most debilitating symptoms of GO. Additional studies are warranted to define the benefit to risk ratio of the somatostatin analogs in this indication...

..When hypersecretion is unilateral or largely predominant in one size, surgery is very useful, when hypertension or hypokaliemia are poorly controlled, when medications are unwell tolerated, especially in men...

..4% vs. 0 (P = 0.04)]. It is concluded from this study that suppressive L-T(4) therapy is effective in reducing solitary thyroid nodule volume and improving infraclinical extranodular changes...

..In this perspective, Pendred's syndrome would appear as a genetic disorder in anion transportation...

..The diversity of multihormonal resistance contributes to the various phenotypes of the disease. Some clinical discomfort and medical consequences of the disease can be treated or prevented with hormone supplementation or modulation...

..Radioactive iodine constitutes an alternative to surgery for voluminous, compressive, hyperfunctionnal goiters, especially in older people...

..Familial hyperparathyroidism can be related to mutations of the menin (MEN1), Ret (MEN2), HRPT 1 and 2 genes or calcium sensor, and have different management, work-up and prognosis...

..It constitutes a document that the Society deems useful for distribution concerning the management of thyroid nodules, which is current, efficient and cost effective...

..This suggests the possible involvement of another gene or uncommon abnormality of RET gene...

..The aim of our study was to assess the influence of this variant on the age of onset, clinical, biological and pathological features of sMTC...

..In order to evaluate the efficacy of 131 Iodine on goitre volume and on thyroid function, we studied a cohort of patients exhibiting a multinodular and toxic or non toxic goitre...

..PHP Ia may therefore be an independent etiology of hypercalcitoninemia and hyperresponsiveness to pentagastrin infusion...

..The physiopathology and the evolution of these two cases are discussed with the data available in the literature...

..Gitelman syndrome (GS) is a tubulopathy caused by SLC12A3 gene mutations, which lead to hypokalaemic alkalosis, secondary hyperaldosteronism, hypomagnesaemia and hypocalciuria...

..This result may be explained by the efficacy of corticosteroid therapy on cerebral edema. The prognosis was poor with tumor infiltration of the leptomeninges and death 16 months after diagnosis...

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..Treatment of the cause is essential in secondary hypercalciuria, in addition to diet (low sodium intake, normocalcic diet, hydration), associated with thiazide diuretics and biphosphonates if necessary...

..The aim of this study was to investigate the effect of chronic alcoholic intoxication on plasma calcitonin (CT) levels...

..Calcitonin determination is available, more reproducible than other specific pancreatic endocrine markers and could be effective for diagnosis and follow-up of such foregut-derived endocrine neoplasia...

..However, in matched studies comparing pregnant and nonpregnant women recurrence risk and cancer mortality are not significantly different...

..The understanding of action mechanisms of these two enzymes currently leads to 11beta-OHSD inhibitors development, therefore opening new therapeutic strategies, especially in metabolic syndrome...

..We suggest that cabergoline should be considered as an alternative treatment in cases of pituitary adenomas that resist traditional treatments...

..FUTURE PROSPECTS AND PROJECTS: Fundamental approach will allow a best comprehension of physiopathogenic mechanisms of these disorders and the improvement of therapeutic management...

..Although extrapyramidal syndrome has never been reported in lipodystrophic patients, it may nevertheless be linked to the LMNA mutation since multiple neurological features have been associated with alterations in lamins A/C...

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..PTH analogs, calcimimetic drugs and anti-PTH immunization now provide attractive management perspectives...

..Moreover, hypoglycemia induced by fructose absorption, unexplained liver disease, irritable bowel syndrome or familial gout in an adult is suggestive of the diagnosis...

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..High ferritin levels are not synonymous with iron overload and may in some cases be a simple marker of insulin resistance...

..The utility of antiNIS antibodies determination is not yet proved...

..8% with the total panel of sera. The majority of assays demonstrated high diagnostic performance. We encountered some false-positive results at borderline positive levels, and the nonrecognition of some sera by competitive assays...

..Patients with delayed Ca under 8.0 mg/dl and/or delayed Ph above 4.0 mg/dl are at high risk to develop permanent hypocalcemia...

..The natural history of multiple endocrine neoplasia type 1 (MEN1) is known through single-institution or single-family studies. We aimed to analyze the risk factors and causes of death in a large cohort of MEN1 patients...

..Autoimmune polyendocrine syndrome type 1 (APS1) has been poorly evaluated in France. We focused on the north-western part of the country to describe clinical phenotypes, especially severe forms of the disease, and AIRE gene mutations...

..Cardiac hypertrophy and advanced atherosclerosis were frequent. FPLD patients should receive careful neuromuscular and cardiac examination whatever the underlying LMNA mutation...

..We report a 57-year-old woman who presented with this entity and that illustrates both the diagnostic difficulty and disease course after intravenous corticosteroid therapy...

..Further studies are warranted to confirm whether this new mutation is causing MTC only or could be associated with Hirschsprung's disease...

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..FAS AND THYROID CANCER: Tumoral cells are resistant to apoptosis by inhibiting the apoptotic signal transduction and exert Fas counter-attack by inducing apoptosis of antitumoral lymphocytes...

..There is currently no treatment that can permanently resolve the functional and aesthetic problems of dermopathy and acropachy...

..The treatment of recurrences was surgical, by MIBG or by external radiotherapy. Nine patients had a family history of chromaffin tumor(s). The genetic survey made in five of these nine patients was positive in all cases...

..With diagnosis of these diseases deleterious therapeutics can be avoided. The discovery of this receptor has led to new therapeutic prospects such as calcimimetics for hyperthyroidism...