Marie Christine Vantyghem

Summary

Affiliation: CHRU de Lille
Country: France

Publications

  1. ncbi request reprint Management strategies for brittle diabetes
    M C Vantyghem
    Endocrinology and Metabolism Department ERIT M0106, Lille University Hospital, 6 Rue du Pr Laguesse, 59037 Lille Cedex, France
    Ann Endocrinol (Paris) 67:287-96. 2006
  2. pmc Continuous glucose monitoring after islet transplantation in type 1 diabetes: an excellent graft function (β-score greater than 7) Is required to abrogate hyperglycemia, whereas a minimal function is necessary to suppress severe hypoglycemia (β-score grea
    Marie Christine Vantyghem
    Endocrinologie et Metabolisme, Hopital Huriez, Institut National de la Santé et de la Recherche Médicale Unité 859, Centre Hospitalier et Universitaire de Lille, 1 rue Polonovski, F 59045 Lille, France
    J Clin Endocrinol Metab 97:E2078-83. 2012
  3. doi request reprint [Hypotension from endocrine origin]
    Marie Christine Vantyghem
    Centre Hospitalier Regional Universitaire de Lille, Hopital Huriez, Service d Endocrinologie et Maladies Métaboliques, 59000 Lille, France
    Presse Med 41:1137-50. 2012
  4. doi request reprint How to diagnose a lipodystrophy syndrome
    Marie Christine Vantyghem
    INSERM U859, Service d Endocrinologie et Maladies Métaboliques, Hopital Huriez, CHRU de Lille, 1, rue Polonovski, 59000 Lille, France
    Ann Endocrinol (Paris) 73:170-89. 2012
  5. ncbi request reprint Thyroid carcinomas involving follicular and parafollicular C cells: seventeen cases with characterization of RET oncogenic activation
    M C Vantyghem
    Department of Endocrinology and Metabolism, University Hospital, Lille, France
    Thyroid 14:842-7. 2004
  6. doi request reprint Fertility and obstetrical complications in women with LMNA-related familial partial lipodystrophy
    M C Vantyghem
    Service d Endocrinologie Métabolisme Clinique Linquette, Centre Hospitalier Regional et Universitaire de Lille, 6 Rue du Pr Laguesse, Lille, France
    J Clin Endocrinol Metab 93:2223-9. 2008
  7. ncbi request reprint Familial partial lipodystrophy due to the LMNA R482W mutation with multinodular goitre, extrapyramidal syndrome and primary hyperaldosteronism
    M C Vantyghem
    Endocrinology and Metabolism, Lille University Hospital, 6 Rue du Pr Laguesse, F 59037 Lille, France
    Clin Endocrinol (Oxf) 67:247-9. 2007
  8. ncbi request reprint Calcitonin levels do not decrease with weaning in chronic alcoholism
    M C Vantyghem
    Endocrinology and Metabolism Department, Lille University Hospital, Lille Cedex, France
    Thyroid 17:213-7. 2007
  9. ncbi request reprint [11beta-hydroxysteroide dehydrogenases. Recent advances]
    M C Vantyghem
    Service d Endocrinologie et Métabolisme, clinique d endocrinologie Marc Linquette, 6, rue du Professeur Laguesse, CHRU de Lille, 59037 Lille Cedex, France
    Ann Endocrinol (Paris) 68:349-56. 2007
  10. ncbi request reprint [Iron overload and insulin resistance]
    M C Vantyghem
    Service d Endocrinologie et Métabolisme, CHU, Lille
    Presse Med 34:1391-8. 2005

Detail Information

Publications61

  1. ncbi request reprint Management strategies for brittle diabetes
    M C Vantyghem
    Endocrinology and Metabolism Department ERIT M0106, Lille University Hospital, 6 Rue du Pr Laguesse, 59037 Lille Cedex, France
    Ann Endocrinol (Paris) 67:287-96. 2006
    ..Implantable pumps have advantages for patients who either weigh more than 80 kgs or have abnormalities of kidney or liver function or are highly sensitised...
  2. pmc Continuous glucose monitoring after islet transplantation in type 1 diabetes: an excellent graft function (β-score greater than 7) Is required to abrogate hyperglycemia, whereas a minimal function is necessary to suppress severe hypoglycemia (β-score grea
    Marie Christine Vantyghem
    Endocrinologie et Metabolisme, Hopital Huriez, Institut National de la Santé et de la Recherche Médicale Unité 859, Centre Hospitalier et Universitaire de Lille, 1 rue Polonovski, F 59045 Lille, France
    J Clin Endocrinol Metab 97:E2078-83. 2012
    ..For the last 10 yr, continuous glucose monitoring (CGM) has brought up new insights into the accuracy of blood glucose analysis...
  3. doi request reprint [Hypotension from endocrine origin]
    Marie Christine Vantyghem
    Centre Hospitalier Regional Universitaire de Lille, Hopital Huriez, Service d Endocrinologie et Maladies Métaboliques, 59000 Lille, France
    Presse Med 41:1137-50. 2012
    ..An accurate etiological diagnosis should allow treat efficiently endocrine hypotension without inducing hypertension in supine posture...
  4. doi request reprint How to diagnose a lipodystrophy syndrome
    Marie Christine Vantyghem
    INSERM U859, Service d Endocrinologie et Maladies Métaboliques, Hopital Huriez, CHRU de Lille, 1, rue Polonovski, 59000 Lille, France
    Ann Endocrinol (Paris) 73:170-89. 2012
    ..Other therapeutic options will undoubtedly be developed, dependent on pathophysiological advances, which today tend to classify genetically determined lipodystrophy as being related to laminopathy or to lipid droplet disorders...
  5. ncbi request reprint Thyroid carcinomas involving follicular and parafollicular C cells: seventeen cases with characterization of RET oncogenic activation
    M C Vantyghem
    Department of Endocrinology and Metabolism, University Hospital, Lille, France
    Thyroid 14:842-7. 2004
    ..This suggests the possible involvement of another gene or uncommon abnormality of RET gene...
  6. doi request reprint Fertility and obstetrical complications in women with LMNA-related familial partial lipodystrophy
    M C Vantyghem
    Service d Endocrinologie Métabolisme Clinique Linquette, Centre Hospitalier Regional et Universitaire de Lille, 6 Rue du Pr Laguesse, Lille, France
    J Clin Endocrinol Metab 93:2223-9. 2008
    ....
  7. ncbi request reprint Familial partial lipodystrophy due to the LMNA R482W mutation with multinodular goitre, extrapyramidal syndrome and primary hyperaldosteronism
    M C Vantyghem
    Endocrinology and Metabolism, Lille University Hospital, 6 Rue du Pr Laguesse, F 59037 Lille, France
    Clin Endocrinol (Oxf) 67:247-9. 2007
    ..Although extrapyramidal syndrome has never been reported in lipodystrophic patients, it may nevertheless be linked to the LMNA mutation since multiple neurological features have been associated with alterations in lamins A/C...
  8. ncbi request reprint Calcitonin levels do not decrease with weaning in chronic alcoholism
    M C Vantyghem
    Endocrinology and Metabolism Department, Lille University Hospital, Lille Cedex, France
    Thyroid 17:213-7. 2007
    ..The aim of this study was to investigate the effect of chronic alcoholic intoxication on plasma calcitonin (CT) levels...
  9. ncbi request reprint [11beta-hydroxysteroide dehydrogenases. Recent advances]
    M C Vantyghem
    Service d Endocrinologie et Métabolisme, clinique d endocrinologie Marc Linquette, 6, rue du Professeur Laguesse, CHRU de Lille, 59037 Lille Cedex, France
    Ann Endocrinol (Paris) 68:349-56. 2007
    ..The understanding of action mechanisms of these two enzymes currently leads to 11beta-OHSD inhibitors development, therefore opening new therapeutic strategies, especially in metabolic syndrome...
  10. ncbi request reprint [Iron overload and insulin resistance]
    M C Vantyghem
    Service d Endocrinologie et Métabolisme, CHU, Lille
    Presse Med 34:1391-8. 2005
    ..High ferritin levels are not synonymous with iron overload and may in some cases be a simple marker of insulin resistance...
  11. ncbi request reprint [Cystic fibrosis diabetes in adult]
    M C Vantyghem
    Service d endocrinologie et métabolismes, 6, rue du Pr Laguesse Centre Hospitalo Universitaire, 59037 Lille Cedex
    Ann Endocrinol (Paris) 66:347-54. 2005
    ..In conclusion, the aim of treatment of cystic fibrosis is to prevent the lung function decline by controlling inflammation and infection, to implement endo- and exo-crine pancreas insufficiency, and to improve nutritional status...
  12. ncbi request reprint Effects of non-steroid immunosuppressive drugs on insulin secretion in transplantation
    M C Vantyghem
    Endocrinology and Metabolism Department, Lille University Hospital, 59037 Lille Cedex, France
    Ann Endocrinol (Paris) 68:21-7. 2007
    ..Finally, steroids are mainly detrimental because they accentuate insulin resistance whereas anticalcineurins, in particular tacrolimus, lower insulin synthesis...
  13. ncbi request reprint Phenotype and HFE genotype in a population with abnormal iron markers recruited from an Endocrinology Department
    Marie Christine Vantyghem
    Endocrinology and Metabolism Department, Lille University Hospital, France
    Eur J Endocrinol 154:835-41. 2006
    ..The aim of this study was to describe HFE genotype in a population of patients with altered iron markers recruited in an Endocrinology Department and to define the possible phenotype-genotype relationships...
  14. ncbi request reprint Patients with familial partial lipodystrophy of the Dunnigan type due to a LMNA R482W mutation show muscular and cardiac abnormalities
    M C Vantyghem
    Department of Endocrinology and Metabolism, Lille University Hospital, 6 rue du Prof Laguesse, 59037 Lille Cedex, France
    J Clin Endocrinol Metab 89:5337-46. 2004
    ..Cardiac hypertrophy and advanced atherosclerosis were frequent. FPLD patients should receive careful neuromuscular and cardiac examination whatever the underlying LMNA mutation...
  15. ncbi request reprint Eligibility of diabetic patients for islet transplantation alone
    M C Vantyghem
    Endocrinology and Metabolism Department, and INSERM ERIT 0106, Lille University Hospital, Lille, France
    Transplant Proc 36:1106-7. 2004
    ..Equally important is the measurement of C-peptide, plasma creatinine, and microalbuminuria...
  16. doi request reprint Hyponatremia and antidiuresis syndrome
    Marie Christine Vantyghem
    Service d Endocrinologie et Maladies Métaboliques, Hopital Huriez, Centre Hospitalier Regional Universitaire de Lille, 1, rue Polonovski, 59000 Lille, France
    Ann Endocrinol (Paris) 72:500-12. 2011
    ..Obviously treatment of a corticotropic deficit, even subtle, should not be overlooked, as well as the introduction of fludrocortisone in isolated hypoaldosteronism and discontinuation of iatrogenic drugs...
  17. ncbi request reprint Diabetes cell therapy: a decade later
    M C Vantyghem
    Unit of Endocrinology and Metabolism, Endocrine Surgery and Nephrology Department, Lille University Hospital, Lille, France
    Minerva Endocrinol 36:23-39. 2011
    ..Currently and until a more complete assessment of the 5- and probably 10-year overall benefit-risk ratio is available, islet transplantation remains a clinical research procedure...
  18. doi request reprint Who should benefit from diabetes cell therapy?
    M C Vantyghem
    INSERM U 859, Endocrinology and Metabolism, Endocrine Surgery and Nephrology Department, Lille University Hospital, 59037 Lille Cedex, France
    Ann Endocrinol (Paris) 70:443-8. 2009
    ....
  19. ncbi request reprint Kinetics of diabetes-associated autoantibodies after sequential intraportal islet allograft associated with kidney transplantation in type 1 diabetes
    M C Vantyghem
    Department of Endocrinology and Metabolism, INSERM ERIT 0106, Lille University Hospital, 6 Rue du Pr Laguesse, 59037 Lille Cedex, France
    Diabetes Metab 29:595-601. 2003
    ....
  20. doi request reprint [Hypoglycemia and endocrine effects of adults' inborn errors of metabolism]
    M C Vantyghem
    Service d Endocrinologie et Métabolisme, Clinique Marc Linquette, 59037 Lille Cedex, France
    Ann Endocrinol (Paris) 70:25-42. 2009
    ..Hypogonadism is almost constant in galactosemia, frequent in CDG syndromes, cystinosis and iron overload. Most of the time, a specialized advice is required, which is one of the mission of reference centres...
  21. doi request reprint Intraperitoneal insulin infusion versus islet transplantation: comparative study in patients with type 1 diabetes
    Marie Christine Vantyghem
    INSERM U 859, Diabetes Cell Therapy Lille University Hospital, Lille Cedex, France
    Transplantation 87:66-71. 2009
    ..The purpose of this article was to compare two strategies for insulin delivery in brittle type 1 diabetic patients: intraperitoneal insulin infusion (IPII) through an implantable pump and intraportal islet transplantation (IIT)...
  22. ncbi request reprint Eligibility of diabetic patients receiving dialysis for islet after kidney transplantation
    M C Vantyghem
    Endocrinology and Metabolism Department, and INSERM ERIT 0106, Lille University Hospital, Lille, France
    Transplant Proc 36:1103-5. 2004
    ....
  23. doi request reprint Quantitative in vivo islet potency assay in normoglycemic nude mice correlates with primary graft function after clinical transplantation
    Robert Caiazzo
    INSERM U859, Thérapie Cellulaire du Diabète, Faculte de Medecine, Lille, France
    Transplantation 86:360-3. 2008
    ..85, P<0.01). QIVIPA appears as a reliable test to monitor islet graft potency, applicable to validate new methods to produce primary islets or other human insulin secreting cells...
  24. pmc Primary graft function, metabolic control, and graft survival after islet transplantation
    Marie Christine Vantyghem
    University Lille Nord de France, Lille, France
    Diabetes Care 32:1473-8. 2009
    ..CONCLUSIONS Optimal PGF was associated with prolonged graft survival and better metabolic control after islet transplantation. This early outcome may represent a valuable end point in future clinical trials...
  25. ncbi request reprint Influence of preservation solution on human islet isolation outcome
    Thomas Hubert
    INSERM U859, Diabetes Cell Therapy, Faculty of Medicine, Lille 2 University, Lille, France
    Transplantation 83:270-6. 2007
    ..The influence of the preservation solution used for in situ perfusion of the donor and pancreas storage on islet isolation has received little attention...
  26. ncbi request reprint In vivo and in vitro effect of sirolimus on insulin secretion
    Sophie Marcelli-Tourvieille
    Department of Endocrinology and Metabolism and Endocrine Surgery, INSERM Unit M859, Diabetes Cell Therapy, Lille University Hospital, Lille, France
    Transplantation 83:532-8. 2007
    ..The effects of sirolimus on insulin secretion are still debated. Our aim was to investigate the effects of sirolimus, both (1) in vivo in healthy minipigs; and (2) in vitro on human islets...
  27. doi request reprint Should genetic testing be performed in each patient with sporadic pheochromocytoma at presentation?
    Pascal Pigny
    Laboratoire de Biochimie Hormonologie, métabolisme nutrition, Oncologie, Centre de Biologie et Pathologie, CHRU de Lille, France
    Eur J Endocrinol 160:227-31. 2009
    ..This high frequency together with the financial support provided to reference laboratories of molecular genetics by the French government led to a nearly systematic screening in each patient with a pheochromocytoma...
  28. doi request reprint Local-regional recurrence of sporadic or syndromic abdominal extra-adrenal paraganglioma: incidence, characteristics, and outcome
    Sam Van Slycke
    Univ Lille Nord de France, CHULille, Lille, France
    Surgery 146:986-92. 2009
    ..Operative excision of abdominal extra-adrenal paragangliomas (EAPs) does not preclude the late development of local-regional recurrence. We describe the incidence, characteristics, and outcome of this rarely reported feature...
  29. ncbi request reprint Selection of diabetic patients for islet transplantation. A single-center experience
    M C Vantyghem
    Endocrinology and Metabolism Department, INSERM ERIT M 0106, Diabetes Cell Therapy Lille University Hospital, 59037 Lille, France
    Diabetes Metab 30:417-23. 2004
    ..Since the Edmonton protocol, islet transplantation (IT) offers the prospect of adequate glycemic control with no major surgical risk. In our single-center experience of IT, we studied the recruitment of eligible diabetic patients...
  30. pmc Hypoglycaemia related to inherited metabolic diseases in adults
    Claire Douillard
    Service d Endocrinologie et Maladies Métaboliques, Hopital Claude Huriez, Centre Hospitalier Regional et Universitaire de Lille, France
    Orphanet J Rare Dis 7:26. 2012
    ....
  31. ncbi request reprint Circulating and cell-bound antibodies increase coxsackievirus B4-induced production of IFN-alpha by peripheral blood mononuclear cells from patients with type 1 diabetes
    Didier Hober
    Laboratory of Virology, UPRES EA Viral Pathogenesis of Diabetes Type 1, University Hospital, and University Lille 2, 59037 Lille, France
    J Gen Virol 83:2169-76. 2002
    ..These studies demonstrate that CVB4, through interactions with circulating and/or cell-bound IgGs, can strongly induce the production of IFN-alpha by PBMCs from patients with type 1 diabetes...
  32. ncbi request reprint Acute insulin response (AIR): review of protocols and clinical interest in islet transplantation
    S Marcelli-Tourvieille
    Diabetes Cell Therapy, INSERM ERIT 0106, Lille University Hospital, 59037 Lille, France
    Diabetes Metab 32:295-303. 2006
    ..These specific indications, however, need to be confirmed by future studies and completed by other approaches such as insulin sensitivity studies and in vivo morphological assessment of islet mass...
  33. doi request reprint Long-term survival after adrenalectomy for stage I/II adrenocortical carcinoma (ACC): a retrospective comparative cohort study of laparoscopic versus open approach
    Gianluca Donatini
    Department of General and Endocrine Surgery, Lille Regional University Hospital, Lille, France
    Ann Surg Oncol 21:284-91. 2014
    ..In a retrospective cohort study we compared the outcome of LA versus open adrenalectomy (OA) in the treatment of stage I and II ACC...
  34. doi request reprint Regulation and functional effects of ZNT8 in human pancreatic islets
    Bruno Lefebvre
    Univ Lille Nord de France, F 59000 Lille, France
    J Endocrinol 214:225-32. 2012
    ..Prospects for increasing ZNT8 expression and/or activity may prove beneficial in type 2 diabetes in humans...
  35. doi request reprint [Half of the patients with primary hyperparathyroidisms have a vitamin D deficiency: aggravating the osseous attack]
    Fritz Line Velayoudom-Cephise
    CHRU de Lille, Clinique Marc Linquette, Service d Endocrinologie Métabolisme, 59037 Lille Cedex, France
    Presse Med 40:e120-7. 2011
    ..PHPT is asymptomatic for 80% of patients and responsible for a decrease in bone mineral density particularly in women. Vitamin D deficiency increases the risk of bone fractures...
  36. pmc Metabolic syndrome and collateral vessel formation in patients with documented occluded coronary arteries: association with hyperglycaemia, insulin-resistance, adiponectin and plasminogen activator inhibitor-1
    Frederic Mouquet
    Departments of Cardiology, Centre Hospitalier Regional Universitaire, Lille, France
    Eur Heart J 30:840-9. 2009
    ..We hypothesized that such patients, in the event of a coronary occlusion, might exhibit a less developed collateral circulation...
  37. ncbi request reprint [Pseudo-hypoaldosteronisms]
    Marie Christine Vantyghem
    Service d Endocrinologie et Métabolisme, Centre hospitalo universitaire de Lille 59
    Presse Med 33:123-9. 2004
    ..These WNK kinases constitute a new signalisation pathway that would regulate blood pressure and homeostasy of Na+, K+, H+ and Cl- ions...
  38. ncbi request reprint Clinical evaluation of a new sensitive calcitonin assay: study of specificity
    M D'Herbomez
    Institut de Médecine Nucléaire, Centre Hospitalier Regional Universitaire, 59037 Lille Cedex, France
    Clin Chim Acta 311:149-55. 2001
    ....
  39. ncbi request reprint Contribution of genetic analysis in screening for MEN1 among patients with sporadic disease and one or more typical manifestation
    M F Odou
    Laboratoire de Biochimie Biologie Moléculaire, Pôle de Pathologie Biologie, Eurasanté, CHRU de Lille, France
    Ann Endocrinol (Paris) 67:581-7. 2006
    ..In a sporadic context with at least two established manifestations of MEN1, the overall probability of identifying a mutation was 26%, warranting MEN1 genotypic analysis...
  40. doi request reprint Diabetes insipidus
    Clara Leroy
    Service d Endocrinologie et Maladies Métaboliques, centre hospitalier régional universitaire de Lille CHRU de LIlle, hôpital Huriez Inserm U 859, 1, rue Polonovski, 59000 Lille, France
    Ann Endocrinol (Paris) 74:496-507. 2013
    ..Current advances in DI concern the etiological work-up, with in particular the identification of IgG4-related hypophysitis or many genetic abnormalities, opening the field of targeted therapies in the years to come...
  41. ncbi request reprint Profile and outcome of pure androgen-secreting adrenal tumors in women: experience of 21 cases
    Sebastián Moreno
    Clinique Chirurgicale, Service de Chirurgie Générale et Endocrienne, Universite de Lille, Hopital Claude Huriez, Rue Michel Polonovski, 59037 Lille Cedex, France
    Surgery 136:1192-8. 2004
    ..The aim of the study was to determine the outcome and possible prognostic factors of pure androgen-secreting adrenal tumors (PASATs)...
  42. ncbi request reprint [Riedel's thyroiditis: current aspects]
    Pierrette Perimenis
    Service d endocrinologie et métabolismes, CHRU de Lille, F 59037 Lille Cedex, France
    Presse Med 37:1015-21. 2008
    ..There is not yet any consensus about the role of anti-TNFalpha agents and other immunosuppressive treatment for either local or more general forms of multifocal fibrosclerotic diseases...
  43. pmc Endocrine manifestations related to inherited metabolic diseases in adults
    Marie Christine Vantyghem
    Service d Endocrinologie et Maladies Métaboliques, 1, rue Polonovski, Hopital C Huriez, Centre Hospitalier Regional et Universitaire de Lille, 59037 Lille Cedex, France
    Orphanet J Rare Dis 7:11. 2012
    ..This is a new and growing field and is not yet very well recognized in adulthood despite its consequences on growth, bone metabolism and fertility. For this reason, physicians managing adult patients should be aware of these diagnoses...
  44. doi request reprint A part of the VP4 capsid protein exhibited by coxsackievirus B4 E2 is the target of antibodies contained in plasma from patients with type 1 diabetes
    Pierre Sauter
    Laboratoire de virologie UPRES EA3610, Faculté de Médecine Université Lille 2, CHRU Lille, Lille, France
    J Med Virol 80:866-78. 2008
    ....
  45. doi request reprint Acute insulin response to arginine in deceased donors predicts the outcome of human islet isolation
    T Hubert
    INSERM U859, Thérapie Cellulaire du Diabète, Faculte de Medecine, Lille, France
    Am J Transplant 8:872-6. 2008
    ..If routinely performed in deceased donors, this simple test could significantly reduce the failure rate of human islet isolation...
  46. ncbi request reprint Oxidative markers in diabetic ketoacidosis
    M C Vantyghem
    Endocrinology Department, Biochemistry Laboratory, CHRU, Lille, France
    J Endocrinol Invest 23:732-6. 2000
    ....
  47. ncbi request reprint Non-esterified fatty acids are deleterious for human pancreatic islet function at physiological glucose concentration
    M Dubois
    ERIT M 0106 Diabetes Cell therapy, INSERM, Faculty of Medicine, University of Lille, 1 place de Verdun, 59 045, Lille Cedex, France
    Diabetologia 47:463-9. 2004
    ..We examined the influence of non-esterified fatty acids, with or without concomitant increased glucose concentrations, on human islet function and on the expression of genes involved in lipid metabolism...
  48. ncbi request reprint Extreme subcutaneous insulin resistance: a misunderstood syndrome
    B Soudan
    Laboratory of Endocrinology, Lille University Hospital, Lille, France
    Diabetes Metab 29:539-46. 2003
    ..This case report of acquired SIR raises the question of its treatment and mechanisms. Regarding treatment, intraperitoneal delivery of insulin appears to be the best solution, but the mechanisms underlying SIR still remain unclear...
  49. doi request reprint Does the RET variant G691S influence the features of sporadic medullary thyroid carcinoma?
    C Cardot-Bauters
    Service d Endocrinologie et Maladies Métaboliques, Clinique Marc Linquette, Lille, France
    Clin Endocrinol (Oxf) 69:506-10. 2008
    ..The aim of our study was to assess the influence of this variant on the age of onset, clinical, biological and pathological features of sMTC...
  50. ncbi request reprint Responses of the steroid circadian system to alcohol in humans: Importance of the time and duration of intake
    Thierry Danel
    Service d Endocrinologie et Maladies Métaboliques, Centre Hospitalier Regional Universitaire, 59037 Lille Cedex, France
    Chronobiol Int 23:1025-34. 2006
    ....
  51. ncbi request reprint Urinary cortisol metabolites in the assessment of peripheral thyroid hormone action: overt and subclinical hypothyroidism
    M C Vantyghem
    Service d Endocrinologie et Maladies Métaboliques, C H R U, Lille, France
    J Endocrinol Invest 21:219-25. 1998
    ..The aim of this study was to determine if urinary cortisol metabolite ratios are a good index of peripheral thyroid hormone action in subclinical hypothyroidism...
  52. ncbi request reprint [Monogenic severe insulin resistance syndromes]
    D Vincent-Desplanques
    Service d endocrinologie et métabolismes, 6, rue du Pr Laguesse, Centre Hospitalier Universitaire, 59037 Lille Cedex, France
    Rev Med Interne 26:866-73. 2005
    ....
  53. ncbi request reprint Doctor, my son is so tired... about a case of hereditary fructose intolerance
    M J Guery
    Service d Endocrinologie et Métabolisme, Clinique Marc Linquette, CHU de Lille, 6, rue du Professeur Laguesse, 59037 Lille Cedex, France
    Ann Endocrinol (Paris) 68:456-9. 2007
    ..Moreover, hypoglycemia induced by fructose absorption, unexplained liver disease, irritable bowel syndrome or familial gout in an adult is suggestive of the diagnosis...
  54. ncbi request reprint Adrenal minerlocorticoids pathway and its clinical applications
    A Ghulam
    Laboratoire de Biochimie Endocrinologique, C H R U, 59037 Lille Cedex, France
    Clin Chim Acta 330:99-110. 2003
  55. ncbi request reprint Aldosterone-producing adenoma without hypertension: a report of two cases
    M C Vantyghem
    Department of Endocrinology, CHRU, 59037 Lille Cedex, France
    Eur J Endocrinol 141:279-85. 1999
    ..This suggests that excess aldosterone induced relative hypertension in these patients whose blood pressure was spontaneously very low. Genetic screening for dexamethasone-sensitive hyperaldosteronism was negative in both patients...
  56. ncbi request reprint New metabolic phenotypes in laminopathies: LMNA mutations in patients with severe metabolic syndrome
    Aurélie Decaudain
    INSERM U680, Paris, F 75012 France
    J Clin Endocrinol Metab 92:4835-44. 2007
    ..We report here the phenotypes of the patients with non-codon 482 mutations and compare them with those of 11 patients with codon 482 mutations. We also studied skin fibroblasts or lymphocytes from seven patients...
  57. pmc Viral protein VP4 is a target of human antibodies enhancing coxsackievirus B4- and B3-induced synthesis of alpha interferon
    Wassim Chehadeh
    Service de Virologie UPRES EA3610, Faculte de Medecine, Universite Lille 2, Bâtiment Paul Boulanger, CHRU Lille, 59037 Lille, France
    J Virol 79:13882-91. 2005
    ..These results show that VP4 is the target of antibodies involved in the plasma-dependent enhancement of CVB4E2- and CVB3-induced IFN-alpha synthesis by PBMC...
  58. ncbi request reprint Assessment of the severity of hypoglycemia and glycemic lability in type 1 diabetic subjects undergoing islet transplantation
    Edmond A Ryan
    Department of Medicine, Clinical Islet Transplant Program, University of Alberta and Capital Health Authority, Edmonton, Alberta, Canada
    Diabetes 53:955-62. 2004
    ....
  59. ncbi request reprint A PRKAR1A mutation associated with primary pigmented nodular adrenocortical disease in 12 kindreds
    Lionel Groussin
    Institut National de la Santé et de la Recherche Médicale U 567, Centre National de la Recherche Scientifique Unite Mixte de Recherche 8104, Universite Rene Descartes, Paris 5, 75014 Paris, France
    J Clin Endocrinol Metab 91:1943-9. 2006
    ..Germline PRKAR1A-inactivating mutations have been observed in both CNC and iPPNAD, but with no apparent genotype-phenotype correlation...
  60. ncbi request reprint [Congenital hypomagnesemia]
    David Montaigne
    Service d Endocrinologie et Métabolisme, Centre Hospitalo Universitaire, Lille 59
    Presse Med 33:1341-8. 2004
    ..However, there are many border-line phenotypes and the pheno-genotype correlation is still imperfect...
  61. doi request reprint Intrahepatic glucose flux as a mechanism for defective intrahepatic islet alpha-cell response to hypoglycemia
    Huarong Zhou
    Pacific Northwest Research Institute, Seattle, Washington 98122, USA
    Diabetes 57:1567-74. 2008
    ....