Pascal Pigny

Summary

Affiliation: CHRU de Lille
Country: France

Publications

  1. doi request reprint Paraganglioma after maternal transmission of a succinate dehydrogenase gene mutation
    Pascal Pigny
    Laboratoire de Biochimie et Hormonologie, Centre de Biologie et Pathologie, Centre Hospitalier Regional and Universitaire, Lille Cedex, France
    J Clin Endocrinol Metab 93:1609-15. 2008
  2. ncbi request reprint A novel 9-base pair duplication in RET exon 8 in familial medullary thyroid carcinoma
    P Pigny
    Laboratoire de Biochimie Secteur commun de Biologie Moléculaire de l Hôpital Huriez, Centre Hospitalier Regional Universitaire, Lille, France
    J Clin Endocrinol Metab 84:1700-4. 1999
  3. doi request reprint Should genetic testing be performed in each patient with sporadic pheochromocytoma at presentation?
    Pascal Pigny
    Laboratoire de Biochimie Hormonologie, métabolisme nutrition, Oncologie, Centre de Biologie et Pathologie, CHRU de Lille, France
    Eur J Endocrinol 160:227-31. 2009
  4. ncbi request reprint Serum anti-Mullerian hormone as a surrogate for antral follicle count for definition of the polycystic ovary syndrome
    P Pigny
    Laboratoire de Biochimie et Hormonologie, Parc Eurasante, Centre Hospitalier Regional Universitaire, 59037 Lille Cedex, France
    J Clin Endocrinol Metab 91:941-5. 2006
  5. ncbi request reprint Increased anti-Müllerian hormone and decreased FSH levels in follicular fluid obtained in women with polycystic ovaries at the time of follicle puncture for in vitro fertilization
    Virginie Desforges-Bullet
    Department of Endocrine Gynaecology and Reproductive Medicine, Hopital Jeanne de Flandre, CHRU and Université de Lille II, Lille, France
    Fertil Steril 94:198-204. 2010
  6. ncbi request reprint Evaluation of denaturing high performance liquid chromatography for the mutational analysis of the MEN1 gene
    Michel Crepin
    Unité Fonctionnelle d Oncologie Laboratoire de Biochimie, Hormonologie, métabolisme nutrition, Oncologie Eurasanté CHRU Lille, Rue du Docteur Yersin, 59037 Lille Cedex, France
    J Mol Endocrinol 36:369-76. 2006
  7. doi request reprint Serum inhibin B during controlled ovarian hyperstimulation: an additional criterion for deciding whether to proceed with egg retrieval
    Christine Decanter
    Department of Endocrine Gynecology and Reproductive Medicine, Hopital Jeanne de Flandre, Centre Hospitalier Regional Universitaire CHRU, Lille, France
    Fertil Steril 91:2419-25. 2009
  8. ncbi request reprint [Genetic diagnosis of phaeochromocytomas and paragangliomas]
    Catherine Cardot-Bauters
    CHRU de Lille, Hopital Claude Huriez, Service d endocrinologie, 59037 Lille Cedex, France Electronic address
    Presse Med 43:460-7. 2014
  9. ncbi request reprint Elevated serum level of anti-mullerian hormone in patients with polycystic ovary syndrome: relationship to the ovarian follicle excess and to the follicular arrest
    Pascal Pigny
    Laboratory of Endocrinology, Clinique Marc Linquette, Hopital Jeanne de Flandre, Lille, France
    J Clin Endocrinol Metab 88:5957-62. 2003
  10. ncbi request reprint Oligoanovulation with polycystic ovaries but not overt hyperandrogenism
    Didier Dewailly
    Department of Endocrine Gynecology and Reproductive Medicine, Hopital Jeanne de Flandre, Centre Hospitalier Regional Universitaire, 59037 Lille, France
    J Clin Endocrinol Metab 91:3922-7. 2006

Collaborators

Detail Information

Publications42

  1. doi request reprint Paraganglioma after maternal transmission of a succinate dehydrogenase gene mutation
    Pascal Pigny
    Laboratoire de Biochimie et Hormonologie, Centre de Biologie et Pathologie, Centre Hospitalier Regional and Universitaire, Lille Cedex, France
    J Clin Endocrinol Metab 93:1609-15. 2008
    ..A hypothetic model, involving the loss of the maternal copy of a tumor suppressor gene mapped to 11p15 in the tumoral tissue, has been proposed to explain this mode of inheritance...
  2. ncbi request reprint A novel 9-base pair duplication in RET exon 8 in familial medullary thyroid carcinoma
    P Pigny
    Laboratoire de Biochimie Secteur commun de Biologie Moléculaire de l Hôpital Huriez, Centre Hospitalier Regional Universitaire, Lille, France
    J Clin Endocrinol Metab 84:1700-4. 1999
    ..Further studies are warranted to confirm whether this new mutation is causing MTC only or could be associated with Hirschsprung's disease...
  3. doi request reprint Should genetic testing be performed in each patient with sporadic pheochromocytoma at presentation?
    Pascal Pigny
    Laboratoire de Biochimie Hormonologie, métabolisme nutrition, Oncologie, Centre de Biologie et Pathologie, CHRU de Lille, France
    Eur J Endocrinol 160:227-31. 2009
    ..This high frequency together with the financial support provided to reference laboratories of molecular genetics by the French government led to a nearly systematic screening in each patient with a pheochromocytoma...
  4. ncbi request reprint Serum anti-Mullerian hormone as a surrogate for antral follicle count for definition of the polycystic ovary syndrome
    P Pigny
    Laboratoire de Biochimie et Hormonologie, Parc Eurasante, Centre Hospitalier Regional Universitaire, 59037 Lille Cedex, France
    J Clin Endocrinol Metab 91:941-5. 2006
    ..Unfortunately, its assessment does not offer sufficient reliability worldwide...
  5. ncbi request reprint Increased anti-Müllerian hormone and decreased FSH levels in follicular fluid obtained in women with polycystic ovaries at the time of follicle puncture for in vitro fertilization
    Virginie Desforges-Bullet
    Department of Endocrine Gynaecology and Reproductive Medicine, Hopital Jeanne de Flandre, CHRU and Université de Lille II, Lille, France
    Fertil Steril 94:198-204. 2010
    ..To confirm the increased levels of anti-Müllerian hormone (AMH) in preovulatory follicles from patients with polycystic ovary syndrome (PCOS) and to study the role of other hormones involved in folliculogenesis in this increased secretion...
  6. ncbi request reprint Evaluation of denaturing high performance liquid chromatography for the mutational analysis of the MEN1 gene
    Michel Crepin
    Unité Fonctionnelle d Oncologie Laboratoire de Biochimie, Hormonologie, métabolisme nutrition, Oncologie Eurasanté CHRU Lille, Rue du Docteur Yersin, 59037 Lille Cedex, France
    J Mol Endocrinol 36:369-76. 2006
    ..In conclusion, genotypic diagnosis of MEN1 can benefit from DHPLC in terms of efficacy, rapidity and cost...
  7. doi request reprint Serum inhibin B during controlled ovarian hyperstimulation: an additional criterion for deciding whether to proceed with egg retrieval
    Christine Decanter
    Department of Endocrine Gynecology and Reproductive Medicine, Hopital Jeanne de Flandre, Centre Hospitalier Regional Universitaire CHRU, Lille, France
    Fertil Steril 91:2419-25. 2009
    ..To determine the predictive value of the inhibin B increment during controlled ovarian hyperstimulation (COH) for differentiating between poor and normal responders and for deciding whether to continue or stop an IVF attempt...
  8. ncbi request reprint [Genetic diagnosis of phaeochromocytomas and paragangliomas]
    Catherine Cardot-Bauters
    CHRU de Lille, Hopital Claude Huriez, Service d endocrinologie, 59037 Lille Cedex, France Electronic address
    Presse Med 43:460-7. 2014
    ..Genetic testing is prescribed by a specialist, as part of a cancer genetics specialist consultation in endocrine tumors. The psychological support is essential throughout the family survey. ..
  9. ncbi request reprint Elevated serum level of anti-mullerian hormone in patients with polycystic ovary syndrome: relationship to the ovarian follicle excess and to the follicular arrest
    Pascal Pigny
    Laboratory of Endocrinology, Clinique Marc Linquette, Hopital Jeanne de Flandre, Lille, France
    J Clin Endocrinol Metab 88:5957-62. 2003
    ..We hypothesize that an increased AMH tone within the cohort could be involved in the follicular arrest of PCOS, by interacting negatively with FSH at the time of selection...
  10. ncbi request reprint Oligoanovulation with polycystic ovaries but not overt hyperandrogenism
    Didier Dewailly
    Department of Endocrine Gynecology and Reproductive Medicine, Hopital Jeanne de Flandre, Centre Hospitalier Regional Universitaire, 59037 Lille, France
    J Clin Endocrinol Metab 91:3922-7. 2006
    ..However, the latter phenotype is controversial, and it is not known to what extent it shares similarities with the others...
  11. doi request reprint Local-regional recurrence of sporadic or syndromic abdominal extra-adrenal paraganglioma: incidence, characteristics, and outcome
    Sam Van Slycke
    Univ Lille Nord de France, CHULille, Lille, France
    Surgery 146:986-92. 2009
    ..Operative excision of abdominal extra-adrenal paragangliomas (EAPs) does not preclude the late development of local-regional recurrence. We describe the incidence, characteristics, and outcome of this rarely reported feature...
  12. ncbi request reprint An analysis of the biochemical diagnosis of 66 pheochromocytomas
    Michèle D'herbomez
    Department of Nuclear Medicine, CHRU, 59037 Lille, France
    Eur J Endocrinol 156:569-75. 2007
    ..The aims of this study were to determine the performance of each variable, to define the optimal diagnostic thresholds and to determine the relative value of assaying chromogranin A (CgA)...
  13. doi request reprint Anti-Müllerian hormone follow-up in young women treated by chemotherapy for lymphoma: preliminary results
    Christine Decanter
    Department of Endocrine Gynaecology and Reproductive Medicine, Hopital Jeanne de Flandre, CHRU, 59037 Lille, France
    Reprod Biomed Online 20:280-5. 2010
    ..In conclusion, longitudinal analysis of AMH during chemotherapy highlights differences between protocols that could contribute to an understanding of ovarian toxicity and, ultimately, be useful in fertility preservation counselling...
  14. doi request reprint Reconciling the definitions of polycystic ovary syndrome: the ovarian follicle number and serum anti-Müllerian hormone concentrations aggregate with the markers of hyperandrogenism
    Didier Dewailly
    Department of Endocrine Gynaecology and Reproductive Medicine, Hopital Jeanne de Flandre, C H R U, 59037 Lille, France
    J Clin Endocrinol Metab 95:4399-405. 2010
    ..We hypothesized that excessive follicle number (FN) assessed by ovarian ultrasonography and/or serum anti-Müllerian hormone (AMH) concentrations may be used as surrogates for the classical markers of HA...
  15. ncbi request reprint The excess in 2-5 mm follicles seen at ovarian ultrasonography is tightly associated to the follicular arrest of the polycystic ovary syndrome
    Didier Dewailly
    Department of Endocrine Gynaecology and Reproductive Medicine, Hopital Jeanne de Flandre, C H R U, 59037 Lille, France
    Hum Reprod 22:1562-6. 2007
    ....
  16. doi request reprint Fertility and obstetrical complications in women with LMNA-related familial partial lipodystrophy
    M C Vantyghem
    Service d Endocrinologie Métabolisme Clinique Linquette, Centre Hospitalier Regional et Universitaire de Lille, 6 Rue du Pr Laguesse, Lille, France
    J Clin Endocrinol Metab 93:2223-9. 2008
    ....
  17. doi request reprint Genetics of pheochromocytoma and paraganglioma: new developments
    P Pigny
    Laboratoire de Biochimie Hormonologie, métabolisme nutrition, Oncologie, Centre de Biologie Pathologie, CHRU de Lille, Lille Cedex, France
    Ann Endocrinol (Paris) 71:76-82. 2010
    ..Finally, practical issues are considered; for us, it would be preferable to apply easy-to-identify clinical predictors to preselect patients eligible for molecular testing in order to improve the efficiency of these high-cost tests...
  18. doi request reprint Anorexia nervosa, osteoporosis and circulating leptin: the missing link
    I Legroux-Gerot
    Department of Rheumatology, University of Lille II, 59037, Lille Cedex, France
    Osteoporos Int 21:1715-22. 2010
    ..Results: Spine BMD and Z-score values were found to be significantly lower in the low tertile compared with the highest tertile. Duration of amenorrhea and leptin level accounted for 27% of the variance in lumbar spine BMD...
  19. ncbi request reprint [Multiple endocrine neoplasias. Recent advances in clinical and genetic diagnosis]
    C Bauters
    Clinique Endocrinologique Marc Linquette, CHRU de Lille, 6, rue du Professeur Laguesse, 59037 Lille, France
    Rev Med Interne 24:721-9. 2003
    ....
  20. ncbi request reprint Contribution of genetic analysis in screening for MEN1 among patients with sporadic disease and one or more typical manifestation
    M F Odou
    Laboratoire de Biochimie Biologie Moléculaire, Pôle de Pathologie Biologie, Eurasanté, CHRU de Lille, France
    Ann Endocrinol (Paris) 67:581-7. 2006
    ..In a sporadic context with at least two established manifestations of MEN1, the overall probability of identifying a mutation was 26%, warranting MEN1 genotypic analysis...
  21. ncbi request reprint Factors influencing bone loss in rheumatoid arthritis: a longitudinal study
    B Cortet
    Department of Rheumatology, CHRU Lille, Hopital R Salengro, France
    Clin Exp Rheumatol 18:683-90. 2000
    ..To assess the occurrence of bone loss in rheumatoid arthritis (RA) and to determine the factors influencing bone loss (particularly the usefulness of bone turnover markers) over an 18-month period...
  22. ncbi request reprint Kinetics of diabetes-associated autoantibodies after sequential intraportal islet allograft associated with kidney transplantation in type 1 diabetes
    M C Vantyghem
    Department of Endocrinology and Metabolism, INSERM ERIT 0106, Lille University Hospital, 6 Rue du Pr Laguesse, 59037 Lille Cedex, France
    Diabetes Metab 29:595-601. 2003
    ....
  23. ncbi request reprint Patients with familial partial lipodystrophy of the Dunnigan type due to a LMNA R482W mutation show muscular and cardiac abnormalities
    M C Vantyghem
    Department of Endocrinology and Metabolism, Lille University Hospital, 6 rue du Prof Laguesse, 59037 Lille Cedex, France
    J Clin Endocrinol Metab 89:5337-46. 2004
    ..Cardiac hypertrophy and advanced atherosclerosis were frequent. FPLD patients should receive careful neuromuscular and cardiac examination whatever the underlying LMNA mutation...
  24. ncbi request reprint Thyroid carcinomas involving follicular and parafollicular C cells: seventeen cases with characterization of RET oncogenic activation
    M C Vantyghem
    Department of Endocrinology and Metabolism, University Hospital, Lille, France
    Thyroid 14:842-7. 2004
    ..This suggests the possible involvement of another gene or uncommon abnormality of RET gene...
  25. doi request reprint Does the RET variant G691S influence the features of sporadic medullary thyroid carcinoma?
    C Cardot-Bauters
    Service d Endocrinologie et Maladies Métaboliques, Clinique Marc Linquette, Lille, France
    Clin Endocrinol (Oxf) 69:506-10. 2008
    ..The aim of our study was to assess the influence of this variant on the age of onset, clinical, biological and pathological features of sMTC...
  26. doi request reprint Falsely elevated serum antimüllerian hormone level in a context of heterophilic interference
    Hélène Cappy
    Department of Endocrine Gynecology and Reproductive Medicine, Hopital Jeanne de Flandre, Centre Hospitalier Regional Universitaire, and Faculty of Medicine of Lille, University of Lille II, Lille, France
    Fertil Steril 99:1729-32. 2013
    ..To describe a case of falsely elevated serum antimüllerian hormone (AMH) level in an infertile 37-year-old woman with rheumatoid arthritis...
  27. ncbi request reprint The human mucin MUC4 is transcriptionally regulated by caudal-related homeobox, hepatocyte nuclear factors, forkhead box A, and GATA endodermal transcription factors in epithelial cancer cells
    Nicolas Jonckheere
    INSERM, U560, Place de Verdun, Lille, F 59045, France
    J Biol Chem 282:22638-50. 2007
    ..Altogether, these results demonstrate that MUC4 is a target gene of endodermal TFs and thus point out an important role for these TFs in regulating MUC4 expression during epithelial differentiation during development, cancer, and repair...
  28. ncbi request reprint Efficient mutation detection in MEN1 gene using a combination of single-strand conformation polymorphism (MDGA) and heteroduplex analysis
    Michel Crepin
    Secteur Oncologie Moléculaire Huriez USN, Laboratoire de Biochimie et Biologie Moleculaire, CHRU, Lille, France
    Electrophoresis 24:26-33. 2003
    ..Together, these methods provide an efficient screen for MEN1 mutations...
  29. doi request reprint Aldosterone, mortality, and acute ischaemic events in coronary artery disease patients outside the setting of acute myocardial infarction or heart failure
    Fabrice Ivanes
    Department of Cardiology, University Hospital, Lille, France
    Eur Heart J 33:191-202. 2012
    ..The present study was designed to evaluate the relationship between the level of aldosterone and the risk of death and acute ischaemic events in CAD patients with a preserved left ventricular (LV) function and no acute MI...
  30. doi request reprint Seminal plasma levels of anti-Müllerian hormone and inhibin B are not predictive of testicular sperm retrieval in nonobstructive azoospermia: a study of 139 men
    Valerie Mitchell
    Laboratoire de Spermiologie, hôpital A Calmette, Groupe de recherche EA 4308 Spermatogenesis and Male Gamete Quality, CHRU, Lille Cedex, France
    Fertil Steril 94:2147-50. 2010
    ..To evaluate the seminal levels of the Sertoli anti-Müllerian hormone (AMH) and inhibin B in the testicular sperm extraction (TESE) in nonobstructive azoospermia...
  31. pmc Primary graft function, metabolic control, and graft survival after islet transplantation
    Marie Christine Vantyghem
    University Lille Nord de France, Lille, France
    Diabetes Care 32:1473-8. 2009
    ..CONCLUSIONS Optimal PGF was associated with prolonged graft survival and better metabolic control after islet transplantation. This early outcome may represent a valuable end point in future clinical trials...
  32. ncbi request reprint Sex hormone-binding globulin, estradiol, and bone turnover markers in male osteoporosis
    C Lormeau
    Department of Rheumatology, Lille University Hospital, 59037 Lille Cedex, France
    Bone 34:933-9. 2004
    ..Finally, our findings are in agreement with previous studies which suggest that serum SHBG is a new biological marker of fracture risk in men...
  33. ncbi request reprint [Paragangliomas: clinical and secretory profile. Result of 39 cases]
    A Lamblin
    Service de Chirurgie Generale et Endocrinienne, Hopital Claude Huriez, 1, rue Michel Polonowski, 59037 Lille Cedex, France
    Ann Chir 130:157-61. 2005
    ..To define a clinical and secretory profile of paragangliomas extra-adrenal chromaffin tumors...
  34. pmc Metabolic syndrome and collateral vessel formation in patients with documented occluded coronary arteries: association with hyperglycaemia, insulin-resistance, adiponectin and plasminogen activator inhibitor-1
    Frederic Mouquet
    Departments of Cardiology, Centre Hospitalier Regional Universitaire, Lille, France
    Eur Heart J 30:840-9. 2009
    ..We hypothesized that such patients, in the event of a coronary occlusion, might exhibit a less developed collateral circulation...
  35. pmc Characterization of the human mucin gene MUC5AC: a consensus cysteine-rich domain for 11p15 mucin genes?
    V Guyonnet Duperat
    Unité INSERM N 377, Lille, France
    Biochem J 305:211-9. 1995
    ..The functional significance for secreted mucins of these cysteine-rich subdomains and the modular organization of mucin peptides are discussed...
  36. ncbi request reprint Changes in serum anti-mullerian hormone level during low-dose recombinant follicular-stimulating hormone therapy for anovulation in polycystic ovary syndrome
    Sophie Catteau-Jonard
    Department of Endocrine Gynaecology and Reproductive Medicine, Hopital Jeanne de Flandre, avenue Eugene Avinee, Centre Hospitalier Regional Universitaire de Lille, 59037 Lille, France
    J Clin Endocrinol Metab 92:4138-43. 2007
    ....
  37. ncbi request reprint Obesity and serum luteinizing hormone level have an independent and opposite effect on the serum inhibin B level in patients with polycystic ovary syndrome
    Christine Cortet-Rudelli
    Department of Diabetology and Endocrinology, Clinique Marc Linquette, C H R U, 59037 Lille, France
    Fertil Steril 77:281-7. 2002
    ....
  38. ncbi request reprint Predictors and prevalence of paraganglioma syndrome associated with mutations of the SDHC gene
    Francesca Schiavi
    Department of Endocrinology, University of Padova, Padova, Italy
    JAMA 294:2057-63. 2005
    ..In contrast with those with germline mutations of the SDHB and SDHD genes, clinical and genetic data on patients with mutations of SDHC are scarce...
  39. pmc Viral protein VP4 is a target of human antibodies enhancing coxsackievirus B4- and B3-induced synthesis of alpha interferon
    Wassim Chehadeh
    Service de Virologie UPRES EA3610, Faculte de Medecine, Universite Lille 2, Bâtiment Paul Boulanger, CHRU Lille, 59037 Lille, France
    J Virol 79:13882-91. 2005
    ..These results show that VP4 is the target of antibodies involved in the plasma-dependent enhancement of CVB4E2- and CVB3-induced IFN-alpha synthesis by PBMC...
  40. ncbi request reprint [von Hippel-Lindau syndrome: molecular diagnosis of two Lebanese families and analysis of the genotype-phenotype correlation]
    Myrna Medlej-Hashim
    Unite de Genetique Medicale, Faculte de Medecine, Université Saint Joseph, Beyrouth, Liban
    J Med Liban 52:51-4. 2004
    ....
  41. pmc The kinesin KIF1Bbeta acts downstream from EglN3 to induce apoptosis and is a potential 1p36 tumor suppressor
    Susanne Schlisio
    Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 22:884-93. 2008
    ....
  42. doi request reprint A germline mutation of the KIF1B beta gene on 1p36 in a family with neural and nonneural tumors
    I Tien Yeh
    Cancer Therapy and Research Center, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Hum Genet 124:279-85. 2008
    ..This may imply the existence of a tissue-specific gene dosage requirement for its tumorigenesis...