Florence Pasquier

Summary

Affiliation: CHRU de Lille
Country: France

Publications

  1. pmc Both common variations and rare non-synonymous substitutions and small insertion/deletions in CLU are associated with increased Alzheimer risk
    Karolien Bettens
    Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, 2610 Antwerpen, Belgium
    Mol Neurodegener 7:3. 2012
  2. ncbi request reprint Memory impairment differs in frontotemporal dementia and Alzheimer's disease
    F Pasquier
    Memory Centre, Department of Neurology, University Hospital of Lille, Lille, France
    Neurocase 7:161-71. 2001
  3. ncbi request reprint Relevance of white matter changes to pre- and poststroke dementia
    F Pasquier
    Department of Neurology, EA 2691 MENRT, University Hospital of Lille, France
    Ann N Y Acad Sci 903:466-9. 2000
  4. ncbi request reprint [Risk factors and mechanisms of post-stroke dementia]
    F Pasquier
    Centre de la Mémoire, Centre Hospitalier et Universitaire de Lille
    Rev Neurol (Paris) 155:749-53. 1999
  5. ncbi request reprint The clinical picture of frontotemporal dementia: diagnosis and follow-up
    F Pasquier
    Memory Clinic, Centre Hospitalier et Universitaire, Lille, France
    Dement Geriatr Cogn Disord 10:10-4. 1999
  6. ncbi request reprint Natural history of frontotemporal dementia: comparison with Alzheimer's disease
    Florence Pasquier
    Memory Clinic, University Hospital, EA 2691, and INSERM U 508, Lille, France
    Dement Geriatr Cogn Disord 17:253-7. 2004
  7. ncbi request reprint Early diagnosis of dementia: neuropsychology
    F Pasquier
    Department of Neurology, Memory Clinic, Centre Hospitalier Regional et Universitaire, Lille, France
    J Neurol 246:6-15. 1999
  8. ncbi request reprint Laboratory investigations and treatment in frontotemporal dementia
    Florence Pasquier
    CHRU Clinique Neurologie, Lille France
    Ann Neurol 54:S32-5. 2003
  9. ncbi request reprint Non-Alzheimer degenerative dementias
    F Pasquier
    Department of Neurology, Centre Hospitalier et Universitaire, Lille, France
    Curr Opin Neurol 11:417-27. 1998
  10. ncbi request reprint Diabetes mellitus and dementia
    F Pasquier
    Department of Neurology, EA 2691, Memory Clinic, Lille, France
    Diabetes Metab 32:403-14. 2006

Detail Information

Publications95

  1. pmc Both common variations and rare non-synonymous substitutions and small insertion/deletions in CLU are associated with increased Alzheimer risk
    Karolien Bettens
    Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, 2610 Antwerpen, Belgium
    Mol Neurodegener 7:3. 2012
    ....
  2. ncbi request reprint Memory impairment differs in frontotemporal dementia and Alzheimer's disease
    F Pasquier
    Memory Centre, Department of Neurology, University Hospital of Lille, Lille, France
    Neurocase 7:161-71. 2001
    ..AD patients with clinical and imaging frontal lobe dysfunction tended to have lower memory performance and to differ even more from FTD patients than AD patients without frontal lobe dysfunction...
  3. ncbi request reprint Relevance of white matter changes to pre- and poststroke dementia
    F Pasquier
    Department of Neurology, EA 2691 MENRT, University Hospital of Lille, France
    Ann N Y Acad Sci 903:466-9. 2000
    ..White matter changes were also associated with an increased risk of poststroke dementia, 2 years after stroke onset. Thus, white matter changes contribute to dementia occurring in stroke patients...
  4. ncbi request reprint [Risk factors and mechanisms of post-stroke dementia]
    F Pasquier
    Centre de la Mémoire, Centre Hospitalier et Universitaire de Lille
    Rev Neurol (Paris) 155:749-53. 1999
    ..Even when vascular lesions and degenerative changes (mainly Alzheimer changes) are not severe enough, no their own, to be the cause of dementia, their summation may reduce the preclinical stage of the degenerative process...
  5. ncbi request reprint The clinical picture of frontotemporal dementia: diagnosis and follow-up
    F Pasquier
    Memory Clinic, Centre Hospitalier et Universitaire, Lille, France
    Dement Geriatr Cogn Disord 10:10-4. 1999
    ..Behavioural disorders evolved with time but restlessness and hyperorality were long-lasting. Imaging showed the progression of a consistent pattern of anterior abnormalities with frequent leukoaraiosis...
  6. ncbi request reprint Natural history of frontotemporal dementia: comparison with Alzheimer's disease
    Florence Pasquier
    Memory Clinic, University Hospital, EA 2691, and INSERM U 508, Lille, France
    Dement Geriatr Cogn Disord 17:253-7. 2004
    ..Frontotemporal dementia (FTD) is a more common cause of dementia than previously recognised. Few data are available regarding the natural course of FTD in terms of survival, nursing home admission and causes of death...
  7. ncbi request reprint Early diagnosis of dementia: neuropsychology
    F Pasquier
    Department of Neurology, Memory Clinic, Centre Hospitalier Regional et Universitaire, Lille, France
    J Neurol 246:6-15. 1999
    ..Moreover, there may be overlap between two or more pathologies, which complicates the diagnostic process. Follow-up of patients is necessary to improve diagnostic accuracy...
  8. ncbi request reprint Laboratory investigations and treatment in frontotemporal dementia
    Florence Pasquier
    CHRU Clinique Neurologie, Lille France
    Ann Neurol 54:S32-5. 2003
  9. ncbi request reprint Non-Alzheimer degenerative dementias
    F Pasquier
    Department of Neurology, Centre Hospitalier et Universitaire, Lille, France
    Curr Opin Neurol 11:417-27. 1998
    ..The approach of studying these diseases has changed considerably with genetic and biochemical analyses. A molecular classification is suggested and the clinical significance of this classification is discussed...
  10. ncbi request reprint Diabetes mellitus and dementia
    F Pasquier
    Department of Neurology, EA 2691, Memory Clinic, Lille, France
    Diabetes Metab 32:403-14. 2006
    ..Many interventions could reduce the cognitive decline associated with DM, yet not enough are taken into account so far...
  11. doi request reprint Implication of the immune system in Alzheimer's disease: evidence from genome-wide pathway analysis
    Jean Charles Lambert
    INSERM U744, Lille, France
    J Alzheimers Dis 20:1107-18. 2010
    ..In conclusion, a systematic search for biological pathways using GWAS data set seems to comfort the primary causes already suspected but may specifically highlight the importance of the immune system in AD...
  12. doi request reprint Study of thyroid hormone receptor alpha gene polymorphisms on Alzheimer's disease
    Louisa Goumidi
    INSERM, U744, Lille, France
    Neurobiol Aging 32:624-30. 2011
    ..19 [0.97-1.45], p=0.10). The relationship between the genetic variability of the THRA gene and AD risk remains uncertain but cannot be entirely excluded...
  13. doi request reprint Is the ornithine transcarbamylase gene a genetic determinant of Alzheimer's disease?
    Franck Hansmannel
    INSERM, U744, Institut Pasteur de Lille, Universite de Lille, Lille, France
    Neurosci Lett 449:76-80. 2009
    ..19, p=0.004). This association was independent of age and ApoE status. Our results support that the OTC gene may be a minor genetic determinant of AD...
  14. doi request reprint Systematic analysis of candidate genes for Alzheimer's disease in a French, genome-wide association study
    Geoffroy Laumet
    INSERM U744, Lille, France
    J Alzheimers Dis 20:1181-8. 2010
    ..Of the genes showing nominal association in our cohorts, TFAM and CHRNB2 appear particularly interesting and warrant further genetic and functional follow-up analyses...
  15. ncbi request reprint A new decision tree combining Abeta 1-42 and p-Tau levels in Alzheimer's diagnosis
    Stephanie Bombois
    Lille University Hospital, Memory Clinic, French National Center for Young Onset Alzheimer s Disease, EA1046, Lille, France
    Curr Alzheimer Res 10:357-64. 2013
    ..For the first time, diagnostic rules for AD based on CSF variables were compared in a single study. Our findings indicate that the measurement of Aβ1-42 and p-Tau levels in the CSF is sufficient to diagnose AD...
  16. doi request reprint What are the causes of pre-existing dementia in patients with intracerebral haemorrhages?
    Charlotte Cordonnier
    Univ Lille Nord de France, EA 1046, Department of Neurology, Roger Salengro Hospital, F 59000 Lille, France
    Brain 133:3281-9. 2010
    ..These findings may contribute to the improvement of prevention and management of patients with intracerebral haemorrhages...
  17. doi request reprint Vascular subcortical hyperintensities predict conversion to vascular and mixed dementia in MCI patients
    Stephanie Bombois
    Department of Neurology, EA 2691, Memory Center, University Hospital 59037 Lille, France
    Stroke 39:2046-51. 2008
    ..The aim of our study was to test the hypothesis that subcortical hyperintensities (SH) are associated with an increased rate of conversion to dementia in MCI patients...
  18. doi request reprint Microbleeds in postmortem brains of patients with Alzheimer disease: a T2*-weighted gradient-echo 7.0 T magnetic resonance imaging study
    Jacques L De Reuck
    Universite Lille Nord de France, UDSL, EA 1046, Lille University Hospital, Lille, France
    Alzheimer Dis Assoc Disord 27:162-7. 2013
    ..04), compared with the controls. MBs prevalence in brains of AD patients had a different topographic distribution according to the absence or presence of severe CAA...
  19. doi request reprint Clinical, neuropathological, and biochemical characterization of the novel tau mutation P332S
    Vincent Deramecourt
    Univ Lille Nord de France, UDSL, Lille, France
    J Alzheimers Dis 31:741-9. 2012
    ..From a clinical point of view, this mutation is associated with considerable intrafamilial phenotypic variation...
  20. ncbi request reprint Subcortical hyperintensities are associated with cognitive decline in patients with mild cognitive impairment
    Stephanie Debette
    Department of Neurology, Memory Center, Lille University Hospital, Lille, France
    Stroke 38:2924-30. 2007
    ..We aimed to test whether cognitive decline is associated with subcortical hyperintensities in patients with mild cognitive impairment (MCI)...
  21. ncbi request reprint Poststroke dementia: influence of hippocampal atrophy
    Marie Anne Cordoliani-Mackowiak
    Department of Neurology, Stroke Unit, University of Lille, Lille, France
    Arch Neurol 60:585-90. 2003
    ..The prevalence of dementia is increased after stroke. Medial temporal lobe atrophy (MTLA) is associated with Alzheimer disease, and with prestroke dementia in patients who have had a stroke...
  22. ncbi request reprint Natural history of primary progressive aphasia
    Emilie Le Rhun
    Department of Neurology, Memory Clinic, University Hospital of Lille, France
    Neurology 65:887-91. 2005
    ..To characterize the natural history of primary progressive aphasia (PPA)...
  23. pmc Is the urea cycle involved in Alzheimer's disease?
    Franck Hansmannel
    INSERM U744, Lille, France
    J Alzheimers Dis 21:1013-21. 2010
    ..None of the other genes in the pathway appeared to be differentially expressed in the AD brain or act as genetic determinants of the disease...
  24. doi request reprint Study of estrogen receptor-α and receptor-β gene polymorphisms on Alzheimer's disease
    Louisa Goumidi
    INSERM, U744 Institut Pasteur de Lille Univ Lille Nord de France UDSL, Lille, France
    J Alzheimers Dis 26:431-9. 2011
    ..Our results reinforce the notion that SNPs in the ESR1 or ESR2 genes do not seem to play a major role in the genetic susceptibility of AD...
  25. ncbi request reprint Depressive symptoms after stroke and relationship with dementia: A three-year follow-up study
    A Verdelho
    Stroke Department and Memory Clinic, Department of Neurology, University of Lille, Roger Salengro Hospital, Lille, France
    Neurology 62:905-11. 2004
    ..To determine frequency, determinants, and time course of poststroke depressive symptoms (DS) and their relationship with dementia...
  26. ncbi request reprint [Differential diagnosis of Alzheimer's disease]
    F Pasquier
    Clinique Neurologique, Centre Hospitalier et Universitaire, , Lille
    Rev Prat 48:1906-11. 1998
    ..Besides, better knowledge on the links between cerebrovascular pathology and Alzheimer's disease, remind us that both pathologies may coexist and should be taken into account...
  27. ncbi request reprint Poststroke dementia
    Didier Leys
    Stroke Department, Department of Neurology, University of Lille II, EA 2691, Rue Emile Laine, Lille, France
    Lancet Neurol 4:752-9. 2005
    ..Patients with PSD have high mortality rates and are likely to be functionally impaired. These patients should be treated according to the current guidelines for stroke prevention...
  28. doi request reprint Association study of the NEDD9 gene with the risk of developing Alzheimer's and Parkinson's disease
    Julien Chapuis
    INSERM, U744, Institut Pasteur de Lille, Universite de Lille 2, Lille, France
    Hum Mol Genet 17:2863-7. 2008
    ..In conclusion, these data indicate that the rs760678 SNP of the NEDD9 gene is at best a weak genetic determinant of AD or PD...
  29. doi request reprint Can the treatment of vascular risk factors slow cognitive decline in Alzheimer's disease patients?
    Florence Richard
    INSERM U744, Lille, France
    J Alzheimers Dis 32:765-72. 2012
    ..In the present article, we review the potential value of managing hypertension, diabetes, hypercholesterolemia or global vascular risk factors in AD patients...
  30. doi request reprint My belief or yours? Differential theory of mind deficits in frontotemporal dementia and Alzheimer's disease
    Raphaël Le Bouc
    Department of Neurology, Universite Lille Nord de France, USLD, CHU Lille, EA 1046, F 59000 Lille, France
    Brain 135:3026-38. 2012
    ....
  31. pmc Early epileptic seizures after stroke are associated with increased risk of new-onset dementia
    Charlotte Cordonnier
    Department of Neurology, University of Lille, Lille, France
    J Neurol Neurosurg Psychiatry 78:514-6. 2007
    ..Those lesions in a brain that just experienced a stroke may have lower thresholds for early epileptic seizures. Therefore, epileptic seizures may be a marker of subclinical brain lesions, which may lead to dementia...
  32. ncbi request reprint Influence of dementia on antithrombotic therapy prescribed before stroke in patients with atrial fibrillation
    Catherine Lefebvre
    Department of Neurology, University of Lille, Lille, and Department of Neurology, Ste Anne Hospital, Paris, France
    Cerebrovasc Dis 21:401-7. 2006
    ..The aim of this study was to test the hypothesis that prestroke dementia influenced the nonprescription of OAC before stroke...
  33. doi request reprint Alzheimer disease with cerebrovascular disease and vascular dementia: clinical features and course compared with Alzheimer disease
    A Bruandet
    INSERM, U744, Lille, France
    J Neurol Neurosurg Psychiatry 80:133-9. 2009
    ..Little is known about the progression of either VaD or AD+CVD. The aim of this study was to compare demographic features, cognitive decline and survival of patients with VaD, AD+CVD and AD alone attending a memory clinic...
  34. pmc Reasons that prevent the inclusion of Alzheimer's disease patients in clinical trials
    Adeline Rollin-Sillaire
    Univ Lille Nord de France, UDSL, Lille, France
    Br J Clin Pharmacol 75:1089-97. 2013
    ..To assess reasons that prevent Alzheimer's disease (AD) patients from being included in clinical trials...
  35. ncbi request reprint Absence of beta-amyloid deposits after immunization in Alzheimer disease with Lewy body dementia
    Stephanie Bombois
    Department of Neurology, Resource and Research Memory Center, University Hospital, Lille, France
    Arch Neurol 64:583-7. 2007
    ....
  36. doi request reprint Action and noun fluency testing to distinguish between Alzheimer's disease and dementia with Lewy bodies
    Xavier Delbeuck
    Centre Memoire de Ressources et de Recherche, EA 1046, Universite Lille Nord de France, Lille, France
    J Clin Exp Neuropsychol 35:259-68. 2013
    ..However, a composite action and animal fluency score was found to be more effective for discriminating between these two groups...
  37. doi request reprint Contribution of single photon emission computed tomography to the differential diagnosis of dementia in a memory clinic
    Adeline Rollin-Sillaire
    EA 1046, Memory Clinic, Univ Lille Nord de France, UDSL, CHU, Lille, France
    J Alzheimers Dis 30:833-45. 2012
    ..For AD and FTLD/PSP/CBDs, agreement between the clinical and SPECT-based diagnoses was always confirmed by neuropathological assessment...
  38. doi request reprint Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease
    Jean Charles Lambert
    INSERM U744, Lille, France
    Nat Genet 41:1094-9. 2009
    ..Previous biological studies support roles of CLU and CR1 in the clearance of beta amyloid (Abeta) peptide, the principal constituent of amyloid plaques, which are one of the major brain lesions of individuals with Alzheimer's disease...
  39. doi request reprint Biomarkers for the early stages of clinical development in Alzheimer's disease
    Regis Bordet
    EA 1046, Faculte de Medecine, Universite de Lille II, Département Universitaire de Pharmacologie, Lille, France
    Therapie 65:285-90, 277-283. 2010
    ....
  40. doi request reprint An analysis of communication in conversation in patients with dementia
    Marc Rousseaux
    Université Lille Nord de la France EA 2691 and Institut d Orthophonie, Lille, France
    Neuropsychologia 48:3884-90. 2010
    ..FTD patients showed most severe difficulties in PC and verbal and non-verbal pragmatics, in relation to their frontal lesions. AD patients had prominent impairment of lexical-semantic operations...
  41. ncbi request reprint Phenotype associated with APP duplication in five families
    Lucie Cabrejo
    Department of Neurology, University Hospital IFRMP, France
    Brain 129:2966-76. 2006
    ..A striking feature consisted in intraneuronal Abetax-40 accumulation located in the granular cell layer of the dentate gyrus and in the pyramidal cell layer of the Ammon's horn...
  42. ncbi request reprint [Treatment of Alzheimer's disease]
    Stephanie Bombois
    centre mémoire de ressource et de recherche, EA 2691, CHRU de Lille, 59037 Lille
    Rev Prat 55:1913-9. 2005
    ..However, AD represents a problem of public health and preventive and curative strategies have to be proposed...
  43. doi request reprint Bilateral temporal glioma presenting as a paraneoplastic limbic encephalitis with pure cognitive impairment
    Vincent Deramecourt
    Department of Neurology and Memory Clinic, University Hospital of Lille and Lille II University, France
    Neurologist 15:208-11. 2009
    ..Clinical and MRI features can mimic paraneoplastic limbic encephalitis (PLE), and the differential diagnosis between these 2 entities may be difficult...
  44. ncbi request reprint Prevalence of risk factors of prion-related disease according to the French circular 138 (DGS/DH/5C/DHOS/E2/2001/138) among patients referred for gastrointestinal endoscopy
    Philippe Bulois
    Service des Maladies de l Appareil digestif, Hopital Claude Huriez, Urgence Respiratoire et Réanimation Médicale, France
    Gastroenterol Clin Biol 29:664-6. 2005
    ..To assess the prevalence of risk factors of prion-related disease transmission in a gastrointestinal endoscopy unit...
  45. doi request reprint Prediction of pathology in primary progressive language and speech disorders
    V Deramecourt
    Memory Clinic, EA 2691, CHRU Lille F 59037 Lille, France
    Neurology 74:42-9. 2010
    ..This study sought to characterize correlations between 1) the different clinical variants of primary progressive language and speech disorders and 2) the pathologic diagnosis...
  46. ncbi request reprint Poststroke dementia: incidence and relationship to prestroke cognitive decline
    H Henon
    Department of Neurology, Stroke Unit, University of Lille, France
    Neurology 57:1216-22. 2001
    ..To evaluate the 3-year incidence of poststroke dementia (PSD) and the influence of prestroke cognitive decline...
  47. ncbi request reprint Is there a typical pattern of brain SPECT imaging in Alzheimer's disease?
    M Steinling
    Brain Functional Imaging Unit, University Hospital, CHRU de Lille, Faculte de Medecine, Universite de Lille II, F 59037 Lille Cedex, France
    Dement Geriatr Cogn Disord 12:371-8. 2001
    ..We hypothesise that the major simplification concerning the pattern observed in AD can be explained by the fact that patients suffering from LBD have previously been included in the groups of AD patients...
  48. ncbi request reprint White matter changes and poststroke dementia
    D Leys
    Department pf Neurology, University of Lille, France
    Dement Geriatr Cogn Disord 9:25-9. 1998
    ....
  49. doi request reprint [Classification of parkinsonian syndromes via factorial discriminant analysis of brain SPECT data]
    A Kreisler
    EA 2683, Service de Neurologie et Pathologie du Mouvement, Hopital Roger Salengro, CHU de Lille, 59037 Lille Cedex, France
    Rev Neurol (Paris) 165:440-8. 2009
    ....
  50. pmc Lipid lowering agents are associated with a slower cognitive decline in Alzheimer's disease
    I Masse
    Department of Neurology, University Hospital, 59037 Lille, France
    J Neurol Neurosurg Psychiatry 76:1624-9. 2005
    ..Lipid lowering agents (LLAs) may have implications for the prevention of Alzheimer's disease...
  51. doi request reprint Diabetes and cognitive impairment: how to evaluate the cognitive status?
    F Pasquier
    Universite Lille Nord de France, UDSL, EA 1046, CHRU, Hopital Roger Salengro, Lille, France
    Diabetes Metab 36:S100-5. 2010
    ..They also have an elevated risk of both vascular dementia and Alzheimer's disease. Cognitive impairment may have consequence on treatment compliance...
  52. ncbi request reprint Leukoaraiosis more than dementia is a predictor of stroke recurrence
    H Henon
    Department of Neurology, Stroke Unit, Memory Clinic, University of Lille, Lille, France
    Stroke 34:2935-40. 2003
    ..Our aim was to determine the influence of prestroke and poststroke dementia on the 3-year risk of stroke recurrence...
  53. pmc Alzheimer's disease and frontotemporal dementia are differentiated by discriminant analysis applied to (99m)Tc HmPAO SPECT data
    P Charpentier
    Department of Neurology, Roger Salengro Hospital, Regional and Universitary Hospital, 59037 Lille Cx, France
    J Neurol Neurosurg Psychiatry 69:661-3. 2000
    ....
  54. ncbi request reprint [Arterial hypertension and cognitive decline]
    D Leys
    Service de neurologie et pathologie neurovasculaire, Hopital Roger Salengro
    Rev Neurol (Paris) 155:743-8. 1999
    ..Preliminary results obtained in elderly subjects with systolic arterial hypertension, support this hypothesis...
  55. doi request reprint [Dementia following bipolar disorder]
    F Lebert
    EA2691, centre de la mémoire de ressources et de recherche, Hopital R Salengro, CHRU de Lille, Lille, France
    Encephale 34:606-10. 2008
    ..In old age BPD, the cognitive decline is more severe and can fulfill the criteria of dementia. However, the characteristics of bipolar disorder dementia are still unknown...
  56. ncbi request reprint Epidemiology of vascular dementia
    D Leys
    Department of Neurology, Stroke and Memory Centers, University of Lille, France
    Haemostasis 28:134-50. 1998
    ..However, white matter changes, and associated Alzheimer pathology, which are both frequent in this age category, may also contribute to the cognitive decline...
  57. ncbi request reprint Sleep disorders in aging and dementia
    S Bombois
    Center for Memory Resources and Research, EA2691, Lille University Hospital, University of Lille Nord de France, Lille Cedex, France
    J Nutr Health Aging 14:212-7. 2010
    ..In healthy but frail elderly people and in early-stage AD patients, sleep should be more thoroughly characterized (notably by using standardized interviews and polysomnographic recording)...
  58. doi request reprint Association study of the GAB2 gene with the risk of developing Alzheimer's disease
    Julien Chapuis
    INSERM, U744, Institut Pasteur de Lille, Universite de Lille 2, Lille, France
    Neurobiol Dis 30:103-6. 2008
    ..3, 95%CI 1.0-1.6, p=0.05) in varepsilon4-carriers. In addition, the rs2373115 did not modulate the extent of tau phosphorylation in the brain of 89 AD cases. The GAB2 gene is at best a minor genetic determinant of AD...
  59. ncbi request reprint Poststroke dementia in the elderly
    Marie Anne Mackowiak-Cordoliani
    Department of Neurology, Memory Clinic, University Hospital, Lille, France
    Drugs Aging 22:483-93. 2005
    ..Better knowledge of the risk factors for PSD, including environmental and genetic factors, should increase the effectiveness of preventive strategies in patients with this condition...
  60. ncbi request reprint Comparison of secondary vascular prevention in practice after cerebral ischemia and coronary heart disease
    Marie Girot
    Department of Neurology, University of Lille, Roger Salengro Hospital, 59037, Lille, France
    J Neurol 251:529-36. 2004
    ..The aim of this study was to compare how secondary prevention measures are applied in practice between patients with a history of CHD or cerebral ischemia...
  61. ncbi request reprint Frontotemporal dementia: a randomised, controlled trial with trazodone
    Florence Lebert
    Memory Clinic, Lille University Hospital, Lille, France
    Dement Geriatr Cogn Disord 17:355-9. 2004
    ..The Mini-Mental State Examination was not modified and trazodone was well tolerated. Results of this first placebo-controlled trial suggest that trazodone is an effective treatment for the behavioural symptoms of FTD...
  62. ncbi request reprint Prevalence and determinants of cognitive impairment in chronic heart failure patients
    Stephanie Debette
    Department of Cardiology, University Hospital of Lille, Lille, France
    Congest Heart Fail 13:205-8. 2007
    ..The severity of cognitive impairment parallels that of CHF. The question of whether this cognitive impairment decreases adherence to treatment and contributes to a worse outcome in CHF patients should be explored...
  63. doi request reprint Rapid categorization of faces and objects in a patient with impaired object recognition
    Muriel Boucart
    LNFP, Universite Lille Nord de France, CNRS, Lille, France
    Neurocase 16:157-68. 2010
    ..Displaying pictures in isolation did not improve performance. The results suggest that rapid categorization can be accomplished on the basis of coarse information without overt recognition...
  64. ncbi request reprint Cognitive decline and survival in Alzheimer's disease according to education level
    A Bruandet
    INSERM, U744, Institut Pasteur de Lille, Universite de Lille 2, Lille, France
    Dement Geriatr Cogn Disord 25:74-80. 2008
    ..We tested the hypothesis that a higher education level is associated with faster cognitive decline and lower survival in a cohort of 670 Alzheimer's disease patients, followed for 3.5 years at the Lille-Bailleul memory centre...
  65. ncbi request reprint Different patterns of Mini Mental Status Examination responses in primary progressive aphasia and Alzheimer's disease
    E Le Rhun
    Department of Neurology, Research and Resource Memory Centre and EA 2691, University Hospital of Lille, Lille, France
    Eur J Neurol 13:1124-7. 2006
    ..Our findings indicate that the various MMSE item scores may be helpful in differentiating PPA and AD in the first few years of the disease...
  66. ncbi request reprint Perception of emotion on faces in frontotemporal dementia and Alzheimer's disease: a longitudinal study
    I Lavenu
    Memory Disorders Unit, Department of Neurology, University Hospital of Lille, EA 2691, Lille, France
    Dement Geriatr Cogn Disord 19:37-41. 2005
    ....
  67. ncbi request reprint Diffuse form of argyrophilic grain disease: a new variant of four-repeat tauopathy different from limbic argyrophilic grain disease
    Claude Alain Maurage
    INSERM U422, Faculte de Medecine, Universite de Lille 2, 1 place de Verdun, 59045 Cedex, Lille, France
    Acta Neuropathol 106:575-83. 2003
    ..We suggest that "diffuse" AGD might be a subgroup of AGD, the specific profile of which is different from that of "limbic" AGD...
  68. ncbi request reprint Influence of prestroke dementia on early and delayed mortality in stroke patients
    Hilde Henon
    Department of Neurology, Hopital Roger Salengro, CHRU of Lille, 59037 Lille, France
    J Neurol 250:10-6. 2003
    ..Dementia adversely influences vital outcome in stroke patients, perhaps partly because the therapeutic approach differs between demented and non-demented patients...
  69. doi request reprint [Molecular actors in Alzheimer's disease: which diagnostic and therapeutic consequences?]
    Luc Buee
    INSERM U837, Place de Verdun, Lille, France
    Therapie 65:401-7. 2010
    ..Until now, mainly amyloid pathology has been targeted un many clinical trials without any success. Both new therapeutic strategies and diagnosis improvement are needed...
  70. doi request reprint [Frontotemporal dementia: behavioral story of a neurological disease]
    Florence Lebert
    Centre de la Mémoire, Hopital Salengro, CHRU de Lille, France
    Psychol Neuropsychiatr Vieil 6:33-41. 2008
    ..However, over time, the occurrence of mutism may lead caregivers to regret the period of behavioral disorders...
  71. pmc Influence of pre-existing dementia on the risk of post-stroke epileptic seizures
    C Cordonnier
    Department of Neurology, Stroke Unit, Hopital Roger Salengro, F 59037 Lille, France
    J Neurol Neurosurg Psychiatry 76:1649-53. 2005
    ..However, the question of whether pre-existing dementia is associated with a higher risk of seizures after stroke has never been studied...
  72. ncbi request reprint Tacrine efficacy in Lewy body dementia
    F Lebert
    Memory Clinic, Centre Hospitalier Universitaire and Faculté de Médecine, Lille, France
    Int J Geriatr Psychiatry 13:516-9. 1998
    ..Response to tacrine varies among patients with Alzheimer's disease (AD). Lewy body dementia (LBD) could be a high responder subtype of AD. The aim of the study was to compare the effects of tacrine in LBD and AD...
  73. ncbi request reprint Biochemical staging of synucleinopathy and amyloid deposition in dementia with Lewy bodies
    V Deramecourt
    Inserm Unit 815, Lille, France
    J Neuropathol Exp Neurol 65:278-88. 2006
    ..The constant and abundant Abeta x-42 deposition in sporadic DLB suggests that synucleinopathy is also promoted by APP dysfunction. Therefore, we conclude that APP is a therapeutic target for both AD and DLB...
  74. pmc Influence of cognitive impairment on the institutionalisation rate 3 years after a stroke
    M Pasquini
    Department of Neurology Stroke Unit, Lille University Hospital, Lille, France
    J Neurol Neurosurg Psychiatry 78:56-9. 2007
    ..Pre-existing cognitive decline and new-onset dementia are common in patients with stroke, but their influence on institutionalisation rates is unknown...
  75. ncbi request reprint Contribution of APOE promoter polymorphisms to Alzheimer's disease risk
    J C Lambert
    INSERM U508, Institut Pasteur de Lille, Lille, France
    Neurology 59:59-66. 2002
    ..To determine whether the effects of APOE promoter polymorphisms on AD are independent of the APOE-epsilon4 allele...
  76. ncbi request reprint Poststroke dementia
    H Henon
    Department of Neurology, Stroke Unit, Lille University Hospital, Lille, France
    Cerebrovasc Dis 22:61-70. 2006
    ..The influence of stroke location, vascular risk factors and silent infarcts remains to be determined. PSD adversely influences the outcome in stroke patients...
  77. ncbi request reprint Evidence for induction of the ornithine transcarbamylase expression in Alzheimer's disease
    F Bensemain
    INSERM, U744, Institut Pasteur de Lille, Universite de Lille 2, Lille, France
    Mol Psychiatry 14:106-16. 2009
    ..In conclusion, our results suggest the involvement of a new pathway in AD brains involving the urea cycle...
  78. doi request reprint Long-term outcome of acute and subacute myelopathies
    S Debette
    Department of Neurology, University Hospital of Lille, Hopital Roger Salengro, CHRU de Lille, 59037, Lille, France
    J Neurol 256:980-8. 2009
    ..Finally, a long-term follow-up is important given the large number of causes that are identified at a distance from the initial event...
  79. ncbi request reprint Silent infarcts in stroke patients: patient characteristics and effect on 2-year outcome
    F Corea
    Department of Neurology, Stroke Unit, University of Lille, Roger Salengro Hospital, 59037 Lille, France
    J Neurol 248:271-8. 2001
    ..66, 95% CI 1.22-5.79). SI did not affect vital or functional outcome or the occurrence of new vascular events within 2 years after stroke. Whether they affect cognitive outcome remains under evaluation over a longer follow-up period...
  80. doi request reprint Phenotype variability in progranulin mutation carriers: a clinical, neuropsychological, imaging and genetic study
    Isabelle Le Ber
    1INSERM, UMR_S679 Neurologie and Thérapeutique Expérimentale, F 75013, Paris, France
    Brain 131:732-46. 2008
    ..Since all the mutations cause a progranulin haploinsufficiency, additional factors probably explain the variable clinical presentation of the disease...
  81. doi request reprint Memantine therapy for Alzheimer disease in real-world practice: an observational study in a large representative sample of French patients
    Jean Sébastien Vidal
    Institut National de la Santé et de la Recherche Médicale INSERM U708, Paris, France
    Alzheimer Dis Assoc Disord 22:125-30. 2008
    ..Approximately one-third of the memantine-treated patients did not strictly fit with the French summary of product characteristic recommendations for the first memantine prescription...
  82. ncbi request reprint Prevalence of subcortical vascular lesions and association with executive function in mild cognitive impairment subtypes
    Stephanie Bombois
    Stroke 38:2595-7. 2007
    ..We sought to describe their frequency and distribution, and to test their association with cognitive characteristics in MCI patients...
  83. ncbi request reprint [Epidemiology of Alzheimer disease and related disorders]
    Catherine Helmer
    INSERM U 593, Universite de Bordeaux II, 146, rue Leo Saignat, 33076 Bordeaux Cedex, France
    Med Sci (Paris) 22:288-96. 2006
    ..Four ways of prevention are credible. The most important is the treatment of vascular risk factors and particularly hypertension. Other ways are nutritional factors, stimulating leisure activities and depression...
  84. ncbi request reprint Efficacy and safety of galantamine in patients with dementia with Lewy bodies: a 24-week open-label study
    Keith Edwards
    Alzheimer s Diagnostic and Treatment Center, Bennington, VT 05201, USA
    Dement Geriatr Cogn Disord 23:401-5. 2007
    ..Dementia with Lewy bodies (DLB) is a common dementia of the elderly. A significant cholinergic deficit has been demonstrated that may be responsive to treatment by cholinesterase inhibitors (ChEIs)...
  85. pmc Patients characteristics with cholinesterase inhibitor resistant hallucinations in dementia with Lewy bodies
    Florence Lebert
    J Neurol Neurosurg Psychiatry 78:1415-6. 2007
  86. ncbi request reprint Research criteria for the diagnosis of Alzheimer's disease: revising the NINCDS-ADRDA criteria
    Bruno Dubois
    INSERM U610, Hopital de la Salpetriere, Paris, France
    Lancet Neurol 6:734-46. 2007
    ..Validation studies in existing and prospective cohorts are needed to advance these criteria and optimise their sensitivity, specificity, and accuracy...
  87. ncbi request reprint Central and peripheral agraphia in Alzheimer's disease: from the case of Auguste D. to a cognitive neuropsychology approach
    Jany Lambert
    Inserm EPHE Universite de Caen Basse Normandie, Unité E0218, Caen, France
    Cortex 43:935-51. 2007
    ..Rather, it points to heterogeneous profiles of agraphia and suggests that the first signs of writing impairment in AD stem from changes at different points in the broad anatomical network subserving spelling and writing abilities...
  88. ncbi request reprint Mutations in SPG11 are frequent in autosomal recessive spastic paraplegia with thin corpus callosum, cognitive decline and lower motor neuron degeneration
    Giovanni Stevanin
    1INSERM, U679, Universite Pierre et Marie Curie Paris 6, UMR S679, Paris, France
    Brain 131:772-84. 2008
    ..In conclusion, our study reveals the high frequency of SPG11 mutations in patients with HSP, a TCC and cognitive impairment, including in isolated patients, and extends the associated phenotype...
  89. doi request reprint Deletion of the progranulin gene in patients with frontotemporal lobar degeneration or Parkinson disease
    Anne Rovelet-Lecrux
    INSERM U 614, Faculty of Medicine, Institute for Biomedical Research, 76000 Rouen, France
    Neurobiol Dis 31:41-5. 2008
    ..This observation provides a final argument that PGRN mutations exert their pathogenic effect through haploinsufficiency and underlines the diversity of clinical presentations associated with these PGRN alterations...
  90. doi request reprint Biochemistry of Tau in Alzheimer's disease and related neurological disorders
    Nicolas Sergeant
    INSERM, U837, Place de Verdun, 59045 Lille, France
    Expert Rev Proteomics 5:207-24. 2008
    ..Finally, recent advances in proteomics technology are essential to develop further therapeutic targets and early predictive and discriminative diagnostic assays for Alzheimer's disease and related disorders...
  91. pmc A polymorphism in CALHM1 influences Ca2+ homeostasis, Abeta levels, and Alzheimer's disease risk
    Ute Dreses-Werringloer
    Litwin Zucker Research Center for the Study of Alzheimer s Disease, The Feinstein Institute for Medical Research, North Shore LIJ, Manhasset, NY 11030, USA
    Cell 133:1149-61. 2008
    ..We propose that CALHM1 encodes an essential component of a previously uncharacterized cerebral Ca(2+) channel that controls Abeta levels and susceptibility to late-onset AD...
  92. ncbi request reprint Tau aggregation in the hippocampal formation: an ageing or a pathological process?
    Andre Delacourte
    Unite INSERM 422, 1, Place de Verdun, 59045 Lille Cedex, France
    Exp Gerontol 37:1291-6. 2002
    ..Tauopathy in the entorhinal and hippocampal formation could be another type of pathological dysfunction of tau proteins, and a therapeutic target to delay AD. Relevant animal models are desperately needed to address this issue...
  93. ncbi request reprint Association study of three polymorphisms of kinesin light-chain 1 gene with Alzheimer's disease
    Claire Marie Dhaenens
    Groupe Vieillissement Cérébral et Maladies Neurodégénératives, INSERM U422, Laboratoire G Biserte et Faculté de Médecine, Universite de Lille 2, Place de Verdun 59045, Lille Cedex, France
    Neurosci Lett 368:290-2. 2004
    ..73, 95% CI: 1.12-2.67, P = 0.012). No synergistic effects were found between the APOE epsilon 4 allele and KNS2 gene polymorphisms...
  94. ncbi request reprint Editorial comment--not all hypertensive subjects have similar risks for white matter lesions: influence of genetic factors
    Didier Leys
    Stroke 35:1061-2. 2004
  95. ncbi request reprint The dynamic time course of semantic memory impairment in Alzheimer's disease: clues from hyperpriming and hypopriming effects
    Bénédicte Giffard
    Inserm E0218 Université de Caen, Laboratoire de Neuropsychologie, CHU Cote de Nacre, 14033 Caen Cedex, France
    Brain 125:2044-57. 2002
    ..The data reveal in an astonishing yet striking manner the dynamic semantic memory degradation in Alzheimer's disease through the apparently paradoxical semantic priming effects...