S Nseir

Summary

Affiliation: CHRU de Lille
Country: France

Publications

  1. ncbi request reprint Microaspiration in intubated critically ill patients: diagnosis and prevention
    Saad Nseir
    Intensive Care Unit, Calmette Hospital, University Hospital of Lille, boulevard du Pr Leclercq, 59037 Lille Cedex, France
    Infect Disord Drug Targets 11:413-23. 2011
  2. ncbi request reprint New methods to clean ICU rooms
    Caroline Blazejewski
    Intensive Care Unit, Calmette Hospital, University Hospital of Lille, boulevard du Pr Leclercq, 59037 Lille Cedex, France
    Infect Disord Drug Targets 11:365-75. 2011
  3. doi request reprint Factors predicting prolonged empirical antifungal treatment in critically ill patients
    Mohamed Zein
    Pôle de Réanimation Médicale, CHRU de Lille, Hopital Salengro, Lille, France
    Ann Clin Microbiol Antimicrob 13:11. 2014
  4. ncbi request reprint Accuracy of leptin serum level in diagnosing ventilator-associated pneumonia: a case-control study
    E Parmentier-Decrucq
    Intensive Care Unit, Calmette Hospital, University Hospital of Lille, Lille, France
    Minerva Anestesiol 80:39-47. 2014
  5. pmc Adverse events during intrahospital transport of critically ill patients: incidence and risk factors
    Erika Parmentier-Decrucq
    Service d Urgence Respiratoire, Réanimation Médicale et Mèdecine Hyperbare, Université de Lille II et Centre Hospitalier et Universitaire de Lille, Lille 59037, France
    Ann Intensive Care 3:10. 2013
  6. pmc Short term Candida albicans colonization reduces Pseudomonas aeruginosa-related lung injury and bacterial burden in a murine model
    Florence Ader
    Department of Infectious Diseases, Croix Rousse Hospital, 104 Grande Rue de la Croix Rousse, Lyon, F 69004, France
    Crit Care 15:R150. 2011
  7. pmc Remifentanil discontinuation and subsequent intensive care unit-acquired infection: a cohort study
    Saad Nseir
    Intensive Care Unit, Calmette Hospital, University Hospital of Lille, boulevard du Pr Leclercq, 59037 Lille Cedex, France
    Crit Care 13:R60. 2009
  8. pmc Continuous control of endotracheal cuff pressure and tracheal wall damage: a randomized controlled animal study
    Saad Nseir
    Intensive Care Unit, Calmette Hospital, University Hospital of Lille, boulevard du Pr Leclercq, 59037 Lille Cedex, France
    Crit Care 11:R109. 2007
  9. ncbi request reprint Pathophysiology of airway colonization in critically ill COPD patient
    Saad Nseir
    Univ Lille Nord de France, F 59000 Lille, France
    Curr Drug Targets 12:514-20. 2011
  10. doi request reprint Prevalence and outcome of severe chronic obstructive pulmonary disease exacerbations caused by multidrug-resistant bacteria
    Saad Nseir
    Intensive Care Unit, Calmette Hospital, University Hospital of Lille, Lille, France
    Curr Opin Pulm Med 14:95-100. 2008

Collaborators

Detail Information

Publications48

  1. ncbi request reprint Microaspiration in intubated critically ill patients: diagnosis and prevention
    Saad Nseir
    Intensive Care Unit, Calmette Hospital, University Hospital of Lille, boulevard du Pr Leclercq, 59037 Lille Cedex, France
    Infect Disord Drug Targets 11:413-23. 2011
    ..Other preventive measures such as subglottic aspiration, tapered shape cuff, guayule latex cuff, lateral horizontal patient position, gastrostomy tube, and postpyloric feeding require further investingation...
  2. ncbi request reprint New methods to clean ICU rooms
    Caroline Blazejewski
    Intensive Care Unit, Calmette Hospital, University Hospital of Lille, boulevard du Pr Leclercq, 59037 Lille Cedex, France
    Infect Disord Drug Targets 11:365-75. 2011
    ..It remains difficult to justify the extra-cost associated with these new methods until more studies can confirm their effectiveness in the management of HAI...
  3. doi request reprint Factors predicting prolonged empirical antifungal treatment in critically ill patients
    Mohamed Zein
    Pôle de Réanimation Médicale, CHRU de Lille, Hopital Salengro, Lille, France
    Ann Clin Microbiol Antimicrob 13:11. 2014
    ..To determine the incidence, risk factors, and impact on outcome of prolonged empirical antifungal treatment in ICU patients...
  4. ncbi request reprint Accuracy of leptin serum level in diagnosing ventilator-associated pneumonia: a case-control study
    E Parmentier-Decrucq
    Intensive Care Unit, Calmette Hospital, University Hospital of Lille, Lille, France
    Minerva Anestesiol 80:39-47. 2014
    ..The main objective of this study was to determine whether leptin deficiency is a risk factor for ventilator-associated pneumonia (VAP)...
  5. pmc Adverse events during intrahospital transport of critically ill patients: incidence and risk factors
    Erika Parmentier-Decrucq
    Service d Urgence Respiratoire, Réanimation Médicale et Mèdecine Hyperbare, Université de Lille II et Centre Hospitalier et Universitaire de Lille, Lille 59037, France
    Ann Intensive Care 3:10. 2013
    ..The objective of the study was to collect prospectively adverse events that occurred during intrahospital transports of critically ill patients and to determine their risk factors...
  6. pmc Short term Candida albicans colonization reduces Pseudomonas aeruginosa-related lung injury and bacterial burden in a murine model
    Florence Ader
    Department of Infectious Diseases, Croix Rousse Hospital, 104 Grande Rue de la Croix Rousse, Lyon, F 69004, France
    Crit Care 15:R150. 2011
    ..This study was designed to investigate whether prior short term Candida albicans airway colonization modulates the pathogenicity of P. aeruginosa in a murine model of pneumonia and to evaluate the effect of fungicidal drug caspofungin...
  7. pmc Remifentanil discontinuation and subsequent intensive care unit-acquired infection: a cohort study
    Saad Nseir
    Intensive Care Unit, Calmette Hospital, University Hospital of Lille, boulevard du Pr Leclercq, 59037 Lille Cedex, France
    Crit Care 13:R60. 2009
    ..The aim of this study was to determine the impact of remifentanil discontinuation on intensive care unit (ICU)-acquired infection...
  8. pmc Continuous control of endotracheal cuff pressure and tracheal wall damage: a randomized controlled animal study
    Saad Nseir
    Intensive Care Unit, Calmette Hospital, University Hospital of Lille, boulevard du Pr Leclercq, 59037 Lille Cedex, France
    Crit Care 11:R109. 2007
    ..We hypothesized that efficient continuous control of the endotracheal cuff pressure using a pneumatic device would reduce tracheal ischemic lesions in piglets ventilated for 48 hours through a high-volume, low-pressure endotracheal tube...
  9. ncbi request reprint Pathophysiology of airway colonization in critically ill COPD patient
    Saad Nseir
    Univ Lille Nord de France, F 59000 Lille, France
    Curr Drug Targets 12:514-20. 2011
    ..Further studies should determine the impact of preventive measures aiming at preventing LRTC on outcome of COPD patients requiring intubation and mechanical ventilation in the ICU...
  10. doi request reprint Prevalence and outcome of severe chronic obstructive pulmonary disease exacerbations caused by multidrug-resistant bacteria
    Saad Nseir
    Intensive Care Unit, Calmette Hospital, University Hospital of Lille, Lille, France
    Curr Opin Pulm Med 14:95-100. 2008
    ..The aim of this review is to discuss recent findings regarding prevalence, risk factors and outcome of severe chronic obstructive pulmonary disease exacerbations caused by multidrug-resistant bacteria...
  11. ncbi request reprint Outcomes of ventilated COPD patients with nosocomial tracheobronchitis: a case-control study
    S Nseir
    Intensive Care Unit, Calmette Hospital, Regional University Center, boulevard du Pr Leclercq, F 59037, Lille Cedex, France
    Infection 32:210-6. 2004
    ..The aim of this study was to determine the impact of nosocomial tracheobronchitis (NTB) related to new bacteria on the outcome in patients with chronic obstructive pulmonary disease (COPD)...
  12. doi request reprint Risk factors for relapse of ventilator-associated pneumonia related to nonfermenting Gram negative bacilli: a case-control study
    Saad Nseir
    Intensive Care Unit, Calmette Hospital, University Hospital of Lille, boulevard du Pr Leclercq, 59037 Lille Cedex, France
    J Infect 56:319-25. 2008
    ..The aim of this study was to determine risk factors for relapse of ventilator-associated pneumonia (VAP) related to nonfermenting Gram negative bacilli (NF-GNB)...
  13. doi request reprint Risk of acquiring multidrug-resistant Gram-negative bacilli from prior room occupants in the intensive care unit
    S Nseir
    Intensive Care Unit, Calmette Hospital, University Hospital of Lille, Lille, France
    Clin Microbiol Infect 17:1201-8. 2011
    ..aeruginosa or A. baumannii is an independent risk factor for acquisition of these bacteria by subsequent room occupants. This relationship was not identified for ESBL-producing GNB...
  14. doi request reprint Factors predicting bacterial involvement in severe acute exacerbations of chronic obstructive pulmonary disease
    Saad Nseir
    Intensive Care Unit, Calmette Hospital, University Hospital of Lille, Lille, France
    Respiration 76:253-60. 2008
    ..Although antibiotic treatment is recommended in patients with severe exacerbation of chronic obstructive pulmonary disease (COPD), a bacterial etiology is found in only a half of these patients...
  15. doi request reprint Impact of polyurethane on variations in tracheal cuff pressure in critically ill patients: a prospective observational study
    Saad Nseir
    Intensive Care Unit, Calmette Hospital, University Hospital of Lille, boulevard du Pr Leclercq, 59037, Lille Cedex, France
    Intensive Care Med 36:1156-63. 2010
    ..To determine the impact of polyurethane (PU) on variations in cuff pressure (P (cuff)) in intubated critically ill patients...
  16. pmc Intensive Care Unit-acquired infection as a side effect of sedation
    Saad Nseir
    Intensive Care Unit, Calmette Hospital, University Hospital of Lille, boulevard du Pr Leclercq, Lille Cedex, France
    Crit Care 14:R30. 2010
    ....
  17. doi request reprint Nosocomial tracheobronchitis
    Saad Nseir
    Intensive Care Unit, Calmette Hospital, University Hospital of Lille, boulevard du Pr Leclercq, Lille Cedex, France
    Curr Opin Infect Dis 22:148-53. 2009
    ..Ventilator-associated tracheobronchitis (VAT) represents an intermediate process between lower respiratory tract colonization and ventilator-associated pneumonia. The aim of this review is to discuss recent findings on VAT...
  18. pmc Antimicrobial treatment for ventilator-associated tracheobronchitis: a randomized, controlled, multicenter study
    Saad Nseir
    Réanimation Médicale, boulevard du Pr Leclercq, Hopital Calmette, CHRU de Lille, 59037 Lille Cedex, France
    Crit Care 12:R62. 2008
    ..We hypothesized that, in patients with VAT, antibiotic treatment would be associated with reduced duration of mechanical ventilation...
  19. ncbi request reprint Relationship between immunosuppression and intensive care unit-acquired multidrug-resistant bacteria: a case-control study
    Saad Nseir
    Intensive Care Unit, Calmette Hospital, University Hospital of Lille, France
    Crit Care Med 35:1318-23. 2007
    ..To determine the relationship between immunosuppression and intensive care unit (ICU)-acquired multidrug-resistant (MDR) bacteria...
  20. doi request reprint Accuracy of American Thoracic Society/Infectious Diseases Society of America criteria in predicting infection or colonization with multidrug-resistant bacteria at intensive-care unit admission
    S Nseir
    Intensive Care Unit, Calmette Hospital, University Hospital of Lille, Lille, France
    Clin Microbiol Infect 16:902-8. 2010
    ..ATS/IDSA criteria had an excellent negative predictive value and a low positive predictive value concerning infection or colonization with MDR bacteria at ICU admission...
  21. ncbi request reprint Nosocomial tracheobronchitis in mechanically ventilated patients: incidence, aetiology and outcome
    S Nseir
    Intensive Care Unit, Calmette Hospital, Regional University Centre, Lille, France
    Eur Respir J 20:1483-9. 2002
    ..Further studies are needed to determine the impact of antibiotics on outcomes of patients with nosocomial tracheobronchitis...
  22. ncbi request reprint [Early and late nosocomial broncho-pulmonary diseases in intensive care. Comparative study of risk factors and of causing bacteria]
    S Nseir
    Hopital Calmette, CHRU, Bd du Pr Leclercq, 59037 Lille
    Presse Med 32:1111-5. 2003
    ..Determine the risk factors and germs responsible for early-onset (E) and late-onset (L) nosocomial broncho-pulmonary infections (NBPI), in order to improve preventive strategies and the choice of initial antibiotherapy...
  23. ncbi request reprint Fatal streptococcal necrotizing fasciitis as a complication of axillary brachial plexus block
    S Nseir
    Service de Reanimation Medicale, Hopital Calmette, CHRU, boulevard du Pr Leclercq, F 59037 Lille Cedex, France
    Br J Anaesth 92:427-9. 2004
    ..Cultures yielded group A Streptococcus. Delay in antibiotic and surgical treatment probably affected the outcome. Early diagnosis and treatment are essential to improve the outcome of streptococcal necrotizing fasciitis...
  24. pmc Effect of ventilator-associated tracheobronchitis on outcome in patients without chronic respiratory failure: a case-control study
    Saad Nseir
    Regional University Centre, Calmette Hospital, EA 3614, Lille II University, Lille, France
    Crit Care 9:R238-45. 2005
    ..Our objective was to determine the effect of ventilator-associated tracheobronchitis (VAT) on outcome in patients without chronic respiratory failure...
  25. ncbi request reprint Impact of ventilator-associated pneumonia on outcome in patients with COPD
    Saad Nseir
    Intensive Care Unit, Calmette Hospital, Regional University Centre, Lille II University, France
    Chest 128:1650-6. 2005
    ..The aim of this study was to determine the impact of ventilator-associated pneumonia (VAP) on outcome in patients with COPD...
  26. ncbi request reprint [Impact of fluoroquinolone use on multidrug-resistant bacteria emergence]
    S Nseir
    Service de Reanimation Medicale, hôpital A Calmette, CHRU de Lille, boulevard du Pr Leclercq, 59037 Lille Cedex, France
    Pathol Biol (Paris) 53:470-5. 2005
    ....
  27. doi request reprint Continuous control of tracheal cuff pressure and microaspiration of gastric contents in critically ill patients
    Saad Nseir
    Intensive Care Unit, Biochemistry Division, Pathology and Biology Center, University Hospital of Lille, France
    Am J Respir Crit Care Med 184:1041-7. 2011
    ....
  28. ncbi request reprint Relationship between tracheotomy and ventilator-associated pneumonia: a case control study
    S Nseir
    Intensive Care Unit, Calmette Hospital, University Hospital of Lille, boulevard du Pr Leclercq, 59037 Lille Cedex, France
    Eur Respir J 30:314-20. 2007
    ..1 (1.1-3.2)) and tracheotomy (0.18 (0.1-0.3)) were associated with VAP. In summary, the present study demonstrates that tracheotomy is independently associated with decreased risk for ventilator-associated pneumonia...
  29. pmc Intensive care unit-acquired Stenotrophomonas maltophilia: incidence, risk factors, and outcome
    Saad Nseir
    Intensive Care Unit, Calmette Hospital, University Hospital of Lille, boulevard du Pr Leclercq, 59037 Lille Cedex, France
    Crit Care 10:R143. 2006
    ..The aim of this study was to determine incidence, risk factors, and impact on outcome of intensive care unit (ICU)-acquired Stenotrophomonas maltophilia...
  30. ncbi request reprint Impact of antifungal treatment on Candida-Pseudomonas interaction: a preliminary retrospective case-control study
    Saad Nseir
    Intensive Care Unit, Calmette Hospital, University Hospital of Lille, boulevard du Pr Leclercq, 59037, Lille Cedex, France
    Intensive Care Med 33:137-42. 2007
    ..aeruginosa pneumonia. The aim of this study was to determine the impact of antifungal treatment on ventilator-associated pneumonia (VAP) or tracheobronchial colonization due to P. aeruginosa...
  31. ncbi request reprint Variations in endotracheal cuff pressure in intubated critically ill patients: prevalence and risk factors
    Saad Nseir
    Calmette Hospital, University Hospital of Lille, France
    Eur J Anaesthesiol 26:229-34. 2009
    ..The aim of this study was to identify prevalence of, and risk factors for, endotracheal cuff underinflation and overinflation...
  32. ncbi request reprint Multiple-drug-resistant bacteria in patients with severe acute exacerbation of chronic obstructive pulmonary disease: Prevalence, risk factors, and outcome
    Saad Nseir
    Intensive Care Unit, Calmette Hospital, University Hospital of Lille, Lille, France
    Crit Care Med 34:2959-66. 2006
    ..To determine prevalence, risk factors, and effect on outcome of multiple-drug-resistant (MDR) bacteria in patients with severe acute exacerbation of chronic obstructive pulmonary disease...
  33. ncbi request reprint Assessing excess nurse work load generated by multiresistant nosocomial bacteria in intensive care
    F F Saulnier
    , Hĵpital Calmette, Lille, France
    Infect Control Hosp Epidemiol 22:273-8. 2001
    ..This may be of importance in evaluating potential links between nurse work load and MRB NIs and in determining the number of nurse hours needed to comply with infection control recommendations...
  34. ncbi request reprint First-generation fluoroquinolone use and subsequent emergence of multiple drug-resistant bacteria in the intensive care unit
    Saad Nseir
    Intensive Care Unit, Calmette Hospital, Regional University Centre, Lille, France
    Crit Care Med 33:283-9. 2005
    ..The objective of this study was to determine the relationship between fluoroquinolone (FQ) use and subsequent emergence of multiple drug-resistant bacteria (MRB) in the intensive care unit (ICU)...
  35. doi request reprint Procalcitonin as a prognostic factor in severe acute exacerbation of chronic obstructive pulmonary disease
    Blandine Rammaert
    Intensive Care Unit, Calmette Hospital, Lille University, Lille Cedex, France
    Respirology 14:969-74. 2009
    ..This study evaluated the clinical and biological predictors of intensive care unit (ICU) mortality in patients with a severe acute exacerbation of COPD...
  36. ncbi request reprint [Ventilator-associated pneumonia and chronic obstructive pulmonary disease]
    B Rammaert
    Clinique des Maladies Respiratoires, hôpital A Calmette, CHRU, Lille, France
    Rev Mal Respir 24:1285-98. 2007
    ....
  37. ncbi request reprint [Pseudomonas aeruginosa and Candida albicans interaction in the respiratory tract: from pathophysiology to a therapeutic perspective]
    F Ader
    Laboratoire de Recherche en Pathologie Infectieuse, EA 2689, Faculte de Medecine de Lille, Place de Verdun, Lille Cedex, France
    Pathol Biol (Paris) 56:164-9. 2008
    ..Experimental studies providing a better understanding of the mechanisms of interaction and clinical studies evaluating the necessity of a antifungal treatment might improve the management of these opportunistic infections...
  38. ncbi request reprint Extensive corrosive injuries of the upper airways and gastrointestinal tract
    S Jaillard
    Clinique de chirurgie thoracique, Centre Hospitalier Universitaire de Lille, France
    J Thorac Cardiovasc Surg 123:186-8. 2002
  39. doi request reprint Daily serum piperacillin monitoring is advisable in critically ill patients
    Nicolas Blondiaux
    Pole de Microbiologie, Centre de Biologie Pathologie, Centre Hospitalier Régional Universitaire CHRU de Lille, Boulevard du Pr J Leclercq, F 59037 Lille, France
    Int J Antimicrob Agents 35:500-3. 2010
    ..In conclusion, in critically ill patients, monitoring and adjustment of serum piperacillin levels is required to prevent overdosing and might also help to correct underdosing, an important cause of antibiotic therapy failure...
  40. ncbi request reprint Epidemiology and prognostic factors of critically ill patients treated with hemodiafiltration
    Stephane Soubrier
    Service de Reanimation Medicale, Hopital Calmette, CHRU, 59037 Lille Cedex, France
    J Crit Care 21:66-72. 2006
    ..The objective of this study is to study the epidemiology, outcome, and prognostic factors of critically ill patients treated with continuous venovenous hemodiafiltration (CVVHDF)...
  41. ncbi request reprint Diagnosis of hospital-acquired pneumonia: postmortem studies
    Saad Nseir
    Service de Reanimation Medicale, hôpital A Calmette, CHRU, Lille, France
    Infect Dis Clin North Am 17:707-16. 2003
    ..Instead, finding a balance between clinical judgment and microbiologic results is crucial to manage patients with VAP appropriately...
  42. pmc Antibodies against glucan, chitin, and Saccharomyces cerevisiae mannan as new biomarkers of Candida albicans infection that complement tests based on C. albicans mannan
    B Sendid
    INSERM U799, Universite Lille 2, Lille, France
    Clin Vaccine Immunol 15:1868-77. 2008
    ..Future trials are necessary to assess the value of these tests in multiparametric analysis, as well as their pathophysiological relevance...
  43. doi request reprint Incidence and prognostic value of right ventricular failure in acute respiratory distress syndrome
    David Osman
    Service de Reanimation Medicale, Hopital de Bicetre, Centre Hospitalo Universitaire de Bicêtre, Assistance Publique Hopitaux de Paris, Université Paris 11 Sud, Le Kremlin Bicetre, France
    Intensive Care Med 35:69-76. 2009
    ..To analyse the incidence and the impact on outcome of right ventricular failure (RVF) in patients with acute respiratory distress syndrome (ARDS)...
  44. ncbi request reprint Can dynamic indicators help the prediction of fluid responsiveness in spontaneously breathing critically ill patients?
    Stephane Soubrier
    Service de Reanimation Medicale, Hopital Calmette, CHRU, boulevard du Pr Leclercq, 59037, Lille Cedex, France
    Intensive Care Med 33:1117-24. 2007
    ..Because changes in intrathoracic pressure during spontaneous breathing (SB) might be insufficient to modify loading conditions of the ventricles, performances of indicators were also assessed during a forced respiratory maneuver...
  45. doi request reprint Acute alcohol withdrawal as a risk factor for intensive care unit-acquired infection
    Saad Nseir
    Crit Care Med 36:3131-2. 2008
  46. doi request reprint Aerosolized antibiotics for ventilator-associated tracheobronchitis: let's go with the flow!
    Saad Nseir
    Crit Care Med 36:2191-2. 2008
  47. pmc Vibrio metschnikovii pneumonia
    Frederic Wallet
    Emerg Infect Dis 11:1641-2. 2005
  48. ncbi request reprint Does polyurethane impact endotracheal cuff pressure?
    Saad Nseir
    Crit Care Med 36:2219; author reply 2219-20. 2008