Research Topics
Species | X LeroySummaryAffiliation: CHRU de Lille Country: France Publications
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Publications
Epithelioid angiomatous nodule of the nasal cavityXavier Leroy
Department of Pathology, University Hospitals, CHRU, Lille 59037, France
Pathol Res Pract 204:929-32. 2008..The main differential diagnosis is an epithelioid hemangioma sharing many morphologic features with EAN. We report these cases to inform of a possibly unusual location of EAN...
Morphologic subtyping of papillary renal cell carcinoma: correlation with prognosis and differential expression of MUC1 between the two subtypesXavier Leroy
Department of Pathology, Lille University Hospitals and the Unity INSERM U560, CHR U, Lille, France
Mod Pathol 15:1126-30. 2002..In conclusion we confirm that the morphologic sub-typing and Fuhrman grade are valuable factors of outcome of papillary renal cell carcinomas and that MUC1 immunostaining is useful in differentiating Type 1 and Type 2 tumors...
Vascular endocan (ESM-1) is markedly overexpressed in clear cell renal cell carcinomaXavier Leroy
Department of Pathology, University Hospital, CHRU and Lille II University, Lille, France
Histopathology 56:180-7. 2010..The aim was to analyse the expression of endocan or endothelial cell-specific molecule-1, which is a proteoglycan up-regulated in presence of pro-angiogenic factors...
Microcystic transitional cell carcinoma: a report of 2 cases arising in the renal pelvisXavier Leroy
Departments of Pathology, University Hospitals of Lille, Lille, France
Arch Pathol Lab Med 126:859-61. 2002..The second patient remained well at her 6-month follow-up examination. Microcystic transitional cell carcinoma is an unusual, deceptively bland variant of urothelial carcinoma, which can mimic benign lesions...
Minimal focus of adenocarcinoma on prostate biopsy: clinicopathological correlationsX Leroy
Department of Pathology, Huriez Hospital, 59045 Lille, France
J Clin Pathol 56:230-2. 2003..To establish the clinicopathological features of minimal volume prostate adenocarcinoma on prostate biopsy...
Gamna-Gandy nodules in a renal clear cell carcinomaXavier Leroy
Department of Pathology, University Hospitals, Lille, France
Arch Pathol Lab Med 127:372. 2003
Expression of human mucin genes in normal kidney and renal cell carcinomaX Leroy
Department of Pathology, University Hospital and Unity INSERM U 377, Lille, France
Histopathology 40:450-7. 2002..Mucins are thought to be implicated in cell protection, cell adhesion and signalling. The aim of this study was to investigate the expression of the human mucin genes (MUC1-4, 5AC, 5B, 6-7) in normal kidney and renal cell carcinoma...
MUC6 is a marker of seminal vesicle-ejaculatory duct epithelium and is useful for the differential diagnosis with prostate adenocarcinomaXavier Leroy
Department of Pathology, Faculty of Medicine, Center Hospitalier Régional et Universitaire, 59045 Lille, France
Am J Surg Pathol 27:519-21. 2003..In contrast, all seminal vesicles were diffusely immunostained with MUC6 antibody. We concluded that MUC6 is a valuable marker of seminal vesicle-ejaculatory duct and is useful for the differential diagnosis with prostate adenocarcinoma...
CD30 and CD117 (c-kit) used in combination are useful for distinguishing embryonal carcinoma from seminomaXavier Leroy
Department of Pathology, University Hospital, Lille, France
J Histochem Cytochem 50:283-5. 2002..Conversely, 11/14 ECs were CD30+/CD117- and none was CD30-/CD117+. Our findings suggest that CD117 and CD30 immunohistochemistry used in combination represents a valuable tool for distinguishing seminoma from EC...
[Organized hematoma of the buttock]Xavier Leroy
Service d'Anatomie Pathologique, , CHRU, 59045 Lille
Ann Pathol 24:203-4. 2004
Immunohistochemical detection of Fas and Fas ligand in sarcomatoid renal cell carcinomaX Leroy
Department of Pathology, University Hospitals of Lille, France
APMIS 109:469-73. 2001..These findings may indicate that Fas ligand is a possible therapeutic molecular target for treatment of SRC...
[Malignant solitary fibrous tumor of pleura with focal expression of cytokeratin]X Leroy
Service d Anatomie et de Cytologie Pathologiques, CHRU, 59045 Lille Cedex
Ann Pathol 21:153-6. 2001..Immunohistochemical study is helpful demonstrating a strong positivity for vimentin and CD 34 and absence of staining for epithelial markers and S-100 protein...
Bilateral renal oncocytosis with renal failureX Leroy
Service d Anatomie et de Cytologie Pathologiques, Faculte de Medecine, Pole Recherche, rue M Polonowski, 59045 Lille Cedex, France
Arch Pathol Lab Med 125:683-5. 2001..His kidneys were involved by numerous tumors. Histologic examination revealed more than 100 oncocytomas and an associated papillary renal cell carcinoma in the right kidney...
Lipoid-cell variant of urothelial carcinoma: a clinicopathologic and immunohistochemical study of five casesXavier Leroy
Department of Pathology, University Hospitals, Lille, France
Am J Surg Pathol 31:770-3. 2007..In the present series, the lipoid-cell variant of urothelial carcinoma was associated with an aggressive behavior and a poor prognosis...
Renal cell carcinoma with rhabdoid features: an aggressive neoplasm with overexpression of p53Xavier Leroy
Centre Hospitalier Universitaire de Lille, Department of Pathology, Parc Eurasante, Lille, nord 59037 France
Arch Pathol Lab Med 131:102-6. 2007..Adult renal cell carcinoma (RCC) with rhabdoid features is a recently recognized morphologic variant of kidney carcinoma. To date, only very few studies have been published on this subject and p53 was not previously studied...
Value of frozen section examination for the management of nonpalpable incidental testicular tumorsXavier Leroy
Department of Pathology, University Hospitals, 59045 Lille, France
Eur Urol 44:458-60. 2003..To determine the value of frozen section examination for the management of small incidental testis tumors...
[MUC1 (EMA): A key molecule of carcinogenesis?]Xavier Leroy
Service d Anatomie Pathologique, Pôle Eurasanté, Bâtiment Biologie Pathologie, CHRU, 59037 Lille
Ann Pathol 26:257-66. 2006..MUC1 appears to be a novel therapeutic target for immunotherapy or anti-tumour vaccines...
[Lipomatous pleomorphic adenoma of the parotid]Xavier Leroy
Service d Anatomie et de Cytologie Pathologiques, pôle Huriez, CHRU, 59045 Lille, France
Ann Pathol 22:219-21. 2002..One year after surgery the patient was alive without recurrence. In conclusion, it is a rare neoplasm who needs to be recognized and discussed with true fatty tumors and lipomatosis...
Utility of cytokeratin 7 for distinguishing chromophobe renal cell carcinoma from renal oncocytomaX Leroy
Department of Pathology, CHRU, Lille, France
Eur Urol 37:484-7. 2000..We studied the immunohistochemical expression of cytokeratin 7 to determine its value in distinguishing chromophobe renal cell carcinoma from renal oncocytoma...
Normal respiratory mucosa, precursor lesions and lung carcinomas: differential expression of human mucin genesM C Copin
Laboratoire de Biochimie et Biologie Moleculaire, Hopital C Huriez CHRU Lille, France, Faculte de Medecine, Universite de Lille II, Lille, France
Front Biosci 6:D1264-75. 2001..These findings are in favor the histogenetic theory of non-small-cell carcinoma originating from a pluripotent mucous cell...
Low-grade tubular myxoid renal tumors: a clinicopathological study of 3 casesS Aubert
Department of Pathology, University Hospital, Lille, France
Int J Surg Pathol 12:179-83. 2004..All patients were healthy after surgery. We describe 3 cases of a new clinicopathological entity entitled low-grade tubular myxoid renal tumor with a benign clinical course...
Tumour necrosis in chromophobe renal cell carcinoma: clinical data to distinguish aggressive variantsL Zini
Department of Urology, Huriez Hospital, Lille, France
Eur J Surg Oncol 34:687-91. 2008..To assess correlation between necrosis on imaging and pathology reports and prognostic value of tumour necrosis in chromophobe renal cell carcinoma (CRCC)...
Solitary fibrous tumour of the kidneyX Leroy
Department of Pathology, CHRU, Lille, France
Urol Int 65:49-52. 2000..The neoplastic cells stained for vimentin and CD34. CD31 was negative. Biologically, we did not find any arguments for malignancy: the flow cytometric study showed diploid histograms, and immunostaining for p53 was negative...
Surgical treatment of primary sarcoma of the lungH L Porte
Department of Thoracic Surgery, Lille University Hospital, Hopital Calmette, 1 Rue du Professeur J Leclercq, 59037 cedex, Lille, France
Eur J Cardiothorac Surg 18:136-42. 2000..To study the results of surgical treatment of primary lung sarcoma...
[Small renal masses: 10 years of treatment in a tertiary referral center in cancer research]A Broucqsault
Service d Urologie, Universite Lille Nord de France, Hopital Huriez, CHU de Lille, Lille, France
Prog Urol 22:692-700. 2012..To analyze the impact of preoperative clinical data that could influence the undertaking of small renal masses (size<4cm) and to direct patients towards surgery or observance or radiofrequency...
Significance of ADC value for detection and characterization of urothelial carcinoma of upper urinary tract using diffusion-weighted MRIA Sufana Iancu
Department of Nephro urological Radiology, Claude Huriez Hospital, CHRU Lille, Universite Lille Nord de France, 1, Rue Michel Polonovski, 59037, Lille, France
World J Urol 31:13-9. 2013..To evaluate utility of diffusion-weighted magnetic resonance imaging (DWI) to detect and predict the histological characteristics of upper urinary tract urothelial carcinomas (UTUCs)...
[Management of testicular lesions in a population of infertile patients]C Butruille
Service d andrologie, CHRU de Lille, Hopital Calmette, Boulevard du Professeur Jules Leclercq, 59037 Lille, France
Prog Urol 22:45-52. 2012..Testicular parenchyma abnormalities and testis cancers are more frequent in infertile men, hence the guidelines recommending a systematic scrotal ultrasound...
Sinonasal mucosal melanoma: retrospective survival study of 25 patientsC Vandenhende
Department of Otorhinolaryngology and Head and Neck Surgery, Huriez Hospital, University of Lille, France
J Laryngol Otol 126:147-51. 2012..To determine potential prognostic factors for survival in patients with mucosal malignant melanoma of the sinonasal tract...
Post-traumatic fibro-osseous lesion of the ribs: a relatively under-recognised entityS Aubert
Department of Pathology, University Hospital, CHRU, Lille, France
J Clin Pathol 59:635-8. 2006..To report the description of a rare benign osseous lesion affecting the ribs entitled post-traumatic fibro-osseous lesion (PTFOL)...
[Localized amyloidosis of the cavum]A Wacrenier
Service d anatomie et cytologie pathologique, Hôpital Huriez CHRU, Lille
Presse Med 32:114-6. 2003..Amyloidosis is characterized by extracellular deposits of proteins...
[Primary large cell neuroendocrine carcinoma of the kidney: morphologic and immunohistochemical features of two cases]D Moukassa
Services d Anatomie et de Cytologie Pathologiques, Hopital Calmette, CHRU 59037 Lille Cedex
Ann Pathol 20:357-60. 2000..We report two cases, a 35-year-old man and a 75-year-old woman who died within 6 and 5-months after surgery despite radical nephrectomy and chemotherapy. Histological and immunohistochemical features are presented...
Ectopic hyperprolactinaemia in a woman with a mesocolic perivascular epithelioid cell tumor ("PEComa")E Proust-Lemoine
Service d Endocrinologie et Maladies Métaboliques, Clinique Marc Linquette, 6, rue du Pr Laguesse, CHRU de Lille, 59037 Lille Cedex, France
Ann Endocrinol (Paris) 69:240-3. 2008..In conclusion, in face of an important hyperprolactinaemia without any hypothalamic-pituitary mass, it remains important to search for an ectopic prolactin production, such as a PEComa...
[Esophageal tuberculosis: an unusual localization in an immunocompetent patient]D Moukassa
Service d Anatomie et Cytologie Pathologiques, CHRU Calmette, Bd Pr J Leclercq 59037 Lille
Bull Soc Pathol Exot 93:287-8. 2000..On follow-up after 3 months, dysphagia, fever, weight loss had disappeared and the ulcerated lesion of oesophagus had improved. The subsequent course of the patient is not known, since she was lost to follow-up...
Respiratory epithelial adenomatoid hamartomas of the sinonasal tractG Mortuaire
Department of Otorhinolaryngology, Head and Neck Surgery, Claude Huriez Hospital Pr Chevalier, University of Lille, CHRU Lille, Lille, France
Eur Arch Otorhinolaryngol 264:451-3. 2007..We should be aware of this entity as a differential diagnosis for inverted papilloma and well-differenciated adenocarcinoma. Fine histopathological analysis is necessary to avoid aggressive surgery for this benign lesion...
Prognostic value of combined p53 and survivin in pT1G3 urothelial carcinoma of the bladderSamia Gonzalez
Department of Pathology, University Hospital, Lille, France
Am J Clin Pathol 129:232-7. 2008..0007). We showed that combined p53 and survivin immunostaining could be helpful in distinguishing patients with a high risk of tumor progression...
Expression of human mucin genes during normal and abnormal renal developmentXavier Leroy
Unit INSERM U560, Department of Pathology, University Hospitals, Lille, France
Am J Clin Pathol 120:544-50. 2003..In malformative cystic diseases, only MUC1 expression was retained; no expression of MUC6 and MUC3 was observed. These results implicate human mucin genes (MUC1, MUC3, and MUC6) in renal morphogenesis processes...
Quantitative RT-PCR assay for MUC3 and VEGF mRNA in renal clear cell carcinoma: relationship with nuclear grade and prognosisXavier Leroy
Unity INSERM U560, Lille, France
Urology 62:771-5. 2003..Deregulation of mucin genes has been demonstrated in several epithelial neoplasms. In the kidney, MUC3 is expressed in normal convoluted tubules and in renal clear cell carcinoma...
Primary atypical carcinoid of the kidney: a classification is neededJean François Quinchon
Pathology 35:353-5. 2003
[Long-term oncological results after conservative surgery for unifocal renal cancer]Cyril Gerard
Service d Urologie, Hopital Claude Huriez, 2, avenue O Lambret, 59035 Lille
Prog Urol 13:14-22. 2003..To evaluate the risk of local recurrence and metastatic spread of renal cancer treated by conservative surgery with a minimum follow-up of 5 years...
Signet-ring cell adenocarcinoma of sinonasal tract: an immunohistochemical study of the mucins profileChristine Castillo
Department of Pathology, CHRU, Parc Eurasante, Nord, Lille, 59037, France
Arch Pathol Lab Med 131:961-4. 2007..Signet-ring cell carcinoma is the rarest form of intestinal-type adenocarcinoma. Only isolated cases have been reported in the literature...
Renal vein ostium wall invasion of renal cell carcinoma with an inferior vena cava tumor thrombus: prediction by renal and vena caval vein diameters and prognostic significanceLaurent Zini
Department of Urology, Lille University Hospital, Lille, Cedex, France
J Urol 179:450-4; discussion 454. 2008..We also determined whether it is a prognostic factor for recurrence and survival after radical nephrectomy and thrombus ablation for renal cell carcinoma with an inferior vena cava tumor thrombus...
Pathologic quiz case: a periosteal swelling of the tibiaSebastien Aubert
Department of Pathology, CHRU, 59045 Lille Cedex, France
Arch Pathol Lab Med 127:e229-30. 2003
Weiss system revisited: a clinicopathologic and immunohistochemical study of 49 adrenocortical tumorsSebastien Aubert
Department of Pathology, Faculty of Medicine, Pole Recherche, Rue Michel Polonovski, CHRU 59045 Lille Cedex, France
Am J Surg Pathol 26:1612-9. 2002..98). The MIB-1 labeling index was significantly higher in malignant tumors (p <0.0001). MIB1 could also help to differentiate malignant from benign adrenocortical tumors...
MUC1 expression is correlated with nuclear grade and tumor progression in pT1 renal clear cell carcinomaXavier Leroy
Department of Pathology, University Hospitals, Lille, France
Am J Clin Pathol 118:47-51. 2002..In contrast, patients with 70% or more stained cells had significantly lower metastasis-free survival rates. We conclude that MUC1 is expressed in RCC and is associated with tumor progression in pT1 RCC...
Galectin-3 upregulation during tumor progression in head and neck cancerSven Saussez
Laboratory of Anatomy, University of Mons Hainaut, Mons, Belgium
Laryngoscope 118:1583-90. 2008..To examine the level of expression of galectin-3 in relation to neoplastic progression of hypopharyngeal squamous cell carcinomas (HSCCs) and laryngeal squamous cell carcinomas (LSCCs)...
Low-grade myxoid renal epithelial neoplasms with distal nephron differentiation: a distinct clinicopathologic entity?Xavier Leroy
Hum Pathol 33:574-5; author reply 575-6. 2002
Gastric heterotopia in the nasopharynxAgnes Wacrenier
Department of Pathology, University Hospitals of Lille, Lille Cedex, France
Int J Pediatr Otorhinolaryngol 64:65-7. 2002..This case is the first described in this localisation. A brief review of the literature and histopathologic differential diagnoses will be study...
Dynamic contrast enhanced, pelvic phased array magnetic resonance imaging of localized prostate cancer for predicting tumor volume: correlation with radical prostatectomy findingsArnauld Villers
Department of Urology, Hospital Claude Huriez, Centre Hospitalier Regional Universitaire de Lille, 59037 Lille, France
J Urol 176:2432-7. 2006..We assessed the value of pelvic phased array dynamic contrast enhanced magnetic resonance imaging for predicting the intraprostatic location and volume of clinically localized prostate cancers...
[A pediculated tumor of the nasopharynx]Samia Gonzalez
Service d'Anatomie Pathologique, , , CHRU 59037 Lille
Ann Pathol 26:41-2. 2006
[Is tumour grade applicable to finasteride-treated prostate cancer?]Vincent Molinie
Fondation Hopital Saint Joseph, Paris, France
Prog Urol 15:387-91. 2005....
Renal cell carcinoma associated with tumor thrombus in the inferior vena cava: surgical strategiesLaurent Zini
Service d'Urologie, Lille, France
Ann Vasc Surg 19:522-8. 2005..In patients with level III thrombus, TEE-guided endoluminal occlusion of the unobstructed infradiaphragmatic IVC simplifies surgical management by obviating the need for exposure of the retrohepatic and supradiaphragmatic IVC...
Testicular natural killer T-cell lymphomaCharles Ballereau
Department of Urology, Center Hospitalier Régional Universitaire CHRU de Lille, Lille, France
Int J Urol 12:223-4. 2005..Despite intensive chemotherapy, the disease progressed rapidly, with death occurring 2 months after diagnosis...
Endoluminal occlusion of the inferior vena cava in renal cell carcinoma with retro- or suprahepatic caval thrombusLaurent Zini
Department of Urology, Lille Regional University Teaching Hospital CHRU, Lille, France
BJU Int 97:1216-20. 2006..To evaluate endoluminal occlusion of the inferior vena cava (IVC) during surgical treatment of renal cell carcinoma (RCC) with either retrohepatic (level II) or suprahepatic (level III) caval tumour thrombus...
Relationships between mucinous gastric carcinoma, MUC2 expression and survivalEmmanuelle Leteurtre
INSERM U560, Lille, France
World J Gastroenterol 12:3324-31. 2006....
[Weiss system: a still in-use diagnostic tool for the assessment of adrenocortical malignancy]Sebastien Aubert
Service d Anatomie Pathologique, pôle biologie pathologie, Parc Eurasante, Avenue Oscar Lambret, CHRU, 59037 Lille Cedex
Ann Pathol 25:545-54. 2005..Besides, the Weiss system is of limited value for the diagnosis of malignancy in oxyphil tumors and children tumors of the adrenal cortex...
Cystic renal cell carcinomas in adults. Is preoperative recognition of multilocular cystic renal cell carcinoma possible?Sebastien Aubert
Department of Pathology, University Hospitals, CHRU 59045, Lille, France
J Urol 174:2115-9. 2005..We correlated clinicopathological and imaging features of multilocular cystic renal cell carcinoma (MCRCC) to propose preoperative criteria for therapeutic modalities...
Calretinin: a valuable marker of normal and neoplastic Leydig cells of the testisDavid Augusto
Department of Pathology, University Hospitals, Lille, France
Appl Immunohistochem Mol Morphol 10:159-62. 2002..Seminomatous and nonseminomatous germ cell tumors were negative. Calretinin is an interesting marker of normal and neoplastic Leydig cells of the testis and may be of value in the diagnosis of atypical LCT...
[Primary neuroectodermal tumour of the kidney invading the wall of the inferior vena cava. Surgical strategy]Laurent Zini
Service d Urologie, CHRU Lille, France
Prog Urol 14:544-7. 2004..They describe the surgical management of this tumour and present a review of the literature...
Dendritic cell infiltration in a patient with seminomatous germ cell tumor of the testis: is there a relationship with infertility and tumor stage?Fabien Saint
Department of Urology, CHRU Lille, Lille, France
J Urol 167:1643-7. 2002..We investigated possible associations of antigen expression with dendritic cells, histiocytic cells and seminoma stage as well as with impaired spermatogenesis...
Effects of long-term finasteride treatment on prostate cancer morphology and clinical outcomeMark A Rubin
Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts, USA
Urology 66:930-4. 2005....
[Infertility and testicular tumour based on a series of 25 patients]Olivier Haddad
Service d andrologie, CHRU Lille, France
Prog Urol 15:1096-100. 2005..To evaluate the frequency of testicular tumours in infertile men and to specify their clinical, ultrasound and histological characteristics...
Prostate cancer computer-assisted diagnosis software using dynamic contrast-enhanced MRIPhilippe Puech
INSERM, U703 of Lille, France
Conf Proc IEEE Eng Med Biol Soc 2007:5567-70. 2007..ProCAD is a computer assisted diagnosis (CAD) software dedicated to prostate DCE-MRI analysis...
Pathologic quiz case: A subcutis nodule of the right thoracic wallDavid Augusto
Department of Pathology, Lille University Hospitals, Lille, France
Arch Pathol Lab Med 127:109-10. 2003
Multiple myeloma presenting with widespread osteosclerotic lesionsDenis Mulleman
Department of Rheumatology, Regional University Hospital, 59037 Lille, France
Joint Bone Spine 71:79-83. 2004..Although exceptional, multiple myeloma must be borne in mind in the presence of diffuse bone sclerosis...
[Giant cell tumor of soft tissues. Report of two cases]Soumaya Ech-Charif
Service d'Anatomie Pathologique, CHRU, , Eurasant, Avenue Oscar Lambret, 59037 Lille Cedex
Ann Pathol 26:26-9. 2006..The malignant variant is debatable. The differential diagnosis includes other tumours rich in osteoclast-like cells...
[Cystic prostate cancer: a clinical entity of ductal carcinoma]Laurent Zini
Service d'Urologie, CHRU Lille
Prog Urol 14:411-3. 2004..The cystic appearance of the peripheral prostatic zone appears to be a distinct clinical and morphological entity of ductal carcinomas. This entity has never been previously reported...
