Didier Hober

Summary

Affiliation: CHRU de Lille
Country: France

Publications

  1. ncbi request reprint Enteroviral pathogenesis of type 1 diabetes
    Didier Hober
    Laboratory of Virology EA3610, University Lille 2, Faculty of Medecine, CHRU Lille Institut Hippocrate, Loos Lez Lille, 59120, France
    Discov Med 10:151-60. 2010
  2. pmc Immunology in the clinic review series; focus on type 1 diabetes and viruses: role of antibodies enhancing the infection with Coxsackievirus-B in the pathogenesis of type 1 diabetes
    D Hober
    Universite Lille 2, CHRU Laboratoire de virologie EA3610, Institut Hippocrate CHRU, 152 Rue du Dr Yersin, Loos Lez Lille, France
    Clin Exp Immunol 168:47-51. 2012
  3. doi request reprint Enteroviral pathogenesis of type 1 diabetes: queries and answers
    Didier Hober
    Universite Lille 2, CHRU, Laboratoire de Virologie EA3610, Lille, France
    Curr Opin Infect Dis 26:263-9. 2013
  4. doi request reprint A part of the VP4 capsid protein exhibited by coxsackievirus B4 E2 is the target of antibodies contained in plasma from patients with type 1 diabetes
    Pierre Sauter
    Laboratoire de virologie UPRES EA3610, Faculté de Médecine Université Lille 2, CHRU Lille, Lille, France
    J Med Virol 80:866-78. 2008
  5. doi request reprint Enteroviruses and type 1 diabetes: towards a better understanding of the relationship
    Hela Jaïdane
    Laboratoire de Virologie EA3610 Pathogenèse Virale du Diabète de Type 1, Faculte de Medecine, Université de Lille Nord de France, CHRU Lille, Centre de Biologie et Pathologie et Parc Eurasanté, Lille Cedex, France
    Rev Med Virol 20:265-80. 2010
  6. doi request reprint Infection of primary cultures of murine splenic and thymic cells with coxsackievirus B4
    Hela Jaïdane
    Virology Laboratory UPRES EA3610, Faculty of Medicine, University of Lille 2, Bâtiment Paul Boulanger, CHRU Lille, 59037 Lille, France
    Microbiol Immunol 52:40-6. 2008
  7. doi request reprint Prolonged viral RNA detection in the central nervous system of one-week-old Swiss albino mice following coxsackievirus B4 and echovirus 9 infection
    Raïda El Hiar
    Laboratoire de Virologie EA3610, Universite Lille 2, Faculte de Medecine, CHRU Lille, Lille, France
    Intervirology 55:435-41. 2012
  8. doi request reprint Higher levels of hepatitis C virus RNA found in blood donors co-infected with HIV as compared to HCV mono-infected donors
    Enagnon Kazali Alidjinou
    Universite Lille 2, Faculte de Medecine, CHRU Lille, Laboratoire de Virologie EA3610, Loos lez Lille 59120, France
    J Infect Dev Ctries 8:1068-71. 2014
  9. doi request reprint Inactivation of coxsackievirus B4, feline calicivirus and herpes simplex virus type 1: unexpected virucidal effect of a disinfectant on a non-enveloped virus applied onto a surface
    Thomas Thevenin
    University Lille 2, Faculty of Medicine, CHRU Lille Laboratory of Virology EA3610, Lille, France
    Intervirology 56:224-30. 2013
  10. ncbi request reprint Specificity of the coxsackievirus B4 VP4 capsid protein investigated in silico
    Anne Goffard
    College of Pharmacy, Universite Lille Nord de France, Lille Cedex, France
    Discov Med 12:153-8. 2011

Collaborators

Detail Information

Publications30

  1. ncbi request reprint Enteroviral pathogenesis of type 1 diabetes
    Didier Hober
    Laboratory of Virology EA3610, University Lille 2, Faculty of Medecine, CHRU Lille Institut Hippocrate, Loos Lez Lille, 59120, France
    Discov Med 10:151-60. 2010
    ..In this review, arguments in favor of a relationship between enterovirus infections and T1D and the mechanisms of the enteroviral pathogenesis of the disease are presented...
  2. pmc Immunology in the clinic review series; focus on type 1 diabetes and viruses: role of antibodies enhancing the infection with Coxsackievirus-B in the pathogenesis of type 1 diabetes
    D Hober
    Universite Lille 2, CHRU Laboratoire de virologie EA3610, Institut Hippocrate CHRU, 152 Rue du Dr Yersin, Loos Lez Lille, France
    Clin Exp Immunol 168:47-51. 2012
    ..Whether enhancing antibodies raised against VP4 can play a role in iterative homologous and/or heterologous CV-B infections and in the persistence of viruses within the host deserves further study...
  3. doi request reprint Enteroviral pathogenesis of type 1 diabetes: queries and answers
    Didier Hober
    Universite Lille 2, CHRU, Laboratoire de Virologie EA3610, Lille, France
    Curr Opin Infect Dis 26:263-9. 2013
    ..Epidemiological and experimental data strongly suggest a role for enteroviruses in the development of T1D, but a lot of controversies and unanswered questions remained. This review focuses on issues that are fueling debate...
  4. doi request reprint A part of the VP4 capsid protein exhibited by coxsackievirus B4 E2 is the target of antibodies contained in plasma from patients with type 1 diabetes
    Pierre Sauter
    Laboratoire de virologie UPRES EA3610, Faculté de Médecine Université Lille 2, CHRU Lille, Lille, France
    J Med Virol 80:866-78. 2008
    ....
  5. doi request reprint Enteroviruses and type 1 diabetes: towards a better understanding of the relationship
    Hela Jaïdane
    Laboratoire de Virologie EA3610 Pathogenèse Virale du Diabète de Type 1, Faculte de Medecine, Université de Lille Nord de France, CHRU Lille, Centre de Biologie et Pathologie et Parc Eurasanté, Lille Cedex, France
    Rev Med Virol 20:265-80. 2010
    ..All of the plausible mechanisms by which enterovirus may be related to T1D will be reviewed here...
  6. doi request reprint Infection of primary cultures of murine splenic and thymic cells with coxsackievirus B4
    Hela Jaïdane
    Virology Laboratory UPRES EA3610, Faculty of Medicine, University of Lille 2, Bâtiment Paul Boulanger, CHRU Lille, 59037 Lille, France
    Microbiol Immunol 52:40-6. 2008
    ..Together these results suggest that infection of splenic and thymic cells can play a role in virus dissemination, and therefore in the pathophysiology of CVB4 infections...
  7. doi request reprint Prolonged viral RNA detection in the central nervous system of one-week-old Swiss albino mice following coxsackievirus B4 and echovirus 9 infection
    Raïda El Hiar
    Laboratoire de Virologie EA3610, Universite Lille 2, Faculte de Medecine, CHRU Lille, Lille, France
    Intervirology 55:435-41. 2012
    ..The mechanisms of virus spreading in the CNS are poorly understood. In the present study, we investigated CV-B4 and E-9 spreading and neurotropism within intraperitoneally inoculated one-week-old Swiss albino mice...
  8. doi request reprint Higher levels of hepatitis C virus RNA found in blood donors co-infected with HIV as compared to HCV mono-infected donors
    Enagnon Kazali Alidjinou
    Universite Lille 2, Faculte de Medecine, CHRU Lille, Laboratoire de Virologie EA3610, Loos lez Lille 59120, France
    J Infect Dev Ctries 8:1068-71. 2014
    ..HIV infection could impact the characteristics of HCV infection in co-infected people. We investigated HCV-HIV co-infection among blood donors in Congo...
  9. doi request reprint Inactivation of coxsackievirus B4, feline calicivirus and herpes simplex virus type 1: unexpected virucidal effect of a disinfectant on a non-enveloped virus applied onto a surface
    Thomas Thevenin
    University Lille 2, Faculty of Medicine, CHRU Lille Laboratory of Virology EA3610, Lille, France
    Intervirology 56:224-30. 2013
    ..To evaluate the effect of a disinfectant onto viruses in suspension on the one hand and applied onto a surface on the other...
  10. ncbi request reprint Specificity of the coxsackievirus B4 VP4 capsid protein investigated in silico
    Anne Goffard
    College of Pharmacy, Universite Lille Nord de France, Lille Cedex, France
    Discov Med 12:153-8. 2011
    ..3% and 9.9%, respectively). In conclusion, the bioinformatic analysis suggests that the region 16-24 of the VP4 capsid protein is the feature of the specificity of the target of infection-enhancing antibodies directed towards CV-B...
  11. ncbi request reprint Enterovirus persistence as a mechanism in the pathogenesis of type 1 diabetes
    Enagnon Kazali Alidjinou
    Universite Lille 2, Faculte de Medecine, CHRU de Lille, Laboratoire de Virologie EA3610, Lille, France
    Discov Med 18:273-82. 2014
    ..The molecular and cellular mechanisms of CVB persistence and the link with the development of T1D should be investigated further. ..
  12. doi request reprint Serum-dependent enhancement of coxsackievirus B4-induced production of IFNα, IL-6 and TNFα by peripheral blood mononuclear cells
    Enagnon Kazali Alidjinou
    Universite Lille 2, Faculte de Medecine, CHRU, Laboratoire de Virologie EA3610, Loos lez Lille 59120, France
    J Mol Biol 425:5020-31. 2013
    ..High levels of IFNα, in addition to TNFα and IL-6, in culture supernatants were obtained when infectious CVB4 was combined with immune serum or IgG, and they were associated with high amounts of intracellular viral RNA. ..
  13. doi request reprint Pathogenesis of type 1 diabetes mellitus: interplay between enterovirus and host
    Didier Hober
    Laboratoire de Virologie EA3610 Pathogenèse Virale du Diabète de Type 1, Faculte de Medecine, Universite Lille 2, CHRU Lille, Centre de Biologie et Pathologie et Institut Hippocrate Parc Eurasanté, Boulevard du Prof J Leclercq, 59037 Lille Cedex, France
    Nat Rev Endocrinol 6:279-89. 2010
    ..An increased activity of the IFIH1 protein may promote the development of T1DM. An improved knowledge of the pathogenic mechanisms of enterovirus infections should help to uncover preventive strategies for T1DM...
  14. doi request reprint Detection of enterovirus RNA in postoperative thyroid tissue specimens
    Rachel Desailloud
    Laboratoire de Virologie UPRES EA3610 Faculté de Médecine, Universite Lille 2, CHRU Lille, Lille, France
    Clin Endocrinol (Oxf) 70:331-4. 2009
    ..A genetic predisposition and environmental factors such as viruses are thought to contribute to the development of autoimmune thyroiditis. Enteroviruses, which are involved in other autoimmune diseases, are attractive candidates...
  15. ncbi request reprint Circulating and cell-bound antibodies increase coxsackievirus B4-induced production of IFN-alpha by peripheral blood mononuclear cells from patients with type 1 diabetes
    Didier Hober
    Laboratory of Virology, UPRES EA Viral Pathogenesis of Diabetes Type 1, University Hospital, and University Lille 2, 59037 Lille, France
    J Gen Virol 83:2169-76. 2002
    ..These studies demonstrate that CVB4, through interactions with circulating and/or cell-bound IgGs, can strongly induce the production of IFN-alpha by PBMCs from patients with type 1 diabetes...
  16. doi request reprint Persistent infection of human pancreatic cells with Coxsackievirus B4 is cured by fluoxetine
    Enagnon Kazali Alidjinou
    Universite Lille 2, Faculte de Medecine, CHRU de Lille, Laboratoire de Virologie EA3610, Lille, France
    Antiviral Res 116:51-4. 2015
    ..These data display that fluoxetine can inhibit the replication of CVB4 and can cure Panc-1 cells chronically infected with CVB4. ..
  17. pmc Viruses contained in droplets applied on warmed surface are rapidly inactivated
    Swan Firquet
    Universite Lille 2, Faculte de Medecine, CHRU Lille, Laboratoire de Virologie EA3610
    Microbes Environ 29:408-12. 2014
    ..It appears that heating can have an unexpected faster virucidal effect than previously described...
  18. doi request reprint Coxsackievirus B4 can infect human pancreas ductal cells and persist in ductal-like cell cultures which results in inhibition of Pdx1 expression and disturbed formation of islet-like cell aggregates
    Famara Sane
    Laboratoire de Virologie EA3610, Universite Lille 2, Faculte de Medecine, CHRU, 59120, Loos Lez Lille, France
    Cell Mol Life Sci 70:4169-80. 2013
    ..These data support the hypothesis of an impact of enteroviruses onto pancreatic ductal cells which are involved in the renewal of pancreatic β-cells...
  19. pmc Inactivation of an enterovirus by airborne disinfectants
    Thomas Thevenin
    Laboratory of Virology EA3610, University Lille 2, Faculty of Medecine, CHRU Lille, Institut Hippocrate, 152 Rue du Dr Yersin, Loos Lez Lille, 59120, France
    BMC Infect Dis 13:177. 2013
    ..The activity of airborne disinfectants on bacteria, fungi and spores has been reported. However, the issue of the virucidal effect of disinfectants spread by fogging has not been studied thoroughly...
  20. pmc Persistent infection of thymic epithelial cells with coxsackievirus B4 results in decreased expression of type 2 insulin-like growth factor
    Hela Jaïdane
    Universite Lille 2, Faculte de Medecine, CHRU, Laboratoire de Virologie EA3610, Loos Lez Lille, France
    J Virol 86:11151-62. 2012
    ..Thus, a persistent infection of a thymic epithelial cell line with enteroviruses like CV-B4 E2 can result in a disturbed production of IGF-2, a protein involved in central self-tolerance toward islet β cells...
  21. ncbi request reprint Role of the capsid protein VP4 in the plasma-dependent enhancement of the Coxsackievirus B4E2-infection of human peripheral blood cells
    Pierre Sauter
    Service de Virologie UPRES EA3610, Faculté de Médecine Université Lille 2, Bâtiment Paul Boulanger, CHRU Lille, 59037 Lille, France
    Virus Res 125:183-90. 2007
    ..Together our results show that VP4 and anti-VP4 antibodies play a role in the plasma-dependent enhancement of CVB4E2 infection of PBMC...
  22. pmc New Insights into the Understanding of Hepatitis C Virus Entry and Cell-to-Cell Transmission by Using the Ionophore Monensin A
    Lucie Fénéant
    Molecular and Cellular Virology Laboratory, Center for Infection and Immunity of Lille, University Lille Nord de France, CNRS UMR8204, Inserm U1019, Pasteur Institute of Lille, Lille, France
    J Virol 89:8346-64. 2015
    ..Thus, HVR1 and ApoE are critical regulators of HCV propagation...
  23. doi request reprint Diagnosis of viral infections using myxovirus resistance protein A (MxA)
    Ilka Engelmann
    Universite de Lille 2, Faculte de Medecine, Centre Hospitalier Regional Universitaire de Lille, Laboratoire de Virologie EA3610, Lille, France
    Pediatrics 135:e985-93. 2015
    ..Myxoma resistance protein 1 (MxA) is induced during viral infections. MxA testing could be helpful to differentiate between viral and bacterial infections...
  24. doi request reprint Detection of hepatitis B virus infection markers in dried plasma spots among patients in Congo-Brazzaville
    Enagnon Kazali Alidjinou
    Universite Lille 2, Faculte de Medecine, CHRU Lille, Laboratoire de Virologie EA3610, Lille, France
    Diagn Microbiol Infect Dis 78:229-31. 2014
    ..Dried plasma samples can represent an alternative to conventional sampling for HBV detection and management of the infection in developing countries. ..
  25. ncbi request reprint Mechanisms and results of the antibody-dependent enhancement of viral infections and role in the pathogenesis of coxsackievirus B-induced diseases
    Pierre Sauter
    Laboratoire de virologie UPRES EA3610, Faculte de Medecine, Universite Lille 2, CHRU de Lille, Centre de Biologie et Parc Eurasanté, Lille 59037, France
    Microbes Infect 11:443-51. 2009
    ..The ADE of coxsackievirus B infection can also be implied in the pathogenesis of diseases like chronic dilated cardiomyopathy or insulin-dependent type 1 diabetes...
  26. doi request reprint (-)-Epigallocatechin-3-gallate is a new inhibitor of hepatitis C virus entry
    Noémie Calland
    Institut Pasteur de Lille, Center for Infection and Immunity of Lille CIIL, Lille, France
    Hepatology 55:720-9. 2012
    ..Finally, by successive inoculation of naïve cells with supernatant of HCV-infected cells in the presence of EGCG, we observed that EGCG leads to undetectable levels of infection after four passages...
  27. doi request reprint Group B coxsackieviruses and autoimmunity: focus on Type 1 diabetes
    Famara Sane
    Laboratory of Virology EA3610, University Lille 2, Faculty of Medecine, CHRU Lille, 59037 Lille, France
    Expert Rev Clin Immunol 7:357-66. 2011
    ..The role of CVB in autoimmunity is complex, and therefore a better understanding of the inducer versus protective effects of these viruses in T1D will help to design new strategies to treat and prevent the disease...
  28. doi request reprint Persistent infection of a carcinoma thyroid cell line with coxsackievirus B
    Rachel Desailloud
    Laboratoire de Virologie UPRES EA3610 Faculté de Médecine, Centre de Biologie Pathologie et Parc Eurasanté, Universite Lille 2, CHRU Lille, Lille, France
    Thyroid 19:369-74. 2009
    ..Recently, we found that EV RNA could be detected in postoperative thyroid specimens. We decided to investigate the infection of a human thyroid cell line with coxsackievirus B4 (CVB4)...
  29. pmc Viruses and thyroiditis: an update
    Rachel Desailloud
    Laboratoire de Virologie UPRES EA3610 Faculté de Médecine, Universite Lille 2, CHRU Lille, Centre de Biologie Pathologie et Parc Eurasanté, 59037 Lille, France
    Virol J 6:5. 2009
    ..Further studies are needed to clarify the relationship between viruses and thyroid diseases, in order to develop new strategies for prevention and/or treatment...
  30. ncbi request reprint Prolonged viral RNA detection in blood and lymphoid tissues from coxsackievirus B4 E2 orally-inoculated Swiss mice
    Hela Jaïdane
    Service de Virologie UPRES EA3610, Faculte de Medecine, Universite Lille 2, Bâtiment Paul Boulanger, CHRU Lille, Lille, France
    Microbiol Immunol 50:971-4. 2006
    ..i. and further in other organ tissues...