T Facon

..These new and emerging therapies provide multiple effective treatment options for MM patients and greatly enhanced treatment strategies for clinicians, all offering promise that has been sorely lacking over the past four decades...

..Bortezomib should be considered an appropriate treatment for elderly and high-risk patients with relapsed multiple myeloma...

..Additionally, the important issue of maintenance treatment needs to be further investigated, especially in elderly patients...

..We assessed whether the addition of thalidomide to this combination, or reduced-intensity stem cell transplantation, would improve survival...

..5 mg/L or higher. Routine FISH Delta13 assessment is strongly recommended for patients considered for HDT...

..These results might be useful in the context of future combinations with innovative drugs...

..These data enable us to elaborate a plasma cell oncogenesis model from MGUS to MM...

..This randomized, placebo-controlled, phase III trial investigated the efficacy of melphalan and prednisone plus thalidomide in patients older than 75 years with newly diagnosed myeloma...

..4). Thalidomide is an effective maintenance therapy in patients with multiple myeloma. Maintenance treatment with pamidronate does not decrease the incidence of bone events...

..In addition, further studies are needed to determine the optimal thalidomide dose and duration...

..Above all, therapeutic progress has been made thanks to thalidomide, bortezomib and lenalidomide, even if the optimal utilisation of these molecules is still to be determined...

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..Serial analyses of individuals with MGUS will be needed to validate this model...

..p15(INK4b) and p16(INK4a) gene methylation might contribute to immortalization of plasma cells rather than malignant transformation in the natural history of MM...

..Patients presenting with either t(4;14) or del(17p) are known to have a short event-free survival (EFS) and overall survival (OS). Some preliminary data suggest that bortezomib is able to overcome these prognostic parameters...

..We report on our experience with 13 cases of jaw osteonecrosis in patients treated with amino-bisphosphonates...

..However, only a minority of patients treated with imatinib have a complete molecular remission...

..The IMiDs, which mechanism is based on stimulation of T lymphopoiesis rather than inhibition of tumour necrosis factor-alpha, are under clinical trials in multiple myeloma with interesting results...

..In this series, we demonstrated that a proliferation marker provides clear-cut additional survival prognostic information to b2m into the ISS model...

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..0001), but not with deletion of chromosome 13. This study emphasises the relationship between PCIN, an easy-to-ascertain marker of intrinsic malignancy of the tumour process, and adverse prognosis...

..0001). HLA-Is is a new marker of multiple myeloma tumor load and provides additional survival prognostic information to beta2-microglobulin...

..Implication of monosomy 13 (Delta13) is unclear in monoclonal gammopathy of undetermined significance (MGUS), and data on DNA content of plasma cells [DNA index (DI)] are rare...

..The aim of this study was to determine the outcome of patients with LGL treated with RIC allogeneic SCT...

..These data confirm the activity of bortezomib and support extended treatment in relapsed multiple myeloma patients tolerating therapy...

..We conducted a randomized trial of the treatment of multiple myeloma with high-dose chemotherapy followed by either one or two successive autologous stem-cell transplantations...

..Changes were comparable to those with pamidronate. AMGN-0007 was well tolerated...

..This phase 3, placebo-controlled trial investigated the efficacy of lenalidomide plus dexamethasone in the treatment of relapsed or refractory multiple myeloma...

..These data emphasized the interest in analyzing these two translocations by fluorescence in situ hybridization in prospective therapeutic trials in order to consider these translocations as distinct entities...

..Future studies will define the most effective or the best sequence of combinations which could improve life expectancy...

..This is the first double-blind, randomized, placebo-controlled study to assess the efficacy of ibandronate, a third-generation amino-bisphosphonate, in preventing SREs in advanced-stage multiple myeloma patients...

..This regimen should be considered as the standard of care before autologous stem cell transplantation in multiple myeloma...

..Studies are currently underway in an attempt to answer this issue...

..In myeloma, the genomic aberrations t(4;14) and del(17p), together with beta2-microglobulin level, are important independent predictors of survival. These findings have implications for the design of risk-adapted treatment strategies...

..Denosumab (AMG 162), a fully human monoclonal antibody to RANKL, was developed to treat patients with skeletal diseases...

..This study compared bortezomib with high-dose dexamethasone in patients with relapsed multiple myeloma who had received one to three previous therapies...

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..The results of allogeneic SCT remain disappointing due to a high transplant mortality. Strategies combining ASCT and reduced-intensity allogeneic SCT are currently being studied...

..The aim of this subset analysis was to determine if bortezomib treatment is associated with increased incidence of varicella-zoster virus (VZV) reactivation in patients with relapsed multiple myeloma (MM)...

..The strong correlations we found might be the basis for a novel genetic classification of MM, as has been previously demonstrated for leukemias and lymphomas. Furthermore, our study supports different models for MM oncogenesis...

..This study demonstrates that sFLC is a new marker in WM disease. Further analysis is required to prospectively study the role of sFLC in monitoring response to therapy and as a prognostic marker in WM patients...

..An abnormal karyotype and a bone marrow (BM) plasmacytosis > 15% were found to be adverse prognostic factors for progression in univariate and multivariate analysis...

..Indeed, urinary markers of bone resorption can easily be measured at diagnosis and have independent prognostic significance to refine the prognosis of MM patients...

..Preliminary results are encouraging. However, a long follow-up is required before concluding that these strategies will overcome cell resistance...

..We concluded that the combination was safe and promising given the rates of response...

..HLA-G rather through its soluble isoform might provide a new way of immune evasion for lymphoid proliferations...

..Further studies with bortezomib as monotherapy and in combination regimens in the treatment of solid and hematologic malignancies are warranted...

..Future studies will be needed to address modified dosing according to emerging pharmacokinetic and pharmacodynamic data and combination therapy which may lead to improved clinical benefit for troxacitabine in hematologic malignancies...