Affiliation: CHRU de Lille
- Influence of internal globus pallidus stimulation on motor cortex activation pattern in Parkinson's diseaseD Devos
Department of Neurology, , Clinique Neurologique, CHRU, 59037 Lille Cedex, France
Clin Neurophysiol 113:1110-20. 2002..The motor cortex activation improvement under stimulation with L-Dopa concerned both the movement preparation and execution but remained very localised to the contralateral motor cortex...
- New syndromic form of benign hereditary chorea is associated with a deletion of TITF-1 and PAX-9 contiguous genesDavid Devos
Department of Neurology, EA 2683 MENRT, Lille, France
Mov Disord 21:2237-40. 2006..Associated signs, sometimes of slight expression, remain of high interest for the clinical and genetic diagnosis of benign hereditary chorea...
- Effect of deep brain stimulation and L-Dopa on electrocortical rhythms related to movement in Parkinson's diseaseD Devos
Department of Neurology and Movement Disorders, EA2683, IFR114, CHRU of Lille, Lille, France
Prog Brain Res 159:331-49. 2006..This mechanism could be involved at the basal ganglia level in the sensorimotor integration implicated in the movement control...
- Predominance of the contralateral movement-related activity in the subthalamo-cortical loopD Devos
Department of Neurology, EA2683, IFR114, Lille University Medical Centre, Hopital R Salengro, Clinique Neurologique, CHRU, F 59037 Lille Cedex, France
Clin Neurophysiol 117:2315-27. 2006..We aimed to study how low- and high-frequency oscillatory activities are modulated by movement in the contralateral and ipsilateral subcorticocortical loops...
- Comparison of desipramine and citalopram treatments for depression in Parkinson's disease: a double-blind, randomized, placebo-controlled studyDavid Devos
Department of Neurology, IFR114, Institute of Predictive Medicine and Therapeutic Research, Lille University Hospital, Lille, France
Mov Disord 23:850-7. 2008..A predominantly noradrenergic tricyclic antidepressant induced a more intense short-term effect on parkinsonian depression than did an SSRI. However, desipramine's lower tolerability may outweigh its slight short-term clinical advantage...
- [Pathophysiological mechanisms implicated by high-frequency stimulation in Parkinson's disease: the restoration of high and low frequency oscillatory systems]D Devos
Service de Neurologie et Pathologie du Mouvement, Centre Hospitalier Universitaire, Lille
Rev Neurol (Paris) 161:1029-43. 2005....
- ERG and anatomical abnormalities suggesting retinopathy in dementia with Lewy bodiesD Devos
Service de Neurologie et Pathologie du Mouvement, EA2683, MENRT, Centre Hospitalier Universitaire de Lille, France
Neurology 65:1107-10. 2005..The retinal dysfunction may be related to slight alteration of the photoreceptors and numerous pale inclusions in the outer plexiform layer found at the post mortem examination, suggesting a specific retinopathy...
- Patient profile, indications, efficacy and safety of duodenal levodopa infusion in advanced Parkinson's diseaseDavid Devos
Department of Neurology, EA2683 IFR114 IMPRT, Hopital R Salengro, CHU Lille, France
Mov Disord 24:993-1000. 2009..Technical problems were commonplace. Duodenal levodopa infusion seems to be an effective last-line therapy for motor complications in Parkinson's disease. Hence, technical improvements and earlier introduction should be considered...
- Subthalamic nucleus stimulation modulates motor cortex oscillatory activity in Parkinson's diseaseD Devos
Department of Neurology, Lille University Medical Center, France
Brain 127:408-19. 2004....
- Effect of L-Dopa on the pattern of movement-related (de)synchronisation in advanced Parkinson's diseaseD Devos
Department of Neurology, EA2683, Lille University Medical Centre, Lille, France
Neurophysiol Clin 33:203-12. 2003..L-Dopa partially restored the abnormal mu and beta rhythm cortical (de)synchronisation patterns over the PSM cortex...
- Subthalamic stimulation influences postmovement cortical somatosensory processing in Parkinson's diseaseD Devos
Department of Neurology, EA2683, Lille University Medical Centre, France
Eur J Neurosci 18:1884-8. 2003..They may improve bradykinesia and cortical deactivation by reestablishing movement-related somatosensory processing at the end of the movement through the basal ganglia into the cortex...
- Heart rate variability and Parkinson's disease severityD Devos
Department of Neurology, EA 2683, CHU Lille, France
J Neural Transm 110:997-1011. 2003..The low LF despite the higher motor activity in group III, due to dyskinesias, suggested a defective cardiovascular up-regulation...
- [Pharmacological hypotheses and therapeutic strategies for gait disorders in Parkinson's disease]D Devos
Service de Neurologie et Pathologie du Mouvement, Clinique Neurologique, Hopital Roger Salengro, EA2683, IMPRT, IFR 114, faculté de médecine Lille 2, CHU de Lille, 59037 Lille Cedex, France
Rev Neurol (Paris) 166:168-77. 2010....
- Dopaminergic and non-dopaminergic pharmacological hypotheses for gait disorders in Parkinson's diseaseDavid Devos
Department of Neurology and Movement Disorders, EA2683, IMPRT, IFR 114, Faculty of Medicine Lille 2, University of Lille Nord de France, Lille University Hospital, Lille, France
Fundam Clin Pharmacol 24:407-21. 2010..The goal of this review is to develop the various pathophysiological hypotheses published to date, in order to underpin and justify ongoing fundamental research and clinical trials in this disease area...
- Improvement of gait by chronic, high doses of methylphenidate in patients with advanced Parkinson's diseaseD Devos
Department of Neurology, Institute of Predictive Medicine and Therapeutic Research, Lille University Medical Centre, Lille, France
J Neurol Neurosurg Psychiatry 78:470-5. 2007..Gait disorders could also be partly related to norepinephrine system impairment, and the pharmacological modulation of both dopamine and norepinephrine pathways could potentially improve the symptomatology...
- Deficient "sensory" beta synchronization in Parkinson's diseaseA Degardin
Department of Neurology, EA2683, Lille University Hospital, France
Clin Neurophysiol 120:636-42. 2009....
- Elevated IL-6 and TNF-alpha levels in patients with ALS: inflammation or hypoxia?C Moreau
Department of Neurology, INSERM, Pasteur Institute of Lille, University Hospital, Lille, France
Neurology 65:1958-60. 2005..Elevated IL-6 levels in ALS could correspond to a normal response to hypoxemia...
- [Continuous dopaminergic stimulation by Duodopa in advanced Parkinson's disease: Efficacy and safety]A Annic
EA, IFR, Hopital Roger Salengro, Centre Hospitalier et Universitaire de Lille, France
Rev Neurol (Paris) 165:718-27. 2009..Continuous intraduodenal infusion of levodopa (Duodopa) via a gastrojejunal tube may be proposed at this stage of the disease and the study of indications and clinical results with Duodopa may develop this new therapeutic alternative...
- Reduced levodopa-induced complications after 5 years of subthalamic stimulation in Parkinson's disease: a second honeymoonClemence Simonin
Department of Neurology and Movement Disorders, Salengro Hospital, EA 2683, Lille University Medical Center, Lille, France
J Neurol 256:1736-41. 2009..Our results suggest that DBS leads to both qualitative and quantitative modulations in the corticostriatal loops...
- High erythropoietin and low vascular endothelial growth factor levels in cerebrospinal fluid from hypoxemic ALS patients suggest an abnormal response to hypoxiaN Just
Department of Pneumology, A Calmette Hospital, Lille University Medical Centre, France
Neuromuscul Disord 17:169-73. 2007..The high EPO levels in hypoxemic ALS patients nevertheless suggest an intact common oxygen-sensor pathway...
- [Mechanisms of deregulated response to hypoxia in sporadic amyotrophic lateral sclerosis: a clinical study]C Moreau
Service de Neurologie et Pathologie du Mouvement, Hopital Roger Salengro, CHRU de Lille, 59037 Lille Cedex, France
Rev Neurol (Paris) 166:279-83. 2010..Inflammatory mediators were strongly elevated, since the early stage of the disease until chronic hypoxemia, suggesting a compensatory mechanism...
- STN-DBS frequency effects on freezing of gait in advanced Parkinson diseaseC Moreau
Clinique Neurologique, Hopital R Salengro, CHU, F 59037 Lille Cedex, France
Neurology 71:80-4. 2008..However, there are no long-term data on the management of gait disorders and freezing in STN-DBS...
- Paradoxical response of VEGF expression to hypoxia in CSF of patients with ALSC Moreau
ALS Center, Department of Neurology, MENRT, France
J Neurol Neurosurg Psychiatry 77:255-7. 2006..There was a negative correlation between VEGF levels and the severity of hypoxaemia in patients with ALS, suggesting deregulation of VEGF in ALS...
- Deregulation of the hypoxia inducible factor-1α pathway in monocytes from sporadic amyotrophic lateral sclerosis patientsC Moreau
Neurology Department, ALS Center, PRES Nord de France, University of Lille 2, Lille University Hospital, Lille, France
Neuroscience 172:110-7. 2011..For the first time, we have demonstrated clinical and functional abnormalities in the HIF-1 pathway during hypoxia in monocytes from sporadic ALS patients...
- Motor preparation is more impaired in Parkinson's disease when sensorimotor integration is involvedE Labyt
Department of Clinical Neurophysiology, EA2683 MENRT, R. Salengro Hospital, University Medical Center, 59037 Lille Cedex, France
Clin Neurophysiol 114:2423-33. 2003..CONCLUSIONS: These results confirm the fact that motor programming is delayed, and provide some insight into what may well be impaired sensorimotor integration in Parkinson's disease...
- The prevalence of Sjögren syndrome in patients with primary progressive multiple sclerosisJ de Seze
Department of Neurology, CHRU de Lille, France
Neurology 57:1359-63. 2001..To assess the prevalence of Sjögren syndrome (SS) in patients with primary progressive MS (PPMS)...
- Autonomic dysfunction in multiple sclerosis: cervical spinal cord atrophy correlatesJ de Seze
Department of Neurology, Hopital R Salengro, CHRU de Lille, 59037 Lille, France
J Neurol 248:297-303. 2001..Furthermore, AD appears to be more closely related to axonal loss, as demonstrated by spinal cord atrophy, than to demyelinating lesions...
- Brief and sustained movements: differences in event-related (de)synchronization (ERD/ERS) patternsF Cassim
Department of Clinical Neurophysiology, Hopital Salengro, CHU, 59037 cedex, Lille, France
Clin Neurophysiol 111:2032-9. 2000..synchronization (ERD/ERS) patterns when the movement is sustained? (2) To determine, from a technical point of view for ERD calculation, if it is possible to take the reference period during muscular activation?..
- Clinical features and genetic analysis of a new form of spinocerebellar ataxiaD Devos
Clinique Neurologique, UF de Neurobiologie, Hopital R Salengro, CHRU, Lille, France
Neurology 56:234-8. 2001..The growing heterogeneity of the autosomal dominant forms of these diseases shows that the genetic etiologies of at least 20% of ADCA have yet to be elucidated...
- A specific clinical pattern of camptocormia in Parkinson's diseaseA-C Lepoutre
Department of Neurology, EA2683, IFR 114, Lille University Medical Centre, Lille, France
J Neurol Neurosurg Psychiatry 77:1229-34. 2006..CONCLUSION: The screening and early management of camptocormia in Parkinson's disease is likely to be important for preventing axial disorders and spinal deformations...
- Slowly progressive spinocerebellar ataxia with extrapyramidal signs and mild cognitive impairment (SCA21)J Delplanque
INSERM U837, Jean Pierre Aubert Research Center, Lille, France
Cerebellum 7:179-83. 2008..Therefore, the gene responsible for SCA21 remains to be identified...
- [Systemic lupus erythematosus presenting with recurrent psychiatric disturbances]C Simonin
Service de Neurologie et Pathologie du Mouvement, Clinique Neurologique
Rev Neurol (Paris) 160:811-6. 2004..Considering the prominence and severity of these behavior disorders, systemic diseases may often be misdiagnosed...
- Progressive MRI abnormalities in late recurrence of Sydenham's choreaC Moreau
, Clinique Neurologique, CHRU, 59037 Lille Cedex, France
J Neurol 252:1341-4. 2005..Since SC is considered to be an autoimmune disease, the progressive MRI abnormalities suggest that certain circumstances may trigger the reactivation of persistent immune disorders...
- [A case of neuropathy mimicking Guillain-BarrÃ© syndrome after arsenic intoxication]M-P Perriol
Neurologie et Pathologie du Mouvement, Clinique Neurologique, EA 2683, CHRU, Lille
Rev Neurol (Paris) 162:374-7. 2006..Moreover, the chelating is not very effective on the neurological complications...
- Study of circadian melatonin secretion pattern at different stages of Parkinson's diseaseR Bordet
Service de Pharmacologie Hospitaliere, Laboratoire de Pharmacologie, Faculte de Medecine, 1 place de Verdun, 59045 Lille Cedex, France
Clin Neuropharmacol 26:65-72. 2003..Despite the lack of a global desynchronization in other circadian biologic rhythms, the circadian secretion pattern of melatonin is modified in patients with LDRMCs...
- Differential susceptibility to the PPAR-γ agonist pioglitazone in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 6-hydroxydopamine rodent models of Parkinson's diseaseC Laloux
EA1046 Département de Pharmacologie Médicale, IMPRT, Universite Lille Nord de France, Faculté de Médecine Pôle Recherche, CHRU, 1 place de Verdun, F 59045 Lille Cedex, France
Pharmacol Res 65:514-22. 2012..This work supports PPAR-agonists to be relevant in the therapeutic strategy research in Parkinson's disease and highlights the importance in evaluating neuroprotective agent in different models...
- Low levels of the vascular endothelial growth factor in CSF from early ALS patientsD Devos
Department of Neurology, R Salengro Hospital, Lille, France
Neurology 62:2127-9. 2004..This finding early in ALS patients suggests a possible role for VEGF gene regulation in the pathogenesis of ALS...
- Alpha-fodrin autoantibodies in the differential diagnosis of MS and SjÃ¶gren syndromeJ de Seze
Department of Neurology, University of Lille, France
Neurology 61:268-9. 2003
- Fluid-attenuated inversion recovery (FLAIR) sequences for the assessment of acute stroke: inter observer and inter technique reproducibilityJean Yves Gauvrit
Service de Neuroradiologie, Hopital Roger Salengro, Rue Emile Laine, 59037, Lille Cedex, France
J Neurol 253:631-5. 2006..The aim of this study was to evaluate interobserver and intertechnique reproducibility of Fluid-Attenuated Inversion Recovery (FLAIR) sequences for the diagnosis of early brain ischemia and arterial occlusion...
- Characteristics of apathy in Parkinson's diseaseKathy Dujardin
Neurology and Movement Disorders Unit, EA2683, Faculty of Medicine and Lille University Hospital, Lille, France
Mov Disord 22:778-84. 2007..Although the neurochemical substrate of apathy remains poorly characterized, the strong link between apathy and cognitive impairment observed in several studies suggests the participation of nondopaminergic circuits...
- Relationship between oscillations in the basal ganglia and synchronization of cortical activityFrancois Cassim
Service de Neurophysiologie Clinique, Hopital Roger Salengro, CHRU de Lille, 59037 Lille Cedex, France
Epileptic Disord 4:S31-45. 2002..Studies of cortical reactivity related to planning of voluntary movement in parkinsonian patients provide evidence that it is possible to influence cortical reactivity through the basal ganglia system...
- Exhaustive, one-year follow-up of subthalamic nucleus deep brain stimulation in a large, single-center cohort of parkinsonian patientsMelissa Tir
Department of Neurology, Salengro Hospital, Lille University Medical Centre, Lille, France
Neurosurgery 61:297-304; discussion 304-5. 2007..The primary objective was to describe the clinical outcome in terms of efficacy and tolerance in STN-DBS patients. A secondary objective was to discuss presurgery clinical characteristics a posteriori as a function of outcome...
- Abnormal cortical mechanisms in voluntary muscle relaxation in de novo parkinsonian patientsEtienne Labyt
Department of Clinical Neurophysiology, R. Salengro Hospital, Lille University Medical Center, Lille Cedex, France
J Clin Neurophysiol 22:192-203. 2005..The authors suggest that this may be due to anomalous activity in inhibitory motor cortical systems and impaired sensorimotor integration of afferent inputs from muscle and joint receptors...
- Utility of the Mattis dementia rating scale to assess the efficacy of rivastigmine in dementia associated with Parkinson's diseaseKathy Dujardin
Neurology and Movement Disorders Unit, Faculty of Medicine and Lille University Hospital, EA2683, Lille, France
J Neurol 253:1154-9. 2006....
- Composite cerebellar functional severity score: validation of a quantitative score of cerebellar impairmentSophie Tezenas du Montcel
AP HP, Department of Biostatistics and Medical Informatics, Pitié Salpêtrière Charles Foix Clinical Research Unit, University Pierre et Marie Curie, Paris, France
Brain 131:1352-61. 2008....
- Neurodegeneration with brain iron accumulation: clinical, radiographic and genetic heterogeneity and corresponding therapeutic optionsFrederik Clement
Department of Neurology, Hopital Roger Salengro, Lille, France
Acta Neurol Belg 107:26-31. 2007..Neurodegeneration with brain iron accumulation (NBIA), formerly known as Hallervorden-Spatz syndrome, is a heterogeneous group of disorders with different treatment options...