Luc J P Defebvre

Summary

Affiliation: CHRU de Lille
Country: France

Publications

  1. ncbi request reprint [Neurophysiology of parkinsonian syndromes]
    L Defebvre
    Service de Neurologie et Pathologie du Mouvement, CHRU, Lille
    Rev Neurol (Paris) 159:3S62-74. 2003
  2. ncbi request reprint Influence of pallidal stimulation and levodopa on gait and preparatory postural adjustments in Parkinson's disease
    Luc J P Defebvre
    Department of Gait Analysis, University of Lille, Lille, France
    Mov Disord 17:76-83. 2002
  3. ncbi request reprint [Motor complications in dopa treatment of parkinson disease: clinical description and evaluation]
    Luc Defebvre
    Clinique Neurologique, Service de Neurologie et Pathologie du Mouvement, EA2683, Hopital R Salengro, CHU, 59037 Lille, France
    Therapie 59:93-6. 2004
  4. ncbi request reprint Myoclonus and extrapyramidal diseases
    L Defebvre
    Department of Neurology and Movement Disorders, EA2683, IFR114, Lille University Medical Centre, Hopital Roger Salengro, 59037 Lille Cedex, France
    Neurophysiol Clin 36:319-25. 2006
  5. ncbi request reprint [Extrapyramidal disorders: interest of myoclonus analysis]
    L Defebvre
    Service de Neurologie et Pathologie du Mouvement, EA2683, CHU, Hopital Roger Salengro, 59037 Lille Cedex
    Rev Neurol (Paris) 163:1115-21. 2007
  6. ncbi request reprint Influence of chronic administration of L-DOPA on event-related desynchronization of mu rhythm preceding voluntary movement in Parkinson's disease
    L Defebvre
    Department of Clinical Neurophysiology, Hospital Salengro, Lille, France
    Electroencephalogr Clin Neurophysiol 109:161-7. 1998
  7. ncbi request reprint [Chronic electric stimulation of the internal globus pallidus and subthalamic nucleus in Parkinson disease]
    L Defebvre
    Service de Neurologie, Hopital Roger Salengro, CHRU, Lille
    Presse Med 29:1525-31. 2000
  8. ncbi request reprint Exhaustive, one-year follow-up of subthalamic nucleus deep brain stimulation in a large, single-center cohort of parkinsonian patients
    Melissa Tir
    Department of Neurology, Salengro Hospital, Lille University Medical Centre, Lille, France
    Neurosurgery 61:297-304; discussion 304-5. 2007
  9. doi request reprint REM sleep behaviour disorder and visuoperceptive dysfunction: a disorder of the ventral visual stream?
    Ana Marques
    Service de Neurophysiologie Clinique, Unité des troubles de la veille et du sommeil, EA 2683, IFR 114, Hopital Roger Salengro, CHRU de Lille, Lille Cedex, 59037, France
    J Neurol 257:383-91. 2010
  10. doi request reprint Effect of external cueing on gait in Huntington's disease
    Arnaud Delval
    Department of Neurology and Movement Disorders, EA 2683, IFR 114, Salengro Hospital, Lille Regional University Hospital, France
    Mov Disord 23:1446-52. 2008

Collaborators

Detail Information

Publications34

  1. ncbi request reprint [Neurophysiology of parkinsonian syndromes]
    L Defebvre
    Service de Neurologie et Pathologie du Mouvement, CHRU, Lille
    Rev Neurol (Paris) 159:3S62-74. 2003
    ....
  2. ncbi request reprint Influence of pallidal stimulation and levodopa on gait and preparatory postural adjustments in Parkinson's disease
    Luc J P Defebvre
    Department of Gait Analysis, University of Lille, Lille, France
    Mov Disord 17:76-83. 2002
    ..This study, based on an objective method, revealed that chronic bilateral GPi stimulation may improve gait and preparatory postural adjustments in severe PD patients with a more limited effect than L-dopa...
  3. ncbi request reprint [Motor complications in dopa treatment of parkinson disease: clinical description and evaluation]
    Luc Defebvre
    Clinique Neurologique, Service de Neurologie et Pathologie du Mouvement, EA2683, Hopital R Salengro, CHU, 59037 Lille, France
    Therapie 59:93-6. 2004
    ..Clinical evaluation of motor complications must be performed precisely to establish the best therapeutic strategy...
  4. ncbi request reprint Myoclonus and extrapyramidal diseases
    L Defebvre
    Department of Neurology and Movement Disorders, EA2683, IFR114, Lille University Medical Centre, Hopital Roger Salengro, 59037 Lille Cedex, France
    Neurophysiol Clin 36:319-25. 2006
    ..However, a subcortical origin cannot always be ruled out...
  5. ncbi request reprint [Extrapyramidal disorders: interest of myoclonus analysis]
    L Defebvre
    Service de Neurologie et Pathologie du Mouvement, EA2683, CHU, Hopital Roger Salengro, 59037 Lille Cedex
    Rev Neurol (Paris) 163:1115-21. 2007
    ..However, a subcortical origin cannot always be ruled out...
  6. ncbi request reprint Influence of chronic administration of L-DOPA on event-related desynchronization of mu rhythm preceding voluntary movement in Parkinson's disease
    L Defebvre
    Department of Clinical Neurophysiology, Hospital Salengro, Lille, France
    Electroencephalogr Clin Neurophysiol 109:161-7. 1998
    ..Delayed ERD onset, which shows that programming of movement is affected in Parkinson's disease, may be partially corrected by L-DOPA therapy...
  7. ncbi request reprint [Chronic electric stimulation of the internal globus pallidus and subthalamic nucleus in Parkinson disease]
    L Defebvre
    Service de Neurologie, Hopital Roger Salengro, CHRU, Lille
    Presse Med 29:1525-31. 2000
    ..This technique is reversible and can be modulated with less adverse effects...
  8. ncbi request reprint Exhaustive, one-year follow-up of subthalamic nucleus deep brain stimulation in a large, single-center cohort of parkinsonian patients
    Melissa Tir
    Department of Neurology, Salengro Hospital, Lille University Medical Centre, Lille, France
    Neurosurgery 61:297-304; discussion 304-5. 2007
    ..The primary objective was to describe the clinical outcome in terms of efficacy and tolerance in STN-DBS patients. A secondary objective was to discuss presurgery clinical characteristics a posteriori as a function of outcome...
  9. doi request reprint REM sleep behaviour disorder and visuoperceptive dysfunction: a disorder of the ventral visual stream?
    Ana Marques
    Service de Neurophysiologie Clinique, Unité des troubles de la veille et du sommeil, EA 2683, IFR 114, Hopital Roger Salengro, CHRU de Lille, Lille Cedex, 59037, France
    J Neurol 257:383-91. 2010
    ..RBD, idiopathic or secondary to PD, is associated with perceptual closure dysfunction. Our results suggest that this perceptual dysfunction is specifically associated with RBD and may be related to a non-dopaminergic impairment...
  10. doi request reprint Effect of external cueing on gait in Huntington's disease
    Arnaud Delval
    Department of Neurology and Movement Disorders, EA 2683, IFR 114, Salengro Hospital, Lille Regional University Hospital, France
    Mov Disord 23:1446-52. 2008
    ..HD patients have difficulty in synchronizing their footsteps with a metronome, mainly due to attentional deficits...
  11. doi request reprint Kinematic angular parameters in PD: reliability of joint angle curves and comparison with healthy subjects
    Arnaud Delval
    Department of Neurology, Lille University Medical Centre, Lille, France
    Gait Posture 28:495-501. 2008
    ..The reliability of joint angle curves and comparisons with control data are of major interest in PD, since variability in gait cycle timing is a feature of this pathology...
  12. doi request reprint Comparison of desipramine and citalopram treatments for depression in Parkinson's disease: a double-blind, randomized, placebo-controlled study
    David Devos
    Department of Neurology, IFR114, Institute of Predictive Medicine and Therapeutic Research, Lille University Hospital, Lille, France
    Mov Disord 23:850-7. 2008
    ..A predominantly noradrenergic tricyclic antidepressant induced a more intense short-term effect on parkinsonian depression than did an SSRI. However, desipramine's lower tolerability may outweigh its slight short-term clinical advantage...
  13. doi request reprint The Lille Apathy Rating Scale: validation of a caregiver-based version
    Kathy Dujardin
    Neurology and Movement Disorders Unit, EA2683, Faculty of Medicine and Lille University Hospital, Lille, France
    Mov Disord 23:845-9. 2008
    ..The LARS-i was seen to have excellent psychometric properties and appears to be valid for use in PD with respect to the patient-based LARS and the informant- and clinician-rated versions of the AES...
  14. doi request reprint Role of attentional resources on gait performance in Huntington's disease
    Arnaud Delval
    Department of Neurology and Movement Disorders, Salengro Hospital, Lille Regional University Hospital, Lille Cedex, France
    Mov Disord 23:684-9. 2008
    ..Patients with HD had greater difficulty walking while performing a concurrent cognitive task; the drain on attentional resources deteriorated walking performance...
  15. doi request reprint Apathy may herald cognitive decline and dementia in Parkinson's disease
    Kathy Dujardin
    Universite Lille Nord de France, France
    Mov Disord 24:2391-7. 2009
    ..These findings suggest that in nondemented, nondepressed PD patients, apathy may be a predictive factor for dementia and cognitive decline over time...
  16. doi request reprint Objective detection of subtle freezing of gait episodes in Parkinson's disease
    Arnaud Delval
    Department of Neurology and Movement Disorders, Regional University Hospital, Lille Cedex, France
    Mov Disord 25:1684-93. 2010
    ..We conclude that time-frequency analysis is an appropriate approach to detect brief and subtle FOG episodes. Future work will need to decide whether this approach can support or even replace expert clinical opinion...
  17. doi request reprint Cognitive complaints in Parkinson's disease: its relationship with objective cognitive decline
    Kathy Dujardin
    Neurology and Movement Disorders Unit, EA2683, Faculty of Medicine and University Medical Center, Lille, France
    J Neurol 257:79-84. 2010
    ..However, the CCI does not enable more accurate screening for PD-associated dementia...
  18. ncbi request reprint Is the paced auditory serial addition test (PASAT) a valid means of assessing executive function in Parkinson's disease?
    Kathy Dujardin
    Neurology and Movement Disorders Unit, Faculty of Medicine and Lille University Hospital, Lille, France
    Cortex 43:601-6. 2007
    ..Our results demonstrate the high sensitivity of the PASAT to cognitive impairment. However, correlation analyses showed that the main factor explaining the PD patients' PASAT impairment was cognitive slowing...
  19. doi request reprint Parkinson's disease dementia can be easily detected in routine clinical practice
    Kathy Dujardin
    Universite Lille Nord de France, UDSL, CNRS FRE3291, Neurology and Movement Disorders Unit, Lille University Medical Center, Lille, France
    Mov Disord 25:2769-76. 2010
    ....
  20. ncbi request reprint Effects of subthalamic nucleus stimulation and levodopa treatment on gait abnormalities in Parkinson disease
    Pierre Krystkowiak
    Department of Gait Analysis, Centre Hospitalier et Universitaire de Lille, France
    Arch Neurol 60:80-4. 2003
    ..Stimulation of the subthalamic nucleus is proposed for the treatment of patients presenting with severe Parkinson disease. The effect on gait is not clearly established...
  21. ncbi request reprint Executive function differences in multiple system atrophy and Parkinson's disease
    Kathy Dujardin
    Neurology and Movement Disorders Unit, Clinique Neurologique, Neurologie A, Hopital Salengro, CHRU de Lille, 59037 Lille Cedex, France
    Parkinsonism Relat Disord 9:205-11. 2003
    ..This study suggests that despite the evidence of some differences in executive function in MSA and PD, the contribution of standard neuropsychological examination to the differential diagnosis of both syndromes remains still limited...
  22. ncbi request reprint New syndromic form of benign hereditary chorea is associated with a deletion of TITF-1 and PAX-9 contiguous genes
    David Devos
    Department of Neurology, EA 2683 MENRT, Lille, France
    Mov Disord 21:2237-40. 2006
    ..Associated signs, sometimes of slight expression, remain of high interest for the clinical and genetic diagnosis of benign hereditary chorea...
  23. ncbi request reprint Characteristics of apathy in Parkinson's disease
    Kathy Dujardin
    Neurology and Movement Disorders Unit, EA2683, Faculty of Medicine and Lille University Hospital, Lille, France
    Mov Disord 22:778-84. 2007
    ..Although the neurochemical substrate of apathy remains poorly characterized, the strong link between apathy and cognitive impairment observed in several studies suggests the participation of nondopaminergic circuits...
  24. ncbi request reprint Oral festination in Parkinson's disease: biomechanical analysis and correlation with festination and freezing of gait
    Caroline Moreau
    Department of Neurology, EA 2683, CHRU, Lille, France
    Mov Disord 22:1503-6. 2007
    ....
  25. ncbi request reprint Abnormal cortical mechanisms in voluntary muscle relaxation in de novo parkinsonian patients
    Etienne Labyt
    Department of Clinical Neurophysiology, R Salengro Hospital, Lille University Medical Center, Lille Cedex, France
    J Clin Neurophysiol 22:192-203. 2005
    ..The authors suggest that this may be due to anomalous activity in inhibitory motor cortical systems and impaired sensorimotor integration of afferent inputs from muscle and joint receptors...
  26. doi request reprint Motor-related circuit dysfunction in MSA-P: Usefulness of combined whole-brain imaging analysis
    Melissa Tir
    Department of Neurology, Roger Salengro Hospital, Lille University Medical Centre, Lille Cedex, France
    Mov Disord 24:863-70. 2009
    ..Our findings suggest that MSA-P is characterized by both macro- and microstructural changes in the sensorimotor circuit...
  27. ncbi request reprint Corticobasal degeneration and Parkinson's disease assessed by HmPaO SPECT: the utility of factorial discriminant analysis
    Alexandre Kreisler
    Department of Neurology, Regional and University Hospital, Lille, France
    Mov Disord 20:1431-8. 2005
    ..We believe that this semiautomatic classification may be a precious tool for reinforcing the current clinical differential diagnosis of CBD and PD...
  28. doi request reprint Intravenous thrombolysis for acute cerebral ischaemia: comparison of outcomes between patients treated at working versus nonworking hours
    Marie Bodenant
    Department of Neurology, University Hospital of Lille, Lille, France
    Cerebrovasc Dis 30:148-56. 2010
    ..Stroke outcomes are worse in patients admitted at nonworking hours (NWH), but whether this is also true in patients treated with intravenous (i.v.) thrombolysis has not been definitely proven...
  29. doi request reprint A genetic variation in the ADORA2A gene modifies age at onset in Huntington's disease
    Claire Marie Dhaenens
    INSERM, U837, Universite Lille Nord de France, USDL, IMPRT, Jean Pierre Aubert Research Centre, Lille, France
    Neurobiol Dis 35:474-6. 2009
    ..Patients harbouring T/T genotype have an earlier AAO of 3.8 years as compared to C/C genotype (p=0.02). Our data thus strengthens the pathophysiological role of A(2A) receptors in Huntington's disease...
  30. doi request reprint Lipid-lowering drugs are associated with delayed onset and slower course of Parkinson's disease
    Eugénie Mutez
    Neurology and Movement Disorders Unit, EA 2683, Lille University and Regional Hospital, Lille, France
    Pharmacol Res 60:41-5. 2009
    ..The course of the disease in patients taking a fibrate did not differ from the controls. These data suggest that lipid-lowering drugs may have a disease modifier effect, with a stronger action for statins than for fibrates...
  31. ncbi request reprint Effect of age on anticipatory postural adjustments in unilateral arm movement
    Séverine Bleuse
    Department of Clinical Neurophysiology, Laboratory of Movement Analysis, Salengro Hospital, CHU, Lille University Medical Center, F 59037 Lille Cedex, France
    Gait Posture 24:203-10. 2006
    ..Hence, local muscle strategies were used to counteract the overall delay in postural preparation revealed by biomechanical parameters...
  32. ncbi request reprint Vertical torque allows recording of anticipatory postural adjustments associated with slow, arm-raising movements
    Séverine Bleuse
    Department of Clinical Neurophysiology, Hopital Salengro, CHU, F 59037 Lille Cedex, France
    Clin Biomech (Bristol, Avon) 20:693-9. 2005
    ..The aim of this study was to use vertical torque to characterise anticipatory postural adjustments in slow movement and to determine the significance of this biomechanical parameter...
  33. ncbi request reprint [Anticipatory postural adjustments associated with arm flexion: interest of vertical torque]
    Séverine Bleuse
    Service de Neurophysiologie Clinique, Hopital Roger Salengro, CHU Lille, 59037 Lille, France
    Neurophysiol Clin 32:352-60. 2002
    ..To find a biomechanical parameter able to characterize postural adjustments in different movement conditions...
  34. ncbi request reprint Neurodegeneration with brain iron accumulation: clinical, radiographic and genetic heterogeneity and corresponding therapeutic options
    Frederik Clement
    Department of Neurology, Hopital Roger Salengro, Lille, France
    Acta Neurol Belg 107:26-31. 2007
    ..Neurodegeneration with brain iron accumulation (NBIA), formerly known as Hallervorden-Spatz syndrome, is a heterogeneous group of disorders with different treatment options...