J Cherfils

Summary

Country: France

Publications

  1. ncbi request reprint Structural mimicry of DH domains by Arfaptin suggests a model for the recognition of Rac-GDP by its guanine nucleotide exchange factors
    J Cherfils
    Laboratoire d Enzymologie et Biochimie Structurales, UPR 9063 CNRS, 1 Avenue de la Terrasse, 91198 Cedex, Gif sur Yvette, France
    FEBS Lett 507:280-4. 2001
  2. pmc The structural GDP/GTP cycle of human Arf6
    S Pasqualato
    Laboratoire d Enzymologie et Biochimie Structurales, CNRS, 1, Avenue de la Terrasse, 91198 Gif sur Yvette cedex and Institut de Pharmacologie Moléculaire et Cellulaire, CNRS, 660 route des Lucioles, 06560 Valbonne, France
    EMBO Rep 2:234-8. 2001
  3. ncbi request reprint Brefeldin A acts to stabilize an abortive ARF-GDP-Sec7 domain protein complex: involvement of specific residues of the Sec7 domain
    A Peyroche
    Service de Biochimie et Génétique Moléculaire, CEA Saclay, Gif sur Yvette, France
    Mol Cell 3:275-85. 1999
  4. ncbi request reprint Structure of the Sec7 domain of the Arf exchange factor ARNO
    J Cherfils
    Laboratoire d Enzymologie et Biochimie Structurales, CNRS UPR 9063, Gif sur Yvette, France
    Nature 392:101-5. 1998
  5. ncbi request reprint On the action of Brefeldin A on Sec7-stimulated membrane-recruitment and GDP/GTP exchange of Arf proteins
    J Cherfils
    Laboratoire d Enzymologie et Biochimie Structurales, CNRS, Avenue de la Terrasse, 91198 Gif sur Yvette Cedex, France
    Biochem Soc Trans 33:635-8. 2005
  6. ncbi request reprint Structure of the small G protein Rap2 in a non-catalytic complex with GTP
    J Menetrey
    Laboratoire d Enzymologie et Biochimie Structurales, Centre National de la Recherche Scientifique, Gif sur Yvette, France
    Proteins 37:465-73. 1999
  7. ncbi request reprint GEFs: structural basis for their activation of small GTP-binding proteins
    J Cherfils
    Laboratoire d Enzymologie et Biochimie Structurales, CNRS, 91198 Gif sur Yvette, France
    Trends Biochem Sci 24:306-11. 1999
  8. pmc Structure of the EMAPII domain of human aminoacyl-tRNA synthetase complex reveals evolutionary dimer mimicry
    L Renault
    Laboratoire d Enzymologie et Biochimie Structurales, CNRS, 1 Avenue de la Terrasse, 91198 Gif sur Yvette Cedex, France
    EMBO J 20:570-8. 2001
  9. ncbi request reprint Arf, Sec7 and Brefeldin A: a model towards the therapeutic inhibition of guanine nucleotide-exchange factors
    M Zeghouf
    Laboratoire d Enzymologie et Biochimie Structurales, CNRS, Avenue de la Terrasse, 91198 Gif sur Yvette Cedex, France
    Biochem Soc Trans 33:1265-8. 2005
  10. ncbi request reprint Three-dimensional structure of nucleoside diphosphate kinase
    J Janin
    Laboratoire d Enzymologie et de Biochimie Structurales CNRS UPR9063, Gif sur Yvette, France
    J Bioenerg Biomembr 32:215-25. 2000

Collaborators

Detail Information

Publications13

  1. ncbi request reprint Structural mimicry of DH domains by Arfaptin suggests a model for the recognition of Rac-GDP by its guanine nucleotide exchange factors
    J Cherfils
    Laboratoire d Enzymologie et Biochimie Structurales, UPR 9063 CNRS, 1 Avenue de la Terrasse, 91198 Cedex, Gif sur Yvette, France
    FEBS Lett 507:280-4. 2001
    ..This provides a model for the exchange mechanism where DH domains first dock onto Rac-GDP at the switch 2 before they undergo domain closure to catalyze GDP dissociation...
  2. pmc The structural GDP/GTP cycle of human Arf6
    S Pasqualato
    Laboratoire d Enzymologie et Biochimie Structurales, CNRS, 1, Avenue de la Terrasse, 91198 Gif sur Yvette cedex and Institut de Pharmacologie Moléculaire et Cellulaire, CNRS, 660 route des Lucioles, 06560 Valbonne, France
    EMBO Rep 2:234-8. 2001
    ..The structure also allows further insight into the lack of spontaneous GTPase activity of Arf proteins...
  3. ncbi request reprint Brefeldin A acts to stabilize an abortive ARF-GDP-Sec7 domain protein complex: involvement of specific residues of the Sec7 domain
    A Peyroche
    Service de Biochimie et Génétique Moléculaire, CEA Saclay, Gif sur Yvette, France
    Mol Cell 3:275-85. 1999
    ..We show that the target of BFA inhibition of ARF exchange activity is an ARF-GDP-Sec7 domain protein complex, and that BFA acts to stabilize this complex to a greater extent for a BFA-sensitive Sec7 domain than for a resistant one...
  4. ncbi request reprint Structure of the Sec7 domain of the Arf exchange factor ARNO
    J Cherfils
    Laboratoire d Enzymologie et Biochimie Structurales, CNRS UPR 9063, Gif sur Yvette, France
    Nature 392:101-5. 1998
    ..Here we report the crystal structure of the Sec7 domain of human ARNO at 2 A resolution and the identification of the site of interaction of ARNO with Arf...
  5. ncbi request reprint On the action of Brefeldin A on Sec7-stimulated membrane-recruitment and GDP/GTP exchange of Arf proteins
    J Cherfils
    Laboratoire d Enzymologie et Biochimie Structurales, CNRS, Avenue de la Terrasse, 91198 Gif sur Yvette Cedex, France
    Biochem Soc Trans 33:635-8. 2005
    ..This leads to the hypothesis that Sec7 activity is inhibited in these ArfGEFs by an intramolecular interaction, which would be released by interaction with a compartment-specific receptor...
  6. ncbi request reprint Structure of the small G protein Rap2 in a non-catalytic complex with GTP
    J Menetrey
    Laboratoire d Enzymologie et Biochimie Structurales, Centre National de la Recherche Scientifique, Gif sur Yvette, France
    Proteins 37:465-73. 1999
    ..Taken together, these observations suggest that the structural mechanisms of small G proteins are significantly driven by entropy-based free energy changes...
  7. ncbi request reprint GEFs: structural basis for their activation of small GTP-binding proteins
    J Cherfils
    Laboratoire d Enzymologie et Biochimie Structurales, CNRS, 91198 Gif sur Yvette, France
    Trends Biochem Sci 24:306-11. 1999
    ..These structures, together with biochemical studies, have allowed a deeper understanding of the mechanisms of activation of Ras-like GTP-binding proteins and suggested how they might represent targets for therapeutic intervention...
  8. pmc Structure of the EMAPII domain of human aminoacyl-tRNA synthetase complex reveals evolutionary dimer mimicry
    L Renault
    Laboratoire d Enzymologie et Biochimie Structurales, CNRS, 1 Avenue de la Terrasse, 91198 Gif sur Yvette Cedex, France
    EMBO J 20:570-8. 2001
    ..The low sequence homology between the extra domain of EMAPII and either its own OB fold or that of Trbps suggests that dimer mimicry originated from convergent evolution rather than gene duplication...
  9. ncbi request reprint Arf, Sec7 and Brefeldin A: a model towards the therapeutic inhibition of guanine nucleotide-exchange factors
    M Zeghouf
    Laboratoire d Enzymologie et Biochimie Structurales, CNRS, Avenue de la Terrasse, 91198 Gif sur Yvette Cedex, France
    Biochem Soc Trans 33:1265-8. 2005
    ..Interfacial inhibitors are proposed as an alternative to competitive inhibitors that may be explored for their inhibition...
  10. ncbi request reprint Three-dimensional structure of nucleoside diphosphate kinase
    J Janin
    Laboratoire d Enzymologie et de Biochimie Structurales CNRS UPR9063, Gif sur Yvette, France
    J Bioenerg Biomembr 32:215-25. 2000
    ..In contrast, we still lack structural data relating to DNA binding and other functions of NDP kinases...
  11. ncbi request reprint RhoGDI-3, a promising system to investigate the regulatory function of rhoGDIs: uncoupling of inhibitory and shuttling functions of rhoGDIs
    E Dransart
    Laboratoire d Enzymologie et Biochimie Structurales, CNRS UPR 9063, F 91198 Gif sur Yvette, France
    Biochem Soc Trans 33:623-6. 2005
    ..They should provide valuable tools for future investigations of the dynamics of membrane extraction or delivery of Rho proteins and their regulation by cellular partners...
  12. ncbi request reprint Crystal structures of GMP kinase in complex with ganciclovir monophosphate and Ap5G
    G Hible
    Laboratoire d Enzymologie et Biochimie Structurales, Batiment 34, CNRS, Avenue de la Terrasse, 91198 Gif sur Yvette Cedex, France
    Biochimie 88:1157-64. 2006
    ....
  13. pmc Crystal structures of the small G protein Rap2A in complex with its substrate GTP, with GDP and with GTPgammaS
    J Cherfils
    Laboratoire d Enzymologie et de Biochimie Structurales, UPR 9063 CNRS, Avenue de la Terrasse, 91198 Gif sur Yvette, France
    EMBO J 16:5582-91. 1997
    ....