Eric Chevet


Country: France


  1. Chevet E, Hetz C, Samali A. Endoplasmic reticulum stress-activated cell reprogramming in oncogenesis. Cancer Discov. 2015;5:586-97 pubmed publisher
  2. Le Reste P, Chevet E. Should the clinic matter to nonphysician scientists?. Sci Signal. 2018;11: pubmed publisher
    ..D.-Ph.D. programs, a system that now needs to reinvent itself. Now, clinically oriented training programs targeting nonphysician scientists have opened new avenues to improve transdisciplinary approaches in health sciences. ..
  3. Manié S, Lebeau J, Chevet E. Cellular mechanisms of endoplasmic reticulum stress signaling in health and disease. 3. Orchestrating the unfolded protein response in oncogenesis: an update. Am J Physiol Cell Physiol. 2014;307:C901-7 pubmed publisher
    ..We discuss these issues in the context of the pathophysiological roles of UPR signaling in cancers. ..
  4. Maurel M, Samali A, Chevet E. Endoplasmic reticulum stress: at the crossroads of inflammation and metabolism in hepatocellular carcinoma development. Cancer Cell. 2014;26:301-303 pubmed publisher
  5. Negroni L, Taouji S, Arma D, Pallares Lupon N, Leong K, Beausang L, et al. Integrative quantitative proteomics unveils proteostasis imbalance in human hepatocellular carcinoma developed on nonfibrotic livers. Mol Cell Proteomics. 2014;13:3473-83 pubmed publisher
    ..As such, this model could provide an additional therapeutic opportunity for those tumors arising on normal liver by targeting the tumor proteostasis network. Data are available via ProteomeXchange with identifier PXD001253. ..
  6. Dejeans N, Barroso K, Fernandez Zapico M, Samali A, Chevet E. Novel roles of the unfolded protein response in the control of tumor development and aggressiveness. Semin Cancer Biol. 2015;33:67-73 pubmed publisher
    ..In the present review, we discuss the specific features of the UPR in various tumor types and the impact of the selective activation of this pathway on cell transformation, tumor development and aggressiveness. ..
  7. Avril T, Chevet E. Proteostasis trumps YAP in colon cancer. Sci Signal. 2015;8:fs18 pubmed publisher
    ..The study further documents the potential strategy of targeting proteostasis to kill cancer cells. ..
  8. Lhomond S, Avril T, Dejeans N, Voutetakis K, Doultsinos D, McMahon M, et al. Dual IRE1 RNase functions dictate glioblastoma development. EMBO Mol Med. 2018;10: pubmed publisher
    ..This study provides the first demonstration of a dual role of IRE1 downstream signaling in cancer and opens a new therapeutic window to abrogate tumor progression. ..
  9. Le Reste P, Avril T, Quillien V, Morandi X, Chevet E. Reprint of: Signaling the Unfolded Protein Response in primary brain cancers. Brain Res. 2016;1648:542-552 pubmed publisher
    ..This article is part of a Special Issue entitled SI:ER stress. ..

More Information


  1. Chevet E, Fessart D, Delom F, Mulot A, Vojtesek B, Hrstka R, et al. Emerging roles for the pro-oncogenic anterior gradient-2 in cancer development. Oncogene. 2013;32:2499-509 pubmed publisher
  2. Marza E, Taouji S, Barroso K, Raymond A, Guignard L, Bonneu M, et al. Genome-wide screen identifies a novel p97/CDC-48-dependent pathway regulating ER-stress-induced gene transcription. EMBO Rep. 2015;16:332-40 pubmed publisher
    ..Together, these results describe a novel role for p97/CDC-48, whereby its role in protein degradation is integrated with its role in regulating expression of ER stress response genes. ..
  3. Le Reste P, Avril T, Quillien V, Morandi X, Chevet E. Signaling the Unfolded Protein Response in primary brain cancers. Brain Res. 2016;1642:59-69 pubmed publisher
  4. Obacz J, Avril T, Le Reste P, Urra H, Quillien V, Hetz C, et al. Endoplasmic reticulum proteostasis in glioblastoma-From molecular mechanisms to therapeutic perspectives. Sci Signal. 2017;10: pubmed publisher
    ..We also discuss the emerging cross-talk between the UPR and related metabolic processes to ensure maintenance of proteostasis, and we highlight possible therapeutic opportunities for targeting the pathway with small molecules. ..
  5. McMahon M, Samali A, Chevet E. Regulation of the unfolded protein response by noncoding RNA. Am J Physiol Cell Physiol. 2017;313:C243-C254 pubmed publisher
  6. Papaioannou A, Chevet E. Driving Cancer Tumorigenesis and Metastasis Through UPR Signaling. Curr Top Microbiol Immunol. 2018;414:159-192 pubmed publisher
    ..In order to describe the emerging role of UPR in cancer biology, these are the points that will be discussed in this chapter. ..