Jean Chastre

Summary

Country: France

Publications

  1. ncbi request reprint New diagnostic and prognostic markers of ventilator-associated pneumonia
    Jean Chastre
    Medical Intensive Care Unit, Pitie Salpetriere Hospital, Pierre and Marie Curie University, Paris, France
    Curr Opin Crit Care 12:446-51. 2006
  2. doi request reprint Other therapeutic modalities and practices: implications for clinical trials of hospital-acquired or ventilator-associated pneumonia
    Jean Chastre
    Service de Reanimation Medicale, Institut de Cardiologie, Hopital Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Universite Pierre et Marie Curie, Paris, France
    Clin Infect Dis 51:S54-8. 2010
  3. doi request reprint Diagnostic techniques and procedures for establishing the microbial etiology of ventilator-associated pneumonia for clinical trials: the pros for quantitative cultures
    Jean Chastre
    Service de Reanimation Medicale, Institut de Cardiologie, Hopital Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Universite Pierre et Marie Curie, Paris, France
    Clin Infect Dis 51:S88-92. 2010
  4. doi request reprint Efficacy and safety of intravenous infusion of doripenem versus imipenem in ventilator-associated pneumonia: a multicenter, randomized study
    Jean Chastre
    Service de Reanimation Medicale, Groupe Hospitalier Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Universite Pierre et Marie Curie Paris 6, Paris, France
    Crit Care Med 36:1089-96. 2008
  5. ncbi request reprint Early predictors for infection recurrence and death in patients with ventilator-associated pneumonia
    Alain Combes
    Service de Reanimation Medicale, Hopital Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Universite Pierre et Marie Curie, Paris 6, France
    Crit Care Med 35:146-54. 2007
  6. ncbi request reprint Impact of methicillin resistance on outcome of Staphylococcus aureus ventilator-associated pneumonia
    Alain Combes
    Service de Reanimation Medicale, Hopital Pitie Salpetriere, 75651 Paris Cedex 13, France
    Am J Respir Crit Care Med 170:786-92. 2004
  7. doi request reprint Outcomes, long-term quality of life, and psychologic assessment of fulminant myocarditis patients rescued by mechanical circulatory support
    Mariana Mirabel
    Service de Reanimation Medicale, Institut de Cardiologie, Hopital Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Universite Pierre et Marie Curie, Paris, France
    Crit Care Med 39:1029-35. 2011
  8. ncbi request reprint Mortality among patients admitted to intensive care units during weekday day shifts compared with "off" hours
    Charles Edouard Luyt
    Service de Reanimation Medicale, Institut de Cardiologie, Groupe Hospitalier Pitie Salpetriere, Paris, France
    Crit Care Med 35:3-11. 2007
  9. ncbi request reprint Use of quantitative cultures and reduced duration of antibiotic regimens for patients with ventilator-associated pneumonia to decrease resistance in the intensive care unit
    Jean Chastre
    Service de Reanimation Medicale, Institut de Cardiologie, Groupe Hospitalier Pitie Salpetriere, 75651 Paris Cedex 13, France
    Clin Infect Dis 43:S75-81. 2006
  10. ncbi request reprint The PRESERVE mortality risk score and analysis of long-term outcomes after extracorporeal membrane oxygenation for severe acute respiratory distress syndrome
    Matthieu Schmidt
    Medical Surgical Intensive Care Unit, iCAN, Institute of Cardiometabolism and Nutrition, Service de Reanimation Medicale, Groupe Hôpital de la Pitié Salpêtrière, Assistance Publique Hopitaux de Paris, Universite Pierre et Marie Curie, Paris 6, 47, Bd de l Hopital, 75651, Paris Cedex 13, France
    Intensive Care Med 39:1704-13. 2013

Detail Information

Publications68

  1. ncbi request reprint New diagnostic and prognostic markers of ventilator-associated pneumonia
    Jean Chastre
    Medical Intensive Care Unit, Pitie Salpetriere Hospital, Pierre and Marie Curie University, Paris, France
    Curr Opin Crit Care 12:446-51. 2006
    ..The purpose of this review is to analyze the potential advantages and drawbacks of using biomarkers of bacterial infection for the diagnosis and prognosis of ventilator-associated pneumonia...
  2. doi request reprint Other therapeutic modalities and practices: implications for clinical trials of hospital-acquired or ventilator-associated pneumonia
    Jean Chastre
    Service de Reanimation Medicale, Institut de Cardiologie, Hopital Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Universite Pierre et Marie Curie, Paris, France
    Clin Infect Dis 51:S54-8. 2010
    ..Until results of these trials are known, antibiotic aerosolization can be recommended only for treating patients with multidrug-resistant VAP, for which no effective intravenous regimen is available...
  3. doi request reprint Diagnostic techniques and procedures for establishing the microbial etiology of ventilator-associated pneumonia for clinical trials: the pros for quantitative cultures
    Jean Chastre
    Service de Reanimation Medicale, Institut de Cardiologie, Hopital Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Universite Pierre et Marie Curie, Paris, France
    Clin Infect Dis 51:S88-92. 2010
    ....
  4. doi request reprint Efficacy and safety of intravenous infusion of doripenem versus imipenem in ventilator-associated pneumonia: a multicenter, randomized study
    Jean Chastre
    Service de Reanimation Medicale, Groupe Hospitalier Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Universite Pierre et Marie Curie Paris 6, Paris, France
    Crit Care Med 36:1089-96. 2008
    ..This large, phase III study compared doripenem with imipenem for the treatment of ventilator-associated pneumonia...
  5. ncbi request reprint Early predictors for infection recurrence and death in patients with ventilator-associated pneumonia
    Alain Combes
    Service de Reanimation Medicale, Hopital Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Universite Pierre et Marie Curie, Paris 6, France
    Crit Care Med 35:146-54. 2007
    ..The objective of this study was to describe resolution of VAP variables and to determine early predictors of VAP recurrence and death...
  6. ncbi request reprint Impact of methicillin resistance on outcome of Staphylococcus aureus ventilator-associated pneumonia
    Alain Combes
    Service de Reanimation Medicale, Hopital Pitie Salpetriere, 75651 Paris Cedex 13, France
    Am J Respir Crit Care Med 170:786-92. 2004
    ....
  7. doi request reprint Outcomes, long-term quality of life, and psychologic assessment of fulminant myocarditis patients rescued by mechanical circulatory support
    Mariana Mirabel
    Service de Reanimation Medicale, Institut de Cardiologie, Hopital Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Universite Pierre et Marie Curie, Paris, France
    Crit Care Med 39:1029-35. 2011
    ....
  8. ncbi request reprint Mortality among patients admitted to intensive care units during weekday day shifts compared with "off" hours
    Charles Edouard Luyt
    Service de Reanimation Medicale, Institut de Cardiologie, Groupe Hospitalier Pitie Salpetriere, Paris, France
    Crit Care Med 35:3-11. 2007
    ....
  9. ncbi request reprint Use of quantitative cultures and reduced duration of antibiotic regimens for patients with ventilator-associated pneumonia to decrease resistance in the intensive care unit
    Jean Chastre
    Service de Reanimation Medicale, Institut de Cardiologie, Groupe Hospitalier Pitie Salpetriere, 75651 Paris Cedex 13, France
    Clin Infect Dis 43:S75-81. 2006
    ....
  10. ncbi request reprint The PRESERVE mortality risk score and analysis of long-term outcomes after extracorporeal membrane oxygenation for severe acute respiratory distress syndrome
    Matthieu Schmidt
    Medical Surgical Intensive Care Unit, iCAN, Institute of Cardiometabolism and Nutrition, Service de Reanimation Medicale, Groupe Hôpital de la Pitié Salpêtrière, Assistance Publique Hopitaux de Paris, Universite Pierre et Marie Curie, Paris 6, 47, Bd de l Hopital, 75651, Paris Cedex 13, France
    Intensive Care Med 39:1704-13. 2013
    ..We also assessed long-term survivors' health-related quality of life (HRQL), respiratory symptoms, and anxiety, depression and post-traumatic stress disorder (PTSD) frequencies...
  11. ncbi request reprint Procalcitonin kinetics as a prognostic marker of ventilator-associated pneumonia
    Charles Edouard Luyt
    Service de Reanimation Medicale, Institut de Cardiologie, Groupe Hospitalier Pitie Salpetriere, 47, Boulevard de l Hopital, 75651 Paris Cedex 13, France
    Am J Respir Crit Care Med 171:48-53. 2005
    ..Multivariate analyses retained serum procalcitonin levels on Days 1, 3, and 7 as strong predictors of unfavorable outcome. Based on these data, procalcitonin could be a prognostic marker of outcome during VAP...
  12. ncbi request reprint Impact of piperacillin resistance on the outcome of Pseudomonas ventilator-associated pneumonia
    Alain Combes
    Groupe Hospitalier Pitie Salpetriere, Assistance Publique, Hôpitaux de Paris Université Pierre et Marie Curie, Paris 6, Service de Reanimation Medicale, Institut de Cardiologie, Paris, France
    Intensive Care Med 32:1970-8. 2006
    ....
  13. doi request reprint Venoarterial extracorporeal membrane oxygenation support for refractory cardiovascular dysfunction during severe bacterial septic shock
    Nicolas Bréchot
    Service de Reanimation Medicale, Institut de Cardiologie, Hopital Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Universite Pierre et Marie Curie, Paris, France
    Crit Care Med 41:1616-26. 2013
    ....
  14. doi request reprint Usefulness of procalcitonin for the diagnosis of ventilator-associated pneumonia
    Charles Edouard Luyt
    Service de Reanimation Medicale, Groupe Hospitalier Pitie Salpetriere, Universite Paris 6, 75651, Paris Cedex 13, France
    Intensive Care Med 34:1434-40. 2008
    ..To assess the predictive capacity for the diagnosis of ventilator-associated pneumonia (VAP) of serum procalcitonin levels before and on the day it is suspected...
  15. doi request reprint Use of procalcitonin to reduce patients' exposure to antibiotics in intensive care units (PRORATA trial): a multicentre randomised controlled trial
    Lila Bouadma
    Service de Reanimation Medicale, Universite Paris 7 Denis Diderot, Hopital Bichat Claude Bernard, Assistance Publique Hopitaux de Paris, Paris, France
    Lancet 375:463-74. 2010
    ..We aimed to establish the effectiveness of an algorithm based on the biomarker procalcitonin to reduce antibiotic exposure in this setting...
  16. doi request reprint Early percutaneous tracheotomy versus prolonged intubation of mechanically ventilated patients after cardiac surgery: a randomized trial
    Jean Louis Trouillet
    Institut de Cardiologie, Hopital de la Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Universite Pierre et Marie Curie, Institut National de la Sante et de la Recherche Medicale, Paris, France
    Ann Intern Med 154:373-83. 2011
    ..Whether early percutaneous tracheotomy in patients who require prolonged mechanical ventilation can shorten mechanical ventilation duration and lower mortality remains controversial...
  17. ncbi request reprint Factors predicting ventilator-associated pneumonia recurrence
    Alain Combes
    Service de Reanimation Medicale, Hopital Pitie Salpetriere, Hopital Bichat, Paris, France
    Crit Care Med 31:1102-7. 2003
    ..To determine the factors associated with ventilator-associated pneumonia recurrence in patients alive after 8 days of treatment for a first episode...
  18. ncbi request reprint Incidence and outcome of polymicrobial ventilator-associated pneumonia
    Alain Combes
    Service de Reanimation Medicale, Hopital Bichat, AP HP, Paris, France
    Chest 121:1618-23. 2002
    ..To determine the epidemiology and outcome of polymicrobial ventilator-associated pneumonia (VAP)...
  19. ncbi request reprint Is tracheostomy associated with better outcomes for patients requiring long-term mechanical ventilation?
    Alain Combes
    Service de Reanimation Medicale, Hopital Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Universite Pierre et Marie Curie, Paris, France
    Crit Care Med 35:802-7. 2007
    ..To evaluate the effect of tracheostomy on intensive care unit (ICU) and in-hospital mortality for patients requiring prolonged (> 3 days) mechanical ventilation (MV)...
  20. pmc Nosocomial infections in adult cardiogenic shock patients supported by venoarterial extracorporeal membrane oxygenation
    Matthieu Schmidt
    Service de Reanimation Medicale, Institut de Cardiologie, Paris Cedex 13, France
    Clin Infect Dis 55:1633-41. 2012
    ..Incidence and impact on adult patients' outcomes of nosocomial infections (NIs) occurring during venoarterial extracorporeal membrane oxygenation (VA-ECMO) support for refractory cardiogenic shock have rarely been described...
  21. doi request reprint Controversies in ventilator-associated pneumonia
    Alain Combes
    Service de Reanimation Medicale, Hopital Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Universite Pierre et Marie Curie, Paris, France
    Semin Respir Crit Care Med 31:47-54. 2010
    ....
  22. doi request reprint Delivering antibiotics to the lungs of patients with ventilator-associated pneumonia: an update
    Charles Edouard Luyt
    Service de Reanimation Medicale, Institut de Cardiologie, Groupe Hospitalier Pitie Salpetriere, Assistance Publique Hopitaux de Paris, 47 83, Boulevard de l Hopital, 75651 Paris Cedex 13, France
    Expert Rev Anti Infect Ther 11:511-21. 2013
    ....
  23. ncbi request reprint Adverse effect on a referral intensive care unit's performance of accepting patients transferred from another intensive care unit
    Alain Combes
    Service de Reanimation Medicale, Hopital Pitie Salpetriere, Paris, France
    Crit Care Med 33:705-10. 2005
    ..To determine whether observed and predicted mortality for intensive care unit (ICU) transfer admissions is different from non-ICU transfer admissions and how that might affect ICU performance evaluation...
  24. ncbi request reprint Does invasive diagnosis of nosocomial pneumonia during off-hours delay treatment?
    Charles Edouard Luyt
    Universite Pierre et Marie Curie, Service de Reanimation Medicale, Groupe Hospitalier Pitie Salpetriere, Assistance Publique Hopitaux de Paris, 47 Boulevard de l Hopital, 75651, Paris Cedex 13, France
    Intensive Care Med 33:734-7. 2007
    ..m. to 8:29 a.m. the next day for night shifts, from Saturday 1:00 p.m. to Monday 8:29 a.m. for weekends, and from 8:30 a.m. to 8:29 a.m. the following morning for public holidays)...
  25. doi request reprint Usefulness of cardiac biomarkers to predict cardiac recovery in patients on extracorporeal membrane oxygenation support for refractory cardiogenic shock
    Charles Edouard Luyt
    Service de Reanimation, Institut de Cardiologie, Groupe Hospitalier Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Paris, France
    J Crit Care 27:524.e7-14. 2012
    ....
  26. doi request reprint Viral infections in the ICU
    Charles Edouard Luyt
    Service de Reanimation Medicale, Institut de Cardiologie, Groupe Hospitalier Pitie Salpetriere, Paris, and Université Paris 6 Pierre et Marie Curie, France
    Curr Opin Crit Care 14:605-8. 2008
    ..The present study reviews the precise role of viruses as causes of pneumonia in mechanically ventilated patients...
  27. ncbi request reprint The impact of methicillin resistance on the outcome of poststernotomy mediastinitis due to Staphylococcus aureus
    Alain Combes
    Service de Reanimation Medicale, Institut de Cardiologie, Hôpital PitiéSalpêtrière, Paris, France
    Clin Infect Dis 38:822-9. 2004
    ..Methicillin resistance did not significantly affect ICU mortality among patients with poststernotomy mediastinitis who benefited from optimal treatments...
  28. ncbi request reprint Role of serial routine microbiologic culture results in the initial management of ventilator-associated pneumonia
    Jan Hayon
    Service de Reanimation Medicale, and Service de Microbiologie, Hôpital Bichat Cl Bernard, Assistance Publique Hopitaux de Paris, Paris, France
    Am J Respir Crit Care Med 165:41-6. 2002
    ..Based on these data, the contribution of routine microbiologic specimens in guiding initial antimicrobial therapy decisions for patients with suspected VAP appears limited...
  29. ncbi request reprint Acute poststernotomy mediastinitis managed with debridement and closed-drainage aspiration: factors associated with death in the intensive care unit
    Jean Louis Trouillet
    Service de Reanimation Medicale, Hôpital La Pitié Salpêtrière Assistance Publique Hôpitaux de Paris, France
    J Thorac Cardiovasc Surg 129:518-24. 2005
    ..The purpose of the study is to describe an intensive care unit's experience in the treatment of poststernotomy mediastinitis and to identify factors associated with intensive care unit death...
  30. ncbi request reprint Morbidity, mortality, and quality-of-life outcomes of patients requiring >or=14 days of mechanical ventilation
    Alain Combes
    Service de Reanimation Medicale, Groupe Hospitalier Pitie Salpetriere, Assistance Publique Hopitaux de Paris, France
    Crit Care Med 31:1373-81. 2003
    ..To determine the outcome and health-related quality of life of patients requiring >or=14 days of mechanical ventilation in the intensive care unit (ICU)...
  31. doi request reprint Predictors of successful extracorporeal membrane oxygenation (ECMO) weaning after assistance for refractory cardiogenic shock
    Nadia Aissaoui
    Service de Reanimation Medicale, Hopital Pitie Salpetriere, Universite Pierre et Marie Curie, Paris 6, Paris, France
    Intensive Care Med 37:1738-45. 2011
    ..This study evaluated a weaning strategy following support for refractory cardiogenic shock to identify clinical, hemodynamic, and Doppler echocardiography parameters associated with successful ECMO removal...
  32. doi request reprint Biomarkers to optimize antibiotic therapy for pneumonia due to multidrug-resistant pathogens
    Charles Edouard Luyt
    Service de Reanimation Medicale, Institut de Cardiologie, Groupe Hospitalier Pitie Salpetriere, Assistance Publique Hopitaux de Paris, France
    Clin Chest Med 32:431-8. 2011
    ..5 ng/mL or has decreased by 80% or more compared with the peak concentration, antibiotics can be stopped. With this strategy, extreme vigilance must be maintained after terminating antimicrobial therapy to detect a recurrent infection...
  33. doi request reprint Prolonged mechanical ventilation after cardiac surgery: outcome and predictors
    Jean Louis Trouillet
    Service de Reanimation Medicale, Institut de Cardiologie, Hopital Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Universite Paris 6 Pierre et Marie Curie, Paris, France
    J Thorac Cardiovasc Surg 138:948-53. 2009
    ..Our objective was to identify patients still requiring mechanical ventilation 3 days after the operation and those successfully weaned by day 10 to avoid needless and potentially hazardous interventions, such as tracheostomy...
  34. ncbi request reprint Comparison of 8 vs 15 days of antibiotic therapy for ventilator-associated pneumonia in adults: a randomized trial
    Jean Chastre
    Service de Reanimation Medicale, Hopital Pitie Salpetriere, AP HP, Paris, France
    JAMA 290:2588-98. 2003
    ..The optimal duration of antimicrobial treatment for ventilator-associated pneumonia (VAP) is unknown. Shortening the length of treatment may help to contain the emergence of multiresistant bacteria in the intensive care unit (ICU)...
  35. doi request reprint Blood oxygenation and decarboxylation determinants during venovenous ECMO for respiratory failure in adults
    Matthieu Schmidt
    Service de Reanimation Medicale, Groupe Hospitalier Pitie Salpetriere, Institute of Cardiometabolism and Nutrition, Assistance Publique Hôpitaux de Paris Université Pierre et Marie Curie, Paris 6, France
    Intensive Care Med 39:838-46. 2013
    ....
  36. ncbi request reprint Clinical and autopsy diagnoses in the intensive care unit: a prospective study
    Alain Combes
    Services de Réanimation Médicale, Hopital Bichat, Assistance Publique Hopitaux de Paris, Paris, France
    Arch Intern Med 164:389-92. 2004
    ..Autopsy rates have declined worldwide, but recent retrospective intensive care unit (ICU) data indicate major discrepancies between more than 25% of clinical and autopsy diagnoses...
  37. doi request reprint Gender impact on the outcomes of critically ill patients with nosocomial infections
    Alain Combes
    Service de Reanimation Medicale, Hopital Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Universite Pierre et Marie Curie, Paris, France
    Crit Care Med 37:2506-11. 2009
    ..Highly controversial data exist regarding gender-related differences in outcomes of severe nosocomial infections, reflecting potential confounders related to case-mixes or heterogeneity of populations evaluated...
  38. ncbi request reprint Value of the clinical pulmonary infection score for the identification and management of ventilator-associated pneumonia
    Charles Edouard Luyt
    Service de Reanimation Medicale, Institut de Cardiologie, Groupe Hospitalier Pitie Salpetriere, 47 Boulevard de l Hopital, 75651 Paris Cedex 13, France
    Intensive Care Med 30:844-52. 2004
    ....
  39. ncbi request reprint Impact of tracheotomy on sedative administration, sedation level, and comfort of mechanically ventilated intensive care unit patients
    Ania Nieszkowska
    Service de Reanimation Medicale, Hopital Pitie Salpetriere, Paris, France
    Crit Care Med 33:2527-33. 2005
    ..To assess the impact of tracheotomy on sedative administration, sedation level, and autonomy of mechanically-ventilated intensive care unit (ICU) patients...
  40. ncbi request reprint Novel and innovative strategies to treat ventilator-associated pneumonia: optimizing the duration of therapy and nebulizing antimicrobial agents
    Ivan Goldstein
    Reanimation Chirurgicale Pierre Viars, Institut de Cardiologie, Hopital Pitie Salpetriere, Paris, France
    Semin Respir Crit Care Med 27:82-91. 2006
    ..The superiority in terms of pulmonary penetration and antibacterial efficacy of this route of administration was demonstrated in a model of ventilated piglets with and without bronchopneumonia...
  41. doi request reprint Pharmacokinetics and tolerability of amikacin administered as BAY41-6551 aerosol in mechanically ventilated patients with gram-negative pneumonia and acute renal failure
    Charles Edouard Luyt
    Service de Reanimation Medicale, Hopital Pitie Salpetriere, Paris, France
    J Aerosol Med Pulm Drug Deliv 24:183-90. 2011
    ..Given the predominantly renal clearance of aminoglycosides, understanding systemic amikacin exposure and safety during administration of BAY41-6551 to patients with acute renal failure (ARF) is clinically important...
  42. pmc Imipenem, meropenem, or doripenem to treat patients with Pseudomonas aeruginosa ventilator-associated pneumonia
    Charles Edouard Luyt
    Service de Reanimation Medicale, Groupe Hospitalier Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Paris, France
    Antimicrob Agents Chemother 58:1372-80. 2014
    ..15) and mortality rates (47%, 25%, and 22%, respectively; P=0.07). Carbapenem resistance emerged similarly among patients treated with any carbapenem. No carbapenem was superior to another for preventing carbapenem resistance emergence...
  43. ncbi request reprint The invasive (quantitative) diagnosis of ventilator-associated pneumonia
    Jean Chastre
    Service de Reanimation Medicale, Institut de Cardiologie, Hopital Pitie Salpetriere, 43 87 bd de l Hôpital, 75651 Paris Cedex 13, France
    Respir Care 50:797-807; discussion 807-12. 2005
    ..Bronchoalveolar lavage may also provide useful clues for the diagnosis of other forms of respiratory failure, such as pulmonary hemorrhage or other types of infections, especially in immunocompromised patients...
  44. doi request reprint Two-dimensional strain rate and Doppler tissue myocardial velocities: analysis by echocardiography of hemodynamic and functional changes of the failed left ventricle during different degrees of extracorporeal life support
    Nadia Aissaoui
    Universite Rene Descartes Paris V, Paris, France
    J Am Soc Echocardiogr 25:632-40. 2012
    ....
  45. pmc Pharmacokinetics and lung delivery of PDDS-aerosolized amikacin (NKTR-061) in intubated and mechanically ventilated patients with nosocomial pneumonia
    Charles Edouard Luyt
    Service de Reanimation Medicale, Groupe Hospitalier Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Université Paris Pierre et Marie Curie, 75651 Paris Cedex 13, France
    Crit Care 13:R200. 2009
    ....
  46. ncbi request reprint Ventilator-associated pneumonia
    Jean Chastre
    Service de Reanimation Medicale, Groupe Hospitalier Pitie Salpetriere, France
    Am J Respir Crit Care Med 165:867-903. 2002
    ..Further trials will be needed to clarify the optimal duration of treatment and the circumstances in which monotherapy can be safely used...
  47. doi request reprint Aerosolized antibiotics to treat ventilator-associated pneumonia
    Charles Edouard Luyt
    Service de Reanimation Medicale, Institut de Cardiologie, Groupe Hospitalier Pitie Salpetriere, 47 83 boulevard de l Hopital, Paris Cedex 13, France
    Curr Opin Infect Dis 22:154-8. 2009
    ..This review summarizes the recent data on antibiotic aerosolization to treat ventilator-associated pneumonia...
  48. ncbi request reprint Herpes simplex virus lung infection in patients undergoing prolonged mechanical ventilation
    Charles Edouard Luyt
    Service de Reanimation Medicale, Institut de Cardiologie, Groupe Hospitalier Pitie Salpetriere, Université de Paris Pierre et Marie Curie, Assistance Publique Hopitaux de Paris, Paris Cedex 13, France
    Am J Respir Crit Care Med 175:935-42. 2007
    ....
  49. doi request reprint Value of the serum procalcitonin level to guide antimicrobial therapy for patients with ventilator-associated pneumonia
    Charles Edouard Luyt
    Service de Reanimation Medicale, Institut de Cardiologie, Groupe Hospitalier Pitie Salpetriere, Paris, France
    Semin Respir Crit Care Med 32:181-7. 2011
    ..Accordingly, for VAP patients, procalcitonin may be used to stop antibiotics as early as day 3 after their initiation, if its concentration is <0.5 ng/mL or has decreased by ≥80%, compared with the first peak concentration...
  50. ncbi request reprint Antimicrobial treatment of hospital-acquired pneumonia
    Jean Yves Fagon
    University Paris 5, Service de Reanimation Medicale, Hopital Europeen Georges Pompidou, 20, rue Leblanc, Paris 75015, France
    Clin Chest Med 26:97-104. 2005
    ..To meet these goals, a strategy for the management of suspected ventilator-associated pneumonia should include obtaining reliable pulmonary specimens for direct microscope examination and cultures before new antibiotics are administered...
  51. doi request reprint Virus-induced acute respiratory distress syndrome: epidemiology, management and outcome
    Charles Edouard Luyt
    Assistance Publique Hopitaux de Paris, Universite Paris 6 Pierre et Marie Curie, Institut de Cardiologie, Groupe Hospitalier Pitie Salpetriere, Service de Reanimation Medicale, 75651 Paris Cedex 13, France
    Presse Med 40:e561-8. 2011
    ..Ganciclovir can be considered for patients with ARDS and histology- or cytology-proven CMV pneumonia...
  52. doi request reprint Pharmacokinetics and safety of panobacumab: specific adjunctive immunotherapy in critical patients with nosocomial Pseudomonas aeruginosa O11 pneumonia
    Qin Lu
    Multidisciplinary Intensive Care Unit, Department of Anesthesiology, La Pitie Salpetriere Hospital, Assistance Publique Hopitaux de Paris, UPMC Paris 6, France
    J Antimicrob Chemother 66:1110-6. 2011
    ..Nosocomial Pseudomonas aeruginosa pneumonia remains a major concern in critically ill patients. We explored the potential impact of microorganism-targeted adjunctive immunotherapy in such patients...
  53. ncbi request reprint Antimicrobial treatment of hospital-acquired pneumonia
    Jean Chastre
    Service de Réanimation Médicale Institut de Cardiologie, Hopital Pitie Salpetriere, Paris, France
    Infect Dis Clin North Am 17:727-37, vi. 2003
    ..Great efforts should be placed to obtain reliable pulmonary specimens for direct microscopic examination and cultures in each patient clinically suspected of having developed nosocomial pneumonia before new antibiotics are administered...
  54. pmc Is bronchoalveolar lavage with quantitative cultures a useful tool for diagnosing ventilator-associated pneumonia?
    Jean Yves Fagon
    Réanimation Médicale, Hopital Europeen Georges Pompidou, Assistance Publique Hopitaux de Paris, Universite Paris Descartes, Paris, France
    Crit Care 11:123. 2007
    ..Such a strategy has two requirements: immediate administration of adequate therapy in patients with true VAP, and avoidance of administering antibiotics in patients without bacterial infection...
  55. doi request reprint Outcomes and long-term quality-of-life of patients supported by extracorporeal membrane oxygenation for refractory cardiogenic shock
    Alain Combes
    Service de Reanimation Medicale, Hopital Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Universite Pierre et Marie Curie, Paris 6, Paris, France
    Crit Care Med 36:1404-11. 2008
    ..To assess the outcomes and long-term quality-of-life of patients supported by extracorporeal membrane oxygenation (ECMO) for refractory cardiogenic shock...
  56. ncbi request reprint Long-term outcomes of pandemic 2009 influenza A(H1N1)-associated severe ARDS
    Charles Edouard Luyt
    Service de Reanimation Medicale, Groupe Hospitalier Pitie Salpetriere, Assistance Publique Hôpitaux de Paris et Université Paris 6 Pierre et Marie Curie, Paris, France
    Chest 142:583-92. 2012
    ..The objective of this study was to compare the 1-year outcomes of survivors of A(H1N1)-associated ARDS, according to use or no use of extracorporeal lung assist (ECLA), using its need as an ARDS severity surrogate...
  57. ncbi request reprint Out-of-hospital extra-corporeal life support implantation during refractory cardiac arrest in a half-marathon runner
    Guillaume Lebreton
    Service de Chirurgie Cardio Thoracique, Hopital Pitie Salpetriere, Universite Pierre et Marie Curie Paris 6, Paris, France
    Resuscitation 82:1239-42. 2011
    ..The cardiogenic shock resolved progressively, enabling ECLS weaning within 48h, while renal, hepatic, and respiratory functions recovered simultaneously...
  58. ncbi request reprint Ventilator-associated pneumonia: what is new?
    Jean Chastre
    Institut de Cardiologie, Hopital Pitie Salpetriere, Paris, France
    Surg Infect (Larchmt) 7:S81-5. 2006
    ..However, effective antimicrobial therapy for patients with true VAP can be achieved while avoiding excessive antibiotic use and the emergence of multidrug-resistant strains in the ICU...
  59. ncbi request reprint Impact of red blood cell transfusion on platelet aggregation and inflammatory response in anemic coronary and noncoronary patients: the TRANSFUSION-2 study (impact of transfusion of red blood cell on platelet activation and aggregation studied with flow c
    Johanne Silvain
    Institut de Cardiologie, Institut National de la Santé et de la Recherche Médicale CMR937, Allies in Cardiovascular Trials Initiatives and Organized Networks Group, Pitié Salpétrière hospital Assistance Publique Hôpitaux de Paris, Universite Pierre et Marie Curie, Paris, France
    J Am Coll Cardiol 63:1289-96. 2014
    ..This study sought to determine whether red blood cell (RBC) transfusion increases in vivo platelet aggregation and inflammation in coronary and noncoronary patients...
  60. doi request reprint What role do viruses play in nosocomial pneumonia?
    Charles Edouard Luyt
    Service de Reanimation Medicale, Institut de Cardiologie, Groupe Hospitalier Pitie Salpetriere, Assistance Publique Hopitaux de Paris, and Université Paris 6 Pierre et Marie Curie, Paris, France
    Curr Opin Infect Dis 27:194-9. 2014
    ..Viruses are an increasingly recognized cause of community-acquired pneumonia (CAP), but their exact role in nosocomial pneumonia is still debated. This review focuses on the role of viruses as a cause of nosocomial pneumonia...
  61. doi request reprint Diffusion tensor imaging to predict long-term outcome after cardiac arrest: a bicentric pilot study
    Charles Edouard Luyt
    Service de Reanimation, School of Medicine, Groupe Hospitalier Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Université Paris Pierre et Marie Curie, Paris, France
    Anesthesiology 117:1311-21. 2012
    ..The authors' objective was to determine whether an assessment with diffusion tensor imaging, a brain magnetic resonance imaging sequence, increases the accuracy of 1 yr functional outcome prediction in cardiac arrest survivors...
  62. ncbi request reprint Conference summary: ventilator-associated pneumonia
    Jean Chastre
    Service de Reanimation Medicale, Institut de Cardiologie, Hopital Pitie Salpetriere, 43 87 bd de l Hôpital, 75651 Paris Cedex 13, France
    Respir Care 50:975-83. 2005
    ....
  63. ncbi request reprint Diagnosis of ventilator-associated pneumonia
    Jean Chastre
    N Engl J Med 356:1469; author reply 1470-1. 2007
  64. ncbi request reprint Infective endocarditis in the intensive care unit: clinical spectrum and prognostic factors in 228 consecutive patients
    Bruno Mourvillier
    Service de Réanimation Médicale et des Maladies Infectieuses, Hopital Bichat Claude Bernard, AP HP, 46 rue Henri Huchard, 75877 Paris Cedex 18, France
    Intensive Care Med 30:2046-52. 2004
    ..To identify factors associated with in-hospital outcome of adult patients admitted to the ICU with infective endocarditis (IE)...
  65. ncbi request reprint Antibiotic prescribing for ventilator-associated pneumonia: get it right from the beginning but be able to rapidly deescalate
    Jean Chastre
    Intensive Care Med 31:1463-5. 2005
  66. ncbi request reprint Methicillin-resistant Staphylococcus aureus prolongs intensive care unit stay in ventilator-associated pneumonia, despite initially appropriate antibiotic therapy
    Andrew F Shorr
    Pulmonary and Critical Care Medicine, Washington Hospital Center, Washington, DC, USA
    Crit Care Med 34:700-6. 2006
    ....
  67. ncbi request reprint Hemodynamic monitoring in shock and implications for management. International Consensus Conference, Paris, France, 27-28 April 2006
    Massimo Antonelli
    Istituto di Anestesiologia e Rianimazione, Policlinico Universitario A Gemelli, Universita Cattolica del Sacro Cuore, Largo A Gemelli, 8, 00168 Rome, Italy
    Intensive Care Med 33:575-90. 2007
    ..The goal of this consensus statement is to provide recommendations regarding the monitoring and management of the critically ill patient with shock...
  68. doi request reprint Year in review in Intensive Care Medicine, 2007. III. Ethics and legislation, health services research, pharmacology and toxicology, nutrition and paediatrics
    Massimo Antonelli
    Department of Intensive Care and Anesthesiology, Policlinico Universitario A Gemelli, Largo A Gemelli, 8, 00168, Rome, Italy
    Intensive Care Med 34:598-609. 2008