Helene Chappuy

Summary

Country: France

Publications

  1. ncbi Parental consent in paediatric clinical research
    H Chappuy
    Département d Urgences Pédiatriques, Hôpital Necker Enfants Malades Faculté de Médecine René Descartes, Paris, France
    Arch Dis Child 91:112-6. 2006
  2. ncbi Children's views on their involvement in clinical research
    Helene Chappuy
    Département d Urgences Pédiatriques, Hopital Necker Enfants Malades, Assistance Publique Hopitaux de Paris et Laboratoire d Ethique Médicale Université René Descartes Paris, France
    Pediatr Blood Cancer 50:1043-6. 2008
  3. ncbi Do parents understand the medical information provided in paediatric emergency departments? A prospective multicenter study
    Helene Chappuy
    Universite Paris Descartes, Service d Urgences Pédiatriques, Hopital Necker Enfants Malades, Assistance Publique Hopitaux de Paris, Paris, France
    Acta Paediatr 101:1089-94. 2012
  4. ncbi Parental comprehension and satisfaction in informed consent in paediatric clinical trials: a prospective study on childhood leukaemia
    H Chappuy
    Service d Urgences Pédiatriques, Hopital Necker Enfants Malades, 149 rue de Sevres, 75743 Paris Cedex 15, France
    Arch Dis Child 95:800-4. 2010
  5. ncbi Length of the treatment and number of doses per day as major determinants of child adherence to acute treatment
    H Chappuy
    Service d Urgences Pédiatriques, Hopital Necker Enfants Malades, Assistance Publique Hopitaux de Paris, Paris, France
    Acta Paediatr 99:433-7. 2010
  6. ncbi [Compliance with medication in children]
    H Chappuy
    , , 149, , 75743 Paris Cedex 15, AP-HP, , France
    Arch Pediatr 12:921-3. 2005
  7. ncbi [Informed consent in pediatric clinical trials]
    H Chappuy
    , , 149, , 75743 Paris Cedex 15, , Paris, France
    Arch Pediatr 12:778-80. 2005
  8. ncbi Pregnancy-related effects on tenofovir pharmacokinetics: a population study with 186 women
    Sihem Benaboud
    Université Paris Descartes Sorbonne Paris Cité, EA3620, Paris, France
    Antimicrob Agents Chemother 56:857-62. 2012
  9. ncbi Readability of the written study information in pediatric research in France
    Véronique Ménoni
    Unité de Recherche Clinique Paris Centre, Hopital Necker Enfants Malades, Assistance Publique Hopitaux de Paris, Paris, France
    PLoS ONE 6:e18484. 2011
  10. ncbi Pregnancy-related effects on lamivudine pharmacokinetics in a population study with 228 women
    Sihem Benaboud
    Universite Paris Descartes, Paris, France
    Antimicrob Agents Chemother 56:776-82. 2012

Collaborators

Detail Information

Publications24

  1. ncbi Parental consent in paediatric clinical research
    H Chappuy
    Département d Urgences Pédiatriques, Hôpital Necker Enfants Malades Faculté de Médecine René Descartes, Paris, France
    Arch Dis Child 91:112-6. 2006
    ....
  2. ncbi Children's views on their involvement in clinical research
    Helene Chappuy
    Département d Urgences Pédiatriques, Hopital Necker Enfants Malades, Assistance Publique Hopitaux de Paris et Laboratoire d Ethique Médicale Université René Descartes Paris, France
    Pediatr Blood Cancer 50:1043-6. 2008
    ..To examine the level of children's understanding of informed consent in clinical trials and factors that may influence these processes...
  3. ncbi Do parents understand the medical information provided in paediatric emergency departments? A prospective multicenter study
    Helene Chappuy
    Universite Paris Descartes, Service d Urgences Pédiatriques, Hopital Necker Enfants Malades, Assistance Publique Hopitaux de Paris, Paris, France
    Acta Paediatr 101:1089-94. 2012
    ..We evaluated the extent to which parents understood the medical information about hospitalization of their child in an emergency department and looked for characteristics likely to increase the risk of poor comprehension...
  4. ncbi Parental comprehension and satisfaction in informed consent in paediatric clinical trials: a prospective study on childhood leukaemia
    H Chappuy
    Service d Urgences Pédiatriques, Hopital Necker Enfants Malades, 149 rue de Sevres, 75743 Paris Cedex 15, France
    Arch Dis Child 95:800-4. 2010
    ....
  5. ncbi Length of the treatment and number of doses per day as major determinants of child adherence to acute treatment
    H Chappuy
    Service d Urgences Pédiatriques, Hopital Necker Enfants Malades, Assistance Publique Hopitaux de Paris, Paris, France
    Acta Paediatr 99:433-7. 2010
    ..To determine the rate of aftercare adherence to prescriptions from a paediatric emergency department and to identify predictors for nonadherence...
  6. ncbi [Compliance with medication in children]
    H Chappuy
    , , 149, , 75743 Paris Cedex 15, AP-HP, , France
    Arch Pediatr 12:921-3. 2005
  7. ncbi [Informed consent in pediatric clinical trials]
    H Chappuy
    , , 149, , 75743 Paris Cedex 15, , Paris, France
    Arch Pediatr 12:778-80. 2005
  8. ncbi Pregnancy-related effects on tenofovir pharmacokinetics: a population study with 186 women
    Sihem Benaboud
    Université Paris Descartes Sorbonne Paris Cité, EA3620, Paris, France
    Antimicrob Agents Chemother 56:857-62. 2012
    ....
  9. ncbi Readability of the written study information in pediatric research in France
    Véronique Ménoni
    Unité de Recherche Clinique Paris Centre, Hopital Necker Enfants Malades, Assistance Publique Hopitaux de Paris, Paris, France
    PLoS ONE 6:e18484. 2011
    ..The aim was to evaluate the readability of research information leaflets (RIL) for minors asked to participate in biomedical research studies and to assess the factors influencing this readability...
  10. ncbi Pregnancy-related effects on lamivudine pharmacokinetics in a population study with 228 women
    Sihem Benaboud
    Universite Paris Descartes, Paris, France
    Antimicrob Agents Chemother 56:776-82. 2012
    ..9. Pregnant women had a 22% higher apparent clearance than nonpregnant and parturient women; however, this increase did not lead to subexposure and should not require a dosage adjustment...
  11. ncbi The readability of information and consent forms in clinical research in France
    Véronique Ménoni
    Unité de Recherche Clinique Paris Centre, Hopital Necker Enfants Malades, Assistance Publique Hopitaux de Paris, Universite Paris Descartes, Paris, France
    PLoS ONE 5:e10576. 2010
    ..These studies all showed that such documents had a low level of readability. Our objective is to evaluate the readability of Information and Consent Forms (ICFs) used in clinical research...
  12. ncbi Comparison of a morphine and midazolam combination with morphine alone for paediatric displaced fractures: a randomized study
    Chrystèle Wille-Ledon
    Service d Urgences Pédiatriques, Hopital Necker Enfants Malades, Assistance Publique Hopitaux de Paris, Universite Paris Descartes, France
    Acta Paediatr 100:e203-7. 2011
    ..To compare the efficacy of sublingual midazolam with oral morphine versus that of oral morphine with placebo in a paediatric population attending an emergency department (ED) with acute long-bone fractures...
  13. ncbi [Informed consent form for biomedical research: a tutorial for redaction]
    Yvette Henin
    INSERM CIC BT505, Paris, France
    Therapie 65:71-94. 2010
    ....
  14. ncbi [Neurological complications revealing infectious endocarditis: 2 case reports]
    V Nouyrigat
    Service des urgences pédiatriques, Hopital Necker Enfants Malades, AP HP, Faculte de Medecine, Universite Paris Descartes, 149, rue de Sevres, 75015 Paris, France
    Arch Pediatr 18:401-4. 2011
    ..Early diagnosis and early treatment will minimize cardiac and neurological morbidities...
  15. ncbi High levels of P-glycoprotein activity in human lymphocytes in the first 6 months of life
    C Giraud
    Universite Paris Descartes, Paris, France
    Clin Pharmacol Ther 85:289-95. 2009
    ..MDR1 gene expression was not influenced by age, nor was it correlated with P-gp activity. The high levels of P-gp activity observed in the lymphocytes of children ~6 months of age may affect the efficacy of intracellular drugs...
  16. ncbi [Sedation in the emergency department: how far can and should we go?]
    G Cheron
    Département des Urgences Pédiatriques, Hopital Necker Enfants Malades, APHP, Universite Paris V, 149, rue de Sevres, 75743 Paris Cedex 15, France
    Arch Pediatr 14:732-4. 2007
  17. ncbi [Consent in paediatric clinical trials]
    Helene Chappuy
    Service de Pharmacologie, Hopital Saint Vincent de Paul, Paris, France
    Therapie 59:421-9. 2004
  18. ncbi Pharmacokinetic modelling of the placental transfer of nelfinavir and its M8 metabolite: a population study using 75 maternal-cord plasma samples
    Deborah Hirt
    Pharmacologie Clinique, Assistance Publique Hopitaux de Paris, Groupe Hospitalier Cochin Saint Vincent De Paul, Faculté de Médecine René Descartes, Universite Paris 5, Paris, France
    Br J Clin Pharmacol 64:634-44. 2007
    ..A population pharmacokinetic model was developed to characterize the transfer of nelfinavir and its active metabolite M8 from maternal to cord plasma and amniotic fluid...
  19. ncbi High levels and safety of oseltamivir carboxylate plasma concentrations after nasogastric administration in critically ill children in a pediatric intensive care unit
    Carole Giraud
    Groupe Hospitalier Broca Cochin Hôtel Dieu, Assistance Publique Hopitaux de Paris, Unite de recherche clinique, Paris, France
    Antimicrob Agents Chemother 55:433-5. 2011
    ..5 and 6.8 mg/kg of body weight. High OC concentrations were found, with a mean level of 678 ± 535 μg/liter. The mean OP concentration was 27 ± 52 μg/liter. No marked side effect was reported...
  20. ncbi Bleeding complications after ritual circumcision: about six children
    Nathalie Bocquet
    Department of Pediatric Emergency, université Paris V René Descartes, Hopital Necker Enfants Malades, 149 Rue Sevres, 75743 Paris, France
    Eur J Pediatr 169:359-62. 2010
    ..To avoid such complications, it is recommended that circumcision should be performed by doctors trained in this procedure. Parents have to be cautioned about the risks of possible complications after this procedure...
  21. ncbi Acute acalculous cholecystitis in a child returning from the Ivory Coast
    Marie Constance Anthoine-Milhomme
    Pediatric Emergency Department, Hopital Necker Enfants Malades, AP HP, Universite Paris, Paris, France
    Pediatr Emerg Care 23:242-3. 2007
    ..We report the case of a 7-year-old child who presented AAC due to plasmodium falciparum infection. The causes of AAC are discussed...
  22. ncbi An unusual cause of extensive edema
    Simon Escoda
    Département des Urgences Pédiatriques, Hopital Necker Enfants Malades, 149 rue de Sevres, 75743 Paris Cedex 15, France
    Pediatr Emerg Care 26:378-9. 2010
    ..We report the case of an 8-month-old boy with a history of kwashiorkor. Even if the diagnosis is not obvious, there is a need to perform a proper diagnosis at admission to avoid inappropriate management...
  23. ncbi Influence of development, HIV infection, and antiretroviral therapies on the gene expression profiles of ABC transporters in human lymphocytes
    Carole Giraud
    Centre de Recherche Clinique Paris Descartes, Groupe Hospitalier Cochin Saint Vincent De Paul, Assistance Publique Hopitaux de Paris, Site Hôpital Tarnier, 75006 Paris, France
    J Clin Pharmacol 50:226-30. 2010
    ..Neither HIV infection nor antiretroviral therapies modulated the gene expression profiles of ABC transporters. In conclusion, drugs that are substrates of BCRP and MRP4, like zidovudine, may have an altered efficacy in newborns...
  24. ncbi Weight related differences in the pharmacokinetics of abacavir in HIV-infected patients
    V Jullien
    Pharmacologie Clinique, Universite Rene Descartes, Groupe Hospitalier Cochin Saint Vincent De Paul, Assitance Publique Hôpitaux de Paris, Paris, France
    Br J Clin Pharmacol 59:183-8. 2005
    ..To study the possible influence of patient characteristics on abacavir pharmacokinetics...