Helene Chappuy

Summary

Country: France

Publications

  1. pmc Parental consent in paediatric clinical research
    H Chappuy
    Département d Urgences Pédiatriques, Hôpital Necker Enfants Malades Faculté de Médecine René Descartes, Paris, France
    Arch Dis Child 91:112-6. 2006
  2. ncbi request reprint Children's views on their involvement in clinical research
    Helene Chappuy
    Département d Urgences Pédiatriques, Hopital Necker Enfants Malades, Assistance Publique Hopitaux de Paris et Laboratoire d Ethique Médicale Université René Descartes Paris, France
    Pediatr Blood Cancer 50:1043-6. 2008
  3. pmc Nasopharyngeal carriage of individual Streptococcus pneumoniae serotypes during pediatric radiologically confirmed community acquired pneumonia following PCV7 introduction in Switzerland
    Helene Chappuy
    Child and Adolescent Department, University Hospital of Geneva, Geneva, Switzerland
    BMC Infect Dis 13:357. 2013
  4. doi request reprint Do parents understand the medical information provided in paediatric emergency departments? A prospective multicenter study
    Helene Chappuy
    Universite Paris Descartes, Service d Urgences Pédiatriques, Hopital Necker Enfants Malades, Assistance Publique Hopitaux de Paris, Paris, France
    Acta Paediatr 101:1089-94. 2012
  5. doi request reprint Length of the treatment and number of doses per day as major determinants of child adherence to acute treatment
    H Chappuy
    Service d Urgences Pédiatriques, Hopital Necker Enfants Malades, Assistance Publique Hopitaux de Paris, Paris, France
    Acta Paediatr 99:433-7. 2010
  6. doi request reprint Parental comprehension and satisfaction in informed consent in paediatric clinical trials: a prospective study on childhood leukaemia
    H Chappuy
    Service d Urgences Pédiatriques, Hopital Necker Enfants Malades, 149 rue de Sevres, 75743 Paris Cedex 15, France
    Arch Dis Child 95:800-4. 2010
  7. ncbi request reprint [Compliance with medication in children]
    H Chappuy
    Département des Urgences Pédiatriques, Hopital Necker Enfants Malades, 149, rue de Sevres, 75743 Paris Cedex 15, AP HP, Universite Paris V, France
    Arch Pediatr 12:921-3. 2005
  8. ncbi request reprint [Informed consent in pediatric clinical trials]
    H Chappuy
    Département des Urgences Pédiatriques, Hopital Necker Enfants Malades, 149, rue de Sevres, 75743 Paris Cedex 15, Universite Paris V, Paris, France
    Arch Pediatr 12:778-80. 2005
  9. ncbi request reprint Abacavir pharmacokinetics in human immunodeficiency virus-infected children ranging in age from 1 month to 16 years: a population analysis
    Vincent Jullien
    Pharmacologie Clinique, Universite Rene Descartes, Groupe Hospitalier Cochin Saint Vincent De Paul, Assistance Publique Hopitaux de Paris, 82 avenue Denfert Rochereau, 75674 Paris Cedex 14, France
    J Clin Pharmacol 45:257-64. 2005
  10. pmc Pregnancy-related effects on tenofovir pharmacokinetics: a population study with 186 women
    Sihem Benaboud
    Université Paris Descartes Sorbonne Paris Cité, EA3620, Paris, France
    Antimicrob Agents Chemother 56:857-62. 2012

Collaborators

Detail Information

Publications28

  1. pmc Parental consent in paediatric clinical research
    H Chappuy
    Département d Urgences Pédiatriques, Hôpital Necker Enfants Malades Faculté de Médecine René Descartes, Paris, France
    Arch Dis Child 91:112-6. 2006
    ....
  2. ncbi request reprint Children's views on their involvement in clinical research
    Helene Chappuy
    Département d Urgences Pédiatriques, Hopital Necker Enfants Malades, Assistance Publique Hopitaux de Paris et Laboratoire d Ethique Médicale Université René Descartes Paris, France
    Pediatr Blood Cancer 50:1043-6. 2008
    ..To examine the level of children's understanding of informed consent in clinical trials and factors that may influence these processes...
  3. pmc Nasopharyngeal carriage of individual Streptococcus pneumoniae serotypes during pediatric radiologically confirmed community acquired pneumonia following PCV7 introduction in Switzerland
    Helene Chappuy
    Child and Adolescent Department, University Hospital of Geneva, Geneva, Switzerland
    BMC Infect Dis 13:357. 2013
    ..Community-acquired pneumonia (CAP) is a serious cause of morbidity among children in developed countries. The real impact of 7-valent pneumococcal conjugate vaccine (PCV7) on pneumococcal pneumonia is difficult to assess accurately...
  4. doi request reprint Do parents understand the medical information provided in paediatric emergency departments? A prospective multicenter study
    Helene Chappuy
    Universite Paris Descartes, Service d Urgences Pédiatriques, Hopital Necker Enfants Malades, Assistance Publique Hopitaux de Paris, Paris, France
    Acta Paediatr 101:1089-94. 2012
    ..We evaluated the extent to which parents understood the medical information about hospitalization of their child in an emergency department and looked for characteristics likely to increase the risk of poor comprehension...
  5. doi request reprint Length of the treatment and number of doses per day as major determinants of child adherence to acute treatment
    H Chappuy
    Service d Urgences Pédiatriques, Hopital Necker Enfants Malades, Assistance Publique Hopitaux de Paris, Paris, France
    Acta Paediatr 99:433-7. 2010
    ..To determine the rate of aftercare adherence to prescriptions from a paediatric emergency department and to identify predictors for nonadherence...
  6. doi request reprint Parental comprehension and satisfaction in informed consent in paediatric clinical trials: a prospective study on childhood leukaemia
    H Chappuy
    Service d Urgences Pédiatriques, Hopital Necker Enfants Malades, 149 rue de Sevres, 75743 Paris Cedex 15, France
    Arch Dis Child 95:800-4. 2010
    ....
  7. ncbi request reprint [Compliance with medication in children]
    H Chappuy
    Département des Urgences Pédiatriques, Hopital Necker Enfants Malades, 149, rue de Sevres, 75743 Paris Cedex 15, AP HP, Universite Paris V, France
    Arch Pediatr 12:921-3. 2005
  8. ncbi request reprint [Informed consent in pediatric clinical trials]
    H Chappuy
    Département des Urgences Pédiatriques, Hopital Necker Enfants Malades, 149, rue de Sevres, 75743 Paris Cedex 15, Universite Paris V, Paris, France
    Arch Pediatr 12:778-80. 2005
  9. ncbi request reprint Abacavir pharmacokinetics in human immunodeficiency virus-infected children ranging in age from 1 month to 16 years: a population analysis
    Vincent Jullien
    Pharmacologie Clinique, Universite Rene Descartes, Groupe Hospitalier Cochin Saint Vincent De Paul, Assistance Publique Hopitaux de Paris, 82 avenue Denfert Rochereau, 75674 Paris Cedex 14, France
    J Clin Pharmacol 45:257-64. 2005
    ..5 +/- 2.5 mg x h/L, which is slightly greater than the mean AUC value reported in adults. This study confirms the relevance of the current weight-based abacavir dosage regimen in pediatric patients...
  10. pmc Pregnancy-related effects on tenofovir pharmacokinetics: a population study with 186 women
    Sihem Benaboud
    Université Paris Descartes Sorbonne Paris Cité, EA3620, Paris, France
    Antimicrob Agents Chemother 56:857-62. 2012
    ....
  11. pmc Readability of the written study information in pediatric research in France
    Véronique Ménoni
    Unité de Recherche Clinique Paris Centre, Hopital Necker Enfants Malades, Assistance Publique Hopitaux de Paris, Paris, France
    PLoS ONE 6:e18484. 2011
    ..The aim was to evaluate the readability of research information leaflets (RIL) for minors asked to participate in biomedical research studies and to assess the factors influencing this readability...
  12. doi request reprint High exposure to zidovudine during the first 2 weeks of life and concentration-toxicity relationships
    Deborah Hirt
    AP HP, Unite de recherche clinique, Hôpital Tarnier, Paris, France CIC 0901 Inserm, Cochin Necker, Paris, France AP HP, Service de Pharmacologie Clinique, Hopital Cochin, Universite Paris Descartes, Sorbonne Paris Cité, Paris, France INSERM CESP U1018 Equipe VIH et IST, Le Kremlin Bicetre, France University of Paris Sud, Le Kremlin Bicetre, France AP HP, Service d Epidémiologie et Santé Publique, Hopital Bicetre, Le Kremlin Bicetre, France AP HP, Service de Neonatologie, hôpital Cochin Port Royal, Paris, France Université Paris Descartes EA 3620, Sorbonne Paris Cité, Paris, France Laboratoire d Ethique Médicale, Universite Paris Descartes, Paris, France Service d Urgences Pédiatriques, Hopital Necker Enfants Malades, Assistance Publique Hopitaux de Paris, Paris, France and AP HP, Unite d immunologie, Hématologie et Rhumatologie pédiatriques
    J Acquir Immune Defic Syndr 63:555-62. 2013
    ....
  13. pmc Pregnancy-related effects on lamivudine pharmacokinetics in a population study with 228 women
    Sihem Benaboud
    Universite Paris Descartes, Paris, France
    Antimicrob Agents Chemother 56:776-82. 2012
    ..9. Pregnant women had a 22% higher apparent clearance than nonpregnant and parturient women; however, this increase did not lead to subexposure and should not require a dosage adjustment...
  14. pmc The readability of information and consent forms in clinical research in France
    Véronique Ménoni
    Unité de Recherche Clinique Paris Centre, Hopital Necker Enfants Malades, Assistance Publique Hopitaux de Paris, Universite Paris Descartes, Paris, France
    PLoS ONE 5:e10576. 2010
    ..These studies all showed that such documents had a low level of readability. Our objective is to evaluate the readability of Information and Consent Forms (ICFs) used in clinical research...
  15. doi request reprint Comparison of a morphine and midazolam combination with morphine alone for paediatric displaced fractures: a randomized study
    Chrystèle Wille-Ledon
    Service d Urgences Pédiatriques, Hopital Necker Enfants Malades, Assistance Publique Hopitaux de Paris, Universite Paris Descartes, France
    Acta Paediatr 100:e203-7. 2011
    ..To compare the efficacy of sublingual midazolam with oral morphine versus that of oral morphine with placebo in a paediatric population attending an emergency department (ED) with acute long-bone fractures...
  16. doi request reprint [Informed consent form for biomedical research: a tutorial for redaction]
    Yvette Henin
    INSERM CIC BT505, Paris, France
    Therapie 65:71-94. 2010
    ....
  17. doi request reprint [Neurological complications revealing infectious endocarditis: 2 case reports]
    V Nouyrigat
    Service des urgences pédiatriques, Hopital Necker Enfants Malades, AP HP, Faculte de Medecine, Universite Paris Descartes, 149, rue de Sevres, 75015 Paris, France
    Arch Pediatr 18:401-4. 2011
    ..Early diagnosis and early treatment will minimize cardiac and neurological morbidities...
  18. doi request reprint High levels of P-glycoprotein activity in human lymphocytes in the first 6 months of life
    C Giraud
    Universite Paris Descartes, Paris, France
    Clin Pharmacol Ther 85:289-95. 2009
    ..MDR1 gene expression was not influenced by age, nor was it correlated with P-gp activity. The high levels of P-gp activity observed in the lymphocytes of children ~6 months of age may affect the efficacy of intracellular drugs...
  19. ncbi request reprint [Sedation in the emergency department: how far can and should we go?]
    G Cheron
    Département des Urgences Pédiatriques, Hopital Necker Enfants Malades, APHP, Universite Paris V, 149, rue de Sevres, 75743 Paris Cedex 15, France
    Arch Pediatr 14:732-4. 2007
  20. doi request reprint Vitamin D deficiency and insufficiency in HIV-infected children and young adults
    Candice Meyzer
    From the Unité de Recherche Clinique Paris Centre, Hopital Necker Enfants Malades, Assistance Publique Hôpitaux de Paris CIC P0901 Mère Enfant, INSERM, Hopital Necker Enfants Malades, Assistance Publique Hopitaux de Paris, Université Paris Descartes EA3620, Universite Paris Descartes, Sorbonne Paris Cité Unité d Immunologie et Hématologie Pédiatriques Urgences Pédiatriques, Hopital Necker Enfants Malades, Assistance Publique Hôpitaux de Paris Laboratoire d Ethique Médicale, Universite Paris Descartes, Paris Centre d Examens de Santé de la Caisse Primaire d Assurance Maladie de la Seine Saint Denis, Bobigny Service d Explorations Fonctionnelles, Hopital Necker Enfants Malades, Assistance Publique Hôpitaux de Paris INSERM U845, équipe Homéostasie du Phosphate, Université Paris Descartes Pharmacologie, Groupe Hospitalier Broca Cochin Hôtel Dieu and Service de Physiologie et Explorations Fonctionnelles, Hopital Europeen Georges Pompidou, Assistance Publique Hopitaux de Paris, Paris, France J M T and M C contributed equally to the study
    Pediatr Infect Dis J 32:1240-4. 2013
    ..Vitamin D insufficiency and HIV infection are both risk factors for chronic disorders, so it is important to consider vitamin D status in HIV-infected patients...
  21. ncbi request reprint [Consent in paediatric clinical trials]
    Helene Chappuy
    Service de Pharmacologie, Hopital Saint Vincent de Paul, Paris, France
    Therapie 59:421-9. 2004
  22. pmc Pharmacokinetic modelling of the placental transfer of nelfinavir and its M8 metabolite: a population study using 75 maternal-cord plasma samples
    Deborah Hirt
    Pharmacologie Clinique, Assistance Publique Hopitaux de Paris, Groupe Hospitalier Cochin Saint Vincent De Paul, Faculté de Médecine René Descartes, Universite Paris 5, Paris, France
    Br J Clin Pharmacol 64:634-44. 2007
    ..A population pharmacokinetic model was developed to characterize the transfer of nelfinavir and its active metabolite M8 from maternal to cord plasma and amniotic fluid...
  23. pmc High levels and safety of oseltamivir carboxylate plasma concentrations after nasogastric administration in critically ill children in a pediatric intensive care unit
    Carole Giraud
    Groupe Hospitalier Broca Cochin Hôtel Dieu, Assistance Publique Hopitaux de Paris, Unite de recherche clinique, Paris, France
    Antimicrob Agents Chemother 55:433-5. 2011
    ..5 and 6.8 mg/kg of body weight. High OC concentrations were found, with a mean level of 678 ± 535 μg/liter. The mean OP concentration was 27 ± 52 μg/liter. No marked side effect was reported...
  24. doi request reprint Bleeding complications after ritual circumcision: about six children
    Nathalie Bocquet
    Department of Pediatric Emergency, université Paris V René Descartes, Hopital Necker Enfants Malades, 149 Rue Sevres, 75743 Paris, France
    Eur J Pediatr 169:359-62. 2010
    ..To avoid such complications, it is recommended that circumcision should be performed by doctors trained in this procedure. Parents have to be cautioned about the risks of possible complications after this procedure...
  25. ncbi request reprint Acute acalculous cholecystitis in a child returning from the Ivory Coast
    Marie Constance Anthoine-Milhomme
    Pediatric Emergency Department, Hopital Necker Enfants Malades, AP HP, Universite Paris, Paris, France
    Pediatr Emerg Care 23:242-3. 2007
    ..We report the case of a 7-year-old child who presented AAC due to plasmodium falciparum infection. The causes of AAC are discussed...
  26. doi request reprint An unusual cause of extensive edema
    Simon Escoda
    Département des Urgences Pédiatriques, Hopital Necker Enfants Malades, 149 rue de Sevres, 75743 Paris Cedex 15, France
    Pediatr Emerg Care 26:378-9. 2010
    ..We report the case of an 8-month-old boy with a history of kwashiorkor. Even if the diagnosis is not obvious, there is a need to perform a proper diagnosis at admission to avoid inappropriate management...
  27. doi request reprint Influence of development, HIV infection, and antiretroviral therapies on the gene expression profiles of ABC transporters in human lymphocytes
    Carole Giraud
    Centre de Recherche Clinique Paris Descartes, Groupe Hospitalier Cochin Saint Vincent De Paul, Assistance Publique Hopitaux de Paris, Site Hôpital Tarnier, 75006 Paris, France
    J Clin Pharmacol 50:226-30. 2010
    ..Neither HIV infection nor antiretroviral therapies modulated the gene expression profiles of ABC transporters. In conclusion, drugs that are substrates of BCRP and MRP4, like zidovudine, may have an altered efficacy in newborns...
  28. pmc Weight related differences in the pharmacokinetics of abacavir in HIV-infected patients
    V Jullien
    Pharmacologie Clinique, Universite Rene Descartes, Groupe Hospitalier Cochin Saint Vincent De Paul, Assitance Publique Hôpitaux de Paris, Paris, France
    Br J Clin Pharmacol 59:183-8. 2005
    ..To study the possible influence of patient characteristics on abacavir pharmacokinetics...