Daniel Chappard

Summary

Country: France

Publications

  1. ncbi Two dental implants designed for immediate loading: a finite element analysis
    Laurent Pierrisnard
    Faculty of Dental Surgery, Montrouge, University of Paris V, France
    Int J Oral Maxillofac Implants 17:353-62. 2002
  2. ncbi Medullar fat influences texture analysis of trabecular microarchitecture on X-ray radiographs
    Daniel Chappard
    INSERM, EMI 0335, LHEA, Faculte de Medecine, 49045 Angers Cedex, France
    Eur J Radiol 58:404-10. 2006
  3. ncbi Effects of risedronate in a rat model of osteopenia due to orchidectomy and disuse: densitometric, histomorphometric and microtomographic studies
    Helene Libouban
    INSERM, U922 LHEA, Faculte de Medecine, 49045 Angers Cedex, France
    Micron 39:998-1007. 2008
  4. doi Computed microtomography of bone specimens for rapid analysis of bone changes associated with malignancy
    Daniel Chappard
    INSERM, U 922 LHEA Remodelage Osseux et Biomatériaux, Faculte de Medecine, Angers Cedex, France
    Anat Rec (Hoboken) 293:1125-33. 2010
  5. doi Orchidectomy models of osteoporosis
    Stephane Blouin
    INSERM, U 922, Universite d Angers, Angers, France
    Methods Mol Biol 455:125-34. 2008
  6. doi Quantification of dendritic cells and osteoclasts in the bone marrow of patients with monoclonal gammopathy
    Nicolas Josselin
    Faculte de Medecine, INSERM, U922 LHEA, 49045, Angers Cedex, France
    Pathol Oncol Res 15:65-72. 2009
  7. doi In vitro assessment of osteoblast and macrophage mobility in presence of β-TCP particles by videomicroscopy
    Johanne Beuvelot
    INSERM, U922 LHEA, Faculte de Medecine, Angers, France
    J Biomed Mater Res A 96:108-15. 2011
  8. ncbi A single pretreatment by zoledronic acid converts metastases from osteolytic to osteoblastic in the rat
    Herve Nyangoga
    INSERM, U922 LHEA, Faculte de Medecine, 49045 Angers Cedex, France
    Microsc Res Tech 73:733-40. 2010
  9. doi Bone grafts cultured with bone marrow stromal cells for the repair of critical bone defects: an experimental study in mice
    Aline Dumas
    INSERM, U922, LHEA, Faculte de Medecine, 49045 Angers Cedex, France
    J Biomed Mater Res A 90:1218-29. 2009
  10. doi Relationships between bone mass and micro-architecture at the mandible and iliac bone in edentulous subjects: a dual X-ray absorptiometry, computerised tomography and microcomputed tomography study
    François Bodic
    INSERM, U922 LHEA, IRIS IBS, Institut de Biologie en Santé, CHU d Angers, Angers, France
    Gerodontology 29:e585-94. 2012

Collaborators

Detail Information

Publications40

  1. ncbi Two dental implants designed for immediate loading: a finite element analysis
    Laurent Pierrisnard
    Faculty of Dental Surgery, Montrouge, University of Paris V, France
    Int J Oral Maxillofac Implants 17:353-62. 2002
    ..The aim of this study was to evaluate by finite element analysis the influence of the design of 3 different dental implants on micromovements, cervical shearing stress intensity, and stress distribution after occlusal loading...
  2. ncbi Medullar fat influences texture analysis of trabecular microarchitecture on X-ray radiographs
    Daniel Chappard
    INSERM, EMI 0335, LHEA, Faculte de Medecine, 49045 Angers Cedex, France
    Eur J Radiol 58:404-10. 2006
    ..The fat content of bone marrow induces noise that can modify some texture parameters. One should take into account the fat content of the marrow when using texture analysis to compare patients with osteoporosis due to various etiologies...
  3. ncbi Effects of risedronate in a rat model of osteopenia due to orchidectomy and disuse: densitometric, histomorphometric and microtomographic studies
    Helene Libouban
    INSERM, U922 LHEA, Faculte de Medecine, 49045 Angers Cedex, France
    Micron 39:998-1007. 2008
    ..In conclusion, ORX and BTX resulted in additive effects on bone loss. Risedronate had protective effects on trabecular bone loss but was less effective on cortical bone...
  4. doi Computed microtomography of bone specimens for rapid analysis of bone changes associated with malignancy
    Daniel Chappard
    INSERM, U 922 LHEA Remodelage Osseux et Biomatériaux, Faculte de Medecine, Angers Cedex, France
    Anat Rec (Hoboken) 293:1125-33. 2010
    ..MicroCT can be used in the immediate postbiopsy period making possible a fast identification of malignancy. However these signs are not specific and must be confirmed by histopathological analysis...
  5. doi Orchidectomy models of osteoporosis
    Stephane Blouin
    INSERM, U 922, Universite d Angers, Angers, France
    Methods Mol Biol 455:125-34. 2008
    ..It induces a decrease of BMD and BV/TV with microarchitecture alterations due to an increased bone remodeling. The present chapter focuses on the ORX surgery in rats and mice...
  6. doi Quantification of dendritic cells and osteoclasts in the bone marrow of patients with monoclonal gammopathy
    Nicolas Josselin
    Faculte de Medecine, INSERM, U922 LHEA, 49045, Angers Cedex, France
    Pathol Oncol Res 15:65-72. 2009
    ..These findings can help in the classification of MGUS in the early stages of the disease and could help to propose preventive treatments...
  7. doi In vitro assessment of osteoblast and macrophage mobility in presence of β-TCP particles by videomicroscopy
    Johanne Beuvelot
    INSERM, U922 LHEA, Faculte de Medecine, Angers, France
    J Biomed Mater Res A 96:108-15. 2011
    ..Data obtained from long-term videomicroscopy are in agreement with in vivo observations confirming the interest of β-TCP to promote osteogenesis...
  8. ncbi A single pretreatment by zoledronic acid converts metastases from osteolytic to osteoblastic in the rat
    Herve Nyangoga
    INSERM, U922 LHEA, Faculte de Medecine, 49045 Angers Cedex, France
    Microsc Res Tech 73:733-40. 2010
    ..Osteosclerosis was associated with increased osteoblastic surfaces. A single zoledronic acid injection turned osteolytic metastases into osteosclerotic and preserved cortical integrity...
  9. doi Bone grafts cultured with bone marrow stromal cells for the repair of critical bone defects: an experimental study in mice
    Aline Dumas
    INSERM, U922, LHEA, Faculte de Medecine, 49045 Angers Cedex, France
    J Biomed Mater Res A 90:1218-29. 2009
    ..No GFP+ cell was noted after 8 weeks. However, pre-implantation culture of the biomaterial with allogenic BMSC greatly enhanced the bone regeneration...
  10. doi Relationships between bone mass and micro-architecture at the mandible and iliac bone in edentulous subjects: a dual X-ray absorptiometry, computerised tomography and microcomputed tomography study
    François Bodic
    INSERM, U922 LHEA, IRIS IBS, Institut de Biologie en Santé, CHU d Angers, Angers, France
    Gerodontology 29:e585-94. 2012
    ....
  11. doi Effect of alpha tocopherol acetate in Walker 256/B cells-induced oxidative damage in a rat model of breast cancer skeletal metastases
    Riadh Badraoui
    INSERM, U 922 LHEA, Faculte de Medecine, 49045 Angers Cedex, France
    Chem Biol Interact 182:98-105. 2009
    ..ATA reduced the oxidative stress damage, enhanced osteosclerosis and tumor cell apoptosis both in vitro and in vivo...
  12. doi Synthesis and use of pHEMA microbeads with human EA.hy 926 endothelial cells
    Herve Nyangoga
    INSERM, U922 LHEA, Faculte de Medecine, 49045 Angers Cedex, France
    J Biomed Mater Res B Appl Biomater 89:501-7. 2009
    ..3D reconstruction of confocal optical sections clearly evidenced the uptake and internalization of microbeads by endothelial cells. pHEMA microbeads could represent potential drug carrier in tumor model of metastases...
  13. doi Migration of wear debris of polyethylene depends on bone microarchitecture
    Helene Libouban
    INSERM, U922, LHEA, Faculte de Medecine, 49045 Angers Cedex, France
    J Biomed Mater Res B Appl Biomater 90:730-7. 2009
    ..This is an explanation for the development of inflammatory reaction at distance from a prosthesis although our study did not include submicron particles...
  14. doi In vitro kinetic study of growth and mineralization of osteoblast-like cells (Saos-2) on titanium surface coated with a RGD functionalized bisphosphonate
    Johanne Beuvelot
    INSERM, U922, LHEA, Faculte de Medecine, Angers, Cedex 49045, France
    J Biomed Mater Res B Appl Biomater 90:873-81. 2009
    ..05). In the present study, this new method was found suitable to anchor RGD containing species on titanium: this favored adhesion and spreading of osteoblast-like cells and mineralization compared to noncoated titanium...
  15. doi The cathepsin K inhibitor AAE581 induces morphological changes in osteoclasts of treated patients
    Daniel Chappard
    INSERM, U922 LHEA, Faculte de Medecine, Angers Cedex, France
    Microsc Res Tech 73:726-32. 2010
    ..Cat-K inhibition (inhibiting the extracellular collagen breakdown) is associated with a compensatory accumulation of intracellular TRAcP that could not be used to complete protein degradation. TRAcP is also known to be degraded by Cat-K...
  16. ncbi Absence of renal lesions in C57BL/KaLwRij mice with advanced myeloma due to 5T2MM cells
    Helene Libouban
    INSERM, EMI 0335 LHEA, Faculte de Medecine, 49045 Angers Cedex, France
    Leuk Res 30:1371-5. 2006
    ..PTH levels decreased in 5T2MM mice, confirming the absence of secondary hyperparathyroidism. Osteolytic lesions appear to be the unique consequence of 5T2MM cells inoculation...
  17. doi Sinus lift augmentation and beta-TCP: a microCT and histologic analysis on human bone biopsies
    Daniel Chappard
    INSERM, U922 LHEA, Faculte de Medecine, Rue Haute de Reculee, 49045 Angers Cedex, France
    Micron 41:321-6. 2010
    ..The material favors the apposition of lamellar bone by osteoblasts and is simultaneous resorbed by two types of cells...
  18. ncbi A non-steroidal anti-inflammatory drug (ketoprofen) does not delay beta-TCP bone graft healing
    Herve Nyangoga
    INSERM, U922 LHEA, Faculte de Medecine, 49045 Angers Cedex, France
    Acta Biomater 6:3310-7. 2010
    ..Ketoprofen had no effect on the amount of bone formed and on the number of labeled macrophages. The influence of small doses of NSAID, given in a short duration period, did not present deleterious effects on bone graft healing...
  19. ncbi Trabecular bone microarchitecture is related to the number of risk factors and etiology in osteoporotic men
    Erick Legrand
    INSERM, EMI 0335 LHEA, Faculte de Medecine, 49045 Angers Cedex, France
    Microsc Res Tech 70:952-9. 2007
    ..In osteoporotic men, higher the number of risk factors, lower the connectivity of trabecular network and higher the vertebral fracture risk...
  20. pmc Three-dimensional characterization of the vascular bed in bone metastasis of the rat by microcomputed tomography (MicroCT)
    Herve Nyangoga
    INSERM, U922 LHEA, IRIS IBS Institut de Biologie en Santé, CHU d Angers, Angers, France
    PLoS ONE 6:e17336. 2011
    ..They are not fully representative of the trajectories of vessels throughout the tissues and are not adapted to analyze changes occurring inside the bone marrow cavities...
  21. doi Glucocorticoids reduce alveolar and trabecular bone in mice
    Béatrice Bouvard
    INSERM, U922, LHEA, IRIS IBM, Institut de Biologie en Santé, CHU d Angers, 4, rue Larrey, 49933 Angers Cedex, France
    Joint Bone Spine 80:77-81. 2013
    ..Glucocorticoid (GC) treatment is the main cause of secondary osteoporosis. There are some controversies about the relationships between alveolar bone loss and bone loss at the appendicular and axial skeleton...
  22. ncbi Bone loss and teeth
    François Bodic
    INSERM EMI 0335 LHEA, Faculte de Medecine, 49045 Angers Cedex, France
    Joint Bone Spine 72:215-21. 2005
    ..To date, there are few reliable methods for obtaining quantitative measurements of bone mineral content in maxillary and mandibular bone...
  23. doi Depth and volume of resorption induced by osteoclasts generated in the presence of RANKL, TNF-alpha/IL-1 or LIGHT
    Guillaume Mabilleau
    INSERM, U922 LHEA Remodelage osseux et Biomatériaux, IRIS IBS, Institut de Biologie en Santé, CHU d Angers, 49933 Angers, France
    Cytokine 57:294-9. 2012
    ..These results provide evidence that although LIGHT appeared elevated in the synovial fluid of RA patients, its role in bone resorption is less than TNF-alpha/IL-1 or RANKL...
  24. doi In vitro calcification of chemically functionalized carbon nanotubes
    Johanne Beuvelot
    INSERM, U LHEA, France
    Acta Biomater 6:4110-7. 2010
    ..Functionalization of SWCNTs with carboxylic groups confers the capacity to induce calcification similar to woven bone...
  25. doi Effects of FGF-2 release from a hydrogel polymer on bone mass and microarchitecture
    Guillaume Mabilleau
    INSERM, U922 LHEA, Faculte de Medecine, 49045 Angers Cedex, France
    Biomaterials 29:1593-600. 2008
    ..The hydrogel polymer allowed the release of FGF-2, which in return enhanced bone regeneration soon after surgery but the effect vanished rapidly...
  26. doi Vertebral fractures are associated with increased cortical porosity in iliac crest bone biopsy of men with idiopathic osteoporosis
    Agnes Ostertag
    INSERM, U606, and Université Paris Diderot, Centre Viggo Petersen, Hopital Lariboisiere, Paris, France
    Bone 44:413-7. 2009
    ..This suggests that the cortical deficit is different in men and in women with fragility fractures...
  27. ncbi Reproducibility of CT-based bone texture parameters of cancellous calf bone samples: influence of slice thickness
    Pascal Guggenbuhl
    INSERM, U642, LTSI, Campus Beaulieu, Bat 22, 35042 Rennes Cedex, France
    Eur J Radiol 67:514-20. 2008
    ..The results were influenced by slice thicknesses, emphasizing the importance of the conditions of acquisition...
  28. doi Biomimetic potential of some methacrylate-based copolymers: a comparative study
    Teodora Zecheru
    INSERM, U922, LHEA, Faculty of Medicine, University of Angers, 1 rue Haute de Reculée, Angers Cedex 49045, France
    Biopolymers 91:966-73. 2009
    ..GlyMA and MOETAC-containing copolymers show promising results for further in vivo mineralization tests, as a potential alternative to the classical bone grafts, in bone tissue engineering...
  29. ncbi Comparison insight bone measurements by histomorphometry and microCT
    Daniel Chappard
    INSERM, EMI 0335, LHEA, Faculte de Medecine, Angers Cedex, France
    J Bone Miner Res 20:1177-84. 2005
    ..Morphometric analysis of 70 bone biopsies was done in parallel by microCT and histomorphometry. microCT provided higher results for trabecular thickness and separation because of the 3D shape of these anatomical objects...
  30. ncbi Mandibular bone loss in an animal model of male osteoporosis (orchidectomized rat): a radiographic and densitometric study
    Emmanuelle Lerouxel
    INSERM EMI 0335, LHEA, Faculte de Medecine, 49045, Angers Cedex, France
    Osteoporos Int 15:814-9. 2004
    ..016). This study confirms that in the male rat, the reduction of sex hormones induced by ORX is associated with a decrease in bone mass in the mandible...
  31. ncbi Iron inhibits hydroxyapatite crystal growth in vitro
    Pascal Guggenbuhl
    INSERM, U 922 LHEA, Faculte de Medecine, Angers Cedex 49045, France
    Metabolism 57:903-10. 2008
    ..Energy dispersive x-ray analysis identified iron in the calcospherites. In vitro, iron is capable to inhibit bone crystal growth with significant changes in crystallinity and carbonate substitution...
  32. ncbi Bone changes in myelofibrosis with myeloid metaplasia: a histomorphometric and microcomputed tomographic study
    Aline Schmidt
    Service d Hématologie UPRES EA 3863, Faculte de Medecine, Angers Cedex, France
    Eur J Haematol 78:500-9. 2007
    ..An uncoupling of bone remodelling was evidenced with an increased life-span of osteoblasts associated with a normal/reduced osteoclast activity. A very complex network of factors is candidate to explain bone changes observed in MMM...
  33. ncbi Rat models of bone metastases
    Stephane Blouin
    Faculte de Medecine, INSERM, EMI 0335 LHEA, 49045 Angers Cedex, France
    Clin Exp Metastasis 22:605-14. 2005
    ..The use of models developed in different species should be more predictive and bring a beam of arguments for a better knowledge of pathophysiological and therapeutic mechanisms...
  34. ncbi Texture analysis of X-ray radiographs is correlated with bone histomorphometry
    Daniel Chappard
    INSERM EMI 0335 LHEA Rhumatologie, Faculte de Medecine, 49045 Angers, France
    J Bone Miner Metab 23:24-9. 2005
    ..Although the relationships between the 2D and 3D trabecular architecture are not fully elucidated, the texture analysis of X-ray films might be a suitable approach to investigate the disorganization of bone in osteoporosis...
  35. ncbi The influence of processes for the purification of human bone allografts on the matrix surface and cytocompatibility
    Aline Dumas
    INSERM, EMI 0335 LHEA, Faculte de Medecine, 49045 Angers Cedex, France
    Biomaterials 27:4204-11. 2006
    ..Whether these changes have clinical consequences on the bone bonding and osseointegration in human necessitate further investigations...
  36. ncbi Central control of bone mass: potential therapeutic implications
    Regis Levasseur
    Rheumatology Department and Bone and Joint Center, Angers Teaching Hospital, 4, rue Larrey, 49 933 Angers cedex 9, France
    Joint Bone Spine 72:474-6. 2005
  37. ncbi Bone structure of the calcaneus: analysis with magnetic resonance imaging and correlation with histomorphometric study
    Nathalie Boutry
    Department of Bone Radiology, Centre Hospitalier Universitaire de Lille, 59037, Lille Cedex, France
    Osteoporos Int 15:827-33. 2004
    ..This study suggests that structural parameters characterizing cancellous bone in the calcaneus can be derived from MR images in the limited spatial resolution regime applicable in vivo...
  38. ncbi Respective roles of porto-septal fibrosis and centrilobular fibrosis in alcoholic liver disease
    Sophie Michalak
    Laboratoire d Anatomie Pathologique, CHU, 49033 Angers Cedex 01, France
    J Pathol 201:55-62. 2003
    ..PTF is more responsible for the amount of fibrosis than CLF. The results of this study also validate the use of the Metavir fibrosis score in alcoholic chronic liver disease...
  39. ncbi Comparison of pencil-, fan-, and cone-beam dual X-ray absorptiometers for evaluation of bone mineral content in excised rat bone
    Helene Libouban
    LHEA GEROM, Laboratoire d Histologie Embryologie, CHU and Faculté de Médecine, Angers Cedex, France
    J Clin Densitom 5:355-61. 2002
    ..This dependence was less pronounced with the cone-beam technology...
  40. ncbi Fractal dimension can distinguish models and pharmacologic changes in liver fibrosis in rats
    Frédéric Moal
    UPRES EA 2170 et 3141, Universite d Angers, France
    Hepatology 36:840-9. 2002
    ..This is the only quantitative morphometric method that can discriminate among the models of fibrosis and is sensitive enough to detect pharmacologically induced changes in liver fibrosis...