Gerard Chaouat

Summary

Country: France

Publications

  1. doi request reprint More than a decade of debates in the preeclampsia (island) workshops: a (personally biased) evolutionary perspective
    Gerard Chaouat
    U976 INSERM, Pavillon Bazin, Hopital Saint Louis, avenue Claude Vellefaux, 75010 Paris, France Electronic address
    J Reprod Immunol 101:70-3. 2014
  2. doi request reprint Inflammation, NK cells and implantation: friend and foe (the good, the bad and the ugly?): replacing placental viviparity in an evolutionary perspective
    Gerard Chaouat
    U 976 INSERM, pavillon Equerre Bazin, Hopital Saint Louis, Paris, France
    J Reprod Immunol 97:2-13. 2013
  3. ncbi request reprint Effectors regulatory T cells in pregnancy (and autoimmunity?)
    Gerard Chaouat
    U 782 INSERM, 32 rue des Carnets, 92141 Clamart, Cedex, France
    Expert Rev Clin Immunol 3:861-9. 2007
  4. ncbi request reprint Immunological similarities between implantation and pre-eclampsia
    Gerard Chaouat
    U 131 IN SERM, Equipe Cytokines et Relation Materno Foetale, Hopital Antoine Beclere, 92141 Clamart Cedex, France
    Am J Reprod Immunol 53:222-9. 2005
  5. ncbi request reprint The Th1/Th2 paradigm: still important in pregnancy?
    Gerard Chaouat
    Unité 782 INSERM, 32 rue des Carnets 92141 Clamart, France
    Semin Immunopathol 29:95-113. 2007
  6. pmc Cytokines: Important for implantation?
    Gerard Chaouat
    U 782 INSERM, Equipe Cytokines et Dialogue Cytokinique Mère Conceptus, Université Paris Sud et Hôpîtal Antoine Béclère, 32 rue des Carnets, Clamart Cedex, France
    J Assist Reprod Genet 24:491-505. 2007
  7. ncbi request reprint Current knowledge on natural killer cells, pregnancy and pre-eclampsia. Introduction
    Gerard Chaouat
    U 782 INSERM, Equipe implantation et dialogue cytokinique mère conceptus, 32 rue des Carnets et Hôpital Antoine Béclère Pavillon Jean Dalsace, 92141 Clamart France
    Reprod Biomed Online 16:170-2. 2008
  8. doi request reprint Comment: Primum non-Nocere
    Gerard Chaouat
    U 782, INSERM, Hopital A Beclere Pavillon Jean Dalsace Maternite, Clamart, France
    Am J Reprod Immunol 60:17-8. 2008
  9. doi request reprint Tolerance to the foetal allograft?
    Gerard Chaouat
    U 782 INSERM, Universite Paris Sud, and Hôpital Antoine Béclère, Clamart, France
    Am J Reprod Immunol 63:624-36. 2010
  10. ncbi request reprint Is there a place for immunomodulation in assisted reproduction techniques?
    Gerard Chaouat
    U131 INSERM, Hospital Antoine Beclere, Avenue de lat Porte de Trivaux, Clamart 92141, France
    J Reprod Immunol 62:29-39. 2004

Collaborators

Detail Information

Publications35

  1. doi request reprint More than a decade of debates in the preeclampsia (island) workshops: a (personally biased) evolutionary perspective
    Gerard Chaouat
    U976 INSERM, Pavillon Bazin, Hopital Saint Louis, avenue Claude Vellefaux, 75010 Paris, France Electronic address
    J Reprod Immunol 101:70-3. 2014
    ..In this short remembrance paper, I survey (what I believe are) key events in the evolution of the concepts of preeclampsia from the first workshop in 1998 to the 2012 one, and from Tahiti to Reunion island, via Mauritius and Tioman Island. ..
  2. doi request reprint Inflammation, NK cells and implantation: friend and foe (the good, the bad and the ugly?): replacing placental viviparity in an evolutionary perspective
    Gerard Chaouat
    U 976 INSERM, pavillon Equerre Bazin, Hopital Saint Louis, Paris, France
    J Reprod Immunol 97:2-13. 2013
    ....
  3. ncbi request reprint Effectors regulatory T cells in pregnancy (and autoimmunity?)
    Gerard Chaouat
    U 782 INSERM, 32 rue des Carnets, 92141 Clamart, Cedex, France
    Expert Rev Clin Immunol 3:861-9. 2007
    ..We review the evidence linking the cyclic recruitment of Tregs in the uterus with preparation for pregnancy, and how this, via endocrine signals, might affect autoimmunity...
  4. ncbi request reprint Immunological similarities between implantation and pre-eclampsia
    Gerard Chaouat
    U 131 IN SERM, Equipe Cytokines et Relation Materno Foetale, Hopital Antoine Beclere, 92141 Clamart Cedex, France
    Am J Reprod Immunol 53:222-9. 2005
    ..Cytokines are involved in implantation success and failure. We envisage that they could be similarly involved in pre-eclampsia (PE)...
  5. ncbi request reprint The Th1/Th2 paradigm: still important in pregnancy?
    Gerard Chaouat
    Unité 782 INSERM, 32 rue des Carnets 92141 Clamart, France
    Semin Immunopathol 29:95-113. 2007
    ..In this review, we replace the emergence of the paradigm in its historical context and then emphasises what it does explain and what it no longer account for. A final reappraisal of the paradigm is suggested...
  6. pmc Cytokines: Important for implantation?
    Gerard Chaouat
    U 782 INSERM, Equipe Cytokines et Dialogue Cytokinique Mère Conceptus, Université Paris Sud et Hôpîtal Antoine Béclère, 32 rue des Carnets, Clamart Cedex, France
    J Assist Reprod Genet 24:491-505. 2007
    ..Cytokines are obviously very important in an established pregnancy, but what about human embryo implantation?..
  7. ncbi request reprint Current knowledge on natural killer cells, pregnancy and pre-eclampsia. Introduction
    Gerard Chaouat
    U 782 INSERM, Equipe implantation et dialogue cytokinique mère conceptus, 32 rue des Carnets et Hôpital Antoine Béclère Pavillon Jean Dalsace, 92141 Clamart France
    Reprod Biomed Online 16:170-2. 2008
    ..As an ultimate consequence in cases of dysfunction/dysregulation, these factors result in implantation failure, abortion or pre-eclampsia...
  8. doi request reprint Comment: Primum non-Nocere
    Gerard Chaouat
    U 782, INSERM, Hopital A Beclere Pavillon Jean Dalsace Maternite, Clamart, France
    Am J Reprod Immunol 60:17-8. 2008
  9. doi request reprint Tolerance to the foetal allograft?
    Gerard Chaouat
    U 782 INSERM, Universite Paris Sud, and Hôpital Antoine Béclère, Clamart, France
    Am J Reprod Immunol 63:624-36. 2010
    ..We will then consider whether it applies to the foetal-maternal relationship and discuss the mechanisms involved in non-rejection of the foeto-placental unit...
  10. ncbi request reprint Is there a place for immunomodulation in assisted reproduction techniques?
    Gerard Chaouat
    U131 INSERM, Hospital Antoine Beclere, Avenue de lat Porte de Trivaux, Clamart 92141, France
    J Reprod Immunol 62:29-39. 2004
    ..We, however, do not reject immunotherapy, but we believe that molecular and cellular defects specific approaches should be used, tailored for the specific pathway whose disruption cause the clinical symptom...
  11. ncbi request reprint TH1/TH2 paradigm in pregnancy: paradigm lost? Cytokines in pregnancy/early abortion: reexamining the TH1/TH2 paradigm
    Gerard Chaouat
    U 131 INSERM, Maternité, Hopital A Beclere, FR 92141 Clamart, France
    Int Arch Allergy Immunol 134:93-119. 2004
    ..Rather, step-specific events have to be considered and a key role is seen in local tissue remodelling, in which immune cytokines play an important role while not always being secreted by immune cells...
  12. ncbi request reprint Reproductive immunology 2003: reassessing the Th1/Th2 paradigm?
    Gerard Chaouat
    U 131 INSERM, Hopital Antoine Beclere, 32 rue des Carnets, 92141 Clamart, France
    Immunol Lett 92:207-14. 2004
    ..We conclude by a repeated warning against the so-called rationales of lymphocyte alloimmunization for therapy of recurrent spontaneous abortion and improvement of implantation rates...
  13. ncbi request reprint Role of the endometrial tripod interleukin-18, -15, and -12 in inadequate uterine receptivity in patients with a history of repeated in vitro fertilization-embryo transfer failure
    Nathalie Ledee-Bataille
    Institut National de Santé et Recherche Médicale INSERM U131, Equipe Cytokines et Relation Materno Foetale, et Service de Gynécologie Obstétrique, Hopital Antoine Béclere AP HP, Clamart, France
    Fertil Steril 83:598-605. 2005
    ....
  14. ncbi request reprint Implantation: can immunological parameters of implantation failure be of interest for pre-eclampsia?
    Gerard Chaouat
    U131 INSERM, Unite Cytokines dans la Relation Materno Fetale, 32 rue des Carnets, 92141 Clamart, France
    J Reprod Immunol 59:205-17. 2003
    ..We draw lessons for preeclampsia, and describe features of a model for its immune aetiology...
  15. pmc TWEAK appears as a modulator of endometrial IL-18 related cytotoxic activity of uterine natural killers
    Marie Petitbarat
    INSERM, U782, Implantation et Dialogue Materno Fœtal, University Paris Sud, UMR S0782, Hopital Antoine Beclere, Clamart, France
    PLoS ONE 6:e14497. 2011
    ..Indeed, previous results suggested that basic TWEAK expression influences the IL-18 related uNK recruitment and local cytotoxicity...
  16. doi request reprint Tumor necrosis factor-like weak inducer of apoptosis (TWEAK)/fibroblast growth factor inducible-14 might regulate the effects of interleukin 18 and 15 in the human endometrium
    Marie Petitbarat
    INSERM, U 782, Equipe Cytokines et Dialogue Cytokinique Mère Conceptus, Universite Paris Sud, UMR S0782, and Hôpital Antoine Béclère, Clamart, France
    Fertil Steril 94:1141-3. 2010
    ....
  17. ncbi request reprint A new role for natural killer cells, interleukin (IL)-12, and IL-18 in repeated implantation failure after in vitro fertilization
    Nathalie Ledee-Bataille
    Cytokines et relation materno foetale, Institut National de la Sante et de la Recherche Medicale, Unité 131, Clamart, France
    Fertil Steril 81:59-65. 2004
    ..To investigate the endometrial immunohistochemical staining of interleukin (IL)-12 and IL-18 and to quantify the CD56 bright natural killer (NK) cells in relation to Doppler vascular disorders...
  18. ncbi request reprint Cytokines, implantation and early abortion: re-examining the Th1/Th2 paradigm leads to question the single pathway, single therapy concept
    Gerard Chaouat
    U131 INSERM, Clamart, France
    Am J Reprod Immunol 50:177-86. 2003
    ..Implantation cytokine networks need to be known in such a perspective...
  19. ncbi request reprint A brief review of recent data on some cytokine expressions at the materno-foetal interface which might challenge the classical Th1/Th2 dichotomy
    Gerard Chaouat
    U 131 INSERM, Equipe cytokines et relation materno faetale, Hopital Antoine Beclere, 92141, Clamart, France
    J Reprod Immunol 53:241-56. 2002
    ....
  20. doi request reprint Early regulators in abortion and implications for a preeclampsia model
    Gerard Chaouat
    Unité 782 INSERM, Hôpital Antoine Béclère et Université Paris Sud Orsay, 92141 Clamart Cedex, France gerard
    J Reprod Immunol 82:131-40. 2009
    ..The implications of these findings for utilising the CBA/JxDBA/2 mating combination as an early onset model of preeclampsia are discussed...
  21. doi request reprint Specific and extensive endometrial deregulation is present before conception in IVF/ICSI repeated implantation failures (IF) or recurrent miscarriages
    Nathalie Ledee
    Inserm U 782, Clamart, France
    J Pathol 225:554-64. 2011
    ..Extensive endometrial deregulations are present before conception in patients who experienced IF or RM with both distinct and common deregulation...
  22. ncbi request reprint Evaluation of Cytokeratin 7 as an accurate intracellular marker with which to assess the purity of human placental villous trophoblast cells by flow cytometry
    Juan Maldonado-Estrada
    INSERM U131, Equipe Cytokines et Régulation Materno Foetale, Maternité, Hopital Antoine Beclere, Clamart, France
    J Immunol Methods 286:21-34. 2004
    ..These results provide evidence that the mutually exclusive pattern of intracellular CK7/vimentin expression of human TC can be used for evaluation by flow cytometry of the purity of primary human trophoblast cells...
  23. doi request reprint Immune regulation at the interface during early steps of murine implantation: involvement of two new cytokines of the IL-12 family (IL-23 and IL-27) and of TWEAK
    Anne Elisabeth Mas
    Unité 782 INSERM, Hôpital Antoine Béclére AP HP 92141 Clamart, France
    Am J Reprod Immunol 59:323-38. 2008
    ..We therefore searched for regulators of the IL-12/IL-18 family of cytokines as well as for antagonist(s) of TNF with potentially selective effects on implantation...
  24. doi request reprint Performance evaluation of microbead and ELISA assays for follicular G-CSF: a non-invasive biomarker of oocyte developmental competence for embryo implantation
    Nathalie Ledee
    INSERM U782, Universite Paris Sud, UMR S0782, Clamart F 92140, France
    J Reprod Immunol 86:126-32. 2010
    ..61 [0.52-0.70] p=0.84). Microbead assay and flow cytometry appeared similarly efficient for quantifying follicular fluid G-CSF and multiplex versus single-plex assays did not influence the reliability of quantification...
  25. ncbi request reprint Immune cells in uteroplacental tissues throughout pregnancy: a brief review
    Gerard Chaouat
    U 782 INSERM, Equipe implantation et dialogue cytokinique mère conceptus, 32 rue des Carnets et Hôpital Antoine Béclère Pavillon Jean Dalsace, 92141 Clamart, France
    Reprod Biomed Online 14:256-66. 2007
    ..Clinical data on the IL-12/IL-18/NK tripod and implantation failure in humans are detailed...
  26. doi request reprint Levels of follicular G-CSF and interleukin-15 appear as noninvasive biomarkers of subsequent successful birth in modified natural in vitro fertilization/intracytoplasmic sperm injection cycles
    Nathalie Ledee
    INSERM U782, University Paris Sud, and AP HP, Service d Histologie, Embryologie, cytogenetique, HôpitalAntoine Béclère, Clamart, France
    Fertil Steril 95:94-8. 2011
    ..The modified natural IVF/intracytoplasmic sperm injection (ICSI) cycle was used as an experimental model by measuring levels of cytokines, chemokines, and growth factors in individual follicular fluids (FF)...
  27. ncbi request reprint Cytokines and implantation
    Gerard Chaouat
    Equipe cytokines et relation materno foetale U131 INSERM, Hopital Antoine Béclere AP HP, Clamart, France
    Chem Immunol Allergy 88:34-63. 2005
    ..The emerging involvement of cytokines in controlling uterine vascularization angiogenesis is reviewed, with emphasis on NK activating factors...
  28. ncbi request reprint Assessment of leukemia inhibitory factor levels by uterine flushing at the time of egg retrieval does not adversely affect pregnancy rates with in vitro fertilization
    Francois Olivennes
    Service de gynécologie obstétrique et médecine de la reproduction, Hopital Antoine Beclere, Clamart, France
    Fertil Steril 79:900-4. 2003
    ..To assess intrauterine levels of leukemia inhibitory factor (LIF) by uterine flushing at the time of egg retrieval and to confirm that the procedure has no detrimental effect on pregnancy rates...
  29. ncbi request reprint Preeclampsia and human reproduction. An essay of a long term reflection
    Pierre Yves Robillard
    Neonatology, Center Hospitalier Sud Reunion, BP 350, 97448 Saint Pierre cedex, Reunion, France
    J Reprod Immunol 59:93-100. 2003
    ..This frontier might even have occurred inside these Homo lineages: because of their relatively small brains, the first species of Homo might not have presented the deep trophoblastic invasion described in Homo sapiens...
  30. ncbi request reprint Etiology of preeclampsia: maternal vascular predisposition and couple disease--mutual exclusion or complementarity?
    Pierre Yves Robillard
    Neonatology, Groupe Hospitalier Sud Reunion, BP 350, 97448 Saint Pierre cedex, Reunion, France
    J Reprod Immunol 76:1-7. 2007
    ..Here, we reflect on what can be respective parts of the disease in preeclamptic couples, and on preeclampsia as a marker of subjects susceptible to vascular disease...
  31. ncbi request reprint Fourth International Workshop on immunology of pre-eclampsia, December 2004, Reunion, France
    Gerard Chaouat
    INSERM U131, Unité Cytokines dans la Relation Materno Faetale, 32 rue des Carnets, 92141 Clamart, France
    J Reprod Immunol 67:103-11. 2005
    ....
  32. doi request reprint Decreased immune response in alexithymic women: a cross-sectional study
    Olivier Guilbaud
    Département de Psychiatrie de l adolescent et du jeune adulte, Institut Mutualiste Montsouris, Paris, France
    Biomed Pharmacother 63:297-304. 2009
    ..This study further demonstrates that alexithymic women have altered immune function, with a predominance of depressed cell-mediated immunity and a skewed Th1/Th2 ratio towards Th2 response...
  33. ncbi request reprint Immune cells in uteroplacental tissues throughout pregnancy: a brief review
    Gerard Chaouat
    U 782 INSERM, Equipe implantation et dialogue cytokinique mère conceptus, 32 rue des Carnets et Hôpital Antoine Béclère Pavillon Jean Dalsace, 92141 Clamart France
    Reprod Biomed Online 14:83-93. 2007
    ..Clinical data on the IL-12 /IL-18/NK tripod and implantation failure in humans are detailed...
  34. ncbi request reprint Should we re-examine the status of lymphocyte alloimmunization therapy for recurrent spontaneous abortion?
    Gerard Chaouat
    U 131 INSERM, Department of Obstetrics Gynaecology Hôpital A Béclère, Clamart, France
    Am J Reprod Immunol 50:433-8. 2003
    ..This treatment has been the subject of debate for a long period of time. Recently, it has been proposed to extend such a treatment for implantation failure in humans, and I was asked to express my opinion on this topic...
  35. ncbi request reprint Predominant intracellular expression of CXCR4 and CCR5 in purified primary trophoblast cells from first trimester and term human placentae
    Juan Maldonado-Estrada
    INSERM U 131, Equipe Cytokines et Relation Materno Foetale, Hôpital Béclère, Clamart, France
    Am J Reprod Immunol 50:291-301. 2003
    ..The aim of the present study was to define the expression of CXCR4 and CCR5 on non-cultured non-stimulated primary human trophoblast cells (TCs) immediately after their immunopurification...