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Genomes and Genes | Gerard ChaouatSummaryCountry: France Publications
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Publications
Inflammation, NK cells and implantation: friend and foe (the good, the bad and the ugly?): replacing placental viviparity in an evolutionary perspectiveGerard Chaouat
U 976 INSERM, pavillon Equerre Bazin, Hopital Saint Louis, avenue Claude Vellefaux, 75010 Paris, France Electronic address
J Reprod Immunol 97:2-13. 2013....
Effectors regulatory T cells in pregnancy (and autoimmunity?)Gerard Chaouat
U 782 INSERM, 32 rue des Carnets, 92141 Clamart, Cedex, France
Expert Rev Clin Immunol 3:861-9. 2007..We review the evidence linking the cyclic recruitment of Tregs in the uterus with preparation for pregnancy, and how this, via endocrine signals, might affect autoimmunity...- Tolerance to the foetal allograft?Gerard Chaouat
U 782 INSERM, Universite Paris Sud, and Hôpital Antoine Béclère, Clamart, France
Am J Reprod Immunol 63:624-36. 2010..We will then consider whether it applies to the foetal-maternal relationship and discuss the mechanisms involved in non-rejection of the foeto-placental unit... - Comment: Primum non-NocereGerard Chaouat
U 782, INSERM, Hopital A Beclere Pavillon Jean Dalsace Maternite, Clamart, France
Am J Reprod Immunol 60:17-8. 2008 - Current knowledge on natural killer cells, pregnancy and pre-eclampsia. IntroductionGerard Chaouat
U 782 INSERM, Equipe implantation et dialogue cytokinique mère conceptus, 32 rue des Carnets et Hôpital Antoine Béclère Pavillon Jean Dalsace, 92141 Clamart France
Reprod Biomed Online 16:170-2. 2008..As an ultimate consequence in cases of dysfunction/dysregulation, these factors result in implantation failure, abortion or pre-eclampsia... 
Cytokines: Important for implantation?Gerard Chaouat
U 782 INSERM, Equipe Cytokines et Dialogue Cytokinique Mère Conceptus, Université Paris Sud et Hôpîtal Antoine Béclère, 32 rue des Carnets, Clamart Cedex, France
J Assist Reprod Genet 24:491-505. 2007..Cytokines are obviously very important in an established pregnancy, but what about human embryo implantation?..- The Th1/Th2 paradigm: still important in pregnancy?Gerard Chaouat
Unité 782 INSERM, 32 rue des Carnets 92141 Clamart, France
Semin Immunopathol 29:95-113. 2007..In this review, we replace the emergence of the paradigm in its historical context and then emphasises what it does explain and what it no longer account for. A final reappraisal of the paradigm is suggested... - Immunological similarities between implantation and pre-eclampsiaGerard Chaouat
U 131 IN SERM, Equipe Cytokines et Relation Materno Foetale, Hopital Antoine Beclere, 92141 Clamart Cedex, France
Am J Reprod Immunol 53:222-9. 2005..Cytokines are involved in implantation success and failure. We envisage that they could be similarly involved in pre-eclampsia (PE)... - Is there a place for immunomodulation in assisted reproduction techniques?Gerard Chaouat
U131 INSERM, Hospital Antoine Beclere, Avenue de lat Porte de Trivaux, Clamart 92141, France
J Reprod Immunol 62:29-39. 2004..We, however, do not reject immunotherapy, but we believe that molecular and cellular defects specific approaches should be used, tailored for the specific pathway whose disruption cause the clinical symptom... - TH1/TH2 paradigm in pregnancy: paradigm lost? Cytokines in pregnancy/early abortion: reexamining the TH1/TH2 paradigmGerard Chaouat
U 131 INSERM, Maternité, Hopital A Beclere, FR 92141 Clamart, France
Int Arch Allergy Immunol 134:93-119. 2004..Rather, step-specific events have to be considered and a key role is seen in local tissue remodelling, in which immune cytokines play an important role while not always being secreted by immune cells... - Reproductive immunology 2003: reassessing the Th1/Th2 paradigm?Gerard Chaouat
U 131 INSERM, Hopital Antoine Beclere, 32 rue des Carnets, 92141 Clamart, France
Immunol Lett 92:207-14. 2004..We conclude by a repeated warning against the so-called rationales of lymphocyte alloimmunization for therapy of recurrent spontaneous abortion and improvement of implantation rates... - Role of the endometrial tripod interleukin-18, -15, and -12 in inadequate uterine receptivity in patients with a history of repeated in vitro fertilization-embryo transfer failureNathalie Ledee-Bataille
Institut National de Santé et Recherche Médicale INSERM U131, Equipe Cytokines et Relation Materno Foetale, et Service de Gynécologie Obstétrique, Hopital Antoine Béclere AP HP, Clamart, France
Fertil Steril 83:598-605. 2005.... - Implantation: can immunological parameters of implantation failure be of interest for pre-eclampsia?Gerard Chaouat
U131 INSERM, Unite Cytokines dans la Relation Materno Fetale, 32 rue des Carnets, 92141 Clamart, France
J Reprod Immunol 59:205-17. 2003..We draw lessons for preeclampsia, and describe features of a model for its immune aetiology... - Cytokines, implantation and early abortion: re-examining the Th1/Th2 paradigm leads to question the single pathway, single therapy conceptGerard Chaouat
U131 INSERM, Clamart, France
Am J Reprod Immunol 50:177-86. 2003..Implantation cytokine networks need to be known in such a perspective... - Tumor necrosis factor-like weak inducer of apoptosis (TWEAK)/fibroblast growth factor inducible-14 might regulate the effects of interleukin 18 and 15 in the human endometriumMarie Petitbarat
INSERM, U 782, Equipe Cytokines et Dialogue Cytokinique Mère Conceptus, Universite Paris Sud, UMR S0782, and Hôpital Antoine Béclère, Clamart, France
Fertil Steril 94:1141-3. 2010.... - A new role for natural killer cells, interleukin (IL)-12, and IL-18 in repeated implantation failure after in vitro fertilizationNathalie Ledee-Bataille
Cytokines et relation materno foetale, Institut National de la Sante et de la Recherche Medicale, Unité 131, Clamart, France
Fertil Steril 81:59-65. 2004..To investigate the endometrial immunohistochemical staining of interleukin (IL)-12 and IL-18 and to quantify the CD56 bright natural killer (NK) cells in relation to Doppler vascular disorders... - TWEAK appears as a modulator of endometrial IL-18 related cytotoxic activity of uterine natural killersMarie Petitbarat
INSERM, U782, Implantation et Dialogue Materno Fœtal, University Paris Sud, UMR S0782, Hopital Antoine Beclere, Clamart, France
PLoS ONE 6:e14497. 2011..Indeed, previous results suggested that basic TWEAK expression influences the IL-18 related uNK recruitment and local cytotoxicity... - Specific and extensive endometrial deregulation is present before conception in IVF/ICSI repeated implantation failures (IF) or recurrent miscarriagesNathalie Ledee
Inserm U 782, Clamart, France
J Pathol 225:554-64. 2011..Extensive endometrial deregulations are present before conception in patients who experienced IF or RM with both distinct and common deregulation... - Early regulators in abortion and implications for a preeclampsia modelGerard Chaouat
Unité 782 INSERM, Hôpital Antoine Béclère et Université Paris Sud Orsay, 92141 Clamart Cedex, France gerard
J Reprod Immunol 82:131-40. 2009..The implications of these findings for utilising the CBA/JxDBA/2 mating combination as an early onset model of preeclampsia are discussed... - A brief review of recent data on some cytokine expressions at the materno-foetal interface which might challenge the classical Th1/Th2 dichotomyGerard Chaouat
U 131 INSERM, Equipe cytokines et relation materno faetale, Hopital Antoine Beclere, 92141, Clamart, France
J Reprod Immunol 53:241-56. 2002.... - Immune regulation at the interface during early steps of murine implantation: involvement of two new cytokines of the IL-12 family (IL-23 and IL-27) and of TWEAKAnne Elisabeth Mas
Unité 782 INSERM, Hôpital Antoine Béclére AP HP 92141 Clamart, France
Am J Reprod Immunol 59:323-38. 2008..We therefore searched for regulators of the IL-12/IL-18 family of cytokines as well as for antagonist(s) of TNF with potentially selective effects on implantation... - Immune cells in uteroplacental tissues throughout pregnancy: a brief reviewGerard Chaouat
U 782 INSERM, Equipe implantation et dialogue cytokinique mère conceptus, 32 rue des Carnets et Hôpital Antoine Béclère Pavillon Jean Dalsace, 92141 Clamart, France
Reprod Biomed Online 14:256-66. 2007..Clinical data on the IL-12/IL-18/NK tripod and implantation failure in humans are detailed... - Performance evaluation of microbead and ELISA assays for follicular G-CSF: a non-invasive biomarker of oocyte developmental competence for embryo implantationNathalie Ledee
INSERM U782, Universite Paris Sud, UMR S0782, Clamart F 92140, France
J Reprod Immunol 86:126-32. 2010..61 [0.52-0.70] p=0.84). Microbead assay and flow cytometry appeared similarly efficient for quantifying follicular fluid G-CSF and multiplex versus single-plex assays did not influence the reliability of quantification... - Cytokines and implantationGerard Chaouat
Equipe cytokines et relation materno foetale U131 INSERM, Hopital Antoine Béclere AP HP, Clamart, France
Chem Immunol Allergy 88:34-63. 2005..The emerging involvement of cytokines in controlling uterine vascularization angiogenesis is reviewed, with emphasis on NK activating factors... - Levels of follicular G-CSF and interleukin-15 appear as noninvasive biomarkers of subsequent successful birth in modified natural in vitro fertilization/intracytoplasmic sperm injection cyclesNathalie Ledee
INSERM U782, University Paris Sud, and AP HP, Service d Histologie, Embryologie, cytogenetique, HôpitalAntoine Béclère, Clamart, France
Fertil Steril 95:94-8. 2011..The modified natural IVF/intracytoplasmic sperm injection (ICSI) cycle was used as an experimental model by measuring levels of cytokines, chemokines, and growth factors in individual follicular fluids (FF)... - Assessment of leukemia inhibitory factor levels by uterine flushing at the time of egg retrieval does not adversely affect pregnancy rates with in vitro fertilizationFrancois Olivennes
Service de gynécologie obstétrique et médecine de la reproduction, Hopital Antoine Beclere, Clamart, France
Fertil Steril 79:900-4. 2003..To assess intrauterine levels of leukemia inhibitory factor (LIF) by uterine flushing at the time of egg retrieval and to confirm that the procedure has no detrimental effect on pregnancy rates... - Preeclampsia and human reproduction. An essay of a long term reflectionPierre Yves Robillard
Neonatology, Center Hospitalier Sud Reunion, BP 350, 97448 Saint Pierre cedex, Reunion, France
J Reprod Immunol 59:93-100. 2003..This frontier might even have occurred inside these Homo lineages: because of their relatively small brains, the first species of Homo might not have presented the deep trophoblastic invasion described in Homo sapiens... - Etiology of preeclampsia: maternal vascular predisposition and couple disease--mutual exclusion or complementarity?Pierre Yves Robillard
Neonatology, Groupe Hospitalier Sud Reunion, BP 350, 97448 Saint Pierre cedex, Reunion, France
J Reprod Immunol 76:1-7. 2007..Here, we reflect on what can be respective parts of the disease in preeclamptic couples, and on preeclampsia as a marker of subjects susceptible to vascular disease... - Fourth International Workshop on immunology of pre-eclampsia, December 2004, Reunion, FranceGerard Chaouat
INSERM U131, Unité Cytokines dans la Relation Materno Faetale, 32 rue des Carnets, 92141 Clamart, France
J Reprod Immunol 67:103-11. 2005.... - Immune cells in uteroplacental tissues throughout pregnancy: a brief reviewGerard Chaouat
U 782 INSERM, Equipe implantation et dialogue cytokinique mère conceptus, 32 rue des Carnets et Hôpital Antoine Béclère Pavillon Jean Dalsace, 92141 Clamart France
Reprod Biomed Online 14:83-93. 2007..Clinical data on the IL-12 /IL-18/NK tripod and implantation failure in humans are detailed... - Should we re-examine the status of lymphocyte alloimmunization therapy for recurrent spontaneous abortion?Gerard Chaouat
U 131 INSERM, Department of Obstetrics Gynaecology Hôpital A Béclère, Clamart, France
Am J Reprod Immunol 50:433-8. 2003..This treatment has been the subject of debate for a long period of time. Recently, it has been proposed to extend such a treatment for implantation failure in humans, and I was asked to express my opinion on this topic... - Predominant intracellular expression of CXCR4 and CCR5 in purified primary trophoblast cells from first trimester and term human placentaeJuan Maldonado-Estrada
INSERM U 131, Equipe Cytokines et Relation Materno Foetale, Hôpital Béclère, Clamart, France
Am J Reprod Immunol 50:291-301. 2003..The aim of the present study was to define the expression of CXCR4 and CCR5 on non-cultured non-stimulated primary human trophoblast cells (TCs) immediately after their immunopurification...