Pascal Chanez

Summary

Country: France

Publications

  1. ncbi request reprint Lipoxins are potential endogenous antiinflammatory mediators in asthma
    Caroline Bonnans
    Clinique des Maladies Respiratoires, INSERM U454 IFR 3, CHU, Montpellier, France
    Am J Respir Crit Care Med 165:1531-5. 2002
  2. ncbi request reprint [Difficult asthma]
    Pascal Chanez
    Clinique des Maladies Respiratoires, CHU, Montpellier 34
    Presse Med 35:1497-506. 2006
  3. ncbi request reprint Severe asthma in adults: what are the important questions?
    Pascal Chanez
    INSERM U454 and Clinique des Maladies Respiratoires, Montpellier, France
    J Allergy Clin Immunol 119:1337-48. 2007
  4. ncbi request reprint [Corticosteroid therapy of asthma]
    P Chanez
    Clinique des Maladies Respiratoires, CHU de Montpellier
    Presse Med 29:1469-78. 2000
  5. ncbi request reprint [Severe asthma]
    Pascal Chanez
    Departement des Maladies Respiratoires, AP HM, Universite de la Mediterranee, F 13009 Marseille, France
    Presse Med 37:99-105. 2008
  6. ncbi request reprint 15-lipoxygenase: a Janus enzyme?
    Pascal Chanez
    Clinique des Maladies Respiratoires, INSERM U454 IFR 3, CHU Montpellier, France
    Am J Respir Cell Mol Biol 27:655-8. 2002
  7. ncbi request reprint Effects of inhaled corticosteroids on pathology in asthma and chronic obstructive pulmonary disease
    Pascal Chanez
    Clinique des Maladies Respiratoires, Hopital Arnaud de Villeneuve, 371 Avenue du Doyen Gaston Giraud, 34295 Montpellier Cedex 5, France
    Proc Am Thorac Soc 1:184-90. 2004
  8. ncbi request reprint Interference of psychological factors in difficult-to-control asthma
    Laurence Halimi
    Clinique des Maladies Respiratoires, Hopital Arnaud de Villeneuve, 371 Av du Doyen Gaston Giraud 34295 Montpellier Cedex 5, France
    Respir Med 101:154-61. 2007
  9. ncbi request reprint [Asthma. Evidence based respiratory medicine: 2nd update workshop of the SPLF]
    P Chanez
    Hopital Arnaud de Villeneuve, Clinique des Maladies Respiratoires, Montpellier, France
    Rev Mal Respir 21:853-5. 2004
  10. ncbi request reprint [What is the status of oral corticotherapy in asthma?]
    Pascal Chanez
    Service de Pneumologie, Hopital Arnaud de Villeneuve, 34295 Montpellier Cedex 5
    Rev Prat 55:1340-1. 2005

Collaborators

Detail Information

Publications41

  1. ncbi request reprint Lipoxins are potential endogenous antiinflammatory mediators in asthma
    Caroline Bonnans
    Clinique des Maladies Respiratoires, INSERM U454 IFR 3, CHU, Montpellier, France
    Am J Respir Crit Care Med 165:1531-5. 2002
    ..Moreover, pertussis toxin reversed LXA4- and LXB4-inhibited IL-8 release. These findings suggest that lipoxins have potential antiinflammatory action in asthma...
  2. ncbi request reprint [Difficult asthma]
    Pascal Chanez
    Clinique des Maladies Respiratoires, CHU, Montpellier 34
    Presse Med 35:1497-506. 2006
    ..They will need to be validated in clinical research for subsequent use that is wider but more rational because targeted at phenotypes likely to benefit from them...
  3. ncbi request reprint Severe asthma in adults: what are the important questions?
    Pascal Chanez
    INSERM U454 and Clinique des Maladies Respiratoires, Montpellier, France
    J Allergy Clin Immunol 119:1337-48. 2007
    ..Inhaled corticosteroids and bronchodilators are the mainstay of treatment, but patients with SRA remain uncontrolled, indicating a need for new therapies...
  4. ncbi request reprint [Corticosteroid therapy of asthma]
    P Chanez
    Clinique des Maladies Respiratoires, CHU de Montpellier
    Presse Med 29:1469-78. 2000
    ..Glucocorticoids are the gold standard treatment in asthma affecting most of the components involved in bronchial inflammation. Inhaled steroids are recommended early in most countries...
  5. ncbi request reprint [Severe asthma]
    Pascal Chanez
    Departement des Maladies Respiratoires, AP HM, Universite de la Mediterranee, F 13009 Marseille, France
    Presse Med 37:99-105. 2008
    ....
  6. ncbi request reprint 15-lipoxygenase: a Janus enzyme?
    Pascal Chanez
    Clinique des Maladies Respiratoires, INSERM U454 IFR 3, CHU Montpellier, France
    Am J Respir Cell Mol Biol 27:655-8. 2002
  7. ncbi request reprint Effects of inhaled corticosteroids on pathology in asthma and chronic obstructive pulmonary disease
    Pascal Chanez
    Clinique des Maladies Respiratoires, Hopital Arnaud de Villeneuve, 371 Avenue du Doyen Gaston Giraud, 34295 Montpellier Cedex 5, France
    Proc Am Thorac Soc 1:184-90. 2004
    ..The effects of these drugs on structural changes in COPD have not been investigated extensively. Long-term prospective studies are needed to demonstrate the potential for ICSs to affect the natural history of chronic bronchial diseases...
  8. ncbi request reprint Interference of psychological factors in difficult-to-control asthma
    Laurence Halimi
    Clinique des Maladies Respiratoires, Hopital Arnaud de Villeneuve, 371 Av du Doyen Gaston Giraud 34295 Montpellier Cedex 5, France
    Respir Med 101:154-61. 2007
    ..Most patients with asthma can be controlled with suitable medication, but 5-10% of them remain difficult to control despite optimal management...
  9. ncbi request reprint [Asthma. Evidence based respiratory medicine: 2nd update workshop of the SPLF]
    P Chanez
    Hopital Arnaud de Villeneuve, Clinique des Maladies Respiratoires, Montpellier, France
    Rev Mal Respir 21:853-5. 2004
  10. ncbi request reprint [What is the status of oral corticotherapy in asthma?]
    Pascal Chanez
    Service de Pneumologie, Hopital Arnaud de Villeneuve, 34295 Montpellier Cedex 5
    Rev Prat 55:1340-1. 2005
  11. ncbi request reprint Synthesis and anti-inflammatory effect of lipoxins in human airway epithelial cells
    Caroline Bonnans
    Clinique des Maladies Respiratoires, INSERM U454 IFR 3, CHU Montpellier, France
    Biomed Pharmacother 61:261-7. 2007
    ..Together, these findings indicate that differentiated human bronchial epithelium synthesizes LX in vivo which could have autocrine actions through its specific receptor FPRL-1 to promote resolution of airway inflammation...
  12. doi request reprint Impact of comorbidities on COPD-specific health-related quality of life
    Pierre Regis Burgel
    Service de Pneumologie, Hopital Cochin, AP HP and Université Paris Descartes, Sorbonne Paris Cité, Paris 75014, France
    Respir Med 107:233-41. 2013
    ..Comorbidities are frequent in subjects with COPD, but their contribution to health-related quality of life (HRQoL) impairment is not clearly established...
  13. ncbi request reprint Severe asthma is associated with a loss of LX4, an endogenous anti-inflammatory compound
    Isabelle Vachier
    Clinique des Maladies Respiratoires, CHU, Montpellier, France
    J Allergy Clin Immunol 115:55-60. 2005
    ..They are produced by different enzymatic pathways. Patients with severe asthma present ongoing airway inflammation despite chronic long-term treatment including oral glucocorticoids...
  14. doi request reprint Non-invasive assessment of small airway remodelling in smokers
    Arnaud Bourdin
    Dept of Respiratory Diseases, CHU Montpellier, France
    COPD 7:102-10. 2010
    ..The SCGB1A1/IL8 ratio measured in sputum is a potentially valuable biomarker for non-invasive assessment of SA remodelling in smokers...
  15. doi request reprint Regulation of CXCR/IL-8 in human airway epithelial cells
    Delphine Gras
    Clinique des Maladies Respiratoires, CHU Montpellier, Montpellier, France
    Int Arch Allergy Immunol 152:140-50. 2010
    ..The objective of this work was to determine whether CXC receptors were involved in human small airway epithelial cell (SAEC) activity by incubating them with IL-8; the investigation also included a proteomic approach...
  16. ncbi request reprint Small airway impairment in moderate to severe asthmatics without significant proximal airway obstruction
    Thierry Perez
    Clinique des Maladies Respiratoires, Hopital Calmette, CHRU Lille et Université Lille Nord de France, 59037 Lille Cedex, France
    Respir Med 107:1667-74. 2013
    ....
  17. doi request reprint Mild asthma in overweight women: A new phenotype?
    Marissa Engbers
    CHU Montpellier, Respiratory Department, Hopital Arnaud de Villeneuve, 371 Av Doyen Gaston Giraud, 34295 Montpellier CX 5, France
    Respir Med 104:1138-44. 2010
    ..The aim of the study was to determine responsiveness to AMP and MCh in overweight compared with normal weight asthmatics...
  18. doi request reprint Impact of rhinitis on asthma control in children: association with FeNO
    Raphael Chiron
    Department of Respiratory Diseases, CHU Montpellier, Hospital Arnaud de Villeneuve, Montpellier, France
    J Asthma 47:604-8. 2010
    ..The prevalence of rhinitis is high and frequently observed in association with asthma. Although the persistence of predisposing factors such as rhinitis is frequently observed in adults, this has not yet been confirmed in children...
  19. pmc Association between occupational exposure and the clinical characteristics of COPD
    Denis Caillaud
    Service de Pneumologie, Hopital Gabriel Montpied, Clermont Ferrand 63003, France
    BMC Public Health 12:302. 2012
    ..The aim of this study was to explore the contribution of occupational exposures on clinical pattern of COPD...
  20. ncbi request reprint Specificity of basement membrane thickening in severe asthma
    Arnaud Bourdin
    Service des Maladies Respiratoires, Hopital Arnaud de Villeneuve, Centre Hospitalo Universitaire de Montpellier, France
    J Allergy Clin Immunol 119:1367-74. 2007
    ..A wide range of results, at baseline or after therapeutic intervention, have been reported using different measurement methods...
  21. ncbi request reprint High levels of urinary leukotriene E4 excretion in steroid treated patients with severe asthma
    Isabelle Vachier
    Clinique des Maladies Respiratoires, INSERM U454, Hopital Arnaud de Villeneuve, 371 Av du Doyen Gaston Giraud, 34295 Montpellier 5, France
    Respir Med 97:1225-9. 2003
    ..The findings support previous indications that one important component in asthmatic airway inflammation, the cysteinyl-leukotriene pathway remains relatively unopposed by oral glucocorticoids...
  22. ncbi request reprint [The measurement of exhaled nitric oxide, a new tool in the management of asthma?]
    Raphael Chiron
    Service des Maladies Respiratoires, Hopital Arnaud de Villeneuve, 371 Avenue du Doyen Gaston Giraud, 34295 Montpellier cedex 05, France
    Presse Med 33:1451-8. 2004
    ..Nevertheless, this tool has not yet been validated in the daily treatment of asthma and further research is still ongoing...
  23. doi request reprint Cough and sputum production are associated with frequent exacerbations and hospitalizations in COPD subjects
    Pierre Regis Burgel
    Service de Pneumologie, Hopital Cochin, Assistance Publique Hopitaux de Paris, 27 rue du Faubourg St Jacques, Paris Cedex 14, France
    Chest 135:975-82. 2009
    ..Our objective was to identify features associated with chronic cough and sputum production in COPD subjects...
  24. ncbi request reprint [Definitions of asthma, assessment of disease severity and control]
    Pascal Chanez
    Departement des Maladies Respiratoires, AP HM, laboratoire d immunologie Inserm CNRS U 600, UMR6212, Universite de la Mediterranee, 13015 Marseille
    Rev Prat 61:320-4. 2011
    ..It is more linked to the natural history representing a marker of a persistent chronic disease...
  25. doi request reprint Immunologic therapeutic interventions in asthma: impact on natural history
    Arnaud Bourdin
    Department of Respiratory Disease, Hopital Arnaud de Villeneuve, CHU Montpellier, Montpellier, France
    Clin Chest Med 33:585-97. 2012
    ..Here, the authors review all potential available therapeutics based on immunologic pathways involved in asthma pathophysiology during the last decade...
  26. doi request reprint Limited short-term steroid responsiveness is associated with thickening of bronchial basement membrane in severe asthma
    Arnaud Bourdin
    Department of Respiratory Diseases, Centre Hospitalier et Universitaire CHU Montpellier, France
    Chest 141:1504-11. 2012
    ..We aimed to determine whether the presence of pathologic features of airway remodeling in patients with asthma was associated with steroid responsiveness in the short term...
  27. ncbi request reprint Enhanced frequency of CD18- and CD49b-expressing T cells in peripheral blood of asthmatic patients correlates with disease severity
    Massilva Rahmoun
    INSERM U454, CHU de Montpellier, Montpellier, France
    Int Arch Allergy Immunol 140:139-49. 2006
    ..The aim of this study was to investigate whether the presence of T cells concomitantly expressing these molecules could be detected in asthmatic patients and represent Tr1 cells...
  28. ncbi request reprint Modulation of cadherin and catenins expression by tumor necrosis factor-alpha and dexamethasone in human bronchial epithelial cells
    Nathalie Carayol
    Clinique des Maladies Respiratoires, Hopital Arnaud de Villeneuve, Montpellier, France
    Am J Respir Cell Mol Biol 26:341-7. 2002
    ..We demonstrated, using Western blot analysis and immunofluorescence, that proinflammatory cytokines could be responsible for structural damage to the epithelium and that this process was potentially reversed by steroids...
  29. ncbi request reprint [Asthma phenotypes]
    Pascal Chanez
    Departement des Maladies Respiratoires, AP HM, Laboratoire d Immunologie, Inserm CNRS U 600, UMR6212, Universite de la Mediterranee, 13009 Marseille
    Rev Prat 60:307-13. 2010
    ..The criteria used to phenotype asthma are issued from current clinical, functional and pathophysiological findings. The defined phenotypes will take benefit from more focused therapeutical avenues...
  30. pmc Relationship between CT air trapping criteria and lung function in small airway impairment quantification
    Sebastien Bommart
    Radiology Department, CHU Montpellier, 371 avenue Doyen Gaston Giraud 34295, Montpellier Cedex 05, France
    BMC Pulm Med 14:29. 2014
    ..We aimed to evaluate software-assisted CT quantification of air trapping for assessing small airway obstruction and determine which CT criteria better predict small airway obstruction on single breath nitrogen test (SBNT)...
  31. doi request reprint Small airways diseases, excluding asthma and COPD: an overview
    Pierre Regis Burgel
    Service de Pneumologie, Hopital Cochin, AP HP, Universite Paris Descartes, Paris, France
    Eur Respir Rev 22:131-47. 2013
    ..Pathogenesis, clinical presentation, a computed tomography scan and pulmonary function test findings are reviewed, and therapeutic options are described with the objective of providing an integrative approach to these disorders...
  32. doi request reprint Omalizumab-induced decrease of FcξRI expression in patients with severe allergic asthma
    Pascal Chanez
    INSERM U 600, CNRS UMR 6212, Universite de la Mediterranee, Marseille, France
    Respir Med 104:1608-17. 2010
    ..This has not been investigated in patients with uncontrolled severe persistent allergic asthma...
  33. doi request reprint An update on the efficacy and safety of aclidinium bromide in patients with COPD
    Khuder Alagha
    Respiratory Department, AP HM, Inserm CNRS U 600, UMR6212, Universite de la Mediterranee, 13009 Marseille, France
    Ther Adv Respir Dis 5:19-28. 2011
    ..Aclidinium is now moving to phase III clinical development for chronic obstructive pulmonary disease (COPD)...
  34. ncbi request reprint Evaluation and management of severe asthma
    Mina Gaga
    Asthma Centre and 7th Respiratory Medicine Department, Sotiria Hospital, Athens, Greece
    Curr Med Chem 14:1049-59. 2007
    ..In this report, the authors review the various issues of guideline based therapy but also new approaches that include anti-IgE antibodies, anti-cytokines (anti-IL-5, anti-IL9, anti-TNF)...
  35. ncbi request reprint Air trapping in mild and moderate asthma: effect of inhaled corticosteroids
    José Manuel Tunon-de-Lara
    Universite Bordeaux 2, Institut National de la Santé et de la Recherche Medicale U885, Centre Hospitalier Universitaire CHU de Bordeaux, F 33076 Bordeaux, France
    J Allergy Clin Immunol 119:583-90. 2007
    ..Hydrofluoroalkane-beclomethasone dipropionate (HFA-BDP) is deposited across all sizes of airways, including the small ones. However, its long-term effect on air trapping remains unknown in uncontrolled asthma...
  36. ncbi request reprint [Severe hard-to-treat refractory asthma: the only asthma issue of the 21st century?]
    Pascal Chanez
    Presse Med 37:97-8. 2008
  37. ncbi request reprint A dose-ranging study of indacaterol in obstructive airways disease, with a tiotropium comparison
    Stephen Rennard
    University of Nebraska Medical Center, Pulmonary and Critical Care Medicine, Omaha, Nebraska 68198 5885, USA
    Respir Med 102:1033-44. 2008
    ..Indacaterol demonstrated a good overall safety and tolerability profile...
  38. ncbi request reprint Safety, tolerability and efficacy of indacaterol, a novel once-daily beta(2)-agonist, in patients with COPD: a 28-day randomised, placebo controlled clinical trial
    Jutta Beier
    insaf Respiratory Research Institute, Biebricher Allee 34, D 65187 Wiesbaden, Germany
    Pulm Pharmacol Ther 20:740-9. 2007
    ..There was no statistical difference at any dose between the safety of indacaterol and placebo. Furthermore, this study supports the previously demonstrated 24-h bronchodilator efficacy of indacaterol...
  39. ncbi request reprint [Targeted immunologic therapies for severe asthma]
    Marc Humbert
    Service de Pneumologie et Reanimation Respiratoire, AP HP, Hopital Antoine Beclere, Universite Paris Sud, F 92140 Clamart, France
    Presse Med 37:173-81. 2008
    ..The first targeted treatment approved for severe difficult-to-control allergic asthma is an anti-IgE monoclonal antibody (omalizumab)...
  40. ncbi request reprint Corticosteroid-induced epithelial shedding in asthma
    Nathalie Carayol
    Am J Respir Crit Care Med 166:1290-1; author reply 1291. 2002
  41. ncbi request reprint Persistent activation of nuclear factor-kappaB signaling pathway in severe uncontrolled asthma
    Rosalia Gagliardo
    Istituto di Biomedicina e Immunologia Molecolare, Consiglio Nazionale delle Ricerche, Palermo, Via Ugo La Malfa 153, 90146 Palermo, Italy
    Am J Respir Crit Care Med 168:1190-8. 2003
    ..Our data suggest that exaggerated NF-kappaB activation perpetuates inflammatory mediators production in severe asthma...