- Lipoxins are potential endogenous antiinflammatory mediators in asthmaCaroline Bonnans
Clinique des Maladies Respiratoires, INSERM U454 IFR 3, CHU, Montpellier, France
Am J Respir Crit Care Med 165:1531-5. 2002..Moreover, pertussis toxin reversed LXA4- and LXB4-inhibited IL-8 release. These findings suggest that lipoxins have potential antiinflammatory action in asthma...
- [Difficult asthma]Pascal Chanez
Clinique des Maladies Respiratoires, CHU, Montpellier 34
Presse Med 35:1497-506. 2006..They will need to be validated in clinical research for subsequent use that is wider but more rational because targeted at phenotypes likely to benefit from them...
- Severe asthma in adults: what are the important questions?Pascal Chanez
INSERM U454 and Clinique des Maladies Respiratoires, Montpellier, France
J Allergy Clin Immunol 119:1337-48. 2007..Inhaled corticosteroids and bronchodilators are the mainstay of treatment, but patients with SRA remain uncontrolled, indicating a need for new therapies...
- [Corticosteroid therapy of asthma]P Chanez
Clinique des Maladies Respiratoires, CHU de Montpellier
Presse Med 29:1469-78. 2000..Glucocorticoids are the gold standard treatment in asthma affecting most of the components involved in bronchial inflammation. Inhaled steroids are recommended early in most countries...
- Interference of psychological factors in difficult-to-control asthmaLaurence Halimi
Clinique des Maladies Respiratoires, Hopital Arnaud de Villeneuve, 371 Av du Doyen Gaston Giraud 34295 Montpellier Cedex 5, France
Respir Med 101:154-61. 2007..Most patients with asthma can be controlled with suitable medication, but 5-10% of them remain difficult to control despite optimal management...
- [What is the status of oral corticotherapy in asthma?]Pascal Chanez
Service de Pneumologie, Hopital Arnaud de Villeneuve, 34295 Montpellier Cedex 5
Rev Prat 55:1340-1. 2005
- [Severe asthma]Pascal Chanez
Departement des Maladies Respiratoires, AP HM, Universite de la Mediterranee, F 13009 Marseille, France
Presse Med 37:99-105. 2008....
- [Asthma. Evidence based respiratory medicine: 2nd update workshop of the SPLF]P Chanez
Hopital Arnaud de Villeneuve, Clinique des Maladies Respiratoires, Montpellier, France
Rev Mal Respir 21:853-5. 2004
- Effects of inhaled corticosteroids on pathology in asthma and chronic obstructive pulmonary diseasePascal Chanez
Clinique des Maladies Respiratoires, Hopital Arnaud de Villeneuve, 371 Avenue du Doyen Gaston Giraud, 34295 Montpellier Cedex 5, France
Proc Am Thorac Soc 1:184-90. 2004..The effects of these drugs on structural changes in COPD have not been investigated extensively. Long-term prospective studies are needed to demonstrate the potential for ICSs to affect the natural history of chronic bronchial diseases...
- 15-lipoxygenase: a Janus enzyme?Pascal Chanez
Clinique des Maladies Respiratoires, INSERM U454 IFR 3, CHU Montpellier, France
Am J Respir Cell Mol Biol 27:655-8. 2002
- Synthesis and anti-inflammatory effect of lipoxins in human airway epithelial cellsCaroline Bonnans
Clinique des Maladies Respiratoires, INSERM U454 IFR 3, CHU Montpellier, France
Biomed Pharmacother 61:261-7. 2007..Together, these findings indicate that differentiated human bronchial epithelium synthesizes LX in vivo which could have autocrine actions through its specific receptor FPRL-1 to promote resolution of airway inflammation...
- Impact of comorbidities on COPD-specific health-related quality of lifePierre Regis Burgel
Service de Pneumologie, Hopital Cochin, AP HP and Université Paris Descartes, Sorbonne Paris Cité, Paris 75014, France
Respir Med 107:233-41. 2013..Comorbidities are frequent in subjects with COPD, but their contribution to health-related quality of life (HRQoL) impairment is not clearly established...
- Severe asthma is associated with a loss of LX4, an endogenous anti-inflammatory compoundIsabelle Vachier
Clinique des Maladies Respiratoires, CHU, Montpellier, France
J Allergy Clin Immunol 115:55-60. 2005..They are produced by different enzymatic pathways. Patients with severe asthma present ongoing airway inflammation despite chronic long-term treatment including oral glucocorticoids...
- Non-invasive assessment of small airway remodelling in smokersArnaud Bourdin
Dept of Respiratory Diseases, CHU Montpellier, France
COPD 7:102-10. 2010..The SCGB1A1/IL8 ratio measured in sputum is a potentially valuable biomarker for non-invasive assessment of SA remodelling in smokers...
- Regulation of CXCR/IL-8 in human airway epithelial cellsDelphine Gras
Clinique des Maladies Respiratoires, CHU Montpellier, Montpellier, France
Int Arch Allergy Immunol 152:140-50. 2010..The objective of this work was to determine whether CXC receptors were involved in human small airway epithelial cell (SAEC) activity by incubating them with IL-8; the investigation also included a proteomic approach...
- Small airway impairment in moderate to severe asthmatics without significant proximal airway obstructionThierry Perez
Clinique des Maladies Respiratoires, Hopital Calmette, CHRU Lille et Université Lille Nord de France, 59037 Lille Cedex, France
Respir Med 107:1667-74. 2013....
- Impact of rhinitis on asthma control in children: association with FeNORaphael Chiron
Department of Respiratory Diseases, CHU Montpellier, Hospital Arnaud de Villeneuve, Montpellier, France
J Asthma 47:604-8. 2010..The prevalence of rhinitis is high and frequently observed in association with asthma. Although the persistence of predisposing factors such as rhinitis is frequently observed in adults, this has not yet been confirmed in children...
- Mild asthma in overweight women: A new phenotype?Marissa Engbers
CHU Montpellier, Respiratory Department, Hopital Arnaud de Villeneuve, 371 Av Doyen Gaston Giraud, 34295 Montpellier CX 5, France
Respir Med 104:1138-44. 2010..The aim of the study was to determine responsiveness to AMP and MCh in overweight compared with normal weight asthmatics...
- Association between occupational exposure and the clinical characteristics of COPDDenis Caillaud
Service de Pneumologie, Hopital Gabriel Montpied, Clermont Ferrand 63003, France
BMC Public Health 12:302. 2012..The aim of this study was to explore the contribution of occupational exposures on clinical pattern of COPD...
- Prognostic value of cluster analysis of severe asthma phenotypesArnaud Bourdin
Department of Respiratory Diseases, Montpellier, France INSERM U1046, Hopital Arnaud de Villeneuve, Université Montpellier I et 2, Montpellier, France Electronic address
J Allergy Clin Immunol 134:1043-50. 2014..Cross-sectional severe asthma cluster analysis identified different phenotypes. We tested the hypothesis that these clusters will follow different courses...
- Specificity of basement membrane thickening in severe asthmaArnaud Bourdin
Service des Maladies Respiratoires, Hopital Arnaud de Villeneuve, Centre Hospitalo Universitaire de Montpellier, France
J Allergy Clin Immunol 119:1367-74. 2007..A wide range of results, at baseline or after therapeutic intervention, have been reported using different measurement methods...
- [Definitions of asthma, assessment of disease severity and control]Pascal Chanez
Departement des Maladies Respiratoires, AP HM, laboratoire d immunologie Inserm CNRS U 600, UMR6212, Universite de la Mediterranee, 13015 Marseille
Rev Prat 61:320-4. 2011..It is more linked to the natural history representing a marker of a persistent chronic disease...
- [The measurement of exhaled nitric oxide, a new tool in the management of asthma?]Raphael Chiron
Service des Maladies Respiratoires, Hopital Arnaud de Villeneuve, 371 Avenue du Doyen Gaston Giraud, 34295 Montpellier cedex 05, France
Presse Med 33:1451-8. 2004..Nevertheless, this tool has not yet been validated in the daily treatment of asthma and further research is still ongoing...
- High levels of urinary leukotriene E4 excretion in steroid treated patients with severe asthmaIsabelle Vachier
Clinique des Maladies Respiratoires, INSERM U454, Hopital Arnaud de Villeneuve, 371 Av du Doyen Gaston Giraud, 34295 Montpellier 5, France
Respir Med 97:1225-9. 2003..The findings support previous indications that one important component in asthmatic airway inflammation, the cysteinyl-leukotriene pathway remains relatively unopposed by oral glucocorticoids...
- Cough and sputum production are associated with frequent exacerbations and hospitalizations in COPD subjectsPierre Regis Burgel
Service de Pneumologie, Hopital Cochin, Assistance Publique Hopitaux de Paris, 27 rue du Faubourg St Jacques, Paris Cedex 14, France
Chest 135:975-82. 2009..Our objective was to identify features associated with chronic cough and sputum production in COPD subjects...
- Immunologic therapeutic interventions in asthma: impact on natural historyArnaud Bourdin
Department of Respiratory Disease, Hopital Arnaud de Villeneuve, CHU Montpellier, Montpellier, France
Clin Chest Med 33:585-97. 2012..Here, the authors review all potential available therapeutics based on immunologic pathways involved in asthma pathophysiology during the last decade...
- Limited short-term steroid responsiveness is associated with thickening of bronchial basement membrane in severe asthmaArnaud Bourdin
Department of Respiratory Diseases, Centre Hospitalier et Universitaire CHU Montpellier, France
Chest 141:1504-11. 2012..We aimed to determine whether the presence of pathologic features of airway remodeling in patients with asthma was associated with steroid responsiveness in the short term...
- Enhanced frequency of CD18- and CD49b-expressing T cells in peripheral blood of asthmatic patients correlates with disease severityMassilva Rahmoun
INSERM U454, CHU de Montpellier, Montpellier, France
Int Arch Allergy Immunol 140:139-49. 2006..The aim of this study was to investigate whether the presence of T cells concomitantly expressing these molecules could be detected in asthmatic patients and represent Tr1 cells...
- Modulation of cadherin and catenins expression by tumor necrosis factor-alpha and dexamethasone in human bronchial epithelial cellsNathalie Carayol
Clinique des Maladies Respiratoires, Hopital Arnaud de Villeneuve, Montpellier, France
Am J Respir Cell Mol Biol 26:341-7. 2002..We demonstrated, using Western blot analysis and immunofluorescence, that proinflammatory cytokines could be responsible for structural damage to the epithelium and that this process was potentially reversed by steroids...
- [Asthma phenotypes]Pascal Chanez
Departement des Maladies Respiratoires, AP HM, Laboratoire d Immunologie, Inserm CNRS U 600, UMR6212, Universite de la Mediterranee, 13009 Marseille
Rev Prat 60:307-13. 2010..The criteria used to phenotype asthma are issued from current clinical, functional and pathophysiological findings. The defined phenotypes will take benefit from more focused therapeutical avenues...
- Relationship between CT air trapping criteria and lung function in small airway impairment quantificationSebastien Bommart
Radiology Department, CHU Montpellier, 371 avenue Doyen Gaston Giraud 34295, Montpellier Cedex 05, France
BMC Pulm Med 14:29. 2014..We aimed to evaluate software-assisted CT quantification of air trapping for assessing small airway obstruction and determine which CT criteria better predict small airway obstruction on single breath nitrogen test (SBNT)...
- Small airways diseases, excluding asthma and COPD: an overviewPierre Regis Burgel
Service de Pneumologie, Hopital Cochin, AP HP, Universite Paris Descartes, Paris, France
Eur Respir Rev 22:131-47. 2013..Pathogenesis, clinical presentation, a computed tomography scan and pulmonary function test findings are reviewed, and therapeutic options are described with the objective of providing an integrative approach to these disorders...
- Omalizumab-induced decrease of FcξRI expression in patients with severe allergic asthmaPascal Chanez
INSERM U 600, CNRS UMR 6212, Universite de la Mediterranee, Marseille, France
Respir Med 104:1608-17. 2010..This has not been investigated in patients with uncontrolled severe persistent allergic asthma...
- An update on the efficacy and safety of aclidinium bromide in patients with COPDKhuder Alagha
Respiratory Department, AP HM, Inserm CNRS U 600, UMR6212, Universite de la Mediterranee, 13009 Marseille, France
Ther Adv Respir Dis 5:19-28. 2011..Aclidinium is now moving to phase III clinical development for chronic obstructive pulmonary disease (COPD)...
- Safety, tolerability and efficacy of indacaterol, a novel once-daily beta(2)-agonist, in patients with COPD: a 28-day randomised, placebo controlled clinical trialJutta Beier
insaf Respiratory Research Institute, Biebricher Allee 34, D 65187 Wiesbaden, Germany
Pulm Pharmacol Ther 20:740-9. 2007..There was no statistical difference at any dose between the safety of indacaterol and placebo. Furthermore, this study supports the previously demonstrated 24-h bronchodilator efficacy of indacaterol...
- Air trapping in mild and moderate asthma: effect of inhaled corticosteroidsJosé Manuel Tunon-de-Lara
Universite Bordeaux 2, Institut National de la Santé et de la Recherche Medicale U885, Centre Hospitalier Universitaire CHU de Bordeaux, F 33076 Bordeaux, France
J Allergy Clin Immunol 119:583-90. 2007..Hydrofluoroalkane-beclomethasone dipropionate (HFA-BDP) is deposited across all sizes of airways, including the small ones. However, its long-term effect on air trapping remains unknown in uncontrolled asthma...
- Evaluation and management of severe asthmaMina Gaga
Asthma Centre and 7th Respiratory Medicine Department, Sotiria Hospital, Athens, Greece
Curr Med Chem 14:1049-59. 2007..In this report, the authors review the various issues of guideline based therapy but also new approaches that include anti-IgE antibodies, anti-cytokines (anti-IL-5, anti-IL9, anti-TNF)...
- [Severe hard-to-treat refractory asthma: the only asthma issue of the 21st century?]Pascal Chanez
Presse Med 37:97-8. 2008
- A dose-ranging study of indacaterol in obstructive airways disease, with a tiotropium comparisonStephen Rennard
University of Nebraska Medical Center, Pulmonary and Critical Care Medicine, Omaha, Nebraska 68198 5885, USA
Respir Med 102:1033-44. 2008..Indacaterol demonstrated a good overall safety and tolerability profile...
- Persistent activation of nuclear factor-kappaB signaling pathway in severe uncontrolled asthmaRosalia Gagliardo
Istituto di Biomedicina e Immunologia Molecolare, Consiglio Nazionale delle Ricerche, Palermo, Via Ugo La Malfa 153, 90146 Palermo, Italy
Am J Respir Crit Care Med 168:1190-8. 2003..Our data suggest that exaggerated NF-kappaB activation perpetuates inflammatory mediators production in severe asthma...
- Corticosteroid-induced epithelial shedding in asthmaNathalie Carayol
Am J Respir Crit Care Med 166:1290-1; author reply 1291. 2002
- [Targeted immunologic therapies for severe asthma]Marc Humbert
Service de Pneumologie et Reanimation Respiratoire, AP HP, Hopital Antoine Beclere, Universite Paris Sud, F 92140 Clamart, France
Presse Med 37:173-81. 2008..The first targeted treatment approved for severe difficult-to-control allergic asthma is an anti-IgE monoclonal antibody (omalizumab)...