Genomes and Genes
- Characterization of mutations that are synthetic lethal with pol3-13, a mutated allele of DNA polymerase delta in Saccharomyces cerevisiaeRoland Chanet
Institut Curie Recherche, CNRS UMR2027 Institut Curie, Bat 110, Centre Universitaire, 91405 Orsay Cedex, France
Curr Genet 43:337-50. 2003..We propose that the pol3-13 mutant generates replicative problems that need both homologous recombination and an intact checkpoint machinery to be overcome...
- A newly identified essential complex, Dre2-Tah18, controls mitochondria integrity and cell death after oxidative stress in yeastLaurence Vernis
Régulation de la Réplication de l ADN des Eucaryotes, UMR2027 CNRS Institut Curie, INSERM, Universite Paris Sud, Orsay, France
PLoS ONE 4:e4376. 2009..Our results are in favour of an oxidative stress-induced cell death in yeast that involves mitochondria and is controlled by the newly identified Dre2-Tah18 complex...
- Homologous recombination restarts blocked replication forks at the expense of genome rearrangements by template exchangeSarah Lambert
Institut Curie Centre National de la Recherche Scientifique, UMR3348, Réponse Cellulaire aux Perturbations de la Réplication, Universite Paris Sud XI, Orsay, France
Mol Cell 39:346-59. 2010..In contrast, we report that the Srs2 helicase promotes both fork restart and template exchange. Our data demonstrate that template exchange occurs during recombination-dependent fork restart at the expense of genome rearrangements...
- A new Saccharomyces cerevisiae strain with a mutant Smt3-deconjugating Ulp1 protein is affected in DNA replication and requires Srs2 and homologous recombination for its viabilityChristine Soustelle
Commissaritat à l Energy Atomique, UMR 217 CNRS CEA, DSV DRR, Fontenay aux Roses, France
Mol Cell Biol 24:5130-43. 2004..These structures are believed to generate different recombination intermediates. Some of them are fixed by recombination, and others require Srs2 to be reversed and fixed by an alternate pathway...