Research Topics
| Patrick ChamesSummaryCountry: France Publications
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Detail Information
Publications
Therapeutic antibodies for the treatment of pancreatic cancerPatrick Chames
INSERM U624, GDR2352, Marseille Cedex, France
ScientificWorldJournal 10:1107-20. 2010....
[The future of antibody fragments, made of a single immunoglobulin domain]Patrick Chames
Anticorps thérapeutiques et immunociblage, INSERM U624, GDR 3260, 163, Avenue de Luminy, 13288 Marseille Cedex 09, France
Med Sci (Paris) 25:1159-62. 2009..A new class of antibody fragments, made of a single immunoglobulin domain, is emerging as an exciting alternative. This review describes the outstanding properties and the first achievements of these domain antibodies...
Bispecific antibodies for cancer therapy: the light at the end of the tunnel?Patrick Chames
INSERM U624 GDR 3260 Marseille, France
MAbs 1:539-47. 2009..This review describes the most recent advances and clinical study results in the field of bispecific antibodies, a new class of molecules that might outshine conventional mAbs as cancer immunotherapeutics in a near future...
Phage display and selections on cellsKlervi Even-Desrumeaux
INSERM U624, Marseille, France
Methods Mol Biol 907:225-35. 2012..Finally, several possible variants of the protocol are explained in Subheading 4...
Affinity determination of biotinylated antibodies by flow cytometryKlervi Even-Desrumeaux
INSERM U624, Marseille, France
Methods Mol Biol 907:443-9. 2012..Finally, a procedure for K (D) determination by flow cytometry is precisely described...
Phage display and selections on purified antigensJulie Matz
INSERM U624, Marseille, France
Methods Mol Biol 907:213-24. 2012..e. panning, or a selection in solution, using a biotinylated antigen as well as the corresponding screening produces, and gives hints on the advantage and drawbacks of each approach...
Therapeutic antibodies: successes, limitations and hopes for the futurePatrick Chames
Laboratoire d Ingenierie des Systemes Macromoleculaires, CNRS, UPR9027, GDR2352, 31 Chemin Joseph Aiguier, F 13402 Marseille Cedex 20, France
Br J Pharmacol 157:220-33. 2009..This review aims at giving an overview of the current state of the art and describes the most promising avenues that are being followed to create the next generation of antibody-based therapeutic agents...
Strong and oriented immobilization of single domain antibodies from crude bacterial lysates for high-throughput compatible cost-effective antibody array generationKlervi Even-Desrumeaux
INSERM U624, 163 avenue de Luminy case 915, 13288 Marseille Cedex 09, France
Mol Biosyst 6:2241-8. 2010....
