S Chalon

Summary

Country: France

Publications

  1. ncbi request reprint Pharmacological characterization of (E)-N-(4-fluorobut-2-enyl)-2beta-carbomethoxy-3beta-(4'-tolyl)nortropane (LBT-999) as a highly promising fluorinated ligand for the dopamine transporter
    Sylvie Chalon
    Institut National de la Sante et de la Recherche Medicale U619, Tours, France
    J Pharmacol Exp Ther 317:147-52. 2006
  2. ncbi request reprint ADAM is an effective tool for in vivo study of serotonergic function: validation in rat models
    Sylvie Chalon
    INSERM U316, Laboratoire de Biophysique Medicale et Pharmaceutique, UFR des Sciences Pharmaceutiques, 37200 Tours, France
    Synapse 52:136-42. 2004
  3. ncbi request reprint Pharmacological characterization of (E)-N-(3-iodoprop-2-enyl)-2beta-carbomethoxy-3beta-(4'-methylphenyl)n ortropane as a selective and potent inhibitor of the neuronal dopamine transporter
    S Chalon
    Institut National de la Sante et de la Recherche Medicale U316, Laboratoire de Biophysique Medicale et Pharmaceutique, Tours, France
    J Pharmacol Exp Ther 291:648-54. 1999
  4. ncbi request reprint Pharmacological characterization of N,N-dimethyl-2-(2-amino-4-methylphenyl thio)benzylamine as a ligand of the serotonin transporter with high affinity and selectivity
    Sylvie Chalon
    Institut National de la Sante et de la Recherche Medicale U316, Laboratoire de Biophysique Medicale et Pharmaceutique, Universite Francois Rabelais, Tours, France
    J Pharmacol Exp Ther 304:81-7. 2003
  5. ncbi request reprint Hypoxic preconditioning reduces apoptosis in a rat model of immature brain hypoxia-ischaemia
    Sylvain Cantagrel
    INSERM U 316, UFR des Sciences Pharmaceutiques, Tours, France
    Neurosci Lett 347:106-10. 2003
  6. ncbi request reprint Polyunsaturated fatty acids and cerebral function: focus on monoaminergic neurotransmission
    S Chalon
    INSERM U316, Laboratoire Biophysique Médicale et Pharmaceutique, Universite Francois Rabelais, 37200 Tours, France
    Lipids 36:937-44. 2001
  7. ncbi request reprint Time course of changes in striatal dopamine transporters and D2 receptors with specific iodinated markers in a rat model of Parkinson's disease
    S Chalon
    INSERM U316, Laboratoire de Biophysique Medicale et Pharmaceutique, Tours, France
    Synapse 31:134-9. 1999
  8. ncbi request reprint A selective radiobrominated cocaine analogue for imaging of dopamine uptake sites: pharmacological evaluation and PET experiments
    J Helfenbein
    INSERM U316 Laboratoire de Biophysique Médicale et Pharmaceutique, Tours, France
    Life Sci 65:2715-26. 1999
  9. ncbi request reprint Synthesis and in vitro binding properties of halogenated analogues of GBR as new dopamine uptake carrier ligands
    C Foulon
    INSERM U 316, Tours, France
    Int J Rad Appl Instrum B 19:597-600. 1992
  10. ncbi request reprint Synthesis of tropane and nortropane analogues with phenyl substitutions as serotonin transporter ligands
    P Emond
    INSERM U316, Laboratoire de Biophysique Medicale et Pharmaceutique, Universite Francois Rabelais, 31 Avenue Monge, 37200 Tours, France
    Bioorg Med Chem 9:1849-55. 2001

Collaborators

Detail Information

Publications56

  1. ncbi request reprint Pharmacological characterization of (E)-N-(4-fluorobut-2-enyl)-2beta-carbomethoxy-3beta-(4'-tolyl)nortropane (LBT-999) as a highly promising fluorinated ligand for the dopamine transporter
    Sylvie Chalon
    Institut National de la Sante et de la Recherche Medicale U619, Tours, France
    J Pharmacol Exp Ther 317:147-52. 2006
    ..Taken together, these findings demonstrate that LBT-999 is a highly promising agent for in vivo exploration of the DAT. This probe is currently labeled with (18)F for further characterizations...
  2. ncbi request reprint ADAM is an effective tool for in vivo study of serotonergic function: validation in rat models
    Sylvie Chalon
    INSERM U316, Laboratoire de Biophysique Medicale et Pharmaceutique, UFR des Sciences Pharmaceutiques, 37200 Tours, France
    Synapse 52:136-42. 2004
    ....
  3. ncbi request reprint Pharmacological characterization of (E)-N-(3-iodoprop-2-enyl)-2beta-carbomethoxy-3beta-(4'-methylphenyl)n ortropane as a selective and potent inhibitor of the neuronal dopamine transporter
    S Chalon
    Institut National de la Sante et de la Recherche Medicale U316, Laboratoire de Biophysique Medicale et Pharmaceutique, Tours, France
    J Pharmacol Exp Ther 291:648-54. 1999
    ..All of these findings, combined with previously published data, support the use of PE2I as a selective and potent tool to study the DAT both in vivo and in vitro...
  4. ncbi request reprint Pharmacological characterization of N,N-dimethyl-2-(2-amino-4-methylphenyl thio)benzylamine as a ligand of the serotonin transporter with high affinity and selectivity
    Sylvie Chalon
    Institut National de la Sante et de la Recherche Medicale U316, Laboratoire de Biophysique Medicale et Pharmaceutique, Universite Francois Rabelais, Tours, France
    J Pharmacol Exp Ther 304:81-7. 2003
    ....
  5. ncbi request reprint Hypoxic preconditioning reduces apoptosis in a rat model of immature brain hypoxia-ischaemia
    Sylvain Cantagrel
    INSERM U 316, UFR des Sciences Pharmaceutiques, Tours, France
    Neurosci Lett 347:106-10. 2003
    ..We demonstrated here that regulation of apoptotic cell death is one of the mechanisms involved in tolerance to hypoxia-ischaemia induced by hypoxic preconditioning...
  6. ncbi request reprint Polyunsaturated fatty acids and cerebral function: focus on monoaminergic neurotransmission
    S Chalon
    INSERM U316, Laboratoire Biophysique Médicale et Pharmaceutique, Universite Francois Rabelais, 37200 Tours, France
    Lipids 36:937-44. 2001
    ..Animal models are tools of choice for the understanding of such links. Improved prevention and complementary treatment of neurological and psychiatric diseases can be expected from these studies...
  7. ncbi request reprint Time course of changes in striatal dopamine transporters and D2 receptors with specific iodinated markers in a rat model of Parkinson's disease
    S Chalon
    INSERM U316, Laboratoire de Biophysique Medicale et Pharmaceutique, Tours, France
    Synapse 31:134-9. 1999
    ..The exploration of both DAT and D2R would improve follow-up of this disease...
  8. ncbi request reprint A selective radiobrominated cocaine analogue for imaging of dopamine uptake sites: pharmacological evaluation and PET experiments
    J Helfenbein
    INSERM U316 Laboratoire de Biophysique Médicale et Pharmaceutique, Tours, France
    Life Sci 65:2715-26. 1999
    ..These results showed that [76Br]PE2Br is in vivo a potent and selective radioligand suitable for PET imagingof the dopamine transporter...
  9. ncbi request reprint Synthesis and in vitro binding properties of halogenated analogues of GBR as new dopamine uptake carrier ligands
    C Foulon
    INSERM U 316, Tours, France
    Int J Rad Appl Instrum B 19:597-600. 1992
    ..We prepared iodo-GBR labeled with iodide-125 from the brominated derivative and concluded that [123I]iodo-GBR could be a potential tool to explore the in vivo dopamine uptake carrier...
  10. ncbi request reprint Synthesis of tropane and nortropane analogues with phenyl substitutions as serotonin transporter ligands
    P Emond
    INSERM U316, Laboratoire de Biophysique Medicale et Pharmaceutique, Universite Francois Rabelais, 31 Avenue Monge, 37200 Tours, France
    Bioorg Med Chem 9:1849-55. 2001
    ....
  11. ncbi request reprint Neuroprotection of nerve growth factor-loaded microspheres on the D2 dopaminergic receptor positive-striatal neurones in quinolinic acid-lesioned rats: a quantitative autoradiographic assessment with iodobenzamide
    C Gouhier
    INSERM U316, Laboratoire de Biophysique Medicale et Pharmaceutique, Universite Francois Rabelais, UFR des Sciences Pharmaceutiques, Tours, France
    Neurosci Lett 288:71-5. 2000
    ..Moreover, tolerance of microspheres was demonstrated by in vitro autoradiography with the marker of gliosis, [(3)H]-PK 11195...
  12. ncbi request reprint Iodobenzamide for in vivo exploration of central dopamine receptors: evaluation in animal models of supersensitivity
    S Chalon
    INSERM U316, Laboratoire de Biophysique Medicale, Tours, France
    Life Sci 47:729-34. 1990
    ..Thus IBZM labelled with 123I can be a very useful imaging agent for the exploration of D2 receptors in pathological situations...
  13. ncbi request reprint mRNA D(2) dopaminergic receptor expression after hypoxia-ischemia in rat immature brain
    S Cantagrel
    INSERM U316, Faculte de Pharmacie, Tours, France
    Biol Neonate 80:68-73. 2001
    ..The early decrease in mRNA D(2)R could explain the delayed reduced D(2)R after neonatal hypoxia-ischemia...
  14. doi request reprint MPTP intoxication in mice: a useful model of Leigh syndrome to study mitochondrial diseases in childhood
    E Lagrue
    Unité Imagerie et Cerveau, INSERM, U930, Tours, France
    Metab Brain Dis 24:321-35. 2009
    ..01). Taken together, these results confirm that acute MPTP intoxication in young mice provides a reproducible pharmacological paradigm of LS, thus opening new avenues for neuroprotection research...
  15. doi request reprint The specific PKR inhibitor C16 prevents apoptosis and IL-1β production in an acute excitotoxic rat model with a neuroinflammatory component
    C Tronel
    INSERM U930, Tours, France Université François Rabelais de Tours, UMR U930, Tours, France Electronic address
    Neurochem Int 64:73-83. 2014
    ..In conclusion, C16 prevented not only the PKR-induced neuronal loss but also the inflammatory response in this acute excitotoxic in vivo model, highlighting its promising neuroprotective properties to rescue acute brain lesions. ..
  16. doi request reprint Spatio-temporal diffusion of dynamic PET images
    C Tauber
    INSERM U930, CNRS ERL3106, Universite Francois Rabelais, Tours, France
    Phys Med Biol 56:6583-96. 2011
    ..Our simulations suggest that the proposed method can be used to significantly increase the signal-to-noise ratio in dynamic PET imaging...
  17. ncbi request reprint PET and SPECT exploration of central monoaminergic transporters for the development of new drugs and treatments in brain disorders
    D Guilloteau
    INSERM U619, Laboratoire de Biophysique Medicale et Pharmaceutique, Universite Francois Rabelais, Tours, France
    Curr Pharm Des 11:3237-45. 2005
    ....
  18. ncbi request reprint Synthesis and in vitro evaluation of novel derivatives of diphenylsulfide as serotonin transporter ligands
    Johnny Vercouillie
    Universite Francois Rabelais de Tours, INSERM U619, Laboratoire de Biophysique Medicale et Pharmaceutique, 31 Avenue Monge, 37200 Tours, France
    Bioorg Med Chem Lett 16:1297-300. 2006
    ..Three of these exhibited good to high in vitro affinity (0.5 nM < K(i) < 11 nM) and selectivity for the SERT over the other monoamine transporters...
  19. ncbi request reprint Synthesis, radiosynthesis and in vivo preliminary evaluation of [11C]LBT-999, a selective radioligand for the visualisation of the dopamine transporter with PET
    Frederic Dolle
    Service Hospitalier Frederic Joliot, Departement de Recherche Medicale, CEA DSV, Orsay, France
    Bioorg Med Chem 14:1115-25. 2006
    ....
  20. ncbi request reprint Maternal exposure to LPS induces hypomyelination in the internal capsule and programmed cell death in the deep gray matter in newborn rats
    Catherine I Rousset
    INSERM U619, 37000 Tours, France
    Pediatr Res 59:428-33. 2006
    ..This model should be relevant for the study of the pathophysiological mechanisms involved in cerebral white matter damage in preterm human newborns and in the development of therapeutic strategies...
  21. ncbi request reprint Omega-3 fatty acids and monoamine neurotransmission
    Sylvie Chalon
    INSERM U619, Tours, France
    Prostaglandins Leukot Essent Fatty Acids 75:259-69. 2006
    ....
  22. ncbi request reprint [(11)C]MADAM, a new serotonin transporter radioligand characterized in the monkey brain by PET
    Christer Halldin
    Karolinska Institutet, Department of Clinical Neuroscience, Section of Psychiatry, Stockholm, Sweden
    Synapse 58:173-83. 2005
    ..The present characterization of binding in the monkey brain suggests that [(11)C]MADAM is a potential PET radioligand for quantitative studies of 5-HTT binding in the human brain...
  23. ncbi request reprint Lamotrigine is neuroprotective in the energy deficiency model of MPTP intoxicated mice
    Emmanuelle Lagrue
    INSERM, U619, Tours, F 37000 France
    Pediatr Res 62:14-9. 2007
    ..Lamotrigine, a widely used and well-tolerated molecule in young patients, could represent a valuable adjuvant therapy in various energy deficiency conditions during childhood...
  24. ncbi request reprint Ex vivo and in vivo evaluation of (2R,3R)-5-[(18)F]-fluoroethoxy- and fluoropropoxy-benzovesamicol, as PET radioligands for the vesicular acetylcholine transporter
    Nicolas Giboureau
    INSERM, U619, 37000 Tours, France
    Synapse 61:962-70. 2007
    ..The in vivo PET study of [(18)F]2 performed in baboon also revealed rapid defluorination as the main problem. Therefore [(18)F]1 and [(18)F]2 appear to be unsuitable for in vivo imaging of the VAChT using PET...
  25. ncbi request reprint (E)-[125I]-5-AOIBV: a SPECT radioligand for the vesicular acetylcholine transporter
    Patrick Emond
    INSERM U619, 37000 Tours, France
    Nucl Med Biol 34:967-71. 2007
    ..These results made [125I]-( R,R)-5-AOIBV inferior to [125I]-IBVM for the VAChT exploration in vivo...
  26. ncbi request reprint Improved synthesis and metabolic stability analysis of the dopamine transporter ligand [(18)F]FECT
    Satish K Chitneni
    Laboratory for Radiopharmacy, Faculty of Pharmaceutical Sciences, Katholieke Universiteit Leuven, BE 3000, Leuven, Belgium
    Nucl Med Biol 35:75-82. 2008
    ..We report an improved radiosynthesis procedure and affinity data and have analyzed both brain tissue and plasma samples for the presence of radiometabolites as a function of time post intravenous injection of [(18)F]FECT to rats...
  27. doi request reprint IMPY, a potential beta-amyloid imaging probe for detection of prion deposits in scrapie-infected mice
    Pu Jiao Song
    INSERM, U619, F 37000 Tours, France
    Nucl Med Biol 35:197-201. 2008
    ....
  28. doi request reprint Partial recovery of dopaminergic pathway after graft of adult mesenchymal stem cells in a rat model of Parkinson's disease
    Gaëlle Bouchez
    INSERM U930, Laboratory Biophysique médicale and pharmaceutique, UFR Pharmacie, 31 Avenue Monge, Tours, France
    Neurochem Int 52:1332-42. 2008
    ..This cellular approach might be a restorative therapy in Parkinson's disease...
  29. doi request reprint DPA-714, a new translocator protein-specific ligand: synthesis, radiofluorination, and pharmacologic characterization
    Michelle L James
    Department of Pharmacology, University of Sydney, Sydney, New South Wales, Australia
    J Nucl Med 49:814-22. 2008
    ..Radioligands for the TSPO can therefore measure active disease in the brain. This article details the synthesis, radiofluorination, and pharmacologic evaluation of a new TSPO-specific pyrazolopyrimidine, DPA-714...
  30. ncbi request reprint [11C]LBT-999: a suitable radioligand for investigation of extra-striatal dopamine transporter with PET
    Wadad Saba
    CEA, Service Hospitalier Frederic Joliot, DRM DSV, Orsay, France
    Synapse 61:17-23. 2007
    ....
  31. ncbi request reprint Cerebral asymmetry and behavioral lateralization in rats chronically lacking n-3 polyunsaturated fatty acids
    Sylvie Vancassel
    INRA Laboratoire de Nutrition et Sécurité Alimentaire, Jouy en Josas, France
    Biol Psychiatry 58:805-11. 2005
    ....
  32. ncbi request reprint Multiinjection approach for D2 receptor binding quantification in living rats using [11C]raclopride and the beta-microprobe: crossvalidation with in vitro binding data
    Gweltas Mauger
    Unité de Recherche Associée Commissariat á l Energie Atomique Centre National de La Recherche Scientifique, Orsay, France
    J Cereb Blood Flow Metab 25:1517-27. 2005
    ..These results validate the multi-injection modelling approach coupled to beta-microprobe acquisitions as a mean to provide accurate and separate estimates of dopamine D2-receptor density and affinity, in the living rodent striatum...
  33. ncbi request reprint Prenatal 3,4-methylenedioxymethamphetamine (ecstasy) exposure induces long-term alterations in the dopaminergic and serotonergic functions in the rat
    Laurent Galineau
    INSERM U619, IFR135, Laboratoire de Biophysique Médicale and Pharmaceutique, Université François Rabelais des Sciences Pharmaceutiques, 31 Avenue Monge, 37200 Tours, France
    Brain Res Dev Brain Res 154:165-76. 2005
    ..This study suggests that a prenatal exposure to MDMA induces transient and long-term neurochemical and behavioural modifications in dopaminergic and serotonergic functions...
  34. ncbi request reprint Quantification of dopamine transporter by 123I-PE2I SPECT and the noninvasive Logan graphical method in Parkinson's disease
    Caroline Prunier
    Nuclear Medicine Department, Institut National de la Santé et de la Recherche Médicale Unit 316, Bretonneau Hospital, Tours, France
    J Nucl Med 44:663-70. 2003
    ....
  35. ncbi request reprint Synthesis, radiolabeling and preliminary biological evaluation of radiolabeled 5-methyl-6-nitroquipazine, a potential radioligand for the serotonin transporter
    Johan Sandell
    Karolinska Institutet, Department of Clinical Neuroscience, Psychiatry Section, Karolinska Hospital, S 171 76 Stockholm, Sweden
    Bioorg Med Chem Lett 12:3611-3. 2002
    ..The high affinity and the facile labeling of [11C]5-methyl-6-nitroquipazine makes it a promising radioligand for visualization of the serotonin transporter with positron emission tomography...
  36. ncbi request reprint Reversibility of n-3 fatty acid deficiency-induced changes in dopaminergic neurotransmission in rats: critical role of developmental stage
    Ercem Kodas
    INSERM U316, UFR des Sciences Pharmaceutiques, 37200 Tours, France
    J Lipid Res 43:1209-19. 2002
    ..The occurrence of profound n-3 PUFA deficiency during the lactating period could therefore be an environmental insult leading to irreversible damage to specific brain functions...
  37. ncbi request reprint Protection of dopaminergic nigrostriatal afferents by GDNF delivered by microspheres in a rodent model of Parkinson's disease
    Christelle Gouhier
    INSERM U316, Laboratoire de Biophysique Medicale et Pharmaceutique, Universite Francois Rabelais, UFR des Sciences Pharmaceutiques, 37200 Tours, France
    Synapse 44:124-31. 2002
    ..In conclusion, this study demonstrates the neuroprotective action of GDNF delivered by microspheres and suggests that PE2I may be an appropriate radiotracer for use in SPET scintigraphy to follow up treatment of PD in humans...
  38. ncbi request reprint The dopamine mesocorticolimbic pathway is affected by deficiency in n-3 polyunsaturated fatty acids
    Luc Zimmer
    INSERM U316, Laboratoire de Biophysique Medicale et Pharmaceutique, Universite Francois Rabelais, Tours, France
    Am J Clin Nutr 75:662-7. 2002
    ..Several findings in humans support the hypothesis of links between n-3 polyunsaturated fatty acid (PUFA) status and psychiatric diseases...
  39. ncbi request reprint Relevance of different striatal markers in assessment of the MPP+-induced dopaminergic nigrostriatal injury in rat
    Stéphanie Barc
    Groupe d Etudes des Mécanismes Cellulaires de l Ischémie GEMCI, EA 1223, Poitiers, France
    J Neurochem 80:365-74. 2002
    ....
  40. ncbi request reprint Substituted diphenyl sulfides as selective serotonin transporter ligands: synthesis and in vitro evaluation
    Patrick Emond
    INSERM U316, Laboratoire de Biophysique Medicale et Pharmaceutique, 31 Avenue Monge, 37200 Tours, France
    J Med Chem 45:1253-8. 2002
    ..From this series, the most SERT selective derivatives (such as 8b, 8c, and 8g) are now evaluated for their potential as positron emission tomography imaging agents when labeled with carbon-11...
  41. ncbi request reprint Neither the density nor function of striatal dopamine transporters were influenced by chronic n-3 polyunsaturated fatty acid deficiency in rodents
    Ercem Kodas
    INSERM U316, Laboratoire de Biophysique Medicale et Pharmaceutique, Universite Francois Rabelais, UFR des Sciences Pharmaceutiques, 31 Avenue Monge, 37200 Tours, France
    Neurosci Lett 321:95-9. 2002
    ..This suggests lower sensitivity to n-3 PUFA deficiency in the striatum than that previously observed in the frontal cortex...
  42. ncbi request reprint Effect of a diet-induced n-3 PUFA depletion on cholinergic parameters in the rat hippocampus
    Sabah Aïd
    INRA, Laboratoire de Nutrition et Securite Alimentaire, Jouy en Josas, France
    J Lipid Res 44:1545-51. 2003
    ..Thus, we evidenced that an (n-3) PUFA-deficient diet can affect cholinergic neurotransmission, probably via changes in the phospholipid PUFA composition...
  43. ncbi request reprint Pharmacological characterisation of (E)-N-(3-iodoprop-2-enyl)-2beta-carbomethoxy-3beta-(4'-methylphenyl)nortropane (PE2I) binding to the rat neuronal dopamine transporter expressed in COS cells
    Guylène Page
    Laboratoire de Pharmacologie Expérimentale FARL, Université catholique de Louvain 54 10, B 1200 Brussels, Belgium
    Neurochem Int 40:105-13. 2002
    ..Taken together, these data demonstrate that PE2I was a highly potent inhibitor of cloned DAT compared with GBR 12935 and provided a useful tool for further investigations in cells transfected with cDNA encoding the DAT...
  44. ncbi request reprint Synthesis and evaluation of iodine-123 labelled tricyclic tropanes as radioligands for the serotonin transporter
    Mitchell Quinlivan
    Department of Pharmacology, University of Sydney, NSW 2006, Australia
    Nucl Med Biol 30:741-6. 2003
    ..In view of these results [(123)I]1 and [(123)I]2 do not appear to be suitable radioligands for in vivo studies of the SERT...
  45. ncbi request reprint Ropinirole versus L-DOPA effects on striatal opioid peptide precursors in a rodent model of Parkinson's disease: implications for dyskinesia
    Paula Ravenscroft
    School of Biological Sciences, University of Manchester, Manchester M13 9PT, UK
    Exp Neurol 185:36-46. 2004
    ....
  46. ncbi request reprint Time-course of nigrostriatal degeneration in a progressive MPTP-lesioned macaque model of Parkinson's disease
    Wassilios Meissner
    Basal Gang, Laboratoire de Neurophysiologie, CNRS UMR 5543, Universite Victor Segalen, 146 rue Leo Saignat, 33076 Bordeaux Cedex, France
    Mol Neurobiol 28:209-18. 2003
    ..In this article, we examine how this and other chronic MPTP models fit with human pathology...
  47. ncbi request reprint Serotoninergic neurotransmission is affected by n-3 polyunsaturated fatty acids in the rat
    Ercem Kodas
    INSERM U316, Laboratoire de Biophysique Medicale et Pharmaceutique, Universite Francois Rabelais, Tours, France
    J Neurochem 89:695-702. 2004
    ..This suggests that provision of essential fatty acids is durably able to affect brain function and that this is related to the developmental stage during which the deficiency occurs...
  48. ncbi request reprint Ontogeny of the dopamine and serotonin transporters in the rat brain: an autoradiographic study
    Laurent Galineau
    INSERM U619, Laboratoire de Biophysique Medicale et Pharmaceutique, Universite Francois Rabelais, Sciences Pharmaceutiques, 31 Avenue Monge, 37200 Tours, France
    Neurosci Lett 363:266-71. 2004
    ....
  49. ncbi request reprint Involvement of alpha6/alpha3 neuronal nicotinic acetylcholine receptors in neuropsychiatric features of Dementia with Lewy bodies: [(125)I]-alpha-conotoxin MII binding in the thalamus and striatum
    Melissa Ray
    Institute for Ageing and Health, University of Newcastle upon Tyne, MRC Building, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
    Neurosci Lett 372:220-5. 2004
    ....
  50. ncbi request reprint Synthesis and in vitro evaluation of new benzovesamicol analogues as potential imaging probes for the vesicular acetylcholine transporter
    Yolanda Zea-Ponce
    Faculte de Pharmacie, INSERM U619, Laboratoire de Biophysique Medicale, 31 Av Monge, 37200 Tours, France
    Bioorg Med Chem 13:745-53. 2005
    ..4 nM) and (E)-(S,S)-5-AOIBV (Kd=4.3 nM). (R,R)-3, and (R,R)-4 showed the same high affinity for VAChT as (-)-5-IBVM and may be suitable as imaging agents of cholinergic nerve terminals...
  51. doi request reprint Antenatal bacterial endotoxin sensitizes the immature rat brain to postnatal excitotoxic injury
    Catherine I Rousset
    INSERM U930, Universite Francois Rabelais, and Neonatology Hôpital Clocheville, CHRU Tours, Tours, France
    J Neuropathol Exp Neurol 67:994-1000. 2008
    ....
  52. doi request reprint PE2I: a radiopharmaceutical for in vivo exploration of the dopamine transporter
    Patrick Emond
    INSERM, U619, Tours, F 37000 France
    CNS Neurosci Ther 14:47-64. 2008
    ..The excellent properties of PE2I are basis for the development of new DAT tracers for use in future PET explorations using fluor-18...
  53. ncbi request reprint Presymptomatic diagnosis of experimental Parkinsonism with 123I-PE2I SPECT
    Caroline Prunier
    INSERM U316, Laboratoire de Biophysique Medicale et Pharmaceutique, 31 Avenue Monge, 37200 Tours, France
    Neuroimage 19:810-6. 2003
    ..It could now be used clinically for early diagnosis and follow-up of neuroprotective treatment...
  54. doi request reprint Drug-dependent requirement of hippocampal neurogenesis in a model of depression and of antidepressant reversal
    Alexandre Surget
    U930, INSERM, Universite Francois Rabelais de Tours, Tours, France
    Biol Psychiatry 64:293-301. 2008
    ..We investigated causality between changes in hippocampal neurogenesis and the effects of both chronic stress and chronic ADs...
  55. ncbi request reprint Synthesis and in vitro evaluation of N-substituted aza-trozamicol analogs as vesicular acetylcholine transporter ligands
    Thaer Assaad
    Universite Francois Rabelais de Tours, 37200 Tours, France
    Bioorg Med Chem Lett 16:2654-7. 2006
    ..These compounds will be soon radiolabeled with [(125)I] for further biological evaluation using single photon emission computed tomography (SPECT)...
  56. ncbi request reprint Decreased vesicular acetylcholine transporter and alpha(4)beta(2) nicotinic receptor density in the rat brain following 192 IgG-saporin immunolesioning
    Mitchell Quinlivan
    Universite Francois Rabelais de Tours, INSERM U619, Laboratoire de Biophysique Medicale et Pharmaceutique, 31 Avenue Monge, 37200 Tours, France
    Neurosci Lett 415:97-101. 2007
    ..The results with (125)I-A-85380 are unique and are in contrast with work performed in this animal model with other nAChR radioligands, indicating the favourable properties of this radioligand for molecular imaging...