- Exploratory analysis of obsessive compulsive symptom dimensions in children and adolescents: a prospective follow-up studyRichard Delorme
INSERM U513, Faculte de Medecine, Universite Paris XII, Creteil, France
BMC Psychiatry 6:1. 2006..Although a phenotypic continuum from childhood to adulthood has been hypothesized, no factor analytic studies have been performed in juvenile patients, and the stability of OC dimensions in children and adolescents has not been assessed...
- Early-onset obsessive-compulsive disorder: a subgroup with a specific clinical and familial pattern?Nadia Chabane
Service de Psychopathologie de l Enfant et de l Adolescent, Assistance Publique Hopitaux de Paris, Hopital Robert Debre, Paris, France
J Child Psychol Psychiatry 46:881-7. 2005..In this study, the specificity of early-onset OCD was investigated, focusing on the effect of gender, comorbid conditions and familial risk of tics and OCD by studying a population consisting exclusively of patients with early-onset OCD...
- Lack of evidence for association between serotonin transporter gene (5-HTTLPR) and obsessive-compulsive disorder by case control and family association study in humansNadia Chabane
University Department of Psychiatry, INSERM E0 117, Sainte Anne Hospital, Paris, France
Neurosci Lett 363:154-6. 2004..We also performed a family association study on 116 trios including an OCD patient (73 French and 43 German). No association was detected between the 5-HTTLPR polymorphism and OCD in either the case control study or the family study...
- Platelet serotonergic predictors of clinical improvement in obsessive compulsive disorderRichard Delorme
Service de Psychopathologie de l Enfant et de l Adolescent, AP HP, Hopital Robert Debre, Paris, France
J Clin Psychopharmacol 24:18-23. 2004..We tried to identify further peripheral serotonergic parameters that could help predict the clinical outcome of SRI treatment in a sample of patients with OCD...
- Association between the dopamine receptor D4 (DRD4) gene and obsessive-compulsive disorderBruno Millet
INSERM E0117 Paris V, University Department of Psychiatry, Sainte Anne Hospital, Paris, France
Am J Med Genet B Neuropsychiatr Genet 116:55-9. 2003..The results suggest that the 2 allele or a nearby genetic variation could have a protective effect against OCD symptoms...
- Mutations in the gene encoding the synaptic scaffolding protein SHANK3 are associated with autism spectrum disordersChristelle M Durand
Human Genetics and Cognitive Functions, Institut Pasteur, Paris, France
Nat Genet 39:25-7. 2007..These mutations concern only a small number of individuals, but they shed light on one gene dosage-sensitive synaptic pathway that is involved in autism spectrum disorders...
- Platelet serotonergic markers as endophenotypes for obsessive-compulsive disorderRichard Delorme
INSERM U 513, Faculte de Medecine, Creteil, France
Neuropsychopharmacology 30:1539-47. 2005..These alterations may serve as endophenotypic markers in OCD, and could contribute to the study of the biological mechanisms and genetic underpinnings of the disorder...
- Frequency and transmission of glutamate receptors GRIK2 and GRIK3 polymorphisms in patients with obsessive compulsive disorderRichard Delorme
INSERM U 513, Faculte de Medecine, 8 rue du General Sarrail, 94010 Creteil, France
Neuroreport 15:699-702. 2004..03), supporting a functional role for this variant. These findings suggest the need for further investigation of the role of GRIK2 in OCD...
- Admixture analysis of age at onset in obsessive-compulsive disorderRichard Delorme
INSERM U513, Faculte de Medecine, Creteil, France
Psychol Med 35:237-43. 2005..If AAO is a clinical indicator of different biological subtypes, then subgroups based on distinct AAOs should have separate normal distributions as well as different clinical characteristics...
- Autism in three patients with cystic or hyperechogenic kidneys and chromosome 17q12 deletionChantal Loirat
Department of Pediatric Nephrology, Assistance Publique Hopitaux de Paris, Hopital Robert Debre, Universite Paris Diderot, Paris, France
Nephrol Dial Transplant 25:3430-3. 2010..We report autism in 3 out of 53 children with cystic or hyperechogenic kidneys and heterozygous 17q12 region deletion encompassing hepatocyte nuclear factor-1beta (HNF1B)...
- Fringe phenotypes in autism: a review of clinical, biochemical and cognitive studiesVéronique Goussé
Consultation autisme, Service de Psychopathologie de l Enfant et de l Adolescent, Hopital Robert Debre, Assistance Publique Hopitaux de Paris, 75019, Paris, France
Eur Psychiatry 17:120-8. 2002..This review will focus on this last strategy and principally on clinical, biochemical and cognitive traits...
- Four-factor structure of obsessive-compulsive disorder symptoms in children, adolescents, and adultsS Evelyn Stewart
Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
J Am Acad Child Adolesc Psychiatry 47:763-72. 2008..Identification of a category-based OCD symptom dimension structure that is validated for use across child, adolescent, and adult age groups is necessary to guide ongoing translational research...
- Association of the SLC1A1 glutamate transporter gene and obsessive-compulsive disorderS Evelyn Stewart
Psychiatric Neurodevelopmental and Genetics Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
Am J Med Genet B Neuropsychiatr Genet 144:1027-33. 2007..Two separate proximal haplotypes in the glutamate transporter gene, SLC1A1, were recently reported to be associated with OCD among males, but replication is required...
- A genetic family-based association study of OLIG2 in obsessive-compulsive disorderS Evelyn Stewart
Psychiatric Neuroscience Research Division, and Obsessive Compulsive Disorder Clinic, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA
Arch Gen Psychiatry 64:209-14. 2007..The gene for oligodendrocyte lineage transcription factor 2 (OLIG2) is an essential regulator in the development of cells that produce white matter (myelin). The OLIG2 gene is also highly expressed in brain regions implicated in OCD...
- Perception of complex sounds in autism: abnormal auditory cortical processing in childrenNathalie Boddaert
Commissariat a l Energie Atomique, Service Hospitalier Frederic Joliot, 4 Place du General Leclerc, 91406 Orsay, France
Am J Psychiatry 161:2117-20. 2004..Here, they investigated whether this abnormal cortical processing was also present in children with primary autism...
- Expression and genetic variability of PCDH11Y, a gene specific to Homo sapiens and candidate for susceptibility to psychiatric disordersChristelle M Durand
Human Genetics and Cognitive Functions, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France
Am J Med Genet B Neuropsychiatr Genet 141:67-70. 2006..These findings do not support the role of PCDH11Y, or more generally of a frequent specific Y chromosome, in the susceptibility to these neuropsychiatric disorders...
- No association between DUP25 and anxiety disordersCharlotte Neergaard Henrichsen
Division de génétique médicale, Hopitaux Universitaires de Geneve, 1 rue Michel Servet 1211, Geneva 4, Switzerland
Am J Med Genet B Neuropsychiatr Genet 128:80-3. 2004..We have not detected any DUP25. Our results suggest that DUP25 is not common in people with anxiety disorders in the population tested here...
- Association between the COMT locus and obsessive-compulsive disorder in females but not malesJohn P Alsobrook
Child Study Center, Yale University School of Medicine, New Haven, Connecticut, USA
Am J Med Genet 114:116-20. 2002..049), but not in male probands. These findings indicate that COMT may be etiologically relevant to OCD in a gender-specific manner opposite to that shown in previous studies...
- Autism, the superior temporal sulcus and social perceptionMonica Zilbovicius
URM 0205 Brain Imaging in Psychiatry, INSERM CEA, Service Hospitalier Frederic Joliot, CEA, 4 Place du General Leclerc, Orsay 91406, France
Trends Neurosci 29:359-66. 2006..This review is part of the INMED/TINS special issue "Nature and nurture in brain development and neurological disorders", based on presentations at the annual INMED/TINS symposium (http://inmednet.com/)...
- Perception of complex sounds: abnormal pattern of cortical activation in autismNathalie Boddaert
ERM 0205, Division of Life Sciences, Department of Medical Research, INSERM CEA Service Hospitalier Frédéric Joliot, 4 Place du General Leclerc, 91406 Orsay, France
Am J Psychiatry 160:2057-60. 2003..In normal adults, these regions are activated by listening to speech-like sounds. To investigate auditory cortical processing in autism, the authors performed a positron emission tomography activation study...
- [Obsessive-compulsive disorder in children and adolescents]Nadia Chabane
Service de Psychiatrie de l Enfant et de l Adolescent, Hopital Robert Debre, 75935 Paris 19
Rev Prat 57:45-51. 2007..The ongoing refinement of cognitive-behaviour and pharmacological treatment approaches has increased the likelihood that many youngsters with OCD will lead satisfying and relatively normal lives...
- Autism severity and temporal lobe functional abnormalitiesIsabelle Gendry Meresse
ERM 0205 Institut National de la Sante et de la Recherche Médicale CEA, Service Hospitalier F Joliot, DSV, DRM, CEA, Orsay, France
Ann Neurol 58:466-9. 2005..The more severe the autistic syndrome, the more rCBF is low in this region, suggesting that left superior temporal hypoperfusion is related to autistic behavior severity...