Laurent Vinay

Summary

Affiliation: Centre National de la Recherche Scientifique
Country: France

Publications

  1. pmc Perinatal development of the motor systems involved in postural control
    Laurent Vinay
    Centre National de la Recherche Scientifiqu and Universite de la Méditerranée, Laboratoire Plasticité et Physio Pathologie de la Motricité UMR6196, CNRS, F 13402 Marseille, France
    Neural Plast 12:131-9; discussion 263-72. 2005
  2. ncbi Differential maturation of motoneurons innervating ankle flexor and extensor muscles in the neonatal rat
    L Vinay
    CNRS, UniversitA d Aix Marseille II Dévelopement et Pathologie du Mouvement, 31 Chemin Joseph Aiguier, 13402 Marseille Cedex 20, France
    Eur J Neurosci 12:4562-6. 2000
  3. ncbi Perinatal development of lumbar motoneurons and their inputs in the rat
    L Vinay
    CNRS, Développement et Pathologie du mouvement, Marseille, France
    Brain Res Bull 53:635-47. 2000
  4. ncbi Plasticity of spinal cord locomotor networks and contribution of cation-chloride cotransporters
    Laurent Vinay
    Laboratoire Plasticité et Physio Pathologie de la Motricité UMR6196, Centre National de la Recherche Scientifique and Aix Marseille Université, CNRS, 31 Chemin Joseph Aiguier, F 13402 Marseille cx 20, France
    Brain Res Rev 57:103-10. 2008
  5. ncbi Development of posture and locomotion: an interplay of endogenously generated activities and neurotrophic actions by descending pathways
    Laurent Vinay
    DPM, CNRS, 31 Chemin Joseph Aiguier, F 13402 Marseille Cedex 20, France
    Brain Res Brain Res Rev 40:118-29. 2002
  6. doi Differential plasticity of the GABAergic and glycinergic synaptic transmission to rat lumbar motoneurons after spinal cord injury
    Karina Sadlaoud
    Laboratoire Plasticité et Physio Pathologie de la Motricité Unité Mixte de Recherche 6196, Centre National de la Recherche Scientifique and Aix Marseille Université, Marseille, France
    J Neurosci 30:3358-69. 2010
  7. doi Chapter 1--importance of chloride homeostasis in the operation of rhythmic motor networks
    Jean Charles Viemari
    Laboratoire Plasticité et Physio Pathologie de la Motricité UMR6196, Centre National de la Recherche Scientifique CNRS and Aix Marseille Université, 31 Chemin Joseph Aiguier, Marseille Cedex 20, France
    Prog Brain Res 188:3-14. 2011
  8. doi Contribution of the potassium-chloride co-transporter KCC2 to the modulation of lumbar spinal networks in mice
    Aurélie Stil
    Laboratoire Plasticité et Physio Pathologie de la Motricité UMR 6196, CNRS and Aix Marseille Université, Marseille, France
    Eur J Neurosci 33:1212-22. 2011
  9. ncbi Contribution of persistent sodium current to locomotor pattern generation in neonatal rats
    Sabrina Tazerart
    Laboratoire de Plasticité et Physio Pathologie de la Motricité, Unité Mixte de Recherche 6196, Centre National de la Recherche Scientifique, Aix Marseille Universite, Marseille, France
    J Neurophysiol 98:613-28. 2007
  10. ncbi Reversible disorganization of the locomotor pattern after neonatal spinal cord transection in the rat
    Jean Chrétien Norreel
    Développement et Pathologie du mouvement, Centre National de la Recherche Scientifique, F 13402 Marseille Cedex 20, France
    J Neurosci 23:1924-32. 2003

Collaborators

Detail Information

Publications33

  1. pmc Perinatal development of the motor systems involved in postural control
    Laurent Vinay
    Centre National de la Recherche Scientifiqu and Universite de la Méditerranée, Laboratoire Plasticité et Physio Pathologie de la Motricité UMR6196, CNRS, F 13402 Marseille, France
    Neural Plast 12:131-9; discussion 263-72. 2005
    ..g. deficits in motor coordination--might have their roots in the prenatal period, in particular serotonin depletion due to exposure to several environmental and toxicological factors during pregnancy...
  2. ncbi Differential maturation of motoneurons innervating ankle flexor and extensor muscles in the neonatal rat
    L Vinay
    CNRS, UniversitA d Aix Marseille II Dévelopement et Pathologie du Mouvement, 31 Chemin Joseph Aiguier, 13402 Marseille Cedex 20, France
    Eur J Neurosci 12:4562-6. 2000
    ..This may be a critical factor in the development of posture and locomotion...
  3. ncbi Perinatal development of lumbar motoneurons and their inputs in the rat
    L Vinay
    CNRS, Développement et Pathologie du mouvement, Marseille, France
    Brain Res Bull 53:635-47. 2000
    ..The spontaneous embryonic and neonatal network-driven activity, detected at the levels of motoneurons and primary afferent terminals, may play a role in neuronal maturation and in the formation and refinement of sensorimotor connections...
  4. ncbi Plasticity of spinal cord locomotor networks and contribution of cation-chloride cotransporters
    Laurent Vinay
    Laboratoire Plasticité et Physio Pathologie de la Motricité UMR6196, Centre National de la Recherche Scientifique and Aix Marseille Université, CNRS, 31 Chemin Joseph Aiguier, F 13402 Marseille cx 20, France
    Brain Res Rev 57:103-10. 2008
    ..This latter situation is observed early during development and in several pathological conditions, such as epilepsy, neuronal injury and chronic pain...
  5. ncbi Development of posture and locomotion: an interplay of endogenously generated activities and neurotrophic actions by descending pathways
    Laurent Vinay
    DPM, CNRS, 31 Chemin Joseph Aiguier, F 13402 Marseille Cedex 20, France
    Brain Res Brain Res Rev 40:118-29. 2002
    ..These pathways, through the neurotransmitters they contain, especially monoamines, are essential for the expression of some neuronal properties and may regulate several ongoing developmental processes...
  6. doi Differential plasticity of the GABAergic and glycinergic synaptic transmission to rat lumbar motoneurons after spinal cord injury
    Karina Sadlaoud
    Laboratoire Plasticité et Physio Pathologie de la Motricité Unité Mixte de Recherche 6196, Centre National de la Recherche Scientifique and Aix Marseille Université, Marseille, France
    J Neurosci 30:3358-69. 2010
    ..We conclude that the plasticity of GlyR is independent of supraspinal influences whereas that of GABA(A)R is markedly influenced by descending pathways, in particular serotoninergic projections...
  7. doi Chapter 1--importance of chloride homeostasis in the operation of rhythmic motor networks
    Jean Charles Viemari
    Laboratoire Plasticité et Physio Pathologie de la Motricité UMR6196, Centre National de la Recherche Scientifique CNRS and Aix Marseille Université, 31 Chemin Joseph Aiguier, Marseille Cedex 20, France
    Prog Brain Res 188:3-14. 2011
    ..Here, we review some recent data regarding chloride homeostasis in the spinal cord and its contribution to network operation involved in locomotion...
  8. doi Contribution of the potassium-chloride co-transporter KCC2 to the modulation of lumbar spinal networks in mice
    Aurélie Stil
    Laboratoire Plasticité et Physio Pathologie de la Motricité UMR 6196, CNRS and Aix Marseille Université, Marseille, France
    Eur J Neurosci 33:1212-22. 2011
    ..We conclude that neuronal networks within the spinal cord are more excitable in KCC2 mutant mice, which suggests that KCC2 strongly modulates the excitability of spinal cord networks...
  9. ncbi Contribution of persistent sodium current to locomotor pattern generation in neonatal rats
    Sabrina Tazerart
    Laboratoire de Plasticité et Physio Pathologie de la Motricité, Unité Mixte de Recherche 6196, Centre National de la Recherche Scientifique, Aix Marseille Universite, Marseille, France
    J Neurophysiol 98:613-28. 2007
    ....
  10. ncbi Reversible disorganization of the locomotor pattern after neonatal spinal cord transection in the rat
    Jean Chrétien Norreel
    Développement et Pathologie du mouvement, Centre National de la Recherche Scientifique, F 13402 Marseille Cedex 20, France
    J Neurosci 23:1924-32. 2003
    ..These results suggest that descending pathways, in particular serotonergic projections, control the strength of reciprocal inhibition and therefore shape the locomotor pattern in the neonatal rat...
  11. doi Down-regulation of the potassium-chloride cotransporter KCC2 contributes to spasticity after spinal cord injury
    Pascale Boulenguez
    Laboratoire Plasticité et Physio Pathologie de la Motricité UMR6196, Centre National de la Recherche Scientifique CNRS and Aix Marseille Université, Marseille, France
    Nat Med 16:302-7. 2010
    ..Conversely, after SCI, BDNF upregulates KCC2 and restores RDD. Our results open new perspectives for the development of therapeutic strategies to alleviate spasticity...
  12. ncbi Postural modifications and neuronal excitability changes induced by a short-term serotonin depletion during neonatal development in the rat
    Jean François Pflieger
    Développement et Pathologie du mouvement, Centre National de la Recherche Scientifique, F 13402 Marseille, Cedex 20, France
    J Neurosci 22:5108-17. 2002
    ..Interneuronal excitability is crucial for the activity-dependent development of spinal cord networks...
  13. ncbi The persistent sodium current generates pacemaker activities in the central pattern generator for locomotion and regulates the locomotor rhythm
    Sabrina Tazerart
    Laboratoire Plasticité et Physio Pathologie de la Motricité, Unité Mixte de Recherche 6196, Centre National de la Recherche Scientifique, Universite Aix Marseille, F 13402 Marseille Cedex 20, France
    J Neurosci 28:8577-89. 2008
    ..This study provides evidence that I(NaP) generates pacemaker activities in CPG interneurons and contributes to the regulation of the locomotor activity...
  14. ncbi The maturation of locomotor networks
    Francois Clarac
    Institut de Neurosciences Physiologiques et Cognitives INPC, CNRS, Aix Marseille II, 13402 Marseille, France
    Prog Brain Res 143:57-66. 2004
    ..Some neural controls are more clearly demonstrable in the developing animal preparation than in the adult because the latter exhibits an array of complex and redundant adaptive mechanisms...
  15. ncbi Picrotoxin and bicuculline have different effects on lumbar spinal networks and motoneurons in the neonatal rat
    Jean François Pflieger
    DPM, CNRS, 31 Chemin Joseph Aiguier, F 13402 Marseille Cedex 20, France
    Brain Res 935:81-6. 2002
    ..These data demonstrate that bicuculline-M may not reveal accurately the contribution of GABA(A) receptors in motor control and the intrinsic properties of disinhibited networks...
  16. doi Primary afferent terminals acting as excitatory interneurons contribute to spontaneous motor activities in the immature spinal cord
    Rémi Bos
    Laboratoire Plasticité et Physio Pathologie de la Motricité, UMR 6196, Centre National de la Recherche Scientifique, and Aix Marseille Universite, F 13402 Marseille Cedex 20, France
    J Neurosci 31:10184-8. 2011
    ..We conclude that primary afferent fibers act as excitatory interneurons and that GABA, through PADs reaching firing threshold, is still playing a key role in promoting spontaneous activity in neonates...
  17. ncbi Gravity influences the development of inputs from the brain to lumbar motoneurons in the rat
    F Brocard
    Institut de Neurosciences Physiologiques et Cognitives, CNRS, 31 Chemin Joseph Aiguier, 13402 Marseille Cx 20, France
    Neuroreport 14:1697-700. 2003
    ..We concluded that gravity was critical to shape development of the supraspinal afferents in the lumbar spinal cord throughout the postnatal period...
  18. ncbi Inhibitory postsynaptic potentials in lumbar motoneurons remain depolarizing after neonatal spinal cord transection in the rat
    Céline Jean-Xavier
    CNRS, P3M, 31 Chemin Joseph Aiguier, F 13402 Marseille cx 20, France
    J Neurophysiol 96:2274-81. 2006
    ..Therefore influences from the brain stem may play an essential role in the maturation of inhibitory synaptic transmission, possibly by upregulating KCC2 and its functionality...
  19. pmc Dual personality of GABA/glycine-mediated depolarizations in immature spinal cord
    Céline Jean-Xavier
    Laboratoire Plasticité et Physio Pathologie de la Motricité, Centre National de la Recherche Scientifique, Aix Marseille Universite, 31 Chemin Joseph Aiguier, F 13402 Marseille Cedex 20, France
    Proc Natl Acad Sci U S A 104:11477-82. 2007
    ..Our results raise the possibility that inhibitory synapses exert a facilitatory action on distant excitatory inputs and slight changes of E(Cl) may have important consequences for network processing...
  20. doi Sodium-mediated plateau potentials in lumbar motoneurons of neonatal rats
    Mouloud Bouhadfane
    Institut de Neurosciences de la Timone UMR7289, Aix Marseille Université and CNRS, Marseille, France, and Institut de Biologie du Développement de Marseille Luminy UMR6216, Aix Marseille Université and CNRS, Marseille, France
    J Neurosci 33:15626-41. 2013
    ..To conclude, bistable behaviors are, to a large extent, determined by the interplay between three currents: L-type I(Ca), I(NaP), and a Na(+)-mediated I(CaN) flowing through putative TRPV2 channels...
  21. doi Do pacemakers drive the central pattern generator for locomotion in mammals?
    Frédéric Brocard
    Lab Plasticité et Physio Pathologie de la Motricité, Centre National de la Recherche Scientifique, Universite Aix Marseille, Marseille, France
    Neuroscientist 16:139-55. 2010
    ....
  22. doi Characterization of last-order premotor interneurons by transneuronal tracing with rabies virus in the neonatal mouse spinal cord
    Patrice Coulon
    Laboratoire Plasticité et Physio Pathologie de la Motricité, Unité Mixte de Recherche 6196, Centre National de la Recherche Scientifique CNRS and Aix Marseille Université, Marseille, France
    J Comp Neurol 519:3470-87. 2011
    ..To conclude, transneuronal tracing with RV, combined with an immunohistochemical detection of neuronal determinants, allows a very specific mapping of motor networks involved in the control of single muscles...
  23. doi Strategies to restore motor functions after spinal cord injury
    Pascale Boulenguez
    Laboratoire Plasticité et Physio Pathologie de Motricité UMR6196, Centre National de Recherche Scientifique CNRS and Aix Marseille Université, CNRS, 31 Chemin Joseph Aiguier, F 13402 Marseille cx 20, France
    Curr Opin Neurobiol 19:587-600. 2009
    ..Finally, improvements in the understanding of the mechanisms underlying spasticity may lead to new treatments of this disabling complication affecting patients with SCI...
  24. ncbi Developmental up-regulation of the potassium-chloride cotransporter type 2 in the rat lumbar spinal cord
    A Stil
    Laboratoire Plasticité et Physio Pathologie de la Motricité UMR6196, Centre National de la Recherche Scientifique CNRS, Aix Marseille Universite, CNRS, 31 Chemin Joseph Aiguier, F 13402 Marseille cx 20, France
    Neuroscience 164:809-21. 2009
    ..Taken together, the present results indicate that maturation of chloride homeostasis is not completed at birth in the rat and that the upregulation of KCC2 plays a key role in the shift from depolarizing to hyperpolarizing IPSPs...
  25. pmc Prenatal exposure to fenugreek impairs sensorimotor development and the operation of spinal cord networks in mice
    Loubna Khalki
    Laboratoire Pharmacologie, Neurobiologie et Comportement, Centre National de la Recherche Scientifiques et Techniques URAC 37, Cadi Ayyad Université, Marrakech, Maroc Institut de Neurosciences de la Timone, P3M Team, CNRS, Aix Marseille Universite, Marseille, France
    PLoS ONE 8:e80013. 2013
    ..Moreover, spinal neuronal networks are less excitable in prenatally FSAE-exposed mice suggesting that modifications within the central nervous system are responsible, at least in part, for the motor impairments...
  26. ncbi CGP 35348 and CGP 55845A block the baclofen-induced depression of dorsal root evoked potentials in lumbar motoneurons of the neonatal rat
    L Vinay
    CNRS, UPR Neurobiologie et Mouvements, Marseille, France
    Neurosci Lett 214:103-6. 1996
    ..The two GABAB receptor antagonists, CGP 35348 and CGP 55845A blocked the effects of baclofen. These two compounds may be useful tools to study the evolution of GABAB receptor-mediated presynaptic inhibition during ontogenesis...
  27. ncbi Serotonin refines the locomotor-related alternations in the in vitro neonatal rat spinal cord
    E Pearlstein
    Laboratoire Plasticité et Physio Pathologie de la Motricité PM, CNRS and Université de la Méditerranée, UMR 6196, CNRS, 31 Chemin Joseph Aiguier, F 13402 Marseille Cedex 20, France
    Eur J Neurosci 21:1338-46. 2005
    ..These results demonstrate that 5-HT is critical in improving the locomotor-related alternations in the neonatal rat...
  28. ncbi The in vitro neonatal rat spinal cord preparation: a new insight into mammalian locomotor mechanisms
    F Clarac
    Laboratoire Plasticité et Physio Pathologie de la Motricité, CNRS Université de la Méditerranée, 31 Chemin Joseph Aiguier, 13402 Marseille Cedex 20, France
    J Comp Physiol A Neuroethol Sens Neural Behav Physiol 190:343-57. 2004
    ..Studies carried out on this preparation deal with three major areas: (1) relations between spontaneous activity and maturation of spinal network, (2) organisation of the different spinal networks, (3) key role of the descending pathways...
  29. ncbi Close relationship between motor impairments and loss of functional motoneurons in a Charcot-Marie-Tooth type 1A model
    J C Norreel
    Développement et Pathologie du mouvement, CNRS, Marseille, France
    Neuroscience 116:695-703. 2003
    ..These findings may have implications for therapeutic procedures, which should focus on the survival of the motoneuronal pool and/or the maintenance of functional neuro-muscular connexions to reduce motor impairments in humans...
  30. ncbi Role of gravity in the development of posture and locomotion in the neonatal rat
    F Clarac
    CNRS UPR 9011, Neurobiologie et Mouvements, 31 Chemin Joseph Aiguier, BP 71, F 13402, Marseille Cedex 20, France
    Brain Res Brain Res Rev 28:35-43. 1998
    ..Different types of experiments (hypergravity, microgravity) are planned to test this hypothesis...
  31. ncbi Anatomical study of spinobulbar neurons in lampreys
    L Vinay
    Department of Neuroscience, The Nobel Institute for Neurophysiology, Karolinska Institutet, Stockholm, Sweden
    J Comp Neurol 397:475-92. 1998
    ..These cells may, together with the rostral edge cells, be responsible for the locomotor-related modulation of activity in reticulospinal and vestibulospinal neurons...
  32. doi Glucose is an adequate energy substrate for the depolarizing action of GABA and glycine in the neonatal rat spinal cord in vitro
    Rémi Bos
    Institut de Neurosciences de la Timone, Unité Mixte Recherche 7289, Centre National de la Recherche Scientifique, and Aix Marseille Universite, Marseille, France
    J Neurophysiol 107:3107-15. 2012
    ..Glucose at its standard concentration appears to be an adequate ES for the neonatal spinal cord in vitro...
  33. ncbi Deficits of brainstem and spinal cord functions after neonatal hypoxia-ischemia in mice
    Blandine Bellot
    1 Institut de Neurosciences de la Timone P3M Team, UMR 7289, CNRS, Aix Marseille Universite, Marseille, France 2 Pôle de Médecine et Réanimation Néonatales, Assistance Publique Hopitaux de Marseille, Marseille, France
    Pediatr Res 75:723-30. 2014
    ..Dysfunctions of neuromodulatory systems, such as the serotonergic (5-HT) projections, critical for the development of neural networks, have been postulated to underlie behavioral and motor deficits, as well as metabolic changes...