Olaf Mercier

Summary

Affiliation: Centre Chirurgical Marie Lannelongue
Country: France

Publications

  1. doi Chronic thromboembolic pulmonary hypertension: animal models
    Olaf Mercier
    Laboratory of Surgical Research and INSERM U999, Hôpital Marie Lannelongue and Paris Sud University, Le Plessis Robinson, France
    Eur Respir J 41:1200-6. 2013
  2. pmc Increased oxidative stress and severe arterial remodeling induced by permanent high-flow challenge in experimental pulmonary hypertension
    Peter Dorfmuller
    Universite Paris Sud, Faculte de Medecine, Kremlin Bicetre, F 94276, France
    Respir Res 12:119. 2011
  3. doi Regression of flow-induced pulmonary arterial vasculopathy after flow correction in piglets
    Olaf Mercier
    Laboratoire de Chirurgie Expérimentale UPRES EA 2705, Uninersité Paris XI Hôpital Marie Lannelongue, Le Plessis Robinson, France
    J Thorac Cardiovasc Surg 137:1538-46. 2009
  4. doi Endothelin A receptor blockade improves regression of flow-induced pulmonary vasculopathy in piglets
    Olaf Mercier
    INSERM U999, Universite Paris XI, Hopital Marie Lannelongue, Le Plessis Robinson, France
    J Thorac Cardiovasc Surg 140:677-83. 2010
  5. doi Right lung ischemia induces contralateral pulmonary vasculopathy in an animal model
    Edouard Sage
    Laboratoire de Recherche Chirurgicale and INSERM U999, Hopital Marie Lannelongue, Universite Paris Sud, Le Plessis Robinson, France
    J Thorac Cardiovasc Surg 143:967-73. 2012
  6. doi Subclavian artery resection and reconstruction for thoracic inlet cancer: 25 years of experience
    Benoit Lahon
    Department of Thoracic and Vascular Surgery and Heart Lung Transplantation, Thoracic Oncology Institute, Marie Lannelongue Hospital, Le Plessis Robinson, France
    Ann Thorac Surg 96:983-8; discussion 988-9. 2013
  7. doi Factors affecting early and long-term outcomes after completion pneumonectomy
    Olivier Chataigner
    Department of Thoracic and Vascular Surgery and Heart Lung Transplantation, Hopital Marie Lannelongue, Paris Sud University, 133, avenue de la resistance, 92350 Le Plessis Robinson, France
    Eur J Cardiothorac Surg 33:837-43. 2008
  8. pmc Endothelial cell apoptosis in chronically obstructed and reperfused pulmonary artery
    Edouard Sage
    UPRES EA2705, Laboratoire de Chirurgie Experimentale, Hopital Marie Lannelongue, Le Plessis Robinson, France
    Respir Res 9:19. 2008
  9. doi A paradigm shift for sternal reconstruction using a novel titanium rib bridge system following oncological resections
    Dominique Fabre
    Department of Thoracic and Vascular Surgery and Heart Lung Transplantation, Marie Lannelongue Hospital, Paris Sud University, Le Plessis Robinson, France
    Eur J Cardiothorac Surg 42:965-70. 2012
  10. doi Complete resection of pulmonary inflammatory pseudotumors has excellent long-term prognosis
    Dominique Fabre
    Department of Thoracic and Vascular Surgery and Heart Lung Transplantation, Hopital Marie Lannelongue, Le Plessis Robinson, Paris Sud University, France
    J Thorac Cardiovasc Surg 137:435-40. 2009

Collaborators

Detail Information

Publications28

  1. doi Chronic thromboembolic pulmonary hypertension: animal models
    Olaf Mercier
    Laboratory of Surgical Research and INSERM U999, Hôpital Marie Lannelongue and Paris Sud University, Le Plessis Robinson, France
    Eur Respir J 41:1200-6. 2013
    ..This short review analyses strengths and weaknesses of all animal models available to study the pathophysiology of CTEPH...
  2. pmc Increased oxidative stress and severe arterial remodeling induced by permanent high-flow challenge in experimental pulmonary hypertension
    Peter Dorfmuller
    Universite Paris Sud, Faculte de Medecine, Kremlin Bicetre, F 94276, France
    Respir Res 12:119. 2011
    ..The impact of OS on vascular remodeling in PH is still to be determined. We hypothesized, that augmented blood-flow could increase OS and might thereby contribute to DC/inflammatory cell-recruitment and smooth-muscle-cell-proliferation...
  3. doi Regression of flow-induced pulmonary arterial vasculopathy after flow correction in piglets
    Olaf Mercier
    Laboratoire de Chirurgie Expérimentale UPRES EA 2705, Uninersité Paris XI Hôpital Marie Lannelongue, Le Plessis Robinson, France
    J Thorac Cardiovasc Surg 137:1538-46. 2009
    ..The aim of this study was to determine whether correcting high flow led to reversal of the vasculopathy in piglets...
  4. doi Endothelin A receptor blockade improves regression of flow-induced pulmonary vasculopathy in piglets
    Olaf Mercier
    INSERM U999, Universite Paris XI, Hopital Marie Lannelongue, Le Plessis Robinson, France
    J Thorac Cardiovasc Surg 140:677-83. 2010
    ..We wanted to study the effect of the ETA antagonist TBC 3711 on reversal of flow-induced pulmonary vascular lesions...
  5. doi Right lung ischemia induces contralateral pulmonary vasculopathy in an animal model
    Edouard Sage
    Laboratoire de Recherche Chirurgicale and INSERM U999, Hopital Marie Lannelongue, Universite Paris Sud, Le Plessis Robinson, France
    J Thorac Cardiovasc Surg 143:967-73. 2012
    ..The study objective was to determine whether the vasculopathy seen in nonobstructed lung regions in chronic thromboembolic pulmonary hypertension is induced by the local blood flow increase or by factors released by the ischemic lung...
  6. doi Subclavian artery resection and reconstruction for thoracic inlet cancer: 25 years of experience
    Benoit Lahon
    Department of Thoracic and Vascular Surgery and Heart Lung Transplantation, Thoracic Oncology Institute, Marie Lannelongue Hospital, Le Plessis Robinson, France
    Ann Thorac Surg 96:983-8; discussion 988-9. 2013
    ..The purpose of this study was to evaluate long-term outcomes after subclavian artery resection and reconstruction during surgery for thoracic inlet cancer through the anterior transclavicular approach...
  7. doi Factors affecting early and long-term outcomes after completion pneumonectomy
    Olivier Chataigner
    Department of Thoracic and Vascular Surgery and Heart Lung Transplantation, Hopital Marie Lannelongue, Paris Sud University, 133, avenue de la resistance, 92350 Le Plessis Robinson, France
    Eur J Cardiothorac Surg 33:837-43. 2008
    ..To identify factors that affect operative mortality and morbidity and long-term survival after completion pneumonectomy...
  8. pmc Endothelial cell apoptosis in chronically obstructed and reperfused pulmonary artery
    Edouard Sage
    UPRES EA2705, Laboratoire de Chirurgie Experimentale, Hopital Marie Lannelongue, Le Plessis Robinson, France
    Respir Res 9:19. 2008
    ..We hypothesized that endothelial dysfunction is related to increased endothelial-cell (EC) death...
  9. doi A paradigm shift for sternal reconstruction using a novel titanium rib bridge system following oncological resections
    Dominique Fabre
    Department of Thoracic and Vascular Surgery and Heart Lung Transplantation, Marie Lannelongue Hospital, Paris Sud University, Le Plessis Robinson, France
    Eur J Cardiothorac Surg 42:965-70. 2012
    ..The purpose of this report is to evaluate the outcomes in patients undergoing sternal reconstruction using an innovative titanium rib bridge system (STRATOS)...
  10. doi Complete resection of pulmonary inflammatory pseudotumors has excellent long-term prognosis
    Dominique Fabre
    Department of Thoracic and Vascular Surgery and Heart Lung Transplantation, Hopital Marie Lannelongue, Le Plessis Robinson, Paris Sud University, France
    J Thorac Cardiovasc Surg 137:435-40. 2009
    ..We present a single large institutional experience in patients with pulmonary inflammatory pseudotumor and propose guidelines for treatment of this patient population...
  11. doi Right ventricular plasticity in a porcine model of chronic pressure overload
    Julien Guihaire
    Laboratory of Surgical Research and INSERM U999, University of Paris Sud, Marie Lannelongue Hospital, Le Plessis Robinson, France Electronic address
    J Heart Lung Transplant 33:194-202. 2014
    ..We sought to determine the relationship between ventricular-arterial coupling and right ventricular (RV) remodeling in a novel porcine model of progressive pulmonary hypertension (PH)...
  12. ncbi Outcome of full-thickness chest wall resection for isolated breast cancer recurrence
    Dan Levy Faber
    Department of Thoracic and Vascular Surgery and Heart Lung Transplantation, Hopital Marie Lannelongue, Le Plessis Robinson, France
    Eur J Cardiothorac Surg 44:637-42. 2013
    ..We retrospectively reviewed our experience with full-thickness CWR to determine whether long-term outcomes warranted this aggressive procedure...
  13. doi Retrospective institutional study of 31 patients treated for pulmonary artery sarcoma
    Sacha Mussot
    Department of Thoracic and Vascular Surgery and Heart Lung Transplantation, Marie Lannelongue Hospital, Paris Sud University, Le Plessis Robinson, France
    Eur J Cardiothorac Surg 43:787-93. 2013
    ..The study aimed to determine the optimal surgical procedure to treat pulmonary artery sarcomas responsible for pulmonary hypertension...
  14. ncbi Is sacrifying the phrenic nerve during thymoma resection worthwhile?
    Sarah Hamdi
    Service de chirurgie thoracique vasculaire et de transplantation cardiopulmonaire, Centre Chirurgical Marie Lannelongue, Le Plessis Robinson, France
    Eur J Cardiothorac Surg 45:e151-5. 2014
    ..However, en bloc resection including the PN may cause severe postoperative complications, especially in myasthenia gravis patients. The aim of the study was to determine whether a PN involved could be spared during thymoma resection...
  15. doi Long-term outcomes of en bloc resection of non-small cell lung cancer invading the thoracic inlet and spine
    Elie Fadel
    Department of Thoracic and Vascular Surgery and Heart Lung Transplantation, Hopital Marie Lannelongue, Le Plessis Robinson, France
    Ann Thorac Surg 92:1024-30; discussion 1030. 2011
    ..The purpose of this study was to determine whether en bloc resection of non-small cell lung cancer (NSCLC) invading the thoracic inlet (TI) and spine can provide good long-term outcomes...
  16. pmc The beneficial effect of suramin on monocrotaline-induced pulmonary hypertension in rats
    Mohamed Izikki
    INSERM U999, Le Plessis Robinson, France
    PLoS ONE 8:e77073. 2013
    ..All these receptors belong to the receptor tyrosine kinase (RTK) family...
  17. doi Long-term outcome of pleuropneumonectomy for Masaoka stage IVa thymoma
    Dominique Fabre
    Marie Lannelongue Hospital, Le Plessis Robinson, Paris Sud University, Orsay, France
    Eur J Cardiothorac Surg 39:e133-8. 2011
    ..We reviewed retrospectively our single-center experience in order to determine if the benefits warrant the risk of such procedure...
  18. ncbi Composite cervical skin and cartilage flap provides a novel large airway substitute after long-segment tracheal resection
    Dominique Fabre
    Laboratoire de Chirurgie Experimentale, Hopital Marie Lannelongue, Le Plessis Robinson, France
    J Thorac Cardiovasc Surg 138:32-9. 2009
    ..We report the development of an autologous tracheal substitute for long-segment tracheal resection that satisfies these criteria and demonstrates excellent short-term functional results in a large-animal study...
  19. pmc Key Role of the Endothelial TGF-β/ALK1/Endoglin Signaling Pathway in Humans and Rodents Pulmonary Hypertension
    Benoit Gore
    INSERM U999, Le Plessis Robinson, France
    PLoS ONE 9:e100310. 2014
    ..The TGF-β/ALK1/ENG signaling pathway plays a key role in iPAH and experimental hypoxic PH via a direct effect on PECs leading to production of growth factors and inflammatory cytokines involved in the pathogenesis of PAH. ..
  20. doi Non-invasive indices of right ventricular function are markers of ventricular-arterial coupling rather than ventricular contractility: insights from a porcine model of chronic pressure overload
    Julien Guihaire
    Laboratory of Surgical Research and INSERM U999, University of Paris Sud, University of Paris XI, Marie Lannelongue Hospital, 133 avenue de la Resistance, Le Plessis Robinson, France
    Eur Heart J Cardiovasc Imaging 14:1140-9. 2013
    ..To investigate the physiological correlates of indices of RV function in a model of chronic pressure overload...
  21. doi Surgical outcomes in patients with primary mediastinal non-seminomatous germ cell tumours and elevated post-chemotherapy serum tumour markers
    Bertrand De Latour
    Department of Thoracic and Vascular Surgery and Heart Lung Transplantation, Hopital Marie Lannelongue, Le Plessis Robinson, France
    Eur J Cardiothorac Surg 42:66-71; discussion 71. 2012
    ..Persistent serum tumour marker (STM) elevation after chemotherapy usually indicates a poor prognosis. We retrospectively assessed surgical outcomes in patients with high STM levels after chemotherapy for primary mediastinal NSGCT...
  22. ncbi [Is surgery required for patients with isolated adrenal metastasis of non-small cell lung carcinoma?]
    Olaf Mercier
    Service de chirurgie thoracique et vasculaire et de transplantation cardiopulmonaire, Hopital Marie Lannelongue, Le Plessis Robinson
    Presse Med 36:1743-52. 2007
    ..The aim of this study was to review our experience and to identify factors that may affect survival...
  23. doi Long-term outcome of double-lung and heart-lung transplantation for pulmonary hypertension: a comparative retrospective study of 219 patients
    Elie Fadel
    Department of Thoracic and Vascular Surgery and Heart Lung Transplantation, Hopital Marie Lannelongue, Le Plessis Robinson, Paris Sud University, Paris, France
    Eur J Cardiothorac Surg 38:277-84. 2010
    ..At our institution, patients with severe right ventricular dysfunction or congenital systemic-to-pulmonary shunt (CSPS) are preferentially treated with HLT. We sought to determine whether the outcomes warrant continuing this policy...
  24. doi Surgical management of malignant tumours invading the inferior vena cava
    Dominique Fabre
    Department of Thoracic and Vascular Surgery and Heart Lung Transplantation, Marie Lannelongue Hospital, Paris Sud University, Le Plessis Robinson, France
    Eur J Cardiothorac Surg 45:537-42; discussion 542-3. 2014
    ..We describe our experience with regard to patient selection, operative technique and outcomes through a standardized and simplified approach...
  25. doi Cytotoxic cells and granulysin in pulmonary arterial hypertension and pulmonary veno-occlusive disease
    Frederic Perros
    INSERM U999, Centre Chirurgical Marie Lannelongue, 133, avenue de la resistance, F 92350 Le Plessis Robinson, France
    Am J Respir Crit Care Med 187:189-96. 2013
    ..Granulysin (GNLY) represents a powerful effector protein for all these subpopulations...
  26. pmc Sternal replacement with a custom-made titanium plate after resection of a solitary breast cancer metastasis
    Pierre Demondion
    Department of Thoracic and Vascular Surgery and Heart Lung Transplantation, Marie Lannelongue Hospital, Paris Sud University, Le Plessis Robinson, France
    Interact Cardiovasc Thorac Surg 18:145-7. 2014
    ..As it entails lower postoperative risk than previously existing reconstructive materials, the new material used in our sternal reconstruction may extend the existing range of indications of sternectomy for cancer with curative intent. ..
  27. ncbi Long-term results after carinal resection for carcinoma: does the benefit warrant the risk?
    Marc de Perrot
    Department of Thoracic and Vascular Surgery and Heart Lung Transplantation, Centre Chirurgical Marie Lannelongue, Le Plessis Robinson, France
    J Thorac Cardiovasc Surg 131:81-9. 2006
    ..We sought to determine whether the benefit warrants the risk in patients undergoing carinal resection for carcinoma...
  28. doi Experimental models of right heart failure: a window for translational research in pulmonary hypertension
    Julien Guihaire
    Laboratory of Surgical Research, Marie Lannelongue Hospital, University of Paris Sud, Le Plessis Robinson, France
    Semin Respir Crit Care Med 34:689-99. 2013
    ..Further investigations are needed to find new therapeutic approaches for RVF. Current animal models and emerging concepts of translational RV research will be detailed in this review. ..