Jean Louis Mas

..In those who are not good surgical candidates, carotid stenting might be equivalent to surgery, but whether or not any form of carotid revascularization is superior to medical treatment alone remains unknown...

..Studies have shown that antihypertensives, statins and antithrombotic agents are the most successful agents in reducing vascular risk and avoiding unpredictable and life-threatening atherothrombotic events...

..Carotid stenting is less invasive than endarterectomy, but it is unclear whether it is as safe in patients with symptomatic carotid-artery stenosis...

..We now report the results up to 4 years...

..Whether a history of carotid endarterectomy influences patient compliance with medical treatments and physician attitude toward treatments after ischemic stroke or transient ischemic attack (TIA) is not well known...

..We assessed to what extent rapid management of TIA patients admitted to a stroke unit led to specific treatments which can prevent stroke and evaluated the early risk and predictors of stroke in these patients...

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..Absolute annual risks were estimated through weighted meta-regressions with a random effect. To test the predictions of expected event rates derived from our analysis, we used individual patient data...

..The aim of this study was to identify the most likely mechanism of stroke using cervical and cerebral imaging parameters in patients with CAD...

..4% but seems to be higher within the first month and some recurrences are asymptomatic. Patients with connective tissue disease or familial history of CAD have an increased risk of CAD recurrence, but other risk factors remain unknown...

..We reviewed evidence on carotid angioplasty and stenting in carotid stenosis...

..However, risk factors for perioperative stroke and death have not been clearly established. We aimed to estimate the 30-day absolute risks of stroke or death after CAS and investigate sources of heterogeneity...

..Three causes of ischemic stroke (cerebral venous thrombosis, aortic arch atheroma, patent foramen ovale) are detailed...

..To examine differences in risk factor (RF) management between peripheral artery disease (PAD) and coronary artery (CAD) or cerebrovascular disease (CVD), as well as the impact of RF control on major 1-year cardiovascular (CV) event rates...

..In stroke attributable to spontaneous dissection of the cervical artery, it is unclear whether the occurrence and pattern of stroke depend on the degree of stenosis...

..We aimed at quantifying and explaining the underuse of antithrombotic treatments after an ischemic stroke in patients seen in French primary care...

..We assessed the prevalence of >or=50% asymptomatic CAD in patients with ischemic stroke or transient ischemic attack and whether the prevalence is related to traditional vascular risk factors and cervicocephalic atherosclerosis...

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..To assess the value of magnetic resonance (MR) imaging parameters as surrogate markers of stroke duration...

..However, metformin is often not considered in patients with cardiovascular conditions because of concerns about its safety...

..Many patients do not receive prevention consistent with recommendations after stroke, but the relative importance of patient- and physician-related factors is uncertain...

..We assessed the extent of reversible acute DWI lesions (RADs) and their relationships with clinical outcome in patients thrombolyzed ≤4.5 hours from onset...

..Based on a population of TIA patients imaged twice with DWI within the first week after onset, our aim was to estimate the rate of patients with DWI reversible ischemic lesion or with delayed DWI positivity...

..However, few studies have specifically assessed the absolute risk of coronary events in those patients and predictors of such events are not well known...

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..Most patients respond poorly to analgesics. We describe four patients with typical RCA whose headache rapidly disappeared after IV nimodipine treatment was initiated...

..We assessed the reproducibility of MRI for the identification and quantification of carotid atherosclerotic plaque components...

..5-50.1], p = 0.002) values. Interobserver agreement was 0.84 or higher for PAE identification. sCAD was associated with PAE and biological inflammation. Our results support the hypothesis of an underlying arterial inflammation in sCAD...

..Finally, the role of high-resolution MR imaging in the diagnosis of cervical dissection and inflammatory disease of the arterial wall is emphasized...

..To evaluate the respective value of 5 MR sequences to distinguish between stroke patients with and without acute intracerebral hemorrhage (ICH)...

..3%; 95%CI, 1.3 to 2.6; p<0.001). Recruitment that began too late and an over-selected population, with overrepresentation of patients with diabetes and small vessel disease in particular, may partly explain these negative results...

..Our aim was to determine whether diffusion-weighted imaging (DWI) changes associated with transient ischemic attack (TIA) are reversible or correspond to permanent tissue injury...

..Several studies have suggested that exposure to "triggers," could precipitate the onset of ischemic stroke (IS). We performed a systematic review of the potential triggers of IS...

..This Leigh-like encephalopathy appears to be associated with a much more severe outcome than isolated Leber's hereditary optic neuropathy...

..The ABCD(2) score has been shown to predict the early risk of stroke after transient ischemic attack (TIA). The additional predictive value of diffusion-weighted imaging (DWI) and TIA etiology is not well known...

..This highlights the feasibility of diffusion tensor imaging on clinical MR units and its ability to quantify the degree of white matter tract destruction...

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..New medical strategies and the advantages of angioplasty are currently under investigation...

..The aim of the Stroke and Atrial Fibrillation Ensemble (SAFE) II study was to identify the reasons underlying the under-utilization of oral anticoagulation (OAC) in patients with nonvalvular atrial fibrillation (NVAF)...

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..We assessed these factors in 18,992 CVD patients within a worldwide registry of stable outpatients...

..Therefore, it is justified to update these meta-analyses...

..This sign may allow an early detection of high-grade cervical carotid stenosis in stroke patients before dedicated neck imaging is performed...

..To date, no single international database has characterized the atherosclerosis risk factor profile or treatment intensity of individuals with atherothrombosis...

..The treatment decision requires consideration of individual factors to optimize the risk/benefit ratio...

..However, OAC is still underused, even at discharge from neurological centers. The objective of this study was to identify the reasons underlying the prescription of OAC at discharge after an ischemic stroke in patients with NVAF...

..We sought to characterize the risk factors and treatments of a diverse contemporary population of patients with atherothrombosis...

..The purpose of this study was to determine the possible benefit of dual antiplatelet therapy in patients with prior myocardial infarction (MI), ischemic stroke, or symptomatic peripheral arterial disease (PAD)...

..Overall, clopidogrel plus aspirin was not significantly more effective than aspirin alone in reducing the rate of myocardial infarction, stroke, or death from cardiovascular causes. (ClinicalTrials.gov number, NCT00050817.)...

..Use of preventive drugs was lower in patients with a history of ischaemic stroke or PAD, and should increase, accordingly to the results of recent randomized controlled trials...

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..Higher stiffness of carotid wall material and circumferential wall stress could increase the risk of dissection in these patients...

..This variability has to be taken into account when deciding on a potential risky treatment to prevent recurrent strokes...

..Two other randomized multicenter trials-ICSS and CREST-are ongoing. With an intended sample size of up to 7,000 patients, future meta-analyses will allow more-accurate treatment recommendations and subgroup analysis...

..Our aim was to evaluate the contribution of the T2 signal intensity and apparent diffusion coefficient (ADC) changes to signal intensity displayed by DW imaging through the course of hematoma...

..CONCLUSIONS: Although their significance remains unclear, multiple HVSs are more frequently observed in symptomatic patients with multiple intracerebral stenoses than in asymptomatic patients without stenosis...