Jean Louis Lefebvre

Summary

Affiliation: Centre Oscar Lambret
Country: France

Publications

  1. ncbi request reprint [Larynx preservation, state of the art]
    J L Lefebvre
    Département de cancérologie cervicofaciale, Centre Oscar Lambret, 3, rue Combemale, 59020 Lille Cedex, France
    Cancer Radiother 9:37-41. 2005
  2. ncbi request reprint Induction chemotherapy followed by either chemoradiotherapy or bioradiotherapy for larynx preservation: the TREMPLIN randomized phase II study
    Jean Louis Lefebvre
    Head and Neck Department, Centre Oscar Lambret, 3 rue Combemale, Lille, France 59020
    J Clin Oncol 31:853-9. 2013
  3. pmc Surgery for Laryngopharyngeal SCC in the Era of Organ Preservation
    Jean Louis Lefebvre
    Department of Head and Neck, Centre Oscar Lambret, Lille, France
    Clin Exp Otorhinolaryngol 2:159-63. 2009
  4. pmc Laryngeal preservation with induction chemotherapy for hypopharyngeal squamous cell carcinoma: 10-year results of EORTC trial 24891
    J L Lefebvre
    Head and Neck Cancer Department, Centre Oscar Lambret, Lille, France
    Ann Oncol 23:2708-14. 2012
  5. doi request reprint Larynx preservation
    Jean Louis Lefebvre
    Head and Neck Department, Centre Oscar Lambret, Lille, France
    Curr Opin Oncol 24:218-22. 2012
  6. pmc Phase 3 randomized trial on larynx preservation comparing sequential vs alternating chemotherapy and radiotherapy
    J L Lefebvre
    Department of Head and Neck Cancer, Centre Oscar Lambret, 3 rue Frederic Combemale BP 307, FR 59020 Lille Cedex, France
    J Natl Cancer Inst 101:142-52. 2009
  7. ncbi request reprint Current clinical outcomes demand new treatment options for SCCHN
    J L Lefebvre
    Département de Cancérologie Cervico Faciale, Centre Oscar Lambret, Lille, France
    Ann Oncol 16:vi7-vi12. 2005
  8. doi request reprint Larynx preservation clinical trial design: key issues and recommendations--a consensus panel summary
    Jean Louis Lefebvre
    Département de Cancérologie Cervico Faciale, Centre Oscar Lambret, Lille, France
    Head Neck 31:429-41. 2009
  9. doi request reprint Larynx preservation clinical trial design: key issues and recommendations-a consensus panel summary
    Jean Louis Lefebvre
    Département de Cancérologie Cervico Faciale, Centre Oscar Lambret, Lille, France
    Int J Radiat Oncol Biol Phys 73:1293-303. 2009
  10. ncbi request reprint Treatment of laryngeal cancer: the permanent challenge
    Jean Louis Lefebvre
    Head and Neck Department, Centre Oscar Lambret, 3, rue Combemale, 59020 Lille, France
    Expert Rev Anticancer Ther 4:913-20. 2004

Detail Information

Publications37

  1. ncbi request reprint [Larynx preservation, state of the art]
    J L Lefebvre
    Département de cancérologie cervicofaciale, Centre Oscar Lambret, 3, rue Combemale, 59020 Lille Cedex, France
    Cancer Radiother 9:37-41. 2005
    ..The next step could be the combination of induction chemotherapy followed by concurrent chemo-irradiation in good responders. Finally, the place of new drugs (taxanes, targeted therapies) is to be explored in this context...
  2. ncbi request reprint Induction chemotherapy followed by either chemoradiotherapy or bioradiotherapy for larynx preservation: the TREMPLIN randomized phase II study
    Jean Louis Lefebvre
    Head and Neck Department, Centre Oscar Lambret, 3 rue Combemale, Lille, France 59020
    J Clin Oncol 31:853-9. 2013
    ..To compare the efficacy and safety of induction chemotherapy (ICT) followed by chemoradiotherapy (CRT) or bioradiotherapy (BRT) for larynx preservation (LP)...
  3. pmc Surgery for Laryngopharyngeal SCC in the Era of Organ Preservation
    Jean Louis Lefebvre
    Department of Head and Neck, Centre Oscar Lambret, Lille, France
    Clin Exp Otorhinolaryngol 2:159-63. 2009
    ..This discussion underscored the need of a multidisciplinary decision making and the need of a coordinated clinical research...
  4. pmc Laryngeal preservation with induction chemotherapy for hypopharyngeal squamous cell carcinoma: 10-year results of EORTC trial 24891
    J L Lefebvre
    Head and Neck Cancer Department, Centre Oscar Lambret, Lille, France
    Ann Oncol 23:2708-14. 2012
    ..We report the 10-year results of the EORTC trial 24891 comparing a larynx-preservation approach to immediate surgery in hypopharynx and lateral epilarynx squamous cell carcinoma...
  5. doi request reprint Larynx preservation
    Jean Louis Lefebvre
    Head and Neck Department, Centre Oscar Lambret, Lille, France
    Curr Opin Oncol 24:218-22. 2012
    ..Organ preservation, in particular larynx preservation, is a major challenge that has been evaluated during the past 3 decades. This review took in consideration the most recently published articles on this topic...
  6. pmc Phase 3 randomized trial on larynx preservation comparing sequential vs alternating chemotherapy and radiotherapy
    J L Lefebvre
    Department of Head and Neck Cancer, Centre Oscar Lambret, 3 rue Frederic Combemale BP 307, FR 59020 Lille Cedex, France
    J Natl Cancer Inst 101:142-52. 2009
    ..We report results of the randomized phase 3 trial 24954 from the European Organization for Research and Treatment of Cancer...
  7. ncbi request reprint Current clinical outcomes demand new treatment options for SCCHN
    J L Lefebvre
    Département de Cancérologie Cervico Faciale, Centre Oscar Lambret, Lille, France
    Ann Oncol 16:vi7-vi12. 2005
    ..This paper discusses current approaches and recent advances in the treatment of head and neck cancer, specifically squamous cell carcinoma, and suggests future management aims for the different disease stages...
  8. doi request reprint Larynx preservation clinical trial design: key issues and recommendations--a consensus panel summary
    Jean Louis Lefebvre
    Département de Cancérologie Cervico Faciale, Centre Oscar Lambret, Lille, France
    Head Neck 31:429-41. 2009
    ..To develop guidelines for the conduct of phase III clinical trials of larynx preservation in patients with locally advanced laryngeal and hypopharyngeal cancer...
  9. doi request reprint Larynx preservation clinical trial design: key issues and recommendations-a consensus panel summary
    Jean Louis Lefebvre
    Département de Cancérologie Cervico Faciale, Centre Oscar Lambret, Lille, France
    Int J Radiat Oncol Biol Phys 73:1293-303. 2009
    ..To develop guidelines for the conduct of Phase III clinical trials of larynx preservation in patients with locally advanced laryngeal and hypopharyngeal cancer...
  10. ncbi request reprint Treatment of laryngeal cancer: the permanent challenge
    Jean Louis Lefebvre
    Head and Neck Department, Centre Oscar Lambret, 3, rue Combemale, 59020 Lille, France
    Expert Rev Anticancer Ther 4:913-20. 2004
    ..When inoperable, larynx cancers are better treated by combined chemotherapy and irradiation when the performance status of the patient is compatible with such an intensive regimen...
  11. ncbi request reprint Laryngeal preservation in head and neck cancer: multidisciplinary approach
    Jean Louis Lefebvre
    Head and Neck Department, Centre Oscar Lambret, 3 rue Combemale, 59020 Lille, France
    Lancet Oncol 7:747-55. 2006
    ..Findings of basic research and modern imaging should provide useful approaches for selection of patients for various strategies...
  12. doi request reprint Candidates for larynx preservation: the next step?
    Jean Louis Lefebvre
    Département de Cancérologie Cervico Faciale, Centre Oscar Lambret, Lille, France
    Oncologist 15:30-2. 2010
    ..Collaboration among international groups is required to assess which approach would be most beneficial in terms of larynx function preservation, disease control, and survival...
  13. ncbi request reprint Preservation of form and function during management of cancer of the larynx and hypopharynx
    Jean Louis Lefebvre
    Head and Neck Department, Centre Oscar Lambret, 3 Rue Frederic Combemale, 59020 Lille, France
    World J Surg 27:811-6. 2003
    ....
  14. ncbi request reprint A comparative study of the efficacy and safety of fluconazole oral suspension and amphotericin B oral suspension in cancer patients with mucositis
    Jean Louis Lefebvre
    C R L C Oscar Lambret, 1 rue Frédéric Combemale, B P 307 59020 Lille Cedex, France
    Oral Oncol 38:337-42. 2002
    ..The incidence of adverse events was 39% for fluconazole and 44% for amphotericin B. Fluconazole suspension appeared effective and safe...
  15. ncbi request reprint [Induction chemotherapy and larynx preservation: is such practice useful?]
    Jérôme Sarini
    Département de Cancérologie Cervico Faciale, Centre Oscar Lambret, 3, rue Frederic Combemale, 59020 Lille Cedex
    Bull Cancer 89:411-7. 2002
    ..Are results obtained in daily induction chemotherapy usefulness identical to results obtained in larynx preservation studies?..
  16. ncbi request reprint Prognostic significance of wound infections following major head and neck cancer surgery: an open non-comparative prospective study
    Nicolas Penel
    Comité de Lutte contre les Infections Nosocomiales, Centre Oscar Lambret, Lille, France
    Support Care Cancer 12:634-9. 2004
    ..We evaluated the incidence, risk factors and consequences of wound infection (WI) following major head and neck cancer surgery in an open non-comparative study...
  17. ncbi request reprint Previous chemotherapy as a predictor of wound infections in nonmajor head and neck surgery: Results of a prospective study
    Nicolas Penel
    Hygiene Unit, Centre Oscar Lambret, Lille, France
    Head Neck 26:513-7. 2004
    ..The goal of this prospective study was to determine the incidence of wound infections (WI) after clean uncontaminated head and neck cancer procedures and after emergency tracheotomies...
  18. ncbi request reprint Exclusive low-dose-rate brachytherapy in 279 patients with T2N0 mobile tongue carcinoma
    Céline Bourgier
    Department of Radiotherapy, Centre Oscar Lambret, 3 Rue Frederic Combemale, 59000 Lille, France
    Int J Radiat Oncol Biol Phys 63:434-40. 2005
    ..To evaluate the therapeutic results obtained with (192)Ir low-dose-rate interstitial brachytherapy in T2N0 mobile tongue carcinoma...
  19. ncbi request reprint Head and neck soft tissue sarcomas of adult: prognostic value of surgery in multimodal therapeutic approach
    Nicolas Penel
    General Oncology Department, Centre Oscar Lambret, 3, rue F Combemale 59020, Lille, France
    Oral Oncol 40:890-7. 2004
    ..Rhabdomyosarcomas (p = 0.005) and inadequate resection (p = 0.04) were associated with poor outcome. Large resection of AHNSTS in a multimodality approach may afford the best chance of disease control...
  20. ncbi request reprint Multivariate analysis of risk factors for wound infection in head and neck squamous cell carcinoma surgery with opening of mucosa. Study of 260 surgical procedures
    Nicolas Penel
    General Oncology Department, Centre Oscar Lambret, 3, rue F Combemale 59020 Lille, France Hygiene Unit, Centre Oscar Lambret, Lille, France
    Oral Oncol 41:294-303. 2005
    ..This study identified one major risk factor, post-laryngectomy tracheostomy. Long-term curative antibiotherapy must be evaluated in cancer head and neck surgery requiring post-laryngectomy tracheostoma...
  21. ncbi request reprint Sinonasal cancer: Analysis of oncological failures in 156 consecutive cases
    Haitham Mirghani
    Head and Neck Department, Institut Gustave Roussy, Villejuif, France
    Head Neck 36:667-74. 2014
    ..Sinonasal cancers are rare and associated with a poor prognosis. The purpose of this study was to report our experience and analyze the risk factors for oncologic failures...
  22. doi request reprint Salvage stereotactic reirradiation with or without cetuximab for locally recurrent head-and-neck cancer: a feasibility study
    Bénédicte Comet
    Department of Academic Radiotherapy, Centre Oscar Lambret and University Lille II, Lille, France
    Int J Radiat Oncol Biol Phys 84:203-9. 2012
    ..Stereotactic body radiotherapy (SBRT) could offer precise irradiation while sparing healthy tissues. Results of a feasibility study using SBRT with or without cetuximab are reported for reirradiation of recurrent primary HNC...
  23. ncbi request reprint Primary mucosal melanoma of head and neck: prognostic value of clear margins
    Nicolas Penel
    General Oncology Department, Oscar Lambret Cancer Center, Lille, France
    Laryngoscope 116:993-5. 2006
    ..Primary mucosal melanomas of the head and neck (MMHN) are rare and carry a poor outcome. The impact of different treatments on survival is not yet clearly established...
  24. doi request reprint Functional and sensitive outcomes after tongue reconstruction: about a series of 30 patients
    Celia Guerin-Lebailly
    Head and Neck Department, Centre Oscar Lambret, Lille, France
    Oral Oncol 48:272-7. 2012
    ..This study emphasizes good functional results either for swallowing or intelligibility, with higher scores for the FCFF, strengthening the opinion that FCFF is the best choice for tongue reconstruction whenever possible...
  25. ncbi request reprint Psychosocial factors involved in delayed consultation by patients with head and neck cancer
    Olivier Rozniatowski
    Psycho Oncology Unit, Centre Oscar Lambret, BP 307, 59020 Lille Cedex, France
    Head Neck 27:274-80. 2005
    ..We studied this delay in seeking consultation, focusing on psychosocial variables such as professional and social background, the involvement of a spouse/partner, and the presence of anxiety and depression...
  26. doi request reprint Larynx preservation: what is the standard treatment?
    Samy Horn
    Academic Radiation Oncology Department, Centre Oscar Lambret, Service Academique de Radiotherapy, 3 Rue Frederic Combemale, F 59000 Lille, France
    Crit Rev Oncol Hematol 84:e97-e105. 2012
    ..Over two decades of improvement in nonsurgical management of locally advanced laryngeal cancer is reviewed, including the most recent improvements with the introduction of taxanes and anti-EGFR targeted therapy...
  27. doi request reprint Head and neck cancer surgery in the elderly--does age influence the postoperative course?
    Pedro Ricardo Milet
    Cervico Facial Oncology Department, Centre Oscar Lambret, Lille, France Head and Neck Surgery Department, Brazilian National Institute of Cancer INCA, Rio de Janeiro, Brazil
    Oral Oncol 46:92-5. 2010
    ..3 [0.7-14.9], p=0.22). In our experience, the postoperative course in elderly patients is not significantly different from that than in younger patients...
  28. ncbi request reprint Survival prognostic factors for lateral bucco-pharyngeal junction squamous cell carcinoma
    Yann Mallet
    Head and Neck Cancerology Department, Centre Oscar Lambret, Lille, France
    Eur Arch Otorhinolaryngol 265:S25-8. 2008
    ..For example, surgery must be proposed whenever deemed possible. It is in an independent factor in our series. All the statuses linked to the population type, tumor extension and tumor differentiation are also discussed...
  29. ncbi request reprint Factors determining length of the postoperative hospital stay after major head and neck cancer surgery
    Nicolas Penel
    Département de Cancérologie Générale, Centre Oscar Lambret, 3 Rue F Combemale, Lille, France
    Oral Oncol 44:555-62. 2008
    ..Two variables (duration of surgical procedure and occurrence of nosocomial infections) were associated with LOS and might be improved by appropriate strategies...
  30. ncbi request reprint A simple predictive model for postoperative mortality after head and neck cancer surgery with opening of mucosa
    Nicolas Penel
    General Oncology Department, Oscar Lambret Centre, 3 Rue F Combemale, Lille 59020 BP 207, France
    Oral Oncol 43:174-80. 2007
    ..63% for patients without risk factor and was 6.41% for those with one or two risk factors. This model identifies easily high-risk patients for major head and neck cancer surgery. A multicenter validation is necessary...
  31. doi request reprint Nodal recurrence of sinonasal cancer: does the risk of cervical relapse justify a prophylactic neck treatment?
    Haitham Mirghani
    Head and Neck Department, Institut Gustave Roussy, Villejuif, France
    Oral Oncol 49:374-80. 2013
    ..Prophylactic neck treatment issue remains controversial. The aim of this study was to analyze the pattern of neck failure and to identify any prognostic factors that may influence neck control...
  32. ncbi request reprint Prognosis of hypercalcemia in aerodigestive tract cancers: study of 136 recent cases
    Nicolas Penel
    Département de Cancérologie Générale, Centre Oscar Lambret, 3, rue F Combemale, 59020 Lille, France
    Oral Oncol 41:884-9. 2005
    ..16 CI 95% 1.01-4.63). Despite use of diphosphonates (infusions of pamidronate), hypercalcemia is associated with very poor prognosis. Tumour location and level of calcemia had no prognostic value...
  33. ncbi request reprint Cisplatin, fluorouracil, and docetaxel in unresectable head and neck cancer
    Jan B Vermorken
    Department of Medical Oncology, Universitair Ziekenhuis Antwerpen, Edegem, Belgium
    N Engl J Med 357:1695-704. 2007
    ..We compared TPF with PF as induction chemotherapy in patients with locoregionally advanced, unresectable disease...
  34. ncbi request reprint American Society of Clinical Oncology clinical practice guideline for the use of larynx-preservation strategies in the treatment of laryngeal cancer
    David G Pfister
    American Society of Clinical Oncology, Alexandria, VA, VA 22314, USA
    J Clin Oncol 24:3693-704. 2006
    ..This guideline is intended for use by oncologists in the care of patients outside of clinical trials...
  35. ncbi request reprint Cancer of the larynx
    Lisa Licitra
    START Project, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy
    Crit Rev Oncol Hematol 47:65-80. 2003
    ..The loco-regional extent of the disease determines the success of cure. Surgery and radiotherapy represent the main therapeutic options. The choice between these two procedures is often controversial...
  36. ncbi request reprint International Consortium on Head and Neck Cancer Awareness (ICOHANCA)
    Crispian Scully
    IAOO, UCL Eastman Dental Institute, 256 Gray s Inn Road, London, WC1X 8LD, UK
    Oral Oncol 43:841-2. 2007
  37. ncbi request reprint Organ and voice preservation in advanced laryngeal cancer
    Alfio Ferlito
    Department of Otolaryngology Head and Neck Surgery, University of Udine, Policlinico Universitario, Italy
    Acta Otolaryngol 122:438-42. 2002