Affiliation: Centre National de la Recherche Scientifique
Gon S, Camara J, Klungsøyr H, Crooke E, Skarstad K, Beckwith J. A novel regulatory mechanism couples deoxyribonucleotide synthesis and DNA replication in Escherichia coli. EMBO J. 2006;25:1137-47 pubmed
..Accordingly, the conversion of ATP-DnaA to ADP-DnaA after initiation and loading of the beta-subunit DnaN would allow increased nrdAB expression, and consequently, coordinated RNR synthesis and DNA replication during the cell cycle. ..
Gon S, Faulkner M, Beckwith J. In vivo requirement for glutaredoxins and thioredoxins in the reduction of the ribonucleotide reductases of Escherichia coli. Antioxid Redox Signal. 2006;8:735-42 pubmed
..These findings indicate a role for these enzymes either for NrdDG reactivation or some other essential anaerobic process. ..