Regis Coutant

Summary

Affiliation: Centre Hospitalier Universitaire
Country: France

Publications

  1. ncbi request reprint Macroorchidism due to autonomous hyperfunction of Sertoli cells and G(s)alpha gene mutation: an unusual expression of McCune-Albright syndrome in a prepubertal boy
    R Coutant
    Departement de Pediatrie, Centre Hospitalier Universitaire, 49000 Angers, France
    J Clin Endocrinol Metab 86:1778-81. 2001
  2. ncbi request reprint Heterozygous mutation of steroidogenic factor-1 in 46,XY subjects may mimic partial androgen insensitivity syndrome
    Regis Coutant
    Department of Pediatric Endocrinology, University Hospital, 4 rue Larrey, 49033 Angers Cedex 01, France
    J Clin Endocrinol Metab 92:2868-73. 2007
  3. ncbi request reprint Divergent effect of endogenous and exogenous sex steroids on the insulin-like growth factor I response to growth hormone in short normal adolescents
    Regis Coutant
    Department of Pediatrics, University Hospital, 49000 Angers, France
    J Clin Endocrinol Metab 89:6185-92. 2004
  4. ncbi request reprint Effect of single and multiple courses of prenatal corticosteroids on 17-hydroxyprogesterone levels: implication for neonatal screening of congenital adrenal hyperplasia
    Frédérique Gatelais
    Department of Pediatrics, University Hospital, 15 Rue Larrey, 49000 Angers, France
    Pediatr Res 56:701-5. 2004
  5. ncbi request reprint [Puberty in girls with Turner syndrome]
    R Coutant
    Service d endocrinologie pédiatrique, CHU d Angers, Angers, France
    Arch Pediatr 11:557-8. 2004
  6. ncbi request reprint Defect in epinephrine production in children with craniopharyngioma: functional or organic origin?
    Regis Coutant
    Department of Pediatrics, University Hospital, 49000 Angers, France
    J Clin Endocrinol Metab 88:5969-75. 2003
  7. doi request reprint Baseline inhibin B and anti-Mullerian hormone measurements for diagnosis of hypogonadotropic hypogonadism (HH) in boys with delayed puberty
    Regis Coutant
    Department of Pediatric Endocrinology, Center for Rare Diseases in Hormonal Receptivity, Angers University Hospital, 4 rue Larrey, 49033 Angers Cedex 01, France
    J Clin Endocrinol Metab 95:5225-32. 2010
  8. ncbi request reprint Body composition, fasting leptin, and sex steroid administration determine GH sensitivity in peripubertal short children
    R Coutant
    Department of Pediatrics, University Hospital, 49000 Angers, France
    J Clin Endocrinol Metab 86:5805-12. 2001
  9. ncbi request reprint Relationships between placental GH concentration and maternal smoking, newborn gender, and maternal leptin: possible implications for birth weight
    R Coutant
    Department of Pediatrics, University Hospital, 4 rue Larrey, 49000 Angers, France
    J Clin Endocrinol Metab 86:4854-9. 2001
  10. ncbi request reprint Growth and adult height in GH-treated children with nonacquired GH deficiency and idiopathic short stature: the influence of pituitary magnetic resonance imaging findings
    R Coutant
    Department of Pediatrics, University Hospital, 4 rue Larrey, 49000 Angers, France
    J Clin Endocrinol Metab 86:4649-54. 2001

Collaborators

Detail Information

Publications21

  1. ncbi request reprint Macroorchidism due to autonomous hyperfunction of Sertoli cells and G(s)alpha gene mutation: an unusual expression of McCune-Albright syndrome in a prepubertal boy
    R Coutant
    Departement de Pediatrie, Centre Hospitalier Universitaire, 49000 Angers, France
    J Clin Endocrinol Metab 86:1778-81. 2001
    ..This observation demonstrates the usefulness of detailed molecular and biological investigations in atypical cases of MAS...
  2. ncbi request reprint Heterozygous mutation of steroidogenic factor-1 in 46,XY subjects may mimic partial androgen insensitivity syndrome
    Regis Coutant
    Department of Pediatric Endocrinology, University Hospital, 4 rue Larrey, 49033 Angers Cedex 01, France
    J Clin Endocrinol Metab 92:2868-73. 2007
    ..In humans, mutations in steroidogenic factor-1 (SF-1), one of the critical factors involved in testis development, have been reported to cause gonadal dysgenesis with or without adrenal failure in 46,XY individuals...
  3. ncbi request reprint Divergent effect of endogenous and exogenous sex steroids on the insulin-like growth factor I response to growth hormone in short normal adolescents
    Regis Coutant
    Department of Pediatrics, University Hospital, 49000 Angers, France
    J Clin Endocrinol Metab 89:6185-92. 2004
    ..Fat percentage was a positive determinant of the responsiveness to GH, suggesting a link between the energy stores and the anabolic action of GH...
  4. ncbi request reprint Effect of single and multiple courses of prenatal corticosteroids on 17-hydroxyprogesterone levels: implication for neonatal screening of congenital adrenal hyperplasia
    Frédérique Gatelais
    Department of Pediatrics, University Hospital, 15 Rue Larrey, 49000 Angers, France
    Pediatr Res 56:701-5. 2004
    ..50, p <0.001). Multiple courses of steroids in preterm infants decrease 17-OHP values by approximately 30% in filter-paper blood, thus raising the risk of false-negative results in screening programs for CAH...
  5. ncbi request reprint [Puberty in girls with Turner syndrome]
    R Coutant
    Service d endocrinologie pédiatrique, CHU d Angers, Angers, France
    Arch Pediatr 11:557-8. 2004
  6. ncbi request reprint Defect in epinephrine production in children with craniopharyngioma: functional or organic origin?
    Regis Coutant
    Department of Pediatrics, University Hospital, 49000 Angers, France
    J Clin Endocrinol Metab 88:5969-75. 2003
    ..There is no proof of a univocal origin, either organic or functional. Whether abnormal catecholamine secretion alters glucose level during fasting or acute illness, or hampers adaptation to exercise, requires further studies...
  7. doi request reprint Baseline inhibin B and anti-Mullerian hormone measurements for diagnosis of hypogonadotropic hypogonadism (HH) in boys with delayed puberty
    Regis Coutant
    Department of Pediatric Endocrinology, Center for Rare Diseases in Hormonal Receptivity, Angers University Hospital, 4 rue Larrey, 49033 Angers Cedex 01, France
    J Clin Endocrinol Metab 95:5225-32. 2010
    ..Yet, the therapeutic choices for puberty induction depend on accurate diagnosis and may influence future fertility...
  8. ncbi request reprint Body composition, fasting leptin, and sex steroid administration determine GH sensitivity in peripubertal short children
    R Coutant
    Department of Pediatrics, University Hospital, 49000 Angers, France
    J Clin Endocrinol Metab 86:5805-12. 2001
    ..This study indicates that 1) GH sensitivity is determined by fat mass, serum fasting leptin, C-peptide, and FFA; and 2) oral ethinyl E2 and im T have divergent effects on the IGF-I response to a single administration of GH...
  9. ncbi request reprint Relationships between placental GH concentration and maternal smoking, newborn gender, and maternal leptin: possible implications for birth weight
    R Coutant
    Department of Pediatrics, University Hospital, 4 rue Larrey, 49000 Angers, France
    J Clin Endocrinol Metab 86:4854-9. 2001
    ..The relationships between maternal leptin and PGH and between cord blood leptin and IGF-I are consistent with the hypothesis that leptin could contribute to the control of fetal growth...
  10. ncbi request reprint Growth and adult height in GH-treated children with nonacquired GH deficiency and idiopathic short stature: the influence of pituitary magnetic resonance imaging findings
    R Coutant
    Department of Pediatrics, University Hospital, 4 rue Larrey, 49000 Angers, France
    J Clin Endocrinol Metab 86:4649-54. 2001
    ....
  11. ncbi request reprint Maternal and cord blood ghrelin in the pregnancies of smoking mothers: possible markers of nutrient availability for the fetus
    Natacha Bouhours-Nouet
    Department of Pediatrics, University Hospital, Angers, France
    Horm Res 66:6-12. 2006
    ..To investigate the role of ghrelin in maternal and fetal metabolism, we determined its value in maternal smoking, a specific cause of reduced placenta function and fetal growth...
  12. doi request reprint High birth weight and early postnatal weight gain protect obese children and adolescents from truncal adiposity and insulin resistance: metabolically healthy but obese subjects?
    Natacha Bouhours-Nouet
    Department of Pediatric Endocrinology, University Hospital, 4 rue Larrey, 49000 Angers, France
    Diabetes Care 31:1031-6. 2008
    ..We sought to clarify the effects of high birth weight (HBW) and postnatal weight gain on insulin resistance...
  13. ncbi request reprint The insulin-like growth factor-I response to growth hormone is increased in prepubertal children with obesity and tall stature
    Natacha Bouhours-Nouet
    Department of Pediatrics, University Hospital, 4 rue Larrey, 49033 Angers Cedex 01, France
    J Clin Endocrinol Metab 92:629-35. 2007
    ....
  14. ncbi request reprint Maternal smoking is associated with mitochondrial DNA depletion and respiratory chain complex III deficiency in placenta
    Natacha Bouhours-Nouet
    Institut National de la Santé et de la Recherche Médicale EMI U 00 18, Laboratory of Biochemistry and Molecular Biology, University Hospital of Angers, Angers, France
    Am J Physiol Endocrinol Metab 288:E171-7. 2005
    ..74, P < 0.01), a marker of fetal growth. These results show that maternal smoking is associated with placental mitochondrial dysfunction, which might contribute to restricted fetal growth by limiting energy availability in cells...
  15. doi request reprint Impaired aerobic exercise adaptation in children and adolescents with craniopharyngioma is associated with hypothalamic involvement
    Xavier Piguel
    Department of Pediatric Endocrinology, Angers University Hospital, 4 rue Larrey, 49033 Angers Cedex 01, France
    Eur J Endocrinol 166:215-22. 2012
    ....
  16. doi request reprint Diagnosis of endocrine disease: limitations of the IGF1 generation test in children with short stature
    Regis Coutant
    Endocrinologie Diabétologie Pédiatrique, pôle enfant, CHU Angers, 4 rue Larrey, 49933 Angers, Cedex 9, France
    Eur J Endocrinol 166:351-7. 2012
    ..Given the limitations of the IGFGT in the most severe cases of GHI syndrome (GHIS), the ability of the IGFGT to detect less severe GHIS is doubtful. In a pragmatic approach, the IGFGT may not be useful for the diagnosis of GHIS...
  17. ncbi request reprint [Thyroid dysfunction and pregnancy]
    Patrice Rodien
    Endocrinologie, CHU d Angers, 49033, Angers
    Rev Prat 55:174-9. 2005
    ..Thyroid autoimmunity is associated with hypofertility, particularly with spontaneous abortion. Screening for thyroid dysfunction during pregnancy, although not systematic, should have broad indications...
  18. ncbi request reprint [Acute adrenal insufficiency in the newborn]
    J M Limal
    Unité d Endocrinologie Pédiatrique et Diabète, centre Robert Debré, CHU d Angers, 49933 Angers cedex 09, France
    Arch Pediatr 13:1358-63. 2006
    ..The aim of this work is to focus the attention of paediatricians who examine a newborn because the risk of delayed diagnosis and fatal outcome may be limited if the clinical symptoms are soon recognized...
  19. ncbi request reprint [Precocious puberty in children adopted from foreign countries]
    J M Limal
    Departement de Pediatrie, centre Robert Debré, CHU, 49033 Angers, France
    Arch Pediatr 9:231s-233s. 2002
  20. ncbi request reprint Amplitude of pubertal growth in short stature children with intrauterine growth retardation
    Anne Lienhardt
    Service d endocrinologie pédiatrique, Hopital Saint Vincent de Paul, Paris, France
    Horm Res 57:88-94. 2002
    ..Pubertal growth contributes to 15-18% of adult height. A blunted pubertal peak could contribute to short adult height in short children born with intrauterine growth retardation (IUGR)...
  21. doi request reprint Severe neonatal hypercalcemia caused by subcutaneous fat necrosis without any apparent cutaneous lesion
    Laurent Bonnemains
    Néonatalogie, CHU Angers, 4, rue Larrey, 49000, Angers, France
    Eur J Pediatr 167:1459-61. 2008
    ..Serum calcium levels normalized within a week, and the nodules disappeared without complications. Conclusion: Subcutaneous fat necrosis may induce severe hypercalcemia without any visible cutaneous lesion...