Athel Cornish-Bowden

Summary

Affiliation: Centre National de la Recherche Scientifique
Country: France

Publications

  1. ncbi Detection of errors of interpretation in experiments in enzyme kinetics
    A Cornish-Bowden
    Institut Fédératif Biologie Structurale et Microbiologie, Bioenergetique et Ingenierie des Proteines, Centre National de la Recherche Scientifique, 31 Chemin Joseph Aiguier, Marseille Cedex 20, 13402, France
    Methods 24:181-90. 2001
  2. ncbi Understanding the parts in terms of the whole
    Athel Cornish-Bowden
    Institut Fédératif Biologie Structurale et Microbiologie, Marseille Cedex 20, France
    Biol Cell 96:713-7. 2004
  3. ncbi Metabolic analysis in drug design
    Athel Cornish-Bowden
    CNRS BIP, 31, Chemin Joseph Aiguier, BP 71, 13402 Marseille, France
    C R Biol 326:509-15. 2003
  4. ncbi The role of stoichiometric analysis in studies of metabolism: an example
    Athel Cornish-Bowden
    Bioenergetique et Ingenierie des Proteines, Institut Fédératif Biologie Structurale et Microbiologie, Centre National de la Recherche Scientifique, 31 Chemin Joseph Aiguier, 13402 Marseille Cedex 20, France
    J Theor Biol 216:179-91. 2002
  5. ncbi Stoicheiometric analysis in studies of metabolism
    Athel Cornish-Bowden
    Bioenergetique et Ingenierie des Proteines, Institut Fédératif Biologie Structurale et Microbiologie, Centre National de la Recherche Scientifique, 31 Chemin Joseph Aiguier, B P 71, 13402 Marseille Cedex 20, France
    Biochem Soc Trans 30:43-6. 2002
  6. ncbi Enthalpy-entropy compensation: a phantom phenomenon
    Athel Cornish-Bowden
    Bioenergetique et Ingenierie des Proteines, Institut Fédératif Biologie Structurale et Microbiologie, Centre National de la Recherche Scientifique, 31 Chemin Joseph Aiguier, B P 71, 13402 Marseille Cedex 20, France
    J Biosci 27:121-6. 2002
  7. ncbi Information transfer in metabolic pathways. Effects of irreversible steps in computer models
    A Cornish-Bowden
    Institut Fédératif Biologie Structurale et Microbiologie, Bioenergetique et Ingenierie des Proteines, Centre National de la Recherche Scientifique, Marseille, France
    Eur J Biochem 268:6616-24. 2001
  8. doi Closure to efficient causation, computability and artificial life
    Maria Luz Cardenas
    Unite de Bioenergetique et Ingenierie des Proteines, Centre National de la Recherche Scientifique, 31 Chemin Joseph Aiguier, 13402 Marseille Cedex 20, France
    J Theor Biol 263:79-92. 2010
  9. doi The origins of enzyme kinetics
    Athel Cornish-Bowden
    Unite de Bioenergetique et Ingenierie des Proteines, Institut de Microbiologie de la Mediterranee, Centre National de la Recherche Scientifique, Aix Marseille Universite, 31 Chemin Joseph Aiguier, 13402 Marseille Cedex 20, France
    FEBS Lett 587:2725-30. 2013
  10. ncbi Putting the systems back into systems biology
    Athel Cornish-Bowden
    CNRS BIP, 13402 Marseille Cedex 20, France
    Perspect Biol Med 49:475-89. 2006

Detail Information

Publications21

  1. ncbi Detection of errors of interpretation in experiments in enzyme kinetics
    A Cornish-Bowden
    Institut Fédératif Biologie Structurale et Microbiologie, Bioenergetique et Ingenierie des Proteines, Centre National de la Recherche Scientifique, 31 Chemin Joseph Aiguier, Marseille Cedex 20, 13402, France
    Methods 24:181-90. 2001
    ..Finally, the Scatchard plot (together with the Eadie-Hofstee plot) is used as an example to discuss the dangers of publishing derived information unaccompanied by any primary data...
  2. ncbi Understanding the parts in terms of the whole
    Athel Cornish-Bowden
    Institut Fédératif Biologie Structurale et Microbiologie, Marseille Cedex 20, France
    Biol Cell 96:713-7. 2004
    ..Avoiding this implication of infinite regress represents a major challenge for future investigation...
  3. ncbi Metabolic analysis in drug design
    Athel Cornish-Bowden
    CNRS BIP, 31, Chemin Joseph Aiguier, BP 71, 13402 Marseille, France
    C R Biol 326:509-15. 2003
    ..That is not necessarily easy to find in a complicated system, and typically needs the metabolic network to be analysed in the computer...
  4. ncbi The role of stoichiometric analysis in studies of metabolism: an example
    Athel Cornish-Bowden
    Bioenergetique et Ingenierie des Proteines, Institut Fédératif Biologie Structurale et Microbiologie, Centre National de la Recherche Scientifique, 31 Chemin Joseph Aiguier, 13402 Marseille Cedex 20, France
    J Theor Biol 216:179-91. 2002
    ..Gaussian elimination provides a systematic way of analysing a network in such a way that all the stoichiometric relationships that it contains emerge automatically...
  5. ncbi Stoicheiometric analysis in studies of metabolism
    Athel Cornish-Bowden
    Bioenergetique et Ingenierie des Proteines, Institut Fédératif Biologie Structurale et Microbiologie, Centre National de la Recherche Scientifique, 31 Chemin Joseph Aiguier, B P 71, 13402 Marseille Cedex 20, France
    Biochem Soc Trans 30:43-6. 2002
    ..If exactly the same operations are carried out on a unit matrix of order equal to the number of intermediate metabolites in the pathway, the resulting matrix allows the stoicheiometric constraints to be read off directly...
  6. ncbi Enthalpy-entropy compensation: a phantom phenomenon
    Athel Cornish-Bowden
    Bioenergetique et Ingenierie des Proteines, Institut Fédératif Biologie Structurale et Microbiologie, Centre National de la Recherche Scientifique, 31 Chemin Joseph Aiguier, B P 71, 13402 Marseille Cedex 20, France
    J Biosci 27:121-6. 2002
    ..As with other cases of impossibly good correlation between two biological variables, the explanation is that what purports to be two variables are very largely the same variable looked at in two different ways...
  7. ncbi Information transfer in metabolic pathways. Effects of irreversible steps in computer models
    A Cornish-Bowden
    Institut Fédératif Biologie Structurale et Microbiologie, Bioenergetique et Ingenierie des Proteines, Centre National de la Recherche Scientifique, Marseille, France
    Eur J Biochem 268:6616-24. 2001
    ....
  8. doi Closure to efficient causation, computability and artificial life
    Maria Luz Cardenas
    Unite de Bioenergetique et Ingenierie des Proteines, Centre National de la Recherche Scientifique, 31 Chemin Joseph Aiguier, 13402 Marseille Cedex 20, France
    J Theor Biol 263:79-92. 2010
    ..Here we examine some of the mathematical arguments and clarify the conditions for closure...
  9. doi The origins of enzyme kinetics
    Athel Cornish-Bowden
    Unite de Bioenergetique et Ingenierie des Proteines, Institut de Microbiologie de la Mediterranee, Centre National de la Recherche Scientifique, Aix Marseille Universite, 31 Chemin Joseph Aiguier, 13402 Marseille Cedex 20, France
    FEBS Lett 587:2725-30. 2013
    ..Their methodology has remained the standard approach to steady-state enzyme kinetics ever since...
  10. ncbi Putting the systems back into systems biology
    Athel Cornish-Bowden
    CNRS BIP, 13402 Marseille Cedex 20, France
    Perspect Biol Med 49:475-89. 2006
    ..At a more abstract level, it is necessary for understanding the nature of life, because as long as an organism is treated as no more than a collection of components, one cannot ask the right questions, and certainly cannot answer them...
  11. ncbi Beyond reductionism: metabolic circularity as a guiding vision for a real biology of systems
    Athel Cornish-Bowden
    Institut de Biologie Structurale et Microbiologie, Marseilles, France
    Proteomics 7:839-45. 2007
    ..Among other consequences, this implies that the usual distinction between proteome and metabolome is conceptually artificial -- however useful it may be in practice -- as the proteome is part of the metabolome...
  12. pmc Making systems biology work in the 21st century
    Athel Cornish-Bowden
    CNRS BIP, Institut Fédératif Biologie Structurale et Microbiologie, 31 Chemin Joseph Aiguier, 13402 Marseille Cedex 20, France
    Genome Biol 6:317. 2005
  13. ncbi Organizational invariance in (M,R)-systems
    Athel Cornish-Bowden
    Institut de Biologie Structurale et Microbiologie, CNRS BIP, 31 Chemin Joseph Aiguier, B P 71, F 13402 Marseille Cedex 20
    Chem Biodivers 4:2396-406. 2007
    ..If all of the steps in such a cycle are written as uncatalyzed chemical reactions, then it becomes clear that the organization of the system is fully defined by the chemical properties of the molecules that compose it...
  14. doi Specificity of non-Michaelis-Menten enzymes: necessary information for analyzing metabolic pathways
    Athel Cornish-Bowden
    Bioénergétique et Ingénierie des Protéines, Centre National de la Recherche Scientifique, 31 Chemin Joseph Aiguier, B P 71, 13402 Marseille Cedex 20, France
    J Phys Chem B 114:16209-13. 2010
    ....
  15. ncbi Modulation of metabolite concentrations with no net effect on fluxes
    Luz Cárdenas María
    IBSM BIP CNRS, Marseille, France
    Mol Biol Rep 29:17-20. 2002
    ..The general approach can be extended to systems in which the inhibited enzymes do not catalyse consecutive reactions...
  16. doi Reinhart Heinrich (1946-2006): an annotated bibliography
    Athel Cornish-Bowden
    Unite de Bioenergetique et Ingenierie des Proteines, Centre National de Recherche Scientifique, 31 Chemin Joseph Aiguier, B P 71, 13402 Marseille Cedex, France
    J Theor Biol 252:379-87. 2008
    ..His publications are arranged here according to subject area, together with some introductory notes...
  17. ncbi Biochemistry and evolutionary biology: two disciplines that need each other?
    Athel Cornish-Bowden
    Unite de Bioenergetique et Ingenierie des Proteines, Centre National de la Recherche Scientifique, Aix Marseille Universite, 31 Chemin Joseph Aiguier, 13402 Marseille Cedex 20, France
    J Biosci 39:13-27. 2014
    ..Courses of biochemistry should thus pay attention to the essential role of evolution in selecting the molecules of life. ..
  18. ncbi The threat from creationism to the rational teaching of biology
    Athel Cornish-Bowden
    Laboratoire de Bioenergetique et Ingenierie des Proteines, CNRS, Marseille, France
    Biol Res 40:113-22. 2007
    ..Turkey is now a major source of creationist propaganda outside the USA, and is especially significant in relation to its influence on Muslim populations in Europe. The time for biologists to address the creationist threat is now...
  19. ncbi Self-organization at the origin of life
    Athel Cornish-Bowden
    Unite de Bioenergetique et Ingenierie des Proteines, Centre National de Recherche Scientifique, 31 Chemin Joseph Aiguier, B P 71, 13402 Marseille Cedex 20, France
    J Theor Biol 252:411-8. 2008
    ..To take a further step towards defining what it means to be alive it is necessary to add to a simple (M,R) system some property that represents its identity, and which can be maintained and modified in subsequent generations...
  20. ncbi Metabolic balance sheets
    Athel Cornish-Bowden
    Nature 420:129-30. 2002
  21. ncbi Organizational invariance and metabolic closure: analysis in terms of (M,R) systems
    Juan Carlos Letelier
    Departamento de Biologia, Facultad de Ciencias, Universidad de Chile, Casilla 653, Santiago, Chile
    J Theor Biol 238:949-61. 2006
    ..We conclude that Rosen's insight, although not yet in an easily workable form, represents a valuable tool for understanding metabolic networks...