Arnaud Chevrollier

Summary

Affiliation: Centre Hospitalier Universitaire
Country: France

Publications

  1. doi request reprint Standardized mitochondrial analysis gives new insights into mitochondrial dynamics and OPA1 function
    Arnaud Chevrollier
    CNRS 6214, Angers F 49000, France
    Int J Biochem Cell Biol 44:980-8. 2012
  2. pmc Idebenone increases mitochondrial complex I activity in fibroblasts from LHON patients while producing contradictory effects on respiration
    Claire Angebault
    INSERM U771, Angers 49000, France
    BMC Res Notes 4:557. 2011
  3. pmc OPA1-related dominant optic atrophy is not strongly influenced by mitochondrial DNA background
    Denis Pierron
    Universite Bordeaux 1, Laboratoire d Anthropologie des Populations du Passé, UMR 5199 PACEA, 33400 Talence, France
    BMC Med Genet 10:70. 2009
  4. doi request reprint Adenine nucleotide translocase 2 is a key mitochondrial protein in cancer metabolism
    Arnaud Chevrollier
    CNRS, UMR6214, F 49000 Angers, France
    Biochim Biophys Acta 1807:562-7. 2011
  5. doi request reprint Hereditary optic neuropathies share a common mitochondrial coupling defect
    Arnaud Chevrollier
    Institut National de la Sante et de la Recherche Medicale, U694, Départment de Biochimie et Génétique, Centre Hospitalier Universitaire, Angers, France
    Ann Neurol 63:794-8. 2008
  6. doi request reprint Adenine nucleotide translocase is involved in a mitochondrial coupling defect in MFN2-related Charcot-Marie-Tooth type 2A disease
    Virginie Guillet
    INSERM, U694, Angers, 49000, France
    Neurogenetics 11:127-33. 2010
  7. doi request reprint OPA1-associated disorders: phenotypes and pathophysiology
    Patrizia Amati-Bonneau
    INSERM U694, Angers, France
    Int J Biochem Cell Biol 41:1855-65. 2009
  8. ncbi request reprint Mitochondrial coupling defect in Charcot-Marie-Tooth type 2A disease
    Dominique Loiseau
    Institut National de la Santé et de la Recherche Médicale U694, Angers, France
    Ann Neurol 61:315-23. 2007
  9. doi request reprint Ethambutol-induced optic neuropathy linked to OPA1 mutation and mitochondrial toxicity
    Virginie Guillet
    INSERM, U694, Angers, F 49000, France
    Mitochondrion 10:115-24. 2010
  10. ncbi request reprint Molecular screening of 980 cases of suspected hereditary optic neuropathy with a report on 77 novel OPA1 mutations
    Marc Ferre
    INSERM, U694, Angers, F 49000, France
    Hum Mutat 30:E692-705. 2009

Collaborators

Detail Information

Publications22

  1. doi request reprint Standardized mitochondrial analysis gives new insights into mitochondrial dynamics and OPA1 function
    Arnaud Chevrollier
    CNRS 6214, Angers F 49000, France
    Int J Biochem Cell Biol 44:980-8. 2012
    ....
  2. pmc Idebenone increases mitochondrial complex I activity in fibroblasts from LHON patients while producing contradictory effects on respiration
    Claire Angebault
    INSERM U771, Angers 49000, France
    BMC Res Notes 4:557. 2011
    ..abstract:..
  3. pmc OPA1-related dominant optic atrophy is not strongly influenced by mitochondrial DNA background
    Denis Pierron
    Universite Bordeaux 1, Laboratoire d Anthropologie des Populations du Passé, UMR 5199 PACEA, 33400 Talence, France
    BMC Med Genet 10:70. 2009
    ..In this study, we have tested the influence of mtDNA backgrounds on OPA1 mutations...
  4. doi request reprint Adenine nucleotide translocase 2 is a key mitochondrial protein in cancer metabolism
    Arnaud Chevrollier
    CNRS, UMR6214, F 49000 Angers, France
    Biochim Biophys Acta 1807:562-7. 2011
    ..Since the expression of ANT2 is closely linked to the mitochondrial bioenergetics of tumors, it should be taken into account for individualizing cancer treatments and for the development of anticancer strategies...
  5. doi request reprint Hereditary optic neuropathies share a common mitochondrial coupling defect
    Arnaud Chevrollier
    Institut National de la Sante et de la Recherche Medicale, U694, Départment de Biochimie et Génétique, Centre Hospitalier Universitaire, Angers, France
    Ann Neurol 63:794-8. 2008
    ..Interestingly, the energetic defect was significantly more pronounced in Leber's hereditary optic neuropathy and autosomal dominant optic atrophy patients with a more complex phenotype, the so-called plus phenotype...
  6. doi request reprint Adenine nucleotide translocase is involved in a mitochondrial coupling defect in MFN2-related Charcot-Marie-Tooth type 2A disease
    Virginie Guillet
    INSERM, U694, Angers, 49000, France
    Neurogenetics 11:127-33. 2010
    ..Furthermore, a twofold increase in the expression of ANT led to the reduced efficiency of oxidative phosphorylation in CMT2A cells, suggesting that MFN2 plays a role in controlling ATP/ADP exchanges...
  7. doi request reprint OPA1-associated disorders: phenotypes and pathophysiology
    Patrizia Amati-Bonneau
    INSERM U694, Angers, France
    Int J Biochem Cell Biol 41:1855-65. 2009
    ..Finally, OPA1 represents an important new paradigm for emerging neurodegenerative diseases affecting mitochondrial structure, plasticity and functions...
  8. ncbi request reprint Mitochondrial coupling defect in Charcot-Marie-Tooth type 2A disease
    Dominique Loiseau
    Institut National de la Santé et de la Recherche Médicale U694, Angers, France
    Ann Neurol 61:315-23. 2007
    ..Mutations of the mitofusin 2 gene (MFN2) may account for at least a third of the cases of Charcot-Marie-Tooth disease type 2 (CMT2). This study investigates mitochondrial cellular bioenergetics in MFN2-related CMT2A...
  9. doi request reprint Ethambutol-induced optic neuropathy linked to OPA1 mutation and mitochondrial toxicity
    Virginie Guillet
    INSERM, U694, Angers, F 49000, France
    Mitochondrion 10:115-24. 2010
    ..Mitochondrial genetic variations may therefore be predisposing factors in EMB-induced ocular injury...
  10. ncbi request reprint Molecular screening of 980 cases of suspected hereditary optic neuropathy with a report on 77 novel OPA1 mutations
    Marc Ferre
    INSERM, U694, Angers, F 49000, France
    Hum Mutat 30:E692-705. 2009
    ..Our results highlight the importance of investigating LHON-causing mtDNA mutations as well as OPA1 and OPA3 mutations in cases of suspected hereditary optic neuropathy, even in absence of a family history of the disease...
  11. doi request reprint Mitochondrial bioenergetic background confers a survival advantage to HepG2 cells in response to chemotherapy
    Dominique Loiseau
    INSERM U694, University Hospital Center, Angers, France
    Mol Carcinog 48:733-41. 2009
    ..This suggests that the mitochondrial bioenergetic background of tumors should be considered for anticancer treatment personalization...
  12. doi request reprint Mitochondrial complex I deficiency in GDAP1-related autosomal dominant Charcot-Marie-Tooth disease (CMT2K)
    Julien Cassereau
    INSERM, U694, 4 rue Larrey, Angers, 49933, France
    Neurogenetics 10:145-50. 2009
    ..Thus, besides the regulatory role GDAP1 plays in mitochondrial network dynamics, it may also be involved in energy production and in the control of mitochondrial volume...
  13. doi request reprint Hereditary spastic paraplegia-like disorder due to a mitochondrial ATP6 gene point mutation
    Christophe Verny
    Department of Neurology, Angers University Hospital, School of Medicine, Angers F 49000, France
    Mitochondrion 11:70-5. 2011
    ..This finding extends the genetic heterogeneity of the hereditary spastic paraplegia together with the clinical spectrum of mutations of the ATP6 gene...
  14. ncbi request reprint OPA1 R445H mutation in optic atrophy associated with sensorineural deafness
    Patrizia Amati-Bonneau
    INSERM U694, Laboratoire de Biochimie et Biologie Moleculaire, Centre Hospitalier Universitaire, F 49033 Angers, France
    Ann Neurol 58:958-63. 2005
    ..In addition, OPA1 was found to be widely expressed in the sensory and neural cochlear cells of the guinea pig. Thus, optic atrophy and deafness may be related to energy defects due to a fragmented mitochondrial network...
  15. doi request reprint Bioenergetic defect associated with mKATP channel opening in a mouse model carrying a mitofusin 2 mutation
    Virginie Guillet
    Unité Mixte de Recherche Centre National de Recherche Scientifique CNRS 6214, Institut National de Santé et de Recherche Me dicale INSERM U771, Angers, France
    FASEB J 25:1618-27. 2011
    ..Our results show that the R94Q MFN2 mutation induces a combined defect of complexes II and V linked to the opening of mK(ATP), which could participate in the pathophysiology of the disease...
  16. pmc Metabolically induced heteroplasmy shifting and l-arginine treatment reduce the energetic defect in a neuronal-like model of MELAS
    Valérie Desquiret-Dumas
    Department of Biochemistry and Genetics, Angers University Hospital, School of Medicine, Angers, F 49000, France
    Biochim Biophys Acta 1822:1019-29. 2012
    ..Thus, metabolically induced heteroplasmy shifting and l-arginine therapy may constitute promising therapeutic strategies against MELAS...
  17. pmc A locus-specific database for mutations in GDAP1 allows analysis of genotype-phenotype correlations in Charcot-Marie-Tooth diseases type 4A and 2K
    Julien Cassereau
    INSERM, U771, Angers, F 49000, France
    Orphanet J Rare Dis 6:87. 2011
    ..Locus-specific databases (LSDB) established in the framework of the Human Variome Project provide powerful tools for the investigation of such rare diseases...
  18. ncbi request reprint ANT2 isoform required for cancer cell glycolysis
    Arnaud Chevrollier
    INSERM, U694, Angers, F 49033, France
    J Bioenerg Biomembr 37:307-16. 2005
    ....
  19. pmc Is ABCC6 a genuine mitochondrial protein?
    Marc Ferre
    CNRS 6214 INSERM 1083, Angers University, Angers, France
    BMC Res Notes 6:427. 2013
    ..Circ Res 2012, 111:516-520. We present complementary information based on a bioinformatics analysis, which was not performed in the article cited, to examine the suggestion that ABCC6 is localized to mitochondria...
  20. pmc Resveratrol induces a mitochondrial complex I-dependent increase in NADH oxidation responsible for sirtuin activation in liver cells
    Valérie Desquiret-Dumas
    From Angers Université, Angers F 49000, France
    J Biol Chem 288:36662-75. 2013
    ..Our results open up new perspectives in the understanding of the RSV signaling pathway and highlight the critical importance of RSV doses used for future clinical trials...
  21. ncbi request reprint ANT2 expression under hypoxic conditions produces opposite cell-cycle behavior in 143B and HepG2 cancer cells
    Arnaud Chevrollier
    INSERM E0018, Laboratoire de Biochimie et Biologie Moleculaire, CHU, Angers, France
    Mol Carcinog 42:1-8. 2005
    ..This loss of cell dependence on oxidative metabolism is an important factor in the development of tumors...
  22. ncbi request reprint mtDNA controls expression of the Death Associated Protein 3
    Caroline Jacques
    From INSERM, U694, F 49033 Angers, France
    Exp Cell Res 312:737-45. 2006
    ..The absence of pro-apoptotic DAP3 in these mtDNA-less cells could explain their reduced apoptotic capacity. Our results suggest that the mtDNA content plays a role in cell apoptosis by mediating the expression of DAP3...