Athanase Benetos

Summary

Affiliation: Centre Hospitalier
Country: France

Publications

  1. ncbi request reprint Determinants of arterial stiffness in Greek and French hypertensive men
    Apostolos Achimastos
    Sotiria Hospital, Athens, Greece
    Blood Press 11:218-22. 2002
  2. ncbi request reprint Prognostic value of systolic and diastolic blood pressure in treated hypertensive men
    Athanase Benetos
    Centre d Investigations Préventives et Cliniques, 6 14 rue de la Pérouse, 75116 Paris, France
    Arch Intern Med 162:577-81. 2002
  3. ncbi request reprint Role of modifiable risk factors in life expectancy in the elderly
    Athanase Benetos
    Centre d investigations préventives et cliniques IPC, Paris, and Department of Geriatrics, Medical School of Nancy, Nancy, France
    J Hypertens 23:1803-8. 2005
  4. ncbi request reprint Short telomeres are associated with increased carotid atherosclerosis in hypertensive subjects
    Athanase Benetos
    Centre d Investigations Préventives et Cliniques, 6 14 rue la Pérouse, 75116 Paris, France
    Hypertension 43:182-5. 2004
  5. ncbi request reprint Determinants of accelerated progression of arterial stiffness in normotensive subjects and in treated hypertensive subjects over a 6-year period
    Athanase Benetos
    Centre d Investigations Préventives et Cliniques, Paris, France
    Circulation 105:1202-7. 2002
  6. ncbi request reprint Why cardiovascular mortality is higher in treated hypertensives versus subjects of the same age, in the general population
    Athanase Benetos
    Centre d investigations préventives et cliniques IPC, Paris, France
    J Hypertens 21:1635-40. 2003
  7. ncbi request reprint Telomere length as an indicator of biological aging: the gender effect and relation with pulse pressure and pulse wave velocity
    A Benetos
    Center Investigations Preventives et Cliniques, INSERM U337, Paris, France
    Hypertension 37:381-5. 2001
  8. ncbi request reprint Telomere length as an indicator of biological aging: The gender effect and relation with pulse pressure and pulse wave velocity
    A Benetos
    Center Investigations Preventives et Cliniques IPC, INSERM U337, Paris, France
    Hypertension 37:381-5. 2001
  9. ncbi request reprint Should diastolic and systolic blood pressure be considered for cardiovascular risk evaluation: a study in middle-aged men and women
    A Benetos
    Centre d Investigations Préventives et Cliniques, Paris, France
    J Am Coll Cardiol 37:163-8. 2001
  10. ncbi request reprint Clinical results with bisoprolol 2.5 mg/hydrochlorothiazide 6.25 mg combination in systolic hypertension in the elderly
    Athanase Benetos
    IPC Center, Paris, France
    J Hypertens Suppl 20:S21-5. 2002

Collaborators

Detail Information

Publications98

  1. ncbi request reprint Determinants of arterial stiffness in Greek and French hypertensive men
    Apostolos Achimastos
    Sotiria Hospital, Athens, Greece
    Blood Press 11:218-22. 2002
    ..The higher aortic stiffness found in Greek hypertensives may be explained by the presence of other non-evaluated risk factors and/or patient selection differences...
  2. ncbi request reprint Prognostic value of systolic and diastolic blood pressure in treated hypertensive men
    Athanase Benetos
    Centre d Investigations Préventives et Cliniques, 6 14 rue de la Pérouse, 75116 Paris, France
    Arch Intern Med 162:577-81. 2002
    ..The aim of this study was to assess the cardiovascular risk in hypertensive subjects according to systolic blood pressure (SBP) and diastolic blood pressure (DBP) levels...
  3. ncbi request reprint Role of modifiable risk factors in life expectancy in the elderly
    Athanase Benetos
    Centre d investigations préventives et cliniques IPC, Paris, and Department of Geriatrics, Medical School of Nancy, Nancy, France
    J Hypertens 23:1803-8. 2005
    ..The aim of the present study was to evaluate the role of 'modifiable' risk factors, assessed between the ages of 60 and 70 years, in late survival...
  4. ncbi request reprint Short telomeres are associated with increased carotid atherosclerosis in hypertensive subjects
    Athanase Benetos
    Centre d Investigations Préventives et Cliniques, 6 14 rue la Pérouse, 75116 Paris, France
    Hypertension 43:182-5. 2004
    ....
  5. ncbi request reprint Determinants of accelerated progression of arterial stiffness in normotensive subjects and in treated hypertensive subjects over a 6-year period
    Athanase Benetos
    Centre d Investigations Préventives et Cliniques, Paris, France
    Circulation 105:1202-7. 2002
    ..The aim of the present longitudinal study was to compare the progression of aortic stiffness over a 6-year period in treated hypertensive subjects and normotensive subjects, and to evaluate the determinants of this progression...
  6. ncbi request reprint Why cardiovascular mortality is higher in treated hypertensives versus subjects of the same age, in the general population
    Athanase Benetos
    Centre d investigations préventives et cliniques IPC, Paris, France
    J Hypertens 21:1635-40. 2003
    ..The aim of the present study was to assess whether increased cardiovascular mortality in treated hypertensives could be explained by high blood pressure levels, or by the presence of associated risk factors and/or associated diseases...
  7. ncbi request reprint Telomere length as an indicator of biological aging: the gender effect and relation with pulse pressure and pulse wave velocity
    A Benetos
    Center Investigations Preventives et Cliniques, INSERM U337, Paris, France
    Hypertension 37:381-5. 2001
    ..The longer telomere length in women suggests that for a given chronological age, biological aging of men is more advanced than that of women...
  8. ncbi request reprint Telomere length as an indicator of biological aging: The gender effect and relation with pulse pressure and pulse wave velocity
    A Benetos
    Center Investigations Preventives et Cliniques IPC, INSERM U337, Paris, France
    Hypertension 37:381-5. 2001
    ..The longer telomere length in women suggests that for a given chronological age, biological aging of men is more advanced than that of women...
  9. ncbi request reprint Should diastolic and systolic blood pressure be considered for cardiovascular risk evaluation: a study in middle-aged men and women
    A Benetos
    Centre d Investigations Préventives et Cliniques, Paris, France
    J Am Coll Cardiol 37:163-8. 2001
    ..The goal of this study was to evaluate the role of diastolic blood pressure (DBP) in cardiovascular mortality for different systolic blood pressure (SBP) levels in middle-aged men and women...
  10. ncbi request reprint Clinical results with bisoprolol 2.5 mg/hydrochlorothiazide 6.25 mg combination in systolic hypertension in the elderly
    Athanase Benetos
    IPC Center, Paris, France
    J Hypertens Suppl 20:S21-5. 2002
    ..5/HCTZ 6.25 and amlodipine. Low-dose combination of bisoprolol and hydrochlorothiazide may be an appropriate alternative for elderly patients with systolic hypertension...
  11. doi request reprint Pulse pressure amplification a mechanical biomarker of cardiovascular risk
    Athanase Benetos
    Department of Geriatrics CHU de Nancy, and INSERM U691, University of Nancy, Nancy, France
    J Am Coll Cardiol 55:1032-7. 2010
    ..The aim of this study was to determine whether the carotid/brachial (C/B) ratio is an independent predictor of cardiovascular (CV) risk...
  12. doi request reprint Pulse wave velocity is associated with 1-year cognitive decline in the elderly older than 80 years: the PARTAGE study
    Athanase Benetos
    Department of Geriatrics and Memory Clinique CMRR, University Hospital of Nancy, Nancy, France
    J Am Med Dir Assoc 13:239-43. 2012
    ..The aim of the present longitudinal 1-year cohort analysis was to evaluate the influence of arterial stiffness on cognitive decline in institutionalized subjects older than 80 years...
  13. doi request reprint Correlation between peripheral blood pressure and pulse-wave velocity values in the institutionalized elderly persons 80 years of age and older: the PARTAGE study
    Darko Miljkovic
    Université de Lorraine, Nancy, France
    Am J Hypertens 26:163-73. 2013
    ....
  14. doi request reprint Blood pressure and pulse wave velocity values in the institutionalized elderly aged 80 and over: baseline of the PARTAGE study
    Athanase Benetos
    Department of Geriatrics, University Hospital of Nancy, Nancy, France
    J Hypertens 28:41-50. 2010
    ..In the study herein, we present the baseline data values of this study...
  15. ncbi request reprint Metabolic syndrome and age-related progression of aortic stiffness
    Michel E Safar
    Diagnosis Center, Hotel Dieu Hospital, Paris, France
    J Am Coll Cardiol 47:72-5. 2006
    ..Metabolic syndrome involves an increased progression of arterial stiffness with age and, thus, favors premature senescence...
  16. doi request reprint Mortality and cardiovascular events are best predicted by low central/peripheral pulse pressure amplification but not by high blood pressure levels in elderly nursing home subjects: the PARTAGE (Predictive Values of Blood Pressure and Arterial Stiffness i
    Athanase Benetos
    INSERM U961, Nancy, France
    J Am Coll Cardiol 60:1503-11. 2012
    ....
  17. ncbi request reprint Aortic stiffness is an independent predictor of primary coronary events in hypertensive patients: a longitudinal study
    Pierre Boutouyrie
    Department of Pharmacology and INSERM EMI 0107, Hopital Europeen Georges Pompidou, Paris, France
    Hypertension 39:10-5. 2002
    ..This study provides the first direct evidence in a longitudinal study that aortic stiffness is an independent predictor of primary coronary events in patients with essential hypertension...
  18. ncbi request reprint Aldosterone synthase gene polymorphism, stroke volume and age-related changes in aortic pulse wave velocity in subjects with hypertension
    Michel E Safar
    Diagnosis Centre, Hotel Dieu Hospital, Paris, France
    J Hypertens 23:1159-66. 2005
    ..Whether the aldosterone synthase gene polymorphism (ASGP) CYP11B2 influences the age-related changes in blood pressure (BP) and arterial stiffness in hypertensive subjects has never been investigated...
  19. ncbi request reprint Differences between cardiac and arterial fibrosis and stiffness in aldosterone-salt rats: effect of eplerenone
    Johnny Nehme
    INSERM U572, Paris, France
    J Renin Angiotensin Aldosterone Syst 7:31-9. 2006
    ..Our aim was to determine in vivo the effects of Aldo and the Aldo receptor antagonist eplerenone (Epl) on simultaneous changes in cardiac and arterial structure and function and their interactions...
  20. doi request reprint Recent advances in metabolic syndrome and cardiovascular disease
    Louis Guize
    Centre IPC, 6 14, rue La Pérouse, 75116 Paris, France
    Arch Cardiovasc Dis 101:577-83. 2008
    ..In the 2007 European recommendations for the management of high blood pressure, metabolic syndrome is now taken into consideration for both risk stratification and in selecting the optimal therapeutic strategy for arterial hypertension...
  21. ncbi request reprint Gene polymorphisms of the renin-angiotensin system and age-related changes in systolic and diastolic blood pressure in subjects with hypertension
    Annie Rudnichi
    Diagnosis Center, Hotel Dieu Hospital, Paris, France
    Am J Hypertens 17:321-7. 2004
    ..Few studies have examined to what extent genes might modulate the changes of systolic and diastolic blood pressure (BP) with age although, in older populations, systolic BP and diastolic BP vary with age in opposite directions...
  22. ncbi request reprint Sodium, arterial stiffness, and cardiovascular mortality in hypertensive rats
    Nathalie Mercier
    INSERM, U684, Nancy, France Université Henri Poincaré, UFR Medecine, Nancy, France
    Am J Hypertens 20:319-25. 2007
    ..We examined the effects of early high salt diet (HSD) and angiotensin II type 1 (AT1) receptor antagonist valsartan (Val) on mortality and carotid distensibility in surviving spontaneously hypertensive rats (SHRs)...
  23. ncbi request reprint All-cause mortality associated with specific combinations of the metabolic syndrome according to recent definitions
    Louis Guize
    Centre Investigations Préventives et Cliniques, Paris, France
    Diabetes Care 30:2381-7. 2007
    ..The aim was to evaluate the impact of specific component combinations of the metabolic syndrome on all-cause mortality risk in a large French cohort...
  24. doi request reprint Increased arterial stiffness in nonalcoholic fatty liver disease: the Cardio-GOOSE study
    Paolo Salvi
    Department of Internal Medicine and Geriatrics, INSERM U961, University of Nancy, Nancy, France
    J Hypertens 28:1699-707. 2010
    ..Cardio-GOOSE (Cardio-Gambettola ObservatOry liver Steatosis Estimation) is a population-based cohort study finalized to evaluate the relationship between NAFLD, subclinical vascular damage, and arterial stiffness...
  25. doi request reprint All-cause and cardiovascular mortality using the different definitions of metabolic syndrome
    Athanase Benetos
    Centre d Investigations Préventives et Cliniques IPC Center, Paris, France
    Am J Cardiol 102:188-91. 2008
    ..Subjects identified as having MS using only the recent definitions and not the original definition did not have higher rates of all-cause and CVD mortality compared with subjects without MS during follow-up...
  26. doi request reprint Cardiovascular risk as defined in the 2003 European blood pressure classification: the assessment of an additional predictive value of pulse pressure on mortality
    Frederique Thomas
    Centre d Investigations Préventives et Cliniques, Hotel Dieu Hospital, AP HP, University Paris 5, Paris, France
    J Hypertens 26:1072-7. 2008
    ..This study determines the predictive value of brachial pulse pressure for cardiovascular stroke and coronary mortality in a large population categorized by blood pressure level...
  27. doi request reprint The metabolic syndrome: similar deleterious impact on all-cause mortality in hypertensive and normotensive subjects
    Bruno Pannier
    Centre IPC, Paris, France
    J Hypertens 26:1223-8. 2008
    ..Our aim was to evaluate the 5-year impact of the metabolic syndrome, according to blood pressure status, on all-cause mortality risk in a large French population...
  28. ncbi request reprint Cardiovascular mortality in overweight subjects: the key role of associated risk factors
    Frederique Thomas
    Centre d investigations préventives et cliniques IPC, 75116 Paris, France
    Hypertension 46:654-9. 2005
    ..Because overweight significantly increases the prevalence of associated risk factors, especially hypertension, it should be considered as a major cardiovascular risk determinant...
  29. doi request reprint Relationship between catalase haplotype and arterial aging
    Valerie Nivet-Antoine
    AP HP, Hopital Europeen Georges Pompidou, Service de Biochimie, Paris, France
    Atherosclerosis 227:100-5. 2013
    ..Oxidative stress and particularly catalase (CAT), an antioxidant enzyme, play an important role in endothelial cell pathophysiology, in shear stress response and ultimately in arterial aging...
  30. doi request reprint Association of current weight and birth weight with blood pressure levels in Saharan and European teenager populations
    Paolo Salvi
    Department of Internal Medicine and Geriatrics, INSERM U961, University of Nancy, Nancy, France
    Am J Hypertens 23:379-86. 2010
    ....
  31. ncbi request reprint Relation of plasma total homocysteine to cardiovascular mortality in a French population
    Jacques Blacher
    Department of Internal Medicine, Broussais Hospital and Centre d Investigations Préventives et Cliniques, Paris, France
    Am J Cardiol 90:591-5. 2002
    ..Thus, HCY is an independent risk predictor for CV mortality. Because of extensive adjustment procedures, the present study provides additional epidemiologic evidence for a causal relation between HCY and CV disease...
  32. doi request reprint Evolution of arterial stiffness after kidney transplantation
    Cécile Bachelet-Rousseau
    Department of Nephrology, Brabois Hospital, Nancy University and INSERM EA 4360, Nancy, France
    Nephrol Dial Transplant 26:3386-91. 2011
    ..Little is known about AS evolution after kidney transplantation. The aim of the study was to characterize the evolution of AS after kidney transplantation in a population of ESRD patients, in comparison to those remaining in dialysis...
  33. ncbi request reprint Increased carotid wall elastic modulus and fibronectin in aldosterone-salt-treated rats: effects of eplerenone
    Patrick Lacolley
    INSERM EMI U0107, Paris, France
    Circulation 106:2848-53. 2002
    ..Our aim was to determine the effects of Aldo and the Aldo receptor antagonist eplerenone (Epl) on in vivo mechanical properties of the carotid artery using echo-tracking system...
  34. ncbi request reprint Influence of age, risk factors, and cardiovascular and renal disease on arterial stiffness: clinical applications
    Athanase Benetos
    IPC Center, Paris, France
    Am J Hypertens 15:1101-8. 2002
    ..However, relationships between these three alterations of the arterial wall remain to be explored...
  35. ncbi request reprint Genetic determination of plasma aldosterone levels in essential hypertension
    L Pojoga
    INSERM U337, Broussais Hospital, Paris, France
    Am J Hypertens 11:856-60. 1998
    ..These differences are not associated with variations in blood pressure levels...
  36. pmc A model of canine leukocyte telomere dynamics
    Athanase Benetos
    Geriatric Service, Nancy University Hospital, Nancy, France
    Aging Cell 10:991-5. 2011
    ..telomere shortening afterward might provide information about whether the individual's longevity is calibrated to either one or both factors that define leukocyte TL dynamics...
  37. doi request reprint Association study of gene polymorphisms involved in vascular alterations in elderly hypertensives with subjective memory complaints
    Ghassan Watfa
    Nancy University Hospital and Inserm Clinical Investigation Center, CIC9501, Nancy, France
    Dement Geriatr Cogn Disord 30:440-8. 2010
    ..The aim of the present study was to identify genetic variants associated with the degree of cognitive impairment and the severity of WMH in the same study population, focusing on genes involved in vascular alterations...
  38. ncbi request reprint Impaired fasting glucose, blood pressure and cardiovascular disease mortality
    Patrick Henry
    Service de cardiologie, Lariboisiere Hospital, Paris, France
    Hypertension 40:458-63. 2002
    ..In conclusion, the presence of moderate systolic hypertension can identify subjects with impaired fasting glucose who are at risk of cardiovascular and overall mortality, and vice versa, probably through the metabolic syndrome...
  39. ncbi request reprint Determinants of arterial stiffness in an apparently healthy population over 60 years
    C Alecu
    Department of Neurology, University of Nancy, Nancy, France
    J Hum Hypertens 20:749-56. 2006
    ..Our study also shows that the gender-related differences in arterial stiffness observed in middle-aged subjects are maintained in the elderly...
  40. pmc Functional epistatic interaction between rs6046G>A in F7 and rs5355C>T in SELE modifies systolic blood pressure levels
    Said El Shamieh
    Université de Lorraine, Génétique Cardio vasculaire, EA 4373, Nancy, France
    PLoS ONE 7:e40777. 2012
    ..This phenomenon could be partially due to epistatic interactions. Our aim was to identify epistatic interaction(s) associated with blood pressure levels in a pre-planned two-phase approach...
  41. doi request reprint The impact of the metabolic syndrome--but not of hypertension--on all-cause mortality disappears in the elderly
    Frederique Thomas
    Centre d Investigations Préventives et Cliniques IPC Center, Paris, France
    J Hypertens 29:663-8. 2011
    ..We aimed to determine the impact of the metabolic syndrome on all-cause mortality according to age, in comparison with hypertension alone...
  42. ncbi request reprint Factors influencing arterial stiffness in systolic hypertension in the elderly: role of sodium and the renin-angiotensin system
    Michel E Safar
    Department of Internal Medicine MES, Broussais Hospital, Paris, France
    Am J Hypertens 16:249-58. 2003
    ....
  43. doi request reprint Benefits of the RAS blockade: clinical evidence before the ONTARGET study
    Christine Perret-Guillaume
    Department of Geriatrics, Medical School of Nancy, Nancy, France
    J Hypertens Suppl 27:S3-7. 2009
    ....
  44. ncbi request reprint Creatinine clearance, pulse wave velocity, carotid compliance and essential hypertension
    J J Mourad
    , , Paris, France
    Kidney Int 59:1834-41. 2001
    ....
  45. ncbi request reprint Combined effects of heart rate and pulse pressure on cardiovascular mortality according to age
    F Thomas
    , Paris, France
    J Hypertens 19:863-9. 2001
    ..In women, steady-state stress (evaluated primarily by MAP), but not pulsatile stress, is an important determinant of cardiovascular mortality...
  46. doi request reprint Effects of lean and fat mass on bone mineral density and arterial stiffness in elderly men
    A Benetos
    Department of Medicine and Geriatrics, Brabois Hospital, University Hospital of Nancy, Nancy, France
    Osteoporos Int 20:1385-91. 2009
    ..Our results indicate that elderly men with high lean mass and low fat mass exhibit the best arterial and bone profile with the lowest arterial stiffness and the highest bone mineral density...
  47. ncbi request reprint Cardiovascular mortality in hypertensive men according to presence of associated risk factors
    F Thomas
    , Paris, France
    Hypertension 37:1256-61. 2001
    ..In younger hypertensive subjects, evaluation of CVD risk and therapeutic strategies should target ARFS: In older subjects, the presence of high blood pressure levels seems to be the major determinant of CVD risk...
  48. doi request reprint Comparative study of methodologies for pulse wave velocity estimation
    P Salvi
    Department of Geriatrics, University of Nancy, Nancy, France
    J Hum Hypertens 22:669-77. 2008
    ..The present results indicate the urgent need for evaluation and comparison of the different devices to standardize PWV measurements and establish reference values...
  49. doi request reprint Aortic inflammation, as assessed by hybrid FDG-PET/CT imaging, is associated with enhanced aortic stiffness in addition to concurrent calcification
    Laure Joly
    Department of Geriatric Medicine, CHU Nancy, Nancy, France
    Eur J Nucl Med Mol Imaging 36:979-85. 2009
    ....
  50. ncbi request reprint Genetics of intima-media thickness
    Faiez Zannad
    Department of Cardiovascular Disease, Division of Hypertension and Preventive Cardiology, Equipe d Accueil 3447, Clinical Investigation Center INSERM CHU, University Henri Poincare, Nancy, France
    Curr Opin Lipidol 14:191-200. 2003
    ..The aim of this paper is to review the most recent available data on the genetic determinants of carotid intima-media thickness...
  51. ncbi request reprint Distension capacity of the carotid artery and ambulatory blood pressure monitoring. Effects of age and hypertension
    R S Cunha
    Department of Internal Medicine, Broussais Hospital, Paris, France
    Am J Hypertens 8:343-52. 1995
    ..Thus, in addition to the level of blood pressure, carotid artery distension is specifically influenced by two factors independently implicated in the epidemiologic cardiovascular risk: pulse pressure and heart rate...
  52. ncbi request reprint Positive correlation between the blood pressure and heart rate response to the cold pressor test and the environmental temperature in older hypertensives
    T Postolache
    Department of Internal Medicine, , Paris, France
    Am J Hypertens 6:376-81. 1993
    ..Our findings confirm the higher meteorological dependence of hemodynamics in the elderly, and suggest that the research protocols using the cold pressor test should adjust the response for the previous environmental temperature...
  53. ncbi request reprint Pulse wave velocity as endpoint in large-scale intervention trial. The Complior study. Scientific, Quality Control, Coordination and Investigation Committees of the Complior Study
    R Asmar
    L Institut CardioVasculaire, Paris, France
    J Hypertens 19:813-8. 2001
    ..To evaluate the ability of an antihypertensive therapy to improve arterial stiffness as assessed by aortic pulse wave velocity (PWV) in a large population of hypertensive patients...
  54. ncbi request reprint Life survival and cardiovascular structures following selective beta-blockade in spontaneously hypertensive rats
    A Benetos
    Department of Internal Medicine, Broussais Hospital, Paris, France
    Am J Hypertens 7:186-92. 1994
    ..These results provide evidence that 2 months of selective beta-blockade in adult SHR has an important antihypertrophic cardiac and vascular effect.(ABSTRACT TRUNCATED AT 250 WORDS)..
  55. pmc Tracking and fixed ranking of leukocyte telomere length across the adult life course
    Athanase Benetos
    Geriatric Service, Nancy University Hospital, Nancy, 54511, France Inserm U1116, Faculty of Medicine, Université de Lorraine, Nancy, 54500, France
    Aging Cell 12:615-21. 2013
    ..Accordingly, the links of LTL with atherosclerosis and longevity appear to be established early in life. It is unlikely that lifestyle and its modification during adulthood exert a major impact on LTL ranking. ..
  56. ncbi request reprint Arterial structural changes with verapamil in spontaneously hypertensive rats
    I Koffi
    Department of Internal Medicine and INSERM U337, Broussais Hospital, Paris, France
    Am J Hypertens 12:732-8. 1999
    ....
  57. ncbi request reprint Combined effects of systolic blood pressure and serum cholesterol on cardiovascular mortality in young (<55 years) men and women
    F Thomas
    Center Investigations Preventives et Cliniques IPC, Paris, France
    Eur Heart J 23:528-35. 2002
    ..To evaluate the combined effects of the two most frequent modifiable risk factors, systolic blood pressure and serum cholesterol, on cardiovascular and coronary mortality, in a large French population aged 18 to 55 years...
  58. ncbi request reprint Angiotensin II type 1 receptor-153A/G and 1166A/C gene polymorphisms and increase in aortic stiffness with age in hypertensive subjects
    M Lajemi
    Unité INSERM U337, Institut des Cordeliers, Paris, France
    J Hypertens 19:407-13. 2001
    ..Age is the main determinant responsible for arterial wall changes leading to arterial stiffening. Environmental and genetic factors may however influence the magnitude of the effects of age on large artery stiffness...
  59. ncbi request reprint Effects of valsartan on mechanical properties of the carotid artery in spontaneously hypertensive rats under high-salt diet
    C Labat
    INSERM U337, Paris, France
    Hypertension 38:439-43. 2001
    ..Despite a reduction in mean arterial pressure in HSD rats, AT(1) blockade was not able to prevent the effects of a HSD on pulse pressure, carotid artery stiffness, and hypertrophy...
  60. ncbi request reprint Leisure-time and occupational physical activity in relation to cardiovascular risk factors and eating habits in French adults
    J M Oppert
    Centre d investigations préventives et cliniques IPC, Paris, France
    Public Health Nutr 9:746-54. 2006
    ..To investigate the relationships of two main physical activity domains (during leisure and at work) with cardiovascular risk factors and eating habits...
  61. ncbi request reprint Endothelin gene variants and aortic and cardiac structure in never-treated hypertensives
    M Lajemi
    , Institut des Cordeliers, Paris, France
    Am J Hypertens 14:755-60. 2001
    ..CONCLUSIONS: These results indicate that the influence of endothelin system genes can be detected first on arterial parameters...
  62. ncbi request reprint Response to the cold pressor test in normotensive and hypertensive patients
    A Benetos
    Hypertension Department, Broussais Hospital, Paris, France
    Am J Hypertens 4:627-9. 1991
    ..Therefore it is unlikely that CPT may be used as a predictor test of future hypertension in this population.(ABSTRACT TRUNCATED AT 250 WORDS)..
  63. ncbi request reprint Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients
    S Laurent
    Department of Pharmacology and INSERM U 337, Broussais Hospital, Paris, France
    Hypertension 37:1236-41. 2001
    ..This study provides the first direct evidence that aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in patients with essential hypertension...
  64. ncbi request reprint Vascular effects of intravenous infusion of the angiotensin converting enzyme inhibitor perindoprilat
    A Benetos
    Department of Internal Medicine, Broussais Hospital, Paris, France
    J Hypertens 8:819-26. 1990
    ..01).(abstract truncated at 250 words)..
  65. ncbi request reprint Role of adrenergic tone in mechanical and functional properties of carotid artery during aging
    A Benetos
    Institut National de la Santé et de la Recherche Médicale U 337, Paris, France
    Am J Physiol 265:H1132-8. 1993
    ..We suggest that with aging there is an increased vasoconstricting effect of alpha-agonists and a decreased vasodilatative action of alpha-blockade.(ABSTRACT TRUNCATED AT 250 WORDS)..
  66. ncbi request reprint Pressure-independent contribution of sodium to large artery structure and function in hypertension
    M E Safar
    Department of Internal Medicine and INSERM U337, Broussais Hospital, Paris, France
    Cardiovasc Res 46:269-76. 2000
    ....
  67. pmc Effects of bradykinin B2 receptor antagonism on the hypotensive effects of ACE inhibition
    H Bouaziz
    Department of Internal Medicine, Broussais Hospital, Paris, France
    Br J Pharmacol 113:717-22. 1994
    ..However, the exact mechanism of this interaction remains unclear...
  68. ncbi request reprint [Atrial fibrillation: prevalence, risk factors and mortality in a large French population with 15 years of follow-up]
    Louis Guize
    Centre Investigations Préventives et Cliniques, Paris
    Bull Acad Natl Med 191:791-803; discussion 803-5. 2007
    ..AF was not an independent risk factor for death among men free of cardiopathy and hypertension...
  69. doi request reprint Reference values of aortic pulse wave velocity in the elderly
    Cosmin Alecu
    Geriatric Centre, Brabois Hospital, University of Nancy, Vandoeuvre, France
    J Hypertens 26:2207-12. 2008
    ..There are, however, no generally accepted limits for defining the normal or reference values. The aim of the present study was to define reference values for AoPWV...
  70. pmc Predicting stroke risk in hypertensive patients with coronary artery disease: a report from the INVEST
    Antonio Coca
    Hospital Clinic IDIBAPS, University of Barcelona, Barcelona, Spain
    Stroke 39:343-8. 2008
    ..Accordingly, factors predicting stroke risk in hypertensive, clinically stable coronary artery disease patients were determined with data from the INternational VErapamil SR-trandolapril STudy (INVEST)...
  71. ncbi request reprint Prevalence and determinants of hypertension in the Algerian Sahara
    Mohamed Temmar
    Cardiology Centre, Ghardaia, Algeria
    J Hypertens 25:2218-26. 2007
    ..In-Salah is a city-oasis located in the middle of the Algerian Sahara, a desert area whose drinking water has a high sodium content. No cardiovascular epidemiological studies have ever been conducted in this region...
  72. ncbi request reprint Predictors of adverse outcome among patients with hypertension and coronary artery disease
    Carl J Pepine
    Division of Cardiovascular Medicine, University of Florida, Gainesville, Florida 32610 0277, USA
    J Am Coll Cardiol 47:547-51. 2006
    ..We sought to determine predictors for adverse outcomes in hypertensive patients with coronary artery disease (CAD)...
  73. ncbi request reprint Prognostic value of systolic and diastolic blood pressure in treated hypertensive men: clarification
    Athanase Benetos
    Arch Intern Med 163:121. 2003
  74. ncbi request reprint From 24-hour blood pressure measurements to arterial stiffness: a valid short cut?
    Athanase Benetos
    Hypertension 47:327-8. 2006
  75. ncbi request reprint Does blood pressure control contribute to a more successful aging?
    Athanase Benetos
    Hypertension 46:261-2. 2005
  76. ncbi request reprint Validation of a new non-invasive portable tonometer for determining arterial pressure wave and pulse wave velocity: the PulsePen device
    Paolo Salvi
    Department of Internal Medicine, Bufalini Hospital, Cesena, Italy
    J Hypertens 22:2285-93. 2004
    ..Its software provides absolute arterial pressure values, an assessment of arterial pulse wave contours, an estimation of reflection waves and measurements of PWV...
  77. ncbi request reprint Selective reduction of heart rate by ivabradine: effect on the visco-elastic arterial properties in rats
    Pierre Albaladejo
    Department of Anesthesiology, Beaujon Hospital, Clichy, France
    J Hypertens 22:1739-45. 2004
    ..The heart rate (HR) reduction obtained by ivabradine is associated in rats with a decrease in diastolic blood pressure (DBP) and mean blood pressure (MBP), and with an increased pulsatile carotid arterial diameter...
  78. ncbi request reprint Carotid plaques, but not common carotid intima-media thickness, are independently associated with aortic stiffness
    Mahmoud Zureik
    National Institute of Health and Medical Research INSERM, Unit 258, Hopital Paul Brousse, 16 av Paul Vaillant Couturier, 94807 Villejuif Cedex, France
    J Hypertens 20:85-93. 2002
    ..The present study reports the associations of carotid arterial structure assessed by B-mode ultrasound with carotid-femoral pulse-wave velocity in hypertensive and non-hypertensive subjects...
  79. ncbi request reprint Aortic pulse pressure is related to the presence and extent of coronary artery disease in men undergoing diagnostic coronary angiography: a multicenter study
    Nicolas Danchin
    Department of Cardiology, Hopital Europeen Georges Pompidou, 20 rue Leblanc, 75015 Paris, France
    Am J Hypertens 17:129-33. 2004
    ..In the general population, pulse pressure (PP) is a correlate of cardiovascular outcomes. Few data are available regarding the links between PP and documented coronary artery disease (CAD)...
  80. ncbi request reprint Echogenic carotid plaques are associated with aortic arterial stiffness in subjects with subclinical carotid atherosclerosis
    Mahmoud Zureik
    National Institutes of Health and Medical Research Unit 258, Hopital Paul Brousse, 16 av Paul Vaillant Couturier, 94807 Villejuif Cedex, France
    Hypertension 41:519-27. 2003
    ..Assessment of the joint and interaction effects of plaque morphology and arterial stiffness on the occurrence of cardiovascular events would permit a better identification of high-risk subjects...
  81. ncbi request reprint Resting heart rate in older people: a predictor of survival to age 85
    Athanase Benetos
    J Am Geriatr Soc 51:284-5. 2003
  82. ncbi request reprint Identification and management of the hypertensive patient with elevated heart rate: statement of a European Society of Hypertension Consensus Meeting
    Paolo Palatini
    Department of Clinical and Experimental Medicine, University of Padova, Padua, Italy
    J Hypertens 24:603-10. 2006
  83. ncbi request reprint Impaired arterial elasticity in young patients with white-coat hypertension
    Daniele Longo
    Clinica Medica 4, University of Padova, Town Hospital, San Daniele del Friuli, Vittorio Veneto, Italy
    Blood Press Monit 11:243-9. 2006
    ..Conflict still exists over whether patients with white-coat hypertension are at increased risk of developing target organ damage compared with normotensive individuals...
  84. ncbi request reprint Dogma disputed: can aggressively lowering blood pressure in hypertensive patients with coronary artery disease be dangerous?
    Franz H Messerli
    Division of Cardiology, St Luke s Roosevelt Hospital, New York, New York 10019, USA
    Ann Intern Med 144:884-93. 2006
    ..Because coronary perfusion occurs mainly during diastole, patients with coronary artery disease (CAD) could be at increased risk for coronary events if diastolic pressure falls below critical levels...
  85. ncbi request reprint Clinical determinants of failure in balance tests in elderly subjects
    Patrick Manckoundia
    Departement de Medecine Interne, Centre de Geriatrie et Medecine Interne, Hôpital de Brabois CHU de Nancy, Rue de Morvan, 54511 Vandoeuvre les Nancy, France
    Arch Gerontol Geriatr 47:217-28. 2008
    ..Similar results were found for STS. In conclusion, female sex, overweight, low cognitive status, low self-perception of health and UPD were associated with a higher risk of failure in balance tests...
  86. ncbi request reprint Influence of sex on the relation between heart rate and aortic stiffness
    Pierre Albaladejo
    Hopital Beaujon, Clichy, France
    J Hypertens 21:555-62. 2003
    ..The aim of this study was to evaluate the influence of sex on the heart rate-PWV relationship in two populations of normotensive and hypertensive men and women...
  87. ncbi request reprint [Risk factors for Alzheimer: towards prevention?]
    Thomas Vogel
    Pôle de gériatrie, Hôpital de la Robertsau, Strasbourg
    Presse Med 35:1309-16. 2006
    ..These epidemiologic data raise questions about the diagnostic boundaries between AD and vascular dementia. Additional studies are needed to validate these concepts and to confirm the possible benefits of preventive measures...
  88. doi request reprint Chronic oxidative stress induces a tissue-specific reduction in telomere length in CAST/Ei mice
    Valerie Cattan
    INSERM, U684, 54500 Vandoeuvre les Nancy, France
    Free Radic Biol Med 44:1592-8. 2008
    ..The variable effect of BSO treatment on telomere length in different tissue may result from their different adaptive antioxidative capacity...
  89. ncbi request reprint Pulse pressure and arterial stiffness in type 1 diabetic patients
    Athanase Benetos
    J Hypertens 21:2005-7. 2003
  90. ncbi request reprint White blood cells telomere length is shorter in males with type 2 diabetes and microalbuminuria
    Nicholas Tentolouris
    First Department of Propaedeutic Medicine, Athens University Medical School, Laiko Hospital, Athens, Greece
    Diabetes Care 30:2909-15. 2007
    ..To examine differences in telomere (terminal restriction fragment [TRF]) length and pulse wave velocity (PWV)--an index of arterial stiffness--in patients with type 2 diabetes with and without microalbuminuria (MA)...
  91. ncbi request reprint Impact of clinical, psychological, and social factors on decreased Tinetti test score in community-living elderly subjects: a prospective study with two-year follow-up
    Patrick Manckoundia
    Department of Geriatrics and Internal Medicine, Hospital of Brabois, University Hospital, Vandoeuvre les Nancy, France
    Med Sci Monit 14:CR316-322. 2008
    ..The objective of this study was to analyze the impact of demographic, social, clinical, psychological, and biological parameters on the decline in balance and gait assessed by the Tinetti test (TT) after a two-year follow-up...
  92. ncbi request reprint Relation of depressive mood to plasminogen activator inhibitor, tissue plasminogen activator, and fibrinogen levels in patients with versus without coronary heart disease
    Khadija Lahlou-Laforet
    Department of C L Psychiatry, Faculte de Medecine, Universite Paris Descartes, AP HP, Hopital Europeen Georges Pompidou, France
    Am J Cardiol 97:1287-91. 2006
    ....
  93. ncbi request reprint Pathophysiology of hypertension in the elderly
    Stephane Laurent
    Department of Pharmacology, EMI U 0107 Inserm, Hopital Europeen Georges Pompidou, 20 rue Leblanc, 75015 Paris, France
    Am J Geriatr Cardiol 11:34-9. 2002
    ..In this elderly population, further research is needed concerning the pathophysiology, epidemiology, and pharmacology of hypertension...
  94. ncbi request reprint Total cholesterol and life expectancy in the elderly
    Athanase Benetos
    J Hypertens 23:2327. 2005
  95. ncbi request reprint Aldosterone and telomere length in white blood cells
    Athanase Benetos
    INSERM Unit 684, University of Nancy, 54511 Nancy les Vandoeuvre, France
    J Gerontol A Biol Sci Med Sci 60:1593-6. 2005
    ..The aim of the present study was, therefore, to examine the relationship between plasma aldosterone and telomere length in WBCs...
  96. doi request reprint Five times sit to stand test is a predictor of recurrent falls in healthy community-living subjects aged 65 and older
    Severine Buatois
    J Am Geriatr Soc 56:1575-7. 2008
  97. ncbi request reprint Posturography and risk of recurrent falls in healthy non-institutionalized persons aged over 65
    Severine Buatois
    Balance Control and Motor Performance, UFR STAPS, Henri Poincaré University Nancy 1, Villers les Nancy, France
    Gerontology 52:345-52. 2006
    ..A poor postural stability in older people is associated with an increased risk of falling. The posturographic tool has widely been used to assess balance control; however, its value in predicting falls remains unclear...
  98. ncbi request reprint Impact of increased heart rate on clinical outcomes in hypertension: implications for antihypertensive drug therapy
    Paolo Palatini
    Department of Clinical and Experimental Medicine, University of Padova, Padova, Italy
    Drugs 66:133-44. 2006
    ..Unfortunately, lowering of the heart rate is not a clinically recognised goal. Prospective trials investigating whether treatment of high heart rate can prevent cardiovascular events, notably in hypertensive patients, are warranted...