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Species | Alain BeckSummaryAffiliation: Centre de Recherche Pierre Fabre Country: France Publications
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Publications
The next generation of antibody-drug conjugates comes of ageAlain Beck
Department of Physico Chemistry, Centre d Immunologie Pierre Fabre CIPF, St Julien en Genevois 74164, France
Discov Med 10:329-39. 2010..Several examples of ADCs are presented with emphasis on three major molecules currently in late clinical development as well as next generation thio-mAbs conjugates with improved therapeutic index...
Biosimilar, biobetter, and next generation antibody characterization by mass spectrometryAlain Beck
Centre d Immunologie Pierre Fabre CIPF, 5 Av Napoleon III, BP 60497, 74164 Saint Julien en Genevois, France
Anal Chem 84:4637-46. 2012..In addition, the structural and functional insights gained both by state-of-the art and emerging MS methods used for biobetters and next generation antibodies design and optimization will also be highlighted...- GlycoFi's technology to control the glycosylation of recombinant therapeutic proteinsAlain Beck
Centre d Immunologie Pierre Fabre, 5 Avenue Napoleon III, F74160, Saint Julien en Genevois, France 33 4 50 35 35 55 33 4 50 35 35 90 www cipf com
Expert Opin Drug Discov 5:95-111. 2010..These properties associated with the perspective to industrialize the manufacturing process of Pichia makes it a very promising expression system to produce large-scale batches of therapeutics at a lower cost... - Trends in glycosylation, glycoanalysis and glycoengineering of therapeutic antibodies and Fc-fusion proteinsAlain Beck
Centre d Immunologie Pierre Fabre, 5 Avenue Napoleon III, F74160, Saint Julien en Genevois, France
Curr Pharm Biotechnol 9:482-501. 2008.... - Peptides as tools and drugs for immunotherapiesAlain Beck
Centre d Immunologie Pierre Fabre, 5 Avenue Napoleon III, F74164 Saint Julien en Genevois, Cedex, France
J Pept Sci 13:588-602. 2007.... - [Therapeutic antibodies and related products: choosing the right structure for success]Alain Beck
Centre d immunologie Pierre Fabre www cipf com, 5, Avenue Napoleon III, 74160 Saint Julien en Genevois, France
Med Sci (Paris) 25:1024-32. 2009..Based on the current knowledge, choosing the right antibody format, isotype and glycosylation profile are some of the key issues to address early during the lead selection... - Stability and CTL-activity of P40/ELA melanoma vaccine candidateA Beck
Centre d Immunologie Pierre Fabre CIPF, bioMérieux Pierre Fabre, 5 Avenue Napoleon III, F 74164 Saint Julien en Genevois, France
Biologicals 29:293-8. 2001..We report here that the hydrochloride shows a higher stability than the acetate and may be suitable for use in man... - Characterization by liquid chromatography combined with mass spectrometry of monoclonal anti-IGF-1 receptor antibodies produced in CHO and NS0 cellsAlain Beck
Centre d Immunologie Pierre Fabre, 5 Avenue Napoleon III, 74160 Saint Julien en Genevois, France
J Chromatogr B Analyt Technol Biomed Life Sci 819:203-18. 2005.... - Strategies and challenges for the next generation of therapeutic antibodiesAlain Beck
Centre d Immunologie Pierre Fabre CIPF, 5 Avenue Napoleon III, F74160, Saint Julien en Genevois, France
Nat Rev Immunol 10:345-52. 2010..Here, we discuss strategies to select the best therapeutic antigen targets, to optimize the structure of IgG antibodies and to design related or new structures with additional functions... - Antibody Engineering & Design 2010. 24-25 February 2010, Frankfurt, GermanyAlain Beck
Centre d Immunologie Pierre Fabre, 5 Avenue Napoleon III, 74160 Saint Julien en Genevois, France
IDrugs 13:295-9. 2010..Investigational drugs discussed include 1D4.1-ABT325 (Abbott Laboratories), Sym-004 (Symphogen A/S) and CNTO-607 (Johnson & Johnson)... 
World Antibody Drug Conjugate Summit Europe: February 21-23, 2011; Frankfurt, GermanyAlain Beck
Centre d Immunologie Pierre Fabre, Saint Julien en Genevois, France
MAbs 3:331-7. 2011..In addition, presentations on duocarmycin based-ADCs, alpha emitting immunoconjugates and antibody-conjugated nanoparticles were given by representatives from Syntarga, Algeta and the University of Stuttgart, respectively...- Stability and CTL activity of N-terminal glutamic acid containing peptidesA Beck
Centre d Immunologie Pierre Fabre CIPF, Saint Julien en Genevois, France
J Pept Res 57:528-38. 2001.... - 6th Annual European Antibody Congress 2010: November 29-December 1, 2010, Geneva, SwitzerlandAlain Beck
Physio Chemistry Department, Centre d Immunologie Pierre Fabre, Saint Julien en Genevois, France
MAbs 3:111-32. 2011.... - Synthesis and characterization of Respiratory Syncytial Virus protein G related peptides containing two disulfide bridgesA Beck
Department of Physical Chemistry, Center d Immunologie Pierre Fabre, Saint Julien en Genevois, France
J Pept Res 55:24-35. 2000.... - Passive transfer of serum antibodies induced by BBG2Na, a subunit vaccine, in the elderly protects SCID mouse lungs against respiratory syncytial virus challengeHelene Plotnicky-Gilquin
Centre d Immunologie Pierre Fabre, 5 Av Napoleon III, F74 164, Saint Julien en Genevois, France
Virology 303:130-7. 2002..Thus, BBG2Na is immunogenic in the elderly and confers passive protection in mice after serum transfer. To our knowledge, this is the first description of protective Abs induced by a subunit vaccine in human... - CD4(+) T-cell-mediated antiviral protection of the upper respiratory tract in BALB/c mice following parenteral immunization with a recombinant respiratory syncytial virus G protein fragmentH Plotnicky-Gilquin
Centre d Immunologie Pierre Fabre, 74 164 St Julien en Genevois, France
J Virol 74:3455-63. 2000..Taken together, these results demonstrate for the first time that CD4(+) T cells induced upon parenteral immunization with an RSV G protein fragment play a critical role in URT protection of normal mice against RSV infection... - The way forward, enhanced characterization of therapeutic antibody glycosylation: comparison of three level mass spectrometry-based strategiesElsa Wagner-Rousset
Centre d Immunologie Pierre Fabre, 5 Avenue Napoleon III, 74160 Saint Julien en Genevois, France
J Chromatogr B Analyt Technol Biomed Life Sci 872:23-37. 2008.... - Gamma interferon-dependent protection of the mouse upper respiratory tract following parenteral immunization with a respiratory syncytial virus G protein fragmentHelene Plotnicky-Gilquin
Centre d Immunologie Pierre Fabre, F74164 Saint Julien en Genevois, France
J Virol 76:10203-10. 2002..Together, these results demonstrated for the first time that the T-helper-cell epitope of RSV G protein induces URT protection in mice after parenteral immunization through a Th1-type, IFN-gamma-dependent mechanism... - [Immunoconjugates, drug-armed antibodies to fight against cancer]Jean Francois Haeuw
Centre d Immunologie Pierre Fabre, 5, Avenue Napoleon III, BP 60497, 74160 Saint Julien en Genevois, France jean francois haeuw pierre fabre com
Med Sci (Paris) 25:1046-52. 2009..Today, we know that the efficacy of an immunoconjugate depends not only on the coupled cytotoxic agent, but also on the selected target, the coupling method and the linker... - Synthesis, refolding and protective immune responses of a potential antigen for human Respiratory Syncytial Virus vaccineC Klinguer-Hamour
Centre d'Immunologie Pierre Fabre, , BP 497, F-74164 Saint-Julien-en-Genevois, France
J Pept Res 62:27-36. 2003..Interestingly, we showed in the present study that G20 generated a highly protective antibody response against RSV challenge in Balb/c mice. Therefore, G20 represents a new potential antigen for an RSV vaccine... - Lipophilic quaternary ammonium salt acts as a mucosal adjuvant when co-administered by the nasal route with vaccine antigensC Klinguer
, Centre d'Immunologie Pierre Fabre, , B.P. 497, St. Julien en Genevois, France
Vaccine 19:4236-44. 2001..Furthermore, we provide evidence that the DDA+BBG2Na vaccine does not induce lung immunopathology upon subsequent RSV challenge... - [Monoclonal antibodies for treating infectious diseases]Christine Klinguer-Hamour
Centre d Immunologie Pierre Fabre, 5, Avenue Napoleon III, BP 60497, 74160 Saint Julien en Genevois, France
Med Sci (Paris) 25:1116-20. 2009..The synergies obtained using combinations of anti-infectious mAb and small molecule drugs will certainly offer new opportunities for the treatment of infectious diseases... - A recombinant humanized anti-insulin-like growth factor receptor type I antibody (h7C10) enhances the antitumor activity of vinorelbine and anti-epidermal growth factor receptor therapy against human cancer xenograftsLiliane Goetsch
Centre d Immunologie Pierre Fabre, 5 Avenue Napoleon III, 74160, St Julien en Genevois, France
Int J Cancer 113:316-28. 2005.... - Targeting of nasal mucosa-associated antigen-presenting cells in vivo with an outer membrane protein A derived from Klebsiella pneumoniaeL Goetsch
Centre d Immunologie Pierre Fabre, 74164 Saint Julien en Genevois, France
Infect Immun 69:6434-44. 2001..n. immunization with a subunit of the RSV-A molecule in the absence of any mucosal adjuvant results in both upper and lower respiratory tract protection against RSV-A infection... - The recombinant Klebsiella pneumoniae outer membrane protein OmpA has carrier properties for conjugated antigenic peptidesJ F Haeuw
Centre d Immunologie Pierre Fabre, Saint Julien en Genevois, France
Eur J Biochem 255:446-54. 1998.... - Development of a quantitative assay for residual host cell proteins in a recombinant subunit vaccine against human respiratory syncytial virusN Dagouassat
Centre d Immunologie Pierre Fabre CIPF, 5 Avenue Napoleon III, B P 497, F 74164, Saint Julien en Genevois, France
J Immunol Methods 251:151-9. 2001..The quantification limit was 1.3 ng/ml of HCP, giving a sensitivity range of the assay of 10 to 30 ppm. To our knowledge, this is the first sensitive HCP assay reported for a vaccine... - Identification and characterisation of multiple linear B cell protectopes in the respiratory syncytial virus G proteinU F Power
Centre d Immunologie Pierre Fabre, 74164 Cedex, Saint Julien en Genevois, France
Vaccine 19:2345-51. 2001..However, all the identified murine B cell protectopes were conserved in RSV seropositive humans. Should these protectopes correspond with protection in humans, BBG2Na may constitute a very interesting vaccine candidate against RSV... - Safety and immunogenicity of a novel recombinant subunit respiratory syncytial virus vaccine (BBG2Na) in healthy young adultsU F Power
Centre d Immunologie Pierre Fabre, Saint Julien en Genevois, France
J Infect Dis 184:1456-60. 2001..Antibody responses to 2 murine lung protective epitopes were also highly boosted after vaccination. Therefore, BBG2Na is safe, well tolerated, and highly immunogenic in RSV-seropositive adults... - Development of novel protein scaffolds as alternatives to whole antibodies for imaging and therapy: status on discovery research and clinical validationT Wurch
Centre d Immunologie Pierre Fabre, F74164 Saint Julien en Genevois, France
Curr Pharm Biotechnol 9:502-9. 2008.... - The immunodominant influenza matrix T cell epitope recognized in human induces influenza protection in HLA-A2/K(b) transgenic miceH Plotnicky
Centre d Immunologie Pierre Fabre, 5, Av Napoléon III, 74 164, St Julien en Genevois, France
Virology 309:320-9. 2003..They encourage further in vivo evaluation of T cell epitopes recognized in the context of human MHC molecules... - Insulin-like growth factor receptor type I as a target for cancer therapyNathalie Corvaia
Centre d Immunologie Pierre Fabre, Saint Julien en Genevois, France
Front Biosci (Schol Ed) 5:439-50. 2013..This review will provide an overview of the current knowledge on IGF-IR axis for development of novel therapeutics in Oncology... - Residual DNA quantification in clinical batches of BBG2Na, a recombinant subunit vaccine against human respiratory syncytial virusM Lokteff
Centre d'Immunologie Pierre Fabre, , Saint-Julien-en-Genevois, F-74164, France
Biologicals 29:123-32. 2001..This study also provides data concerning the validation of the hybridisation dot blot assay and the total DNA Threshold(trade mark)assay... - Streptococcus pneumoniae polysaccharides conjugated to the outer membrane protein A from Klebsiella pneumoniae elicit protective antibodiesChristine Libon
Centre d Immunologie Pierre Fabre, 5 Avenue Napoleon III, St Julien en Genevois, France
Vaccine 20:2174-80. 2002..In addition, the humoral response generated is able to protect mice from a bacterial challenge. Our results indicate that P40 could be included in the development of new PS conjugate vaccines... - Structure-antigenicity relationship studies of the central conserved region of human respiratory syncytial virus protein GM Sugawara
Institut de Pharmacologie et de Biologie Structurale--Centre National de la Recherche Scientifique, Toulouse, France
J Pept Res 60:271-82. 2002.... - Ribosomal proteins and DNA-binding protein II from the extreme thermophile Bacillus caldolyticusA Beck
Biol Chem Hoppe Seyler 368:121-30. 1987..Tetragonal and monoclinic crystals of DNA-binding protein II have been obtained which are suitable for X-ray studies and the diffraction patterns of the two crystal forms are shown... - A novel bipolar mode of attachment to aluminium-containing adjuvants by BBG2Na, a recombinant subunit hRSV vaccineN Dagouassat
, Centre d'Immunologie Pierre-Fabre, , BP 497, F74164, Saint-Julien-en-Genevois, France
Vaccine 19:4143-52. 2001..From a physicochemical point of view, this unique property of BBG2Na makes it eminently suitable for combination to either paediatric or elderly multivalent AH- or AP-containing vaccines already in the market or in development... - Genetic immunization and comprehensive screening approaches in HLA-A2 transgenic mice lead to the identification of three novel epitopes in hepatitis C virus NS3 antigenP Martin
, IFR 128 BioSciences Lyon-Gerland, Lyon, France
J Med Virol 74:397-405. 2004..These data increase the pool of NS3-specific CD8+ T cell epitopes available to analyze HCV associated immunity and could contribute to the design and evaluation of candidate vaccines... - Diagnostic utility of FLI-1 monoclonal antibody and dual-colour, break-apart probe fluorescence in situ (FISH) analysis in Ewing's sarcoma/primitive neuroectodermal tumour (EWS/PNET). A comparative study with CD99 and FLI-1 polyclonal antibodiesP Mhawech-Fauceglia
Department of Pathology and Laboratory Medicine, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
Histopathology 49:569-75. 2006.... - Local permutations in the glomerular array of the mouse olfactory bulbJ Strotmann
The Rockefeller University, New York, New York 10021, USA
J Neurosci 20:6927-38. 2000..These local permutations may reflect the developmental history of the glomeruli and are relevant for the construction of spatial odor maps... - New angiographic measurement tool for analysis of small cerebral vessels: application to a subarachnoid haemorrhage model in the ratB Turowski
Institute of Diagnostic Radiology, Neuroradiology, Heinrich Heine University, Moorenstr 5, 40225 Duesselorf, Germany
Neuroradiology 49:129-37. 2007..The purpose of the study was to develop a new method for computerized analysis of small arteries and to demonstrate feasibility on cerebral angiographies of rats acquired on a clinical angiography unit... - FGFR3 and p53 protein expressions in patients with pTa and pT1 urothelial bladder cancerP Mhawech-Fauceglia
Department of Pathology and Laboratory Medicine, Roswell Park Cancer Institute, Elm and Carlton Street, Buffalo, NY 14263, USA
Eur J Surg Oncol 32:231-7. 2006.... - A novel polyarginine containing Smac peptide conjugate that mediates cell death in tumor and healthy cellsS Heckl
Department of Neuroradiology, University of Tubingen, Medical School, Tubingen, Germany
Med Chem 4:348-54. 2008..This was accompanied by cell death. In contrast to expectations, it appears that the apoptotic effects observed do not result from the SmacN7 cargo alone...