L Bardin

Summary

Affiliation: Centre de Recherche Pierre Fabre
Country: France

Publications

  1. ncbi Pharmacological profiles in rats of novel antipsychotics with combined dopamine D2/serotonin 5-HT1A activity: comparison with typical and atypical conventional antipsychotics
    Laurent Bardin
    Division of Neurobiology, Pierre Fabre Research Centre, Castres, France
    Behav Pharmacol 18:103-18. 2007
  2. doi The complex role of serotonin and 5-HT receptors in chronic pain
    Laurent Bardin
    Division of Neurobiology 2, Centre de Recherche Pierre Fabre, Castres, France
    Behav Pharmacol 22:390-404. 2011
  3. doi Comparison of milnacipran, duloxetine and pregabalin in the formalin pain test and in a model of stress-induced ultrasonic vocalizations in rats
    L Bardin
    Division of Neurobiology 2, Centre de Recherche Pierre Fabre, 17, avenue Jean Moulin, 81106 Castres, France
    Neurosci Res 66:135-40. 2010
  4. ncbi Antipsychotic-like vs cataleptogenic actions in mice of novel antipsychotics having D2 antagonist and 5-HT1A agonist properties
    Laurent Bardin
    Division of Neurobiology 2, Centre de Recherche Pierre Fabre, Castres, France
    Neuropsychopharmacology 31:1869-79. 2006
  5. doi Chronic restraint stress induces mechanical and cold allodynia, and enhances inflammatory pain in rat: Relevance to human stress-associated painful pathologies
    L Bardin
    Division of Neurobiology 2, Centre de Recherche Pierre Fabre, 17, avenue Jean Moulin, 81106 Castres, France
    Behav Brain Res 205:360-6. 2009
  6. ncbi Dual, hyperalgesic, and analgesic effects of the high-efficacy 5-hydroxytryptamine 1A (5-HT1A) agonist F 13640 [(3-chloro-4-fluoro-phenyl)-[4-fluoro-4-{[(5-methyl-pyridin-2-ylmethyl)-amino]-methyl}piperidin-1-yl]methanone, fumaric acid salt]: relationship
    Laurent Bardin
    Department of General Pharmacology, Centre de Recherche Pierre Fabre, 17 avenue Jean Moulin, 81106 Castres Cedex, France
    J Pharmacol Exp Ther 312:1034-42. 2005
  7. ncbi Role of spinal 5-HT(1A) receptors in morphine analgesia and tolerance in rats
    Laurent Bardin
    Centre de Recherche Pierre Fabre, 17 avenue Jean Moulin, Castres Cédex F 81106, France
    Eur J Pain 8:253-61. 2004
  8. ncbi Profound, non-opioid analgesia produced by the high-efficacy 5-HT(1A) agonist F 13640 in the formalin model of tonic nociceptive pain
    L Bardin
    Centre de Recherche Pierre Fabre, 17 avenue Jean Moulin, F 81106 Castres Cedex, France
    Pharmacology 67:182-94. 2003
  9. pmc F15063, a compound with D2/D3 antagonist, 5-HT 1A agonist and D4 partial agonist properties. II. Activity in models of positive symptoms of schizophrenia
    R Depoortere
    Division of Neurobiology 2, Centre de Recherche Pierre Fabre, Castres, France
    Br J Pharmacol 151:253-65. 2007
  10. ncbi Large-amplitude 5-HT1A receptor activation: a new mechanism of profound, central analgesia
    F C Colpaert
    Centre de Recherche Pierre Fabre, 17, avenue Jean Moulin, 81106 Castres Cedex, France
    Neuropharmacology 43:945-58. 2002

Detail Information

Publications21

  1. ncbi Pharmacological profiles in rats of novel antipsychotics with combined dopamine D2/serotonin 5-HT1A activity: comparison with typical and atypical conventional antipsychotics
    Laurent Bardin
    Division of Neurobiology, Pierre Fabre Research Centre, Castres, France
    Behav Pharmacol 18:103-18. 2007
    ....
  2. doi The complex role of serotonin and 5-HT receptors in chronic pain
    Laurent Bardin
    Division of Neurobiology 2, Centre de Recherche Pierre Fabre, Castres, France
    Behav Pharmacol 22:390-404. 2011
    ....
  3. doi Comparison of milnacipran, duloxetine and pregabalin in the formalin pain test and in a model of stress-induced ultrasonic vocalizations in rats
    L Bardin
    Division of Neurobiology 2, Centre de Recherche Pierre Fabre, 17, avenue Jean Moulin, 81106 Castres, France
    Neurosci Res 66:135-40. 2010
    ..To summarize, reduction of formalin-induced paw licking/late phase might constitute a useful indicator of potential activity against inflammatory/centrally sensitized pain, as might be expressed in fibromyalgia...
  4. ncbi Antipsychotic-like vs cataleptogenic actions in mice of novel antipsychotics having D2 antagonist and 5-HT1A agonist properties
    Laurent Bardin
    Division of Neurobiology 2, Centre de Recherche Pierre Fabre, Castres, France
    Neuropsychopharmacology 31:1869-79. 2006
    ..Further, they indicate that the balance of affinity and/or efficacy between D2 and 5-HT1A receptors profoundly influences their pharmacological activities, and will likely impact their therapeutic profiles...
  5. doi Chronic restraint stress induces mechanical and cold allodynia, and enhances inflammatory pain in rat: Relevance to human stress-associated painful pathologies
    L Bardin
    Division of Neurobiology 2, Centre de Recherche Pierre Fabre, 17, avenue Jean Moulin, 81106 Castres, France
    Behav Brain Res 205:360-6. 2009
    ....
  6. ncbi Dual, hyperalgesic, and analgesic effects of the high-efficacy 5-hydroxytryptamine 1A (5-HT1A) agonist F 13640 [(3-chloro-4-fluoro-phenyl)-[4-fluoro-4-{[(5-methyl-pyridin-2-ylmethyl)-amino]-methyl}piperidin-1-yl]methanone, fumaric acid salt]: relationship
    Laurent Bardin
    Department of General Pharmacology, Centre de Recherche Pierre Fabre, 17 avenue Jean Moulin, 81106 Castres Cedex, France
    J Pharmacol Exp Ther 312:1034-42. 2005
    ..These results demonstrate that F 13640 induces hyperalgesia and/or analgesia with a time course that parallels the occupancy of 5-HT(1A) receptors and the presence of the compound in blood and brain...
  7. ncbi Role of spinal 5-HT(1A) receptors in morphine analgesia and tolerance in rats
    Laurent Bardin
    Centre de Recherche Pierre Fabre, 17 avenue Jean Moulin, Castres Cédex F 81106, France
    Eur J Pain 8:253-61. 2004
    ..These findings demonstrate that 5-HT(1A) receptor agonists can act in the spinal cord to produce both hyper- and hypo-algesic effects and play a major role in the opioid analgesia and tolerance...
  8. ncbi Profound, non-opioid analgesia produced by the high-efficacy 5-HT(1A) agonist F 13640 in the formalin model of tonic nociceptive pain
    L Bardin
    Centre de Recherche Pierre Fabre, 17 avenue Jean Moulin, F 81106 Castres Cedex, France
    Pharmacology 67:182-94. 2003
    ....
  9. pmc F15063, a compound with D2/D3 antagonist, 5-HT 1A agonist and D4 partial agonist properties. II. Activity in models of positive symptoms of schizophrenia
    R Depoortere
    Division of Neurobiology 2, Centre de Recherche Pierre Fabre, Castres, France
    Br J Pharmacol 151:253-65. 2007
    ..Here, the profile of F15063 was evaluated in models of positive symptoms of schizophrenia and motor side-effects...
  10. ncbi Large-amplitude 5-HT1A receptor activation: a new mechanism of profound, central analgesia
    F C Colpaert
    Centre de Recherche Pierre Fabre, 17, avenue Jean Moulin, 81106 Castres Cedex, France
    Neuropharmacology 43:945-58. 2002
    ....
  11. ncbi In the formalin model of tonic nociceptive pain, 8-OH-DPAT produces 5-HT1A receptor-mediated, behaviorally specific analgesia
    L Bardin
    Centre de Recherche Pierre Fabre, 17 avenue Jean Moulin, F 81106 Cedex, Castres, France
    Eur J Pharmacol 421:109-14. 2001
    ..e., forepaw treading) of the 5-HT syndrome which 8-OH-DPAT also induces...
  12. ncbi The novel analgesic, F 13640, produces intra- and postoperative analgesia in a rat model of surgical pain
    Ivan Kiss
    Klinik für Anästhesie, Intensivmedizin und Schmerztherapie, Alfried Krupp Krankenhaus, 45117 Essen, Germany
    Eur J Pharmacol 523:29-39. 2005
    ..Unlike the opioid, remifentanil, F 13640 caused no hyperalgesia with ongoing postoperative pain, and should remain effective with protracted postoperative use...
  13. pmc F15063, a compound with D2/D3 antagonist, 5-HT 1A agonist and D4 partial agonist properties. III. Activity in models of cognition and negative symptoms
    R Depoortere
    Division of Neurobiology 2, Centre de Recherche Pierre Fabre, Castres, France
    Br J Pharmacol 151:266-77. 2007
    ..However F15063 induced neither catalepsy nor the 'serotonin syndrome'. Here, we evaluated its profile in rat models predictive of efficacy against negative symptoms/cognitive deficits of schizophrenia...
  14. pmc 5-HT1A receptors are involved in the effects of xaliproden on G-protein activation, neurotransmitter release and nociception
    J C Martel
    Division of Neurobiology 2, Centre de Recherche Pierre Fabre, Castres, France
    Br J Pharmacol 158:232-42. 2009
    ..The present study investigated its profile on in vitro transduction, neurochemical responses and acute nociceptive pain tests in rats...
  15. doi Levomilnacipran (F2695), a norepinephrine-preferring SNRI: profile in vitro and in models of depression and anxiety
    A L Auclair
    Neuropsychopharmacology Division, Centre de Recherche Pierre Fabre, 17 avenue Jean Moulin, 81106 Castres, France
    Neuropharmacology 70:338-47. 2013
    ..It is efficacious in models of anti-depressive/anti-stress activity, with minimal potential for locomotor side effects...
  16. doi Apomorphine-induced emesis in dogs: differential sensitivity to established and novel dopamine D2/5-HT(1A) antipsychotic compounds
    Ronan Depoortere
    Division of Neurobiology 2, Centre de Recherche Pierre Fabre, 17, avenue Jean Moulin, 81106 Castres, France
    Eur J Pharmacol 597:34-8. 2008
    ..This model can thus be advantageously used to investigate the pharmacological activity of novel D2 receptor antagonists/partial agonists in dogs...
  17. doi Penile erection and yawning induced by dopamine D2-like receptor agonists in rats: influence of strain and contribution of dopamine D2, but not D3 and D4 receptors
    Ronan Depoortere
    Division of Neurobiology 2, Centre de Recherche Pierre Fabre, Castres, France
    Behav Pharmacol 20:303-11. 2009
    ..5 mg/kg). The present data do not support a major implication of either DA D3 or D4 receptors in the control of PE and YA in rats, but indicate a preponderant role of DA D2 receptors...
  18. doi The antipsychotics clozapine and olanzapine increase plasma glucose and corticosterone levels in rats: comparison with aripiprazole, ziprasidone, bifeprunox and F15063
    Marie Bernadette Assié
    Neurobiology II Division, Centre de Recherche Pierre Fabre, 17 avenue Jean Moulin, 81106 Castres Cedex, France
    Eur J Pharmacol 592:160-6. 2008
    ....
  19. doi Effects of antipsychotics and reference monoaminergic ligands on marble burying behavior in mice
    Liesbeth A Bruins Slot
    Department of Cellular and Molecular Biology bDivision of Neurobiology 2, Pierre Fabre Research Centre, Castres Cedex, France
    Behav Pharmacol 19:145-52. 2008
    ..Inhibition of marble burying behavior may result from the interplay of several receptor systems, including 5-HT2 receptor blockade, dopamine D2 partial agonism and serotonin 5-HT1A agonism...
  20. doi F15599, a preferential post-synaptic 5-HT1A receptor agonist: activity in models of cognition in comparison with reference 5-HT1A receptor agonists
    Ronan Depoortere
    Neurobiology 2 Division, Centre de Recherche Pierre Fabre, 17, avenue Jean Moulin, 81106 Castres, France
    Eur Neuropsychopharmacol 20:641-54. 2010
    ..This suggests that preferential activation of post-synaptic 5-HT(1A) receptors could prove useful in pathologies characterized by cognitive/memory deficiencies, such as schizophrenia and depression...
  21. ncbi F15063, a potential antipsychotic with dopamine D(2)/D(3) antagonist, 5-HT(1A) agonist and D(4) partial agonist properties: (IV) duration of brain D2-like receptor occupancy and antipsychotic-like activity versus plasma concentration in mice
    Marie Bernadette Assié
    Centre de Recherche Pierre Fabre, 17 avenue Jean Moulin, 81106 Castres Cedex, France
    Naunyn Schmiedebergs Arch Pharmacol 375:241-50. 2007
    ..In addition, the durations of action of F15063 and haloperidol in a behavioural model of antipsychotic-like activity were closely correlated to their occupancy of central D2-like receptors, and much longer than their presence in plasma...