M B Assie

Summary

Affiliation: Centre de Recherche Pierre Fabre
Country: France

Publications

  1. ncbi The antipsychotics clozapine and olanzapine increase plasma glucose and corticosterone levels in rats: comparison with aripiprazole, ziprasidone, bifeprunox and F15063
    Marie Bernadette Assié
    Neurobiology II Division, Centre de Recherche Pierre Fabre, 17 avenue Jean Moulin, 81106 Castres Cedex, France
    Eur J Pharmacol 592:160-6. 2008
  2. ncbi F15063, a potential antipsychotic with dopamine D(2)/D(3) antagonist, 5-HT(1A) agonist and D(4) partial agonist properties: (IV) duration of brain D2-like receptor occupancy and antipsychotic-like activity versus plasma concentration in mice
    Marie Bernadette Assié
    Centre de Recherche Pierre Fabre, 17 avenue Jean Moulin, 81106 Castres Cedex, France
    Naunyn Schmiedebergs Arch Pharmacol 375:241-50. 2007
  3. ncbi In vivo occupancy of dopamine D2 receptors by antipsychotic drugs and novel compounds in the mouse striatum and olfactory tubercles
    Marie Bernadette Assié
    Neurobiology II, Centre de Recherche Pierre Fabre, 17 avenue Jean Moulin, 81106, Castres Cedex, France
    Naunyn Schmiedebergs Arch Pharmacol 373:441-50. 2006
  4. ncbi Rapid desensitization of somatodendritic 5-HT1A receptors by chronic administration of the high-efficacy 5-HT1A agonist, F13714: a microdialysis study in the rat
    M B Assie
    Centre de Recherche Pierre Fabre, Castres Cedex, France
    Br J Pharmacol 149:170-8. 2006
  5. ncbi Contrasting contribution of 5-hydroxytryptamine 1A receptor activation to neurochemical profile of novel antipsychotics: frontocortical dopamine and hippocampal serotonin release in rat brain
    Marie Bernadette Assié
    Centre de Recherche Pierre Fabre, 17 avenue Jean Moulin, 81106 Castres Cedex, France
    J Pharmacol Exp Ther 315:265-72. 2005
  6. ncbi F15063, a potential antipsychotic with dopamine D2/D3 receptor antagonist, 5-HT1A receptor agonist and dopamine D4 receptor partial agonist properties: influence on neuronal firing and neurotransmitter release
    Marie Bernadette Assié
    Neurobiology II Division, Centre de Recherche Pierre Fabre, 17 avenue Jean Moulin, 81106 Castres Cedex, France
    Eur J Pharmacol 607:74-83. 2009
  7. ncbi Estimation of apparent pA2 values for WAY 100635 at 5-HT1A receptors regulating 5-hydroxytryptamine release in anaesthetised rats
    M B Assie
    Neurobiology Division II, Centre de Recherche Pierre Fabre, 17 avenue Jean Moulin, 81106 Cedex, Castres, France
    Eur J Pharmacol 409:173-7. 2000
  8. ncbi [(3)H]-8-OH-DPAT binding in the rat brain raphe area: involvement of 5-HT(1A) and non-5-HT(1A) receptors
    M B Assie
    Neurobiology Division II, Centre de Recherche Pierre Fabre, Castre, France
    Br J Pharmacol 130:1348-52. 2000
  9. ncbi Correlation between low/high affinity ratios for 5-HT(1A) receptors and intrinsic activity
    M B Assie
    Centre de Recherche Pierre Fabre, 17 avenue Jean Moulin, 81106, Castres, France
    Eur J Pharmacol 386:97-103. 1999
  10. ncbi 5-HT1A receptor activation and antidepressant-like effects: F 13714 has high efficacy and marked antidepressant potential
    W Koek
    Centre de Recherche Pierre Fabre, 17 Ave Jean Moulin, 81106 Cedex, Castres, France
    Eur J Pharmacol 420:103-12. 2001

Detail Information

Publications19

  1. ncbi The antipsychotics clozapine and olanzapine increase plasma glucose and corticosterone levels in rats: comparison with aripiprazole, ziprasidone, bifeprunox and F15063
    Marie Bernadette Assié
    Neurobiology II Division, Centre de Recherche Pierre Fabre, 17 avenue Jean Moulin, 81106 Castres Cedex, France
    Eur J Pharmacol 592:160-6. 2008
    ....
  2. ncbi F15063, a potential antipsychotic with dopamine D(2)/D(3) antagonist, 5-HT(1A) agonist and D(4) partial agonist properties: (IV) duration of brain D2-like receptor occupancy and antipsychotic-like activity versus plasma concentration in mice
    Marie Bernadette Assié
    Centre de Recherche Pierre Fabre, 17 avenue Jean Moulin, 81106 Castres Cedex, France
    Naunyn Schmiedebergs Arch Pharmacol 375:241-50. 2007
    ..In addition, the durations of action of F15063 and haloperidol in a behavioural model of antipsychotic-like activity were closely correlated to their occupancy of central D2-like receptors, and much longer than their presence in plasma...
  3. ncbi In vivo occupancy of dopamine D2 receptors by antipsychotic drugs and novel compounds in the mouse striatum and olfactory tubercles
    Marie Bernadette Assié
    Neurobiology II, Centre de Recherche Pierre Fabre, 17 avenue Jean Moulin, 81106, Castres Cedex, France
    Naunyn Schmiedebergs Arch Pharmacol 373:441-50. 2006
    ..Taken together, these data support the strategy of simultaneously targeting D2 receptor blockade and 5-HT1A receptor activation for new antipsychotics...
  4. ncbi Rapid desensitization of somatodendritic 5-HT1A receptors by chronic administration of the high-efficacy 5-HT1A agonist, F13714: a microdialysis study in the rat
    M B Assie
    Centre de Recherche Pierre Fabre, Castres Cedex, France
    Br J Pharmacol 149:170-8. 2006
    ....
  5. ncbi Contrasting contribution of 5-hydroxytryptamine 1A receptor activation to neurochemical profile of novel antipsychotics: frontocortical dopamine and hippocampal serotonin release in rat brain
    Marie Bernadette Assié
    Centre de Recherche Pierre Fabre, 17 avenue Jean Moulin, 81106 Castres Cedex, France
    J Pharmacol Exp Ther 315:265-72. 2005
    ....
  6. ncbi F15063, a potential antipsychotic with dopamine D2/D3 receptor antagonist, 5-HT1A receptor agonist and dopamine D4 receptor partial agonist properties: influence on neuronal firing and neurotransmitter release
    Marie Bernadette Assié
    Neurobiology II Division, Centre de Recherche Pierre Fabre, 17 avenue Jean Moulin, 81106 Castres Cedex, France
    Eur J Pharmacol 607:74-83. 2009
    ..Such a profile distinguishes F15063 from SSR181507 and currently available antipsychotic drugs...
  7. ncbi Estimation of apparent pA2 values for WAY 100635 at 5-HT1A receptors regulating 5-hydroxytryptamine release in anaesthetised rats
    M B Assie
    Neurobiology Division II, Centre de Recherche Pierre Fabre, 17 avenue Jean Moulin, 81106 Cedex, Castres, France
    Eur J Pharmacol 409:173-7. 2000
    ..The results also show that orderly microdialysis data can be obtained using cumulative dosing, which enables one to collect dose-response data rapidly, with fewer animals...
  8. ncbi [(3)H]-8-OH-DPAT binding in the rat brain raphe area: involvement of 5-HT(1A) and non-5-HT(1A) receptors
    M B Assie
    Neurobiology Division II, Centre de Recherche Pierre Fabre, Castre, France
    Br J Pharmacol 130:1348-52. 2000
    ..It is suggested that [(3)H]-8-OH-DPAT labels other, as yet unknown binding sites in the raphe...
  9. ncbi Correlation between low/high affinity ratios for 5-HT(1A) receptors and intrinsic activity
    M B Assie
    Centre de Recherche Pierre Fabre, 17 avenue Jean Moulin, 81106, Castres, France
    Eur J Pharmacol 386:97-103. 1999
    ..Their effects, however, appear to be G(i) protein-dependent...
  10. ncbi 5-HT1A receptor activation and antidepressant-like effects: F 13714 has high efficacy and marked antidepressant potential
    W Koek
    Centre de Recherche Pierre Fabre, 17 Ave Jean Moulin, 81106 Cedex, Castres, France
    Eur J Pharmacol 420:103-12. 2001
    ....
  11. ncbi F15063, a potential antipsychotic with D2/D3 antagonist, 5-HT 1A agonist and D4 partial agonist properties. I. In vitro receptor affinity and efficacy profile
    A Newman-Tancredi
    Division of Neurobiology 2, Centre de Recherche Pierre Fabre, Castres, France
    Br J Pharmacol 151:237-52. 2007
    ..We describe the in vitro profile of F15063 (N-[(2,2-dimethyl-2,3-dihydro-benzofuran-7-yloxy)ethyl]-3-(cyclopent-1-enyl)-benzylamine)...
  12. ncbi Design and synthesis of a series of 6-substituted-2-pyridinylmethylamine derivatives as novel, high-affinity, selective agonists at 5-HT1A receptors
    B Vacher
    Pierre Fabre Research Center, 17 avenue Jean Moulin, 81106 Castres Cedex, France
    J Med Chem 41:5070-83. 1998
    ..Structural modifications of the nonpharmacophoric part of the molecule showed, however, that the entire structure was required for affinity at 5-HT1A binding sites...
  13. ncbi Novel derivatives of 2-pyridinemethylamine as selective, potent, and orally active agonists at 5-HT1A receptors
    B Vacher
    Pierre Fabre Research Center, 17 avenue Jean Moulin, 81106 Castres Cedex, France
    J Med Chem 42:1648-60. 1999
    ..Thus, 40, 45, and 54 are potent, orally active 5-HT1A receptor agonists with marked antidepressant potential...
  14. ncbi Signal transduction and functional selectivity of F15599, a preferential post-synaptic 5-HT1A receptor agonist
    A Newman-Tancredi
    Neurobiology 2 Division, Centre de Recherche Pierre Fabre, 17 avenue Jean Moulin, Castres, France
    Br J Pharmacol 156:338-53. 2009
    ..Activation of post-synaptic 5-HT(1A) receptors may provide enhanced therapy against depression. We describe the signal transduction profile of F15599, a novel 5-HT(1A) receptor agonist...
  15. ncbi F 11356, a novel 5-hydroxytryptamine (5-HT) derivative with potent, selective, and unique high intrinsic activity at 5-HT1B/1D receptors in models relevant to migraine
    G W John
    Centre de Recherche Pierre Fabre, Castres Cedex, France
    J Pharmacol Exp Ther 290:83-95. 1999
    ....
  16. ncbi Differential in vivo inhibition of [3H]nemonapride binding by atypical antipsychotics in rat striatum, olfactory lobes, and frontal cortex
    M B Assie
    Division of Neurobiology II, Centre de Recherche Pierre Fabre, Castres, France
    Pharmacology 75:63-8. 2005
    ..The present data suggest that conventional and atypical antipsychotics may be distinguished by their differential occupancy of striatal versus frontocortical D2-like receptors in vivo...
  17. ncbi Levomilnacipran (F2695), a norepinephrine-preferring SNRI: Profile in vitro and in models of depression and anxiety
    A L Auclair
    Neuropsychopharmacology Division, Centre de Recherche Pierre Fabre, 17 avenue Jean Moulin, 81106 Castres, France
    Neuropharmacology 70:338-47. 2013
    ..It is efficacious in models of anti-depressive/anti-stress activity, with minimal potential for locomotor side effects...
  18. ncbi Large-amplitude 5-HT1A receptor activation: a new mechanism of profound, central analgesia
    F C Colpaert
    Centre de Recherche Pierre Fabre, 17, avenue Jean Moulin, 81106 Castres Cedex, France
    Neuropharmacology 43:945-58. 2002
    ....
  19. ncbi 5-HT1A receptors are involved in the effects of xaliproden on G-protein activation, neurotransmitter release and nociception
    J C Martel
    Division of Neurobiology 2, Centre de Recherche Pierre Fabre, Castres, France
    Br J Pharmacol 158:232-42. 2009
    ..The present study investigated its profile on in vitro transduction, neurochemical responses and acute nociceptive pain tests in rats...