E D Carosella

Summary

Affiliation: CEA Saclay
Country: France

Publications

  1. ncbi request reprint HLA-G molecules: from maternal-fetal tolerance to tissue acceptance
    Edgardo D Carosella
    Service de Recherches en Hemato Immunologie, Direction des Sciences du Vivant, Departement de Recherche Medicale, CEA Commissariat à l Energie Atomique, Institut Universitaire d Hematologie, Hopital Saint Louis, 75010 Paris, France
    Adv Immunol 81:199-252. 2003
  2. ncbi request reprint Immunotolerant functions of HLA-G
    E D Carosella
    Service de Recherches en Hemato Immunologie, Hopital Saint Louis, Institut d Hematologie, Paris, France
    Cell Mol Life Sci 55:327-33. 1999
  3. ncbi request reprint HLA-G: a shield against inflammatory aggression
    E D Carosella
    Service de Recherches en Hemato Immunologie, CEA DSV DRM, Hopital Saint Louis, Institut Universitaire d Hematologie, 1 avenue Claude Vellefaux, 75010 Paris, France
    Trends Immunol 22:553-5. 2001
  4. ncbi request reprint [HLA-G: fetomaternal tolerance]
    E D Carosella
    CEA DSV DRM SRHI, Hopital Saint Louis, Paris, France
    C R Acad Sci III 323:675-80. 2000
  5. ncbi request reprint HLA-G2, -G3, and -G4 isoforms expressed as nonmature cell surface glycoproteins inhibit NK and antigen-specific CTL cytolysis
    B Riteau
    , , , , and Fondation Jean Dausset, Paris, France
    J Immunol 166:5018-26. 2001
  6. ncbi request reprint Heterogeneity of HLA-G gene transcription and protein expression in malignant melanoma biopsies
    P Paul
    DSV DRM, SRHI CEA, Commissariat a l Energie Atomique, Centre Hayem, Hopital Saint Louis, Paris, France
    Cancer Res 59:1954-60. 1999
  7. ncbi request reprint Identification of HLA-G7 as a new splice variant of the HLA-G mRNA and expression of soluble HLA-G5, -G6, and -G7 transcripts in human transfected cells
    P Paul
    Service de Recherches en Hemato Immunologie, CEA DRM DSV, Hopital St Louis, Institut Universitaire d Hematologie, Cedex 10, Paris, France
    Hum Immunol 61:1138-49. 2000
  8. ncbi request reprint HLA-G expression in human melanoma cells: protection from NK cytolysis
    F Adrian Cabestre
    CEA, Service de Recherches en Hemato Immunologie, DSV DRM, Hopital Saint Louis, Paris, France
    J Reprod Immunol 43:183-93. 1999
  9. pmc HLA-G expression in melanoma: a way for tumor cells to escape from immunosurveillance
    P Paul
    Direction des Sciences du Vivant Department de Recherche Medicale, Service de Recherches en Hemato Immunologie, Commissariat a l Energie Atomique, Hopital Saint Louis, Centre Hayem, 1, avenue Claude Vellefaux, 75010 Paris, France
    Proc Natl Acad Sci U S A 95:4510-5. 1998
  10. ncbi request reprint HLA-G, -E, -F preworkshop: tools and protocols for analysis of non-classical class I genes transcription and protein expression
    P Paul
    Service de Recherches en Hemato Immunologie, CEA DRM DSV, Hopital St Louis, Institut Universitaire d Hematologie, 1 avenue Claude Vellefaux, 75475, Cedex 10, Paris, France
    Hum Immunol 61:1177-95. 2000

Collaborators

Detail Information

Publications90

  1. ncbi request reprint HLA-G molecules: from maternal-fetal tolerance to tissue acceptance
    Edgardo D Carosella
    Service de Recherches en Hemato Immunologie, Direction des Sciences du Vivant, Departement de Recherche Medicale, CEA Commissariat à l Energie Atomique, Institut Universitaire d Hematologie, Hopital Saint Louis, 75010 Paris, France
    Adv Immunol 81:199-252. 2003
    ..We review these points, with special emphasis on the role of HLA-G in human pathologies, such as cancer, viral infection, and inflammatory diseases, as well as in organ transplantation...
  2. ncbi request reprint Immunotolerant functions of HLA-G
    E D Carosella
    Service de Recherches en Hemato Immunologie, Hopital Saint Louis, Institut d Hematologie, Paris, France
    Cell Mol Life Sci 55:327-33. 1999
    ..In this review, attempts were made to summarize the current state of knowledge of the effects of HLA-G on both natural killer and T cell functions and their implications in materno-fetal tolerance and tumor immunosurveillance...
  3. ncbi request reprint HLA-G: a shield against inflammatory aggression
    E D Carosella
    Service de Recherches en Hemato Immunologie, CEA DSV DRM, Hopital Saint Louis, Institut Universitaire d Hematologie, 1 avenue Claude Vellefaux, 75010 Paris, France
    Trends Immunol 22:553-5. 2001
    ..We propose a novel role for HLA-G as a tissue-protective molecule in inflammatory responses...
  4. ncbi request reprint [HLA-G: fetomaternal tolerance]
    E D Carosella
    CEA DSV DRM SRHI, Hopital Saint Louis, Paris, France
    C R Acad Sci III 323:675-80. 2000
    ....
  5. ncbi request reprint HLA-G2, -G3, and -G4 isoforms expressed as nonmature cell surface glycoproteins inhibit NK and antigen-specific CTL cytolysis
    B Riteau
    , , , , and Fondation Jean Dausset, Paris, France
    J Immunol 166:5018-26. 2001
    ..These findings highlight the immunomodulatory role that HLA-G2, -G3, and -G4 proteins will assume during physiologic or pathologic processes in which HLA-G1 expression is altered...
  6. ncbi request reprint Heterogeneity of HLA-G gene transcription and protein expression in malignant melanoma biopsies
    P Paul
    DSV DRM, SRHI CEA, Commissariat a l Energie Atomique, Centre Hayem, Hopital Saint Louis, Paris, France
    Cancer Res 59:1954-60. 1999
    ....
  7. ncbi request reprint Identification of HLA-G7 as a new splice variant of the HLA-G mRNA and expression of soluble HLA-G5, -G6, and -G7 transcripts in human transfected cells
    P Paul
    Service de Recherches en Hemato Immunologie, CEA DRM DSV, Hopital St Louis, Institut Universitaire d Hematologie, Cedex 10, Paris, France
    Hum Immunol 61:1138-49. 2000
    ....
  8. ncbi request reprint HLA-G expression in human melanoma cells: protection from NK cytolysis
    F Adrian Cabestre
    CEA, Service de Recherches en Hemato Immunologie, DSV DRM, Hopital Saint Louis, Paris, France
    J Reprod Immunol 43:183-93. 1999
    ..Together, these results confirm that HLA-G expression at the surface of tumor cells can participate in the evasion of antitumoral immune responses and favor tumor progression...
  9. pmc HLA-G expression in melanoma: a way for tumor cells to escape from immunosurveillance
    P Paul
    Direction des Sciences du Vivant Department de Recherche Medicale, Service de Recherches en Hemato Immunologie, Commissariat a l Energie Atomique, Hopital Saint Louis, Centre Hayem, 1, avenue Claude Vellefaux, 75010 Paris, France
    Proc Natl Acad Sci U S A 95:4510-5. 1998
    ..It thus appears of critical importance to consider the specific role of HLA-G expression in tumors in the design of future cancer immunotherapies...
  10. ncbi request reprint HLA-G, -E, -F preworkshop: tools and protocols for analysis of non-classical class I genes transcription and protein expression
    P Paul
    Service de Recherches en Hemato Immunologie, CEA DRM DSV, Hopital St Louis, Institut Universitaire d Hematologie, 1 avenue Claude Vellefaux, 75475, Cedex 10, Paris, France
    Hum Immunol 61:1177-95. 2000
    ....
  11. doi request reprint Recent advances on the non-classical major histocompatibility complex class I HLA-G molecule
    C Menier
    Commissariat à l Energie Atomique DSV IBM, Service de Recherches en Hemato Immunologie, Paris, France
    Tissue Antigens 75:201-6. 2010
    ..Furthermore, the role of HLA-G during pregnancy was revisited and its impact in pathologies such as cancer, autoimmune disorders and transplantation was further extended...
  12. ncbi request reprint Increase in HLA-G1 proteolytic shedding by tumor cells: a regulatory pathway controlled by NF-kappaB inducers
    I Zidi
    CEA, Service de Recherches en Hemato Immunologie, DSV DRM, Hopital Saint Louis, Institut Universitaire d Hematologie, 1 avenue Claude Vellefaux, 75010 Paris, France
    Cell Mol Life Sci 63:2669-81. 2006
    ..These results, and the fact that soluble HLA-G1 reduces the cytotoxicity of the NKL cell line, lead us to propose a novel regulatory pathway for HLA-G expression by tumor cells that may have particular relevance in tumor escape...
  13. ncbi request reprint [HLA-G in organ transplantation]
    J Le Maoult
    Service de Recherches en Hemato Immunologie, CEA DSV DRM, Hopital Saint Louis, IUH, 1, avenue Claude Vellefaux, 75010 Paris cedex 10, France
    Pathol Biol (Paris) 52:97-103. 2004
    ....
  14. ncbi request reprint Specific binding of nuclear factors to the HLA-G gene promoter correlates with a lack of HLA-G transcripts in first trimester human fetal liver
    P Moreau
    CEA, Service de Recherches en Hemato Immunologie, DSV, DRM, Centre Hayem, Hopital Saint Louis, Paris, France
    Hum Immunol 59:751-7. 1998
    ....
  15. ncbi request reprint Modulation of HLA-G expression in human thymic and amniotic epithelial cells
    S Lefebvre
    Service de Recherches en Hemato Immunologie, CEA, DSV DRM, Institut d Hematologie, Hopital Saint Louis, Cedex, Paris, France
    Hum Immunol 61:1095-101. 2000
    ..These results also suggest a role for the microenvironment in regulating HLA-G in vivo gene expression in the thymus and amnion membrane...
  16. ncbi request reprint Research on HLA-G: an update
    B Favier
    Service de Recherches en Hemato Immunologie, Commissariat a l Energie Atomique DSV DRM, Hopital Saint Louis, IUH, 1, avenue Claude Vellefaux, 75475 Paris Cedex 10, France
    Tissue Antigens 69:207-11. 2007
    ..The reports presented brought new insight into HLA-G research, and we summarize here the major advances on the HLA-G biology that were reported. Abstracts for all presentations can be found in volume 68 issue number 4 of Tissue Antigens...
  17. pmc The alpha1 domain of HLA-G1 and HLA-G2 inhibits cytotoxicity induced by natural killer cells: is HLA-G the public ligand for natural killer cell inhibitory receptors?
    N Rouas-Freiss
    Service de Recherches en Hemato Immunologie, Commissariat à l Energie Atomique Departement Recherche Medicale, Direction des Sciences du Vivant, Hopital Saint Louis, 1, avenue Claude Vellefaux, 75475 Paris Cedex 10, France
    Proc Natl Acad Sci U S A 94:5249-54. 1997
    ..Because NKIR1 and NKIR2, known to interact with HLA-G, were undetectable on YT2C2, we conclude that a yet-unknown specific receptor for HLA-G1 and HLA-G2 is present on these cells...
  18. ncbi request reprint Altered HLA-G transcription in pre-eclampsia is associated with allele specific inheritance: possible role of the HLA-G gene in susceptibility to the disease
    M O'BRIEN
    CEA, Service de Recherches en Hemato Immunologie, DSV DRM, Hopital Saint Louis, Institut d Hematologie, Paris, France
    Cell Mol Life Sci 58:1943-9. 2001
    ..Thus we provide the first evidence for a possible role of HLA-G in genetic susceptibility to, and pathogenesis of pre-eclampsia...
  19. ncbi request reprint HLA-G turns off erythropoietin receptor signaling through JAK2 and JAK2 V617F dephosphorylation: clinical relevance in polycythemia vera
    C Menier
    Service de Recherches en Hemato Immunologie, CEA DSV I2BM IUH, Hopital Saint Louis, Paris, France
    Leukemia 22:578-84. 2008
    ..Such HLA-G5-mediated inhibition constitutes a new parameter to be considered in the design of future approaches aimed at treating JAK2 V617F-positive myeloproliferative disorders...
  20. ncbi request reprint HLA-G protein processing and transport to the cell surface
    P Moreau
    CEA, Service de Recherche en Hémato Immunologie, Hĵpital Saint Louis, Institut Universitaire d Hematologie, Paris, France
    Cell Mol Life Sci 59:1460-6. 2002
    ..These data reveal that HLA-G presents specific cell trafficking pathways and strongly support the contention that the primary function of HLA-G is as of an inhibitor ligand for immune-competent cells...
  21. pmc Soluble HLA-G protein secreted by allo-specific CD4+ T cells suppresses the allo-proliferative response: a CD4+ T cell regulatory mechanism
    N Lila
    , , Direction des Sciences du Vivant, , , 1 avenue Claude-Vellefaux, 75010 Paris, France
    Proc Natl Acad Sci U S A 98:12150-5. 2001
    ..This inhibition may be reversed by adding the anti-HLA-G 87G antibody to a mixed lymphocyte culture. That may indicate a previously uncharacterized regulatory mechanism of CD4(+) T cell proliferative response...
  22. ncbi request reprint IL-10 selectively induces HLA-G expression in human trophoblasts and monocytes
    P Moreau
    CEA, Service de Recherches en Hemato Immunologie, DSV DRM, Hopital Saint Louis, Centre Hayem, 1 avenue Claude Vellefaux, 75010 Paris, France
    Int Immunol 11:803-11. 1999
    ..This should be taken into consideration in the design of treatment for pathologies of pregnancy...
  23. pmc HLA-G and NK receptor are expressed in psoriatic skin: a possible pathway for regulating infiltrating T cells?
    S Aractingi
    SRHI CEA, DSV DRM, Commissariat a l Energie Atomique, Unite de Dermatologie, Paris, France
    Am J Pathol 159:71-7. 2001
    ..The demonstration of HLA-G and ILT2 expression in psoriatic skin suggests that this pathway may act as an inhibitory feed back aimed to down-regulate the deleterious effects of T-cell infiltrate in this disease...
  24. ncbi request reprint The X1 box of HLA-G promoter is a target site for RFX and Sp1 factors
    P Rousseau
    CEA, Service de Recherche en Hémato Immunologie, DSV DRM, Hopital Saint Louis, Institut d Hematologie, Paris, France
    Hum Immunol 61:1132-7. 2000
    ..The X1 box is the target for RFX complex and an additional factor we identified as Sp1. We propose that the X region in the HLA-G gene promoter might participate to the combination of factors which play a role in HLA-G gene activation...
  25. ncbi request reprint Tumor-specific up-regulation of the nonclassical class I HLA-G antigen expression in renal carcinoma
    E C Ibrahim
    CEA, , DSV/DRM, , Centre Hayem, 75010 Paris, France
    Cancer Res 61:6838-45. 2001
    ....
  26. ncbi request reprint Biology and functions of human leukocyte antigen-G in health and sickness
    J LeMaoult
    Commissariat a l Energie Atomique, Service de Recherches en Hemato Immunologie, Hopital Saint Louis, Paris, France
    Tissue Antigens 62:273-84. 2003
    ..We summarize the key points that were presented and discussed during this meeting...
  27. doi request reprint Soluble HLA-G induces NF-kappaB activation in natural killer cells
    I Zidi
    Commissariat a l Energie Atomique, Service de Recherches en Hemato Immunologie, I2BM, Institut Universitaire d Hematologie, Hopital Saint Louis, 1 avenue Claude Vellefaux, 75010 Paris, France
    J Physiol Biochem 66:39-46. 2010
    ..Our findings may suggest the important role played by NF-kappaB activation after soluble HLA-G stimulation in other NK cells function...
  28. doi request reprint Immunohistochemical study of HLA-G expression in lung transplant recipients
    O Brugiere
    Service de Pneumologie B et de Transplantation Pulmonaire, Centre Hospitalier Universitaire Bichat Claude Bernard, Paris, France
    Am J Transplant 9:1427-38. 2009
    ..We conclude that HLA-G expression in the bronchial epithelium of lung allograft is elevated in some LTx recipients in association with their functional stability, suggesting a potential role of HLA-G as a tolerance marker...
  29. ncbi request reprint HLA-G gene polymorphism segregation within CEPH reference families
    M Kirszenbaum
    CEA DRM Service de Recherches en Hémato Immunologie, Hopital Saint Louis, Centre Hayem, Paris, France
    Hum Immunol 53:140-7. 1997
    ..Only one of the mutations observed was found to be nonsynonymous indicating low polymorphism of the HLA-G molecule...
  30. ncbi request reprint Accelerated telomere shortening and telomerase activation in Fanconi's anaemia
    F Leteurtre
    Service de Recherches en Hemato Immunologie, DSV DRM, CEA, Hopital Saint Louis, Paris, France
    Br J Haematol 105:883-93. 1999
    ..Telomerase, the enzyme that counteracts telomere shortening, was 4.8-fold more active in 25 FA patients than in 15 age-matched healthy controls. A model for the FA disease process is proposed...
  31. ncbi request reprint Functions of HLA-G in the immune system
    B Favier
    Service de Recherches en Hemato Immunologie, Direction des Sciences du Vivant, Departement de Recherche Medicale, Commissariat a l Energie Atomique, Institut Universitaire d Hematologie, Hopital Saint Louis, Paris, France
    Tissue Antigens 69:150-2. 2007
    ..In this review, we will briefly summarize the key advances on the relationships between HLA-G and the immune system and their consequences in pathology...
  32. ncbi request reprint Hypoxia modulates HLA-G gene expression in tumor cells
    Gael Mouillot
    Commissariat a l Energie Atomique, Service de Recherches en Hemato Immunologie, Direction des Sciences du Vivant Dèpartement de Recherche Médicale, Hopital Saint Louis, Institut Universitaire d Hematologie, Paris, France
    Hum Immunol 68:277-85. 2007
    ..Finally, we demonstrated for the first time that the modulation of HLA-G gene expression is dependent of HIF-1 stabilization and thus might be relevant for the control of HLA-G gene expression in hypoxic tumors...
  33. pmc Trogocytosis-based generation of suppressive NK cells
    Julien Caumartin
    Service de Recherches en Hemato Immunologie, Commissariat a l Energie Atomique, Hopital Saint Louis, Paris, France
    EMBO J 26:1423-33. 2007
    ..The broader consequences of membrane sharing between immune and non-immune cells on the function of effectors and the outcome of immune responses are discussed...
  34. ncbi request reprint Immune regulation by pretenders: cell-to-cell transfers of HLA-G make effector T cells act as regulatory cells
    Joel Lemaoult
    Service de Recherches en Hemato Immunologie, Commissariat à l Energie Atomique CEA DSV DRM, Institut Universitaire d Hematologie, Hopital Saint Louis, Paris, France
    Blood 109:2040-8. 2007
    ..These data re-emphasize the significance of HLA-G expression in normal and pathologic situations...
  35. ncbi request reprint HLA-G proteins in cancer: do they provide tumor cells with an escape mechanism?
    Nathalie Rouas-Freiss
    Service de Recherche en Hémato Immunologie, Direction des Sciences du Vivant, Departement de Recherche Medicale, Commissariat a l Energie Atomique, Institut Universitaire d Hematologie, Hopital Saint Louis, Paris, France
    Cancer Res 65:10139-44. 2005
    ....
  36. ncbi request reprint Soluble HLA-G inhibits cell cycle progression in human alloreactive T lymphocytes
    Rajia Bahri
    Institut National de la Santé et de la Recherche Médicale Unité 542, Villejuif, France
    J Immunol 176:1331-9. 2006
    ..In contrast, it induced an accumulation of p27kip, but not p21cip, in activated T cells. HLA-G does not induce apoptosis of alloreactive T cells, but induces p27kip1 and inhibits cell cycle progression...
  37. pmc Indoleamine 2,3 dioxygenase and human leucocyte antigen-G inhibit the T-cell alloproliferative response through two independent pathways
    Solene Le Rond
    Service de Recherches en Hemato Immunologie, CEA DSV DRM, Hopital Saint Louis, IUH, Paris, France
    Immunology 116:297-307. 2005
    ..IDO and HLA-G are thus complementary for inducing and maintaining immune tolerance in physiological (pregnancy) and pathological (tumour and allograft) situations...
  38. ncbi request reprint HLA-G5 expression by trophoblast cells: the facts
    Joel Lemaoult
    Service de Recherches en Hemato Immunologie, CEA DSV DRM, Hopital Saint Louis, IUH, Paris, France
    Mol Hum Reprod 11:719-22. 2005
  39. pmc Modulation of HLA-G expression in human neural cells after neurotropic viral infections
    Monique Lafon
    Unité de Neuroimmunologie Virale, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    J Virol 79:15226-37. 2005
    ..HLA-G may therefore be involved in the escape of certain viruses from the immune response in the nervous system...
  40. ncbi request reprint Report of the Wet Workshop for Quantification of Soluble HLA-G in Essen, 2004
    Vera Rebmann
    Institute of Immunology, University Hospital of Essen, Essen, Germany
    Hum Immunol 66:853-63. 2005
    ..Moreover, a novel soluble HLA-G structure can be predicted that is recognized by the mAb 5A6G7 + mAb W6/32 antibody combination, but not by the one of mAb MEM-G/9 + anti-beta2m...
  41. ncbi request reprint Evidence to support the role of HLA-G5 in allograft acceptance through induction of immunosuppressive/ regulatory T cells
    Solene Le Rond
    Service de Recherches en Hemato Immunologie, Commissariat à l Energie Atomique Direction des Sciences du Vivant, Departement de Recherche Medicale, Hopital Saint Louis, Institut Universitaire d Hematologie, Paris, France
    J Immunol 176:3266-76. 2006
    ..These findings provide evidence supporting the tolerogenic properties of HLA-G and emphasize its potential application as a relevant therapeutic candidate capable of limiting allograft rejection...
  42. ncbi request reprint Modulation of HLA-G and HLA-E expression in human neuronal cells after rabies virus or herpes virus simplex type 1 infections
    Françoise Mégret
    Laboratoire de Neuroimmunologie Virale, Institut Pasteur, Paris, France
    Hum Immunol 68:294-302. 2007
    ..Thus, neurotropic viruses that escape the host immune response totally (RABV) or partially (HSV-1) regulate HLA-G expression on human neuronal cells differentially...
  43. pmc Modulation of dendritic cell differentiation by HLA-G and ILT4 requires the IL-6--STAT3 signaling pathway
    Siyuan Liang
    Center for Molecular Chaperone Radiobiology and Cancer Virology, Department of Medicine, Medical College of Georgia, 1410 Laney Walker Boulevard, Augusta, GA 30912, USA
    Proc Natl Acad Sci U S A 105:8357-62. 2008
    ..We propose a model where SHP-2 and the IL-6-STAT3 signaling pathway play critical roles in the modulation of DC differentiation by ILT4 and HLA-G...
  44. doi request reprint Myocardial HLA-G reliably indicates a low risk of acute cellular rejection in heart transplant recipients
    Rohit Sheshgiri
    Heart Transplant Program, Peter Munk Cardiac Centre, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada
    J Heart Lung Transplant 27:522-7. 2008
    ..We assessed myocardial HLA-G expression in adult heart transplant patients in an attempt to determine the value of this protein in identifying patients with a low risk of acute cellular rejection...
  45. doi request reprint Beyond the increasing complexity of the immunomodulatory HLA-G molecule
    Edgardo D Carosella
    CEA, IBM, Service de Recherches en Hemato Immunologie, Paris, France
    Blood 111:4862-70. 2008
    ..We highlight here what we consider are recent key basic findings on the immunomodulatory function of HLA-G. These strengthen the case for considering HLA-G as clinically relevant...
  46. doi request reprint HLA-G: from biology to clinical benefits
    Edgardo D Carosella
    Institut Universitaire d Hematologie, Service de Recherches en Hemato Immunologie, Hopital Saint Louis, IUH, 1 75010 Paris, France
    Trends Immunol 29:125-32. 2008
    ..These recent findings are important in terms of clinical benefits at both diagnostic and therapeutic levels...
  47. ncbi request reprint Human leukocyte antigen-G5 secretion by human mesenchymal stem cells is required to suppress T lymphocyte and natural killer function and to induce CD4+CD25highFOXP3+ regulatory T cells
    Zohair Selmani
    Institut National de la Santé et de la Recherche Médicale U645, IFR 133, Universite de Franche Comte, Etablissement Français du Sang Bourgogne Franche Comté, Besancon, France
    Stem Cells 26:212-22. 2008
    ..Our results provide evidence that HLA-G5 secreted by MSCs is critical to the suppressive functions of MSCs and should contribute to improving clinical therapeutic trials that use MSCs to prevent GvHD...
  48. ncbi request reprint Expression of tolerogenic HLA-G molecules in cancer prevents antitumor responses
    Nathalie Rouas-Freiss
    CEA, DSV, I2BM, Service de Recherches en Hemato Immunologie, Hopital Saint Louis, IUH, 1 avenue Claude Vellefaux, 75010 Paris, France
    Semin Cancer Biol 17:413-21. 2007
    ..These findings reinforce the role of HLA-G as one mechanism of tumor-driven immune evasion and provide potential targets for testing novel anticancer treatment strategies...
  49. ncbi request reprint CD3+CD4low and CD3+CD8low are induced by HLA-G: novel human peripheral blood suppressor T-cell subsets involved in transplant acceptance
    Abderrahim Naji
    Service de Recherches en Hemato Immunologie, Commissariat à l energie atomique Direction des science, du vivant Departement de la recherche medical CEA DSV DRM, Hopital Saint Louis, Paris, France
    Blood 110:3936-48. 2007
    ..These data define novel immunosuppressive subpopulations of peripheral blood T cells induced by HLA-G with potent implications in peripheral tolerance...
  50. ncbi request reprint HLA-G and cancer
    Edgardo D Carosella
    Semin Cancer Biol 17:411-2. 2007
  51. ncbi request reprint Cellular co-localization of intron-4 containing mRNA and HLA-G soluble protein in melanoma analyzed by fluorescence in situ hybridization
    Déborah Sangrouber
    Service de Recherches en Hemato Immunologie, Commissariat à L Energie Atomique DSV I 2 BM, Institut Universitaire d Hematologie, Hopital Saint Louis, Paris, France
    J Immunol Methods 326:54-62. 2007
    ....
  52. ncbi request reprint Role of HLA-G in innate immunity through direct activation of NF-kappaB in natural killer cells
    Christine Guillard
    Commissariat a l Energie Atomique, Service de Recherches en Hemato Immunologie, Direction des Sciences du Vivant, Institut d Imagerie Biomédicale, Institut Universitaire d Hematologie, Hopital Saint Louis, 1 avenue Claude Vellefaux, 75010 Paris, France
    Mol Immunol 45:419-27. 2008
    ..All these data support an unsuspected role for HLA-G in innate immunity by activating classical NF-kappaB pathway in NK cells...
  53. ncbi request reprint Tolerogenic functions of human leukocyte antigen G: from pregnancy to organ and cell transplantation
    Nathalie Rouas-Freiss
    Service de Recherches en Hemato Immunologie, CEA DSV DRM, Hopital Saint Louis, Institut Universitaire d Hematologie, 1 avenue Claude Vellefaux, 75010 Paris, France
    Transplantation 84:S21-5. 2007
    ..In this paper, we focus our attention on the relevance of HLA-G in transplantation in the light of recent data associating regulatory T cells and HLA-G, and which provide evidence of the role of HLA-G in improving graft acceptance...
  54. ncbi request reprint Soluble HLA-G and HLA-G1 expressing antigen-presenting cells inhibit T-cell alloproliferation through ILT-2/ILT-4/FasL-mediated pathways
    Abderrahim Naji
    Service de Recherches en Hemato Immunologie, Hopital Saint Louis, Institut Universitaire d Hematologie, Paris, France
    Hum Immunol 68:233-9. 2007
    ..Evidence to support such role in vivo was provided by the capacity of purified HLA-G5 from the plasma of the transplanted patient to suppress T-cell alloresponses...
  55. ncbi request reprint Immuno-tolerogenic functions of HLA-G: relevance in transplantation and oncology
    Joel Lemaoult
    Service de Recherches en Hemato Immunologie, Commissariat a l Energie Atomique DSV DRM, Hopital Saint Louis, 1, Avenue Claude Vellefaux 75010, Paris
    Autoimmun Rev 4:503-9. 2005
    ..We review here the functions of HLA-G from an immunological stand point, focusing on the recent advances in this field and on their potential impact in human pathologies, such as cancer and organ transplantation...
  56. ncbi request reprint Switch of HLA-G alternative splicing in a melanoma cell line causes loss of HLA-G1 expression and sensitivity to NK lysis
    Nathalie Rouas-Freiss
    Service de Recherches en Hemato Immunologie, CEA DSV DRM, Hopital Saint Louis, IUH, Paris, France
    Int J Cancer 117:114-22. 2005
    ..Modulating HLA-G at the mRNA splicing level would be an efficient way of lifting in vivo HLA-G-mediated tumor immune escape...
  57. ncbi request reprint Progress of HLA-G in cancer
    Edgardo D Carosella
    Semin Cancer Biol 13:315-6. 2003
  58. pmc In vivo, RFX5 binds differently to the human leucocyte antigen-E, -F, and -G gene promoters and participates in HLA class I protein expression in a cell type-dependent manner
    Philippe Rousseau
    CEA, Service de Recherche en Hémato Immunologie, DSV DRM, Hopital Saint Louis, Institut Universitaire d Hematologie, Paris, France
    Immunology 111:53-65. 2004
    ..RFX5 and CIITA are thus not involved in HLA-G expression and their importance for the surface expression of HLA-E/classical HLA class I molecules may vary depending on the cell type...
  59. ncbi request reprint Analysis of HLA antigen expression in benign and malignant melanocytic lesions reveals that upregulation of HLA-G expression correlates with malignant transformation, high inflammatory infiltration and HLA-A1 genotype
    El Cherif Ibrahim
    CEA, Service de Recherches en Hemato Immunologie, DSV DRM, Hopital Saint Louis, Institut d Hematologie, Paris, France
    Int J Cancer 108:243-50. 2004
    ..These findings may provide new insights in the comprehension of tumor progression and design of therapeutic approaches aimed at enhancing antitumor immune responses in melanoma patients...
  60. ncbi request reprint Exosomes bearing HLA-G are released by melanoma cells
    Beatrice Riteau
    Service de Recherches en Hemato Immunologie, CEA DSV DRM, Hopital Saint Louis, IUH, Paris, France
    Hum Immunol 64:1064-72. 2003
    ..Thus, the presence of tolerogenic HLA-G molecules on melanoma-derived exosomes may provide a novel way for tumors to modulate host's immune response...
  61. ncbi request reprint Expression of HLA-G in human cornea, an immune-privileged tissue
    Magali Le Discorde
    Service de Recherches en Hemato Immunologie, CEA DSV DRM, Institut d Hematologie, Hopital Saint Louis, Paris, France
    Hum Immunol 64:1039-44. 2003
    ..The detection of HLA-G protein in adult corneas leads to the conclusion that this protein may contribute to the maintenance of the privileged immune status of cornea...
  62. ncbi request reprint The 14 bp deletion-insertion polymorphism in the 3' UT region of the HLA-G gene influences HLA-G mRNA stability
    Philippe Rousseau
    Commissariat a l Energie Atomique, SRHI, IUH, Hopital St Louis 1, avenue Claude Vellefaux, Paris, France
    Hum Immunol 64:1005-10. 2003
    ....
  63. ncbi request reprint Human leukocyte antigen-G (HLA-G) expression in biliary epithelial cells is associated with allograft acceptance in liver-kidney transplantation
    Caroline Creput
    Hemato immunology Research Institute, CEA Laboratory, Direction des Sciences du Vivant, Departement de Recherche Medicale, Commissariat a l Energie Atomique, Institut Universitaire d Hematologie, Saint Louis Hospital, 75010 Paris cedex 10, France
    J Hepatol 39:587-94. 2003
    ..The HLA-G molecule is acknowledged to possess tolerogenic properties...
  64. ncbi request reprint Selective expression of HLA-G in malignant and premalignant skin specimens in kidney transplant recipients
    Selim Aractingi
    Commissariat a l Energie Atomique, Hopital Saint Louis, Paris, France
    Int J Cancer 106:232-5. 2003
    ..Cytokines triggered in the course of organ transplantation include IL-10. This molecule may induce expression of HLA-G, which in turn may be implicated in tumor development in transplanted recipients...
  65. ncbi request reprint Characterization of monoclonal antibodies recognizing HLA-G or HLA-E: new tools to analyze the expression of nonclassical HLA class I molecules
    Catherine Menier
    Service de Recherches en Hemato Immunologie, Hopital Saint Louis, IUH, Paris, France
    Hum Immunol 64:315-26. 2003
    ..These new mAbs represent valuable tools to study the expression of HLA-G and HLA-E molecules in cells and tissues under normal and pathologic conditions...
  66. pmc HLA-G gene repression is reversed by demethylation
    Philippe Moreau
    Commissariat a l Energie Atomique, Service de Recherche en Hémato Immunologie, Direction des Sciences du Vivant Department de Recherche Medicale, Institut Universitaire d Hematologie, Hopital Saint Louis, 75010 Paris, France
    Proc Natl Acad Sci U S A 100:1191-6. 2003
    ..Reversal of methylation-mediated repression may directly induce HLA-G cell-surface expression, supporting the idea that HLA-G might be activated by such a mechanism during malignancy, inflammation, and allogenic reactions...
  67. ncbi request reprint Viewpoint on the functionality of the human leukocyte antigen-G null allele at the fetal-maternal interface
    Philippe Moreau
    Service de Recherches en Hemato Immunologie, CEA DSV DRM, Hopital St Louis, Institut Universitaire d Hematologie, 75475 Paris, Cedex 10, France
    Biol Reprod 67:1375-8. 2002
    ..In this context, we have recently described that, like the full-length HLA-G1, the HLA-G2, -G3, and -G4 truncated isoforms may be expressed at the cell surface and may modulate both innate and acquired immune responses...
  68. ncbi request reprint MICA triggering signal for NK cell tumor lysis is counteracted by HLA-G1-mediated inhibitory signal
    Catherine Menier
    Service de Recherche en Hémato Immunologie, Direction des Sciences du Vivant, Departement de Recherche Medicale, Commissariat a l Energie Atomique, Institut Universitaire d Hematologie, Hopital Saint Louis, Paris, France
    Int J Cancer 100:63-70. 2002
    ....
  69. ncbi request reprint Specific activation of the non-classical class I histocompatibility HLA-G antigen and expression of the ILT2 inhibitory receptor in human breast cancer
    Sophie Lefebvre
    Service de Recherches en Hemato Immunologie, DSV DRM, CEA, Institut d Hematologie, Hopital Saint Louis, Centre Hayem, 1 avenue Claude Vellefaux, 75475 Paris Cedex 10, France
    J Pathol 196:266-74. 2002
    ..These results indicate that HLA-G is up-regulated at high frequencies in human breast cancer, where it may impair efficient anti-tumour immunity...
  70. ncbi request reprint HLA-G in cancer: a way to turn off the immune system
    Nathalie Rouas-Freiss
    Senrvice de Recherches en Hémato Immunologie, CEA DSV DRM, Hopital Saint Louis, 1UH, 1 avenue Claude Vellefaux, 75475 Paris 10, France
    Semin Cancer Biol 13:325-36. 2003
    ....
  71. ncbi request reprint Alloreactive CD4+ and CD8+ T cells express the immunotolerant HLA-G molecule in mixed lymphocyte reactions: in vivo implications in transplanted patients
    Solene Le Rond
    Service de Recherches en Hemato Immunologie, CEA DSV DRM, Hopital Saint Louis, IUH, Paris, France
    Eur J Immunol 34:649-60. 2004
    ..The HLA-G-positive T cells we describe here may constitute a cellular source of HLA-G after allotransplantation and may be involved in the improved graft acceptance which is observed in HLA-G-positive transplanted patients...
  72. pmc HLA-G1-expressing antigen-presenting cells induce immunosuppressive CD4+ T cells
    Joel Lemaoult
    Service de Recherches en Hemato Immunologie, Commissariat à l Energie Atomique Département de Recherche Médicale Direction des Sciences du Vivant, Hopital Saint Louis, 1 avenue Claude Vellefaux, 75475 Paris 10, France
    Proc Natl Acad Sci U S A 101:7064-9. 2004
    ..Thus, HLA-G+ APCs might (i) be involved in the direct suppression of immune responses and (ii) contribute to long-term efficient immune escape or tolerance...
  73. ncbi request reprint Linking two immuno-suppressive molecules: indoleamine 2,3 dioxygenase can modify HLA-G cell-surface expression
    Alvaro González-Hernandez
    Clinica Universitaria de Navarra, 31080 Pamplona, Navarra, Spain
    Biol Reprod 73:571-8. 2005
    ..Furthermore, HLA-G cell surface expression regulation by INDO seems to relate to INDO function, but not to tryptophan catabolism itself. Potential implications in fetal-maternal tolerance are discussed...
  74. ncbi request reprint HLA-G*0105N null allele encodes functional HLA-G isoforms
    Magali Le Discorde
    Service de Recherches en Hemato Immunologie, CEA DSV DRM, Institut d Hematologie, Hopital Saint Louis, Paris 75010, France
    Biol Reprod 73:280-8. 2005
    ....
  75. ncbi request reprint HLA-G up-regulates ILT2, ILT3, ILT4, and KIR2DL4 in antigen presenting cells, NK cells, and T cells
    Joel Lemaoult
    Service de Recherches en Hemato Immunologie, Commissariat à L Energie Atomique DRM DSV, Institut Universitaire d Hematologie, Hopital Saint Louis, Paris, France
    FASEB J 19:662-4. 2005
    ..Functionally, up-regulation of inhibitory receptors in immune cells before stimulation might increase their activation thresholds and participate in immune escape mechanisms...
  76. ncbi request reprint Monocytes and T lymphocytes in HIV-1-positive patients express HLA-G molecule
    José M Lozano
    Service of Immunology, Reina Sofia University Hospital, University of Cordoba, School of Medicine, C Menendez Pidal s n, 14004 Cordoba, Spain
    AIDS 16:347-51. 2002
    ..To study the expression of HLA-G on peripheral blood mononuclear cells (PBMC) from HIV-1-infected individuals in order to determine whether this molecule is induced as a consequence of HIV-1 infection...
  77. ncbi request reprint HLA-G gene activation in tumor cells involves cis-acting epigenetic changes
    Gael Mouillot
    Commissariat í l Energie Atomique, Service de Recherches en Hemato Immunologie, Direction des Sciences du Vivant Dèpartement de Recherche Médicale, Institut Universitaire d Hematologie, Hopital Saint Louis, Paris, France
    Int J Cancer 113:928-36. 2005
    ..2 kb. cis-acting epigenetic changes and the fact that demethylating agents activate HLA-G expression at least 5 days following treatment should be taken into account in epigenetic cancer therapies...
  78. ncbi request reprint Erythroblasts secrete the nonclassical HLA-G molecule from primitive to definitive hematopoiesis
    Catherine Menier
    Service de Recherches en Hemato Immunologie, CEA DSV DRM, Hopital Saint Louis, IUH, 1, avenue Claude Vellefaux, 75010 Paris, France
    Blood 104:3153-60. 2004
    ..This new marker, previously known by its immunotolerogeneic properties, may be involved in erythroid differentiation, angiogenesis, or both...
  79. ncbi request reprint Intercellular exchanges of membrane patches (trogocytosis) highlight the next level of immune plasticity
    Julien Caumartin
    Service de Recherches en Hemato Immunologie, Commissariat a l Energie Atomique, Hopital Saint Louis, 1 avenue Claude Vellefaux, 75010 Paris, France
    Transpl Immunol 17:20-2. 2006
    ..We here briefly outline the key findings concerning trogocytosis, and discuss their implications...
  80. ncbi request reprint Implication of HLA-G in human embryo implantation
    Renato Fanchin
    Department of Obstetrics and Gynecology, Hopital Antoine Beclere, Clamart, France
    Hum Immunol 68:259-63. 2007
    ..In particular, studies investigating HLA-G expression on human preimplantation embryos and in the endometrium, as well as its levels in embryo culture supernatants and circulating maternal blood, are discussed...
  81. ncbi request reprint Human leukocyte antigen-G expression after heart transplantation is associated with a reduced incidence of rejection
    Nermine Lila
    Laboratory for the Study of Cardiac Grafts and Prostheses, University of Pierre et Marie Curie, Broussais Hospital, Paris, France
    Circulation 105:1949-54. 2002
    ..In a preliminary study, we showed that HLA-G is expressed in the hearts of some patients after heart transplantation...
  82. ncbi request reprint Soluble human leukocyte antigen-G5 in septic shock: marked and persisting elevation as a predictor of survival
    Guillaume Monneret
    Hospices Civils de Lyon, Hopital Neurologique, Laboratoire d Immunologie, Lyon, France
    Crit Care Med 35:1942-7. 2007
    ..The main objective of the current study was to measure human leukocyte antigen-G (soluble and membrane proteins) in septic shock...
  83. ncbi request reprint Skin carcinoma arising from donor cells in a kidney transplant recipient
    Selim Aractingi
    Unite de Dermatologie, Hopital Tenon, Paris, France
    Cancer Res 65:1755-60. 2005
    ..In conclusion, stem cells originating from a grafted kidney may migrate to the skin, differentiate, or fuse as keratinocytes that could, rarely, undergo cancer transformation...
  84. ncbi request reprint HLA-G in transplantation: a relevant molecule for inhibition of graft rejection?
    Nathalie Rouas-Freiss
    Service de Recherches en Hemato Immunologie, CEA DSV DRM, Hopital Saint Louis, IUH, Paris, France
    Am J Transplant 3:11-6. 2003
    ....
  85. ncbi request reprint Genetic and epigenetic features in radiation sensitivity. Part II: implications for clinical practice and radiation protection
    Michel H Bourguignon
    Direction Générale de la Sûreté Nucléaire et de la Radioprotection, 6 Place du Colonel Bourgoin, 75572, Paris Cedex 12, France
    Eur J Nucl Med Mol Imaging 32:351-68. 2005
    ..The implications for radiation protection of possible hypersensitivity to radiation in a part of the population are discussed, and some guidelines for nuclear medicine professionals are proposed...
  86. ncbi request reprint NK-cell reconstitution after haploidentical hematopoietic stem-cell transplantations: immaturity of NK cells and inhibitory effect of NKG2A override GvL effect
    Stephanie Nguyen
    Laboratoire d Immunologie Cellulaire et Tissulaire INSERM U543, Hopital Pitie Salpetriere, 83 Bvd de l Hôpital 75013 Paris, France
    Blood 105:4135-42. 2005
    ....
  87. ncbi request reprint [Critical analysis of the immunological self/non-self model and of its implicit metaphysical foundations]
    Thomas Pradeu
    Agrégé de philosophie, département de philosophie de l Ecole normale supérieure Ulm Paris, France
    C R Biol 327:481-92. 2004
    ..The 'continuity hypothesis' developed here attempts to give a criterion of immunogenicity that avoids the reproaches leveled at the self model...
  88. ncbi request reprint Maternal antigen presenting cells are a source of plasmatic HLA-G during pregnancy: longitudinal study during pregnancy
    Estibaliz Alegre
    Department of Biochemistry, University Clinic of Navarra, Pamplona, Spain
    Hum Immunol 68:661-7. 2007
    ..Women who experienced miscarriage had previously very low or undetectable plasmatic sHLA-G levels in the second month of pregnancy. Data suggest that undetectable sHLA-G could be a risk of complications...
  89. pmc On the definition of a criterion of immunogenicity
    Thomas Pradeu
    Institut d histoire et de philosophie des sciences et des techniques, Department of Philosophy, Sorbonne University, 13, rue du Four, 75006 Paris, France
    Proc Natl Acad Sci U S A 103:17858-61. 2006
    ..We conclude that immunologists can continue to speak of the self, provided that they admit that the self/nonself discrimination is not an adequate criterion of immunogenicity...
  90. ncbi request reprint Genetic and epigenetic features in radiation sensitivity Part I: cell signalling in radiation response
    Michel H Bourguignon
    Direction Générale de la Sûreté Nucléaire et de la Radioprotection DGSNR, 6 Place du Colonel Bourgoin, 75572, Paris Cedex 12, France
    Eur J Nucl Med Mol Imaging 32:229-46. 2005
    ..DNA repair machinery and cell signalling pathways are considered and their role in radiosensitivity is analysed. The implication of non-targeted and delayed effects in radiosensitivity is also discussed...