Anne Bravard

Summary

Affiliation: CEA Saclay
Country: France

Publications

  1. ncbi Modifications of the antioxidant enzymes in relation to chromosome imbalances in human melanoma cell lines
    A Bravard
    CEA DSV DRR LRCE, BP6, Fontenay aux Roses, France
    Melanoma Res 8:329-35. 1998
  2. ncbi Modulation of antioxidant enzymes p21WAF1 and p53 expression during proliferation and differentiation of human melanoma cell lines
    A Bravard
    CEA DSV DRR, Laboratoire de Radiobiologie Cellulaire, Fontenay aux Roses, France
    Free Radic Biol Med 26:1027-33. 1999
  3. ncbi Contribution of antioxidant enzymes to the adaptive response to ionizing radiation of human lymphoblasts
    A Bravard
    Commissariat a l Energie Atomique, DSV DRR, Fontenay aux Roses, France
    Int J Radiat Biol 75:639-45. 1999
  4. ncbi Correlation between antioxidant status, tumorigenicity and radiosensitivity in sister rat cell lines
    Anne Bravard
    Commissariat a l Energie Atomique CEA, DSV DRR Laboratoire de Radiobiologie Cellulaire and Commissariat à l Energie Atomique CEA, UMR217 CEA CNRS, Fontenay aux Roses Cedex, France
    Carcinogenesis 23:705-11. 2002
  5. ncbi Persistent oxidative stress after ionizing radiation is involved in inherited radiosensitivity
    Anne Tulard
    Departement de Radiobiologie et Radiopathologie, UMR217 CNRS CEA, Commissariat a l Energie Atomique, BP6, F 92265 Fontenay aux Roses, France
    Free Radic Biol Med 35:68-77. 2003
  6. ncbi Inactivation by oxidation and recruitment into stress granules of hOGG1 but not APE1 in human cells exposed to sub-lethal concentrations of cadmium
    Anne Bravard
    CEA, Institut de Radiobiologie Cellulaire et Moleculaire, 18 route du Panorama, F 92265 Fontenay aux Roses, France
    Mutat Res 685:61-9. 2010
  7. ncbi Oxidation status of human OGG1-S326C polymorphic variant determines cellular DNA repair capacity
    Anne Bravard
    CEA, Institut de Radiobiologie Cellulaire et Moleculaire, UMR217 Centre National de la Recherche Scientifique CEA, Fontenay aux Roses, France
    Cancer Res 69:3642-9. 2009
  8. ncbi Rapid inactivation and proteasome-mediated degradation of OGG1 contribute to the synergistic effect of hyperthermia on genotoxic treatments
    Damiano Fantini
    CEA, Institute of Molecular and Cellular Radiobiology, 18 route du Panorama, Fontenay aux Roses, F 92265, France
    DNA Repair (Amst) 12:227-37. 2013
  9. ncbi UVA irradiation induces relocalisation of the DNA repair protein hOGG1 to nuclear speckles
    Anna Campalans
    Departement de Radiobiologie et Radiopathologie, Commissariat a l Energie Atomique, UMR 217 CNRS CEA, 18 route du Panorama, 92265 Fontenay aux Roses, France
    J Cell Sci 120:23-32. 2007
  10. ncbi Redox regulation of human OGG1 activity in response to cellular oxidative stress
    Anne Bravard
    Departement de Radiobiologie et Radiopathologie, CEA, 18 route du Panorama, F 92265 Fontenay aux Roses, France
    Mol Cell Biol 26:7430-6. 2006

Collaborators

Detail Information

Publications10

  1. ncbi Modifications of the antioxidant enzymes in relation to chromosome imbalances in human melanoma cell lines
    A Bravard
    CEA DSV DRR LRCE, BP6, Fontenay aux Roses, France
    Melanoma Res 8:329-35. 1998
    ..These results strengthen the hypothesis that SOD2 has a function as a tumour suppressor gene, but also suggest that the expression of other antioxidant enzymes might be altered in human melanomas...
  2. ncbi Modulation of antioxidant enzymes p21WAF1 and p53 expression during proliferation and differentiation of human melanoma cell lines
    A Bravard
    CEA DSV DRR, Laboratoire de Radiobiologie Cellulaire, Fontenay aux Roses, France
    Free Radic Biol Med 26:1027-33. 1999
    ..Alterations of SOD2 activity may be of particular importance, since variations are observed with both cell growth and cell differentiation...
  3. ncbi Contribution of antioxidant enzymes to the adaptive response to ionizing radiation of human lymphoblasts
    A Bravard
    Commissariat a l Energie Atomique, DSV DRR, Fontenay aux Roses, France
    Int J Radiat Biol 75:639-45. 1999
    ..To investigate whether the adaptive response to ionizing radiation triggered by a low-dose pre-exposure could be due to the activation of the antioxidant defence system...
  4. ncbi Correlation between antioxidant status, tumorigenicity and radiosensitivity in sister rat cell lines
    Anne Bravard
    Commissariat a l Energie Atomique CEA, DSV DRR Laboratoire de Radiobiologie Cellulaire and Commissariat à l Energie Atomique CEA, UMR217 CEA CNRS, Fontenay aux Roses Cedex, France
    Carcinogenesis 23:705-11. 2002
    ..A better understanding of antioxidant defenses might be more informative...
  5. ncbi Persistent oxidative stress after ionizing radiation is involved in inherited radiosensitivity
    Anne Tulard
    Departement de Radiobiologie et Radiopathologie, UMR217 CNRS CEA, Commissariat a l Energie Atomique, BP6, F 92265 Fontenay aux Roses, France
    Free Radic Biol Med 35:68-77. 2003
    ....
  6. ncbi Inactivation by oxidation and recruitment into stress granules of hOGG1 but not APE1 in human cells exposed to sub-lethal concentrations of cadmium
    Anne Bravard
    CEA, Institut de Radiobiologie Cellulaire et Moleculaire, 18 route du Panorama, F 92265 Fontenay aux Roses, France
    Mutat Res 685:61-9. 2010
    ..In contrast to hOGG1, we show here that exposure to Cd does not affect the activity of the second enzyme of the pathway, the major AP endonuclease APE1...
  7. ncbi Oxidation status of human OGG1-S326C polymorphic variant determines cellular DNA repair capacity
    Anne Bravard
    CEA, Institut de Radiobiologie Cellulaire et Moleculaire, UMR217 Centre National de la Recherche Scientifique CEA, Fontenay aux Roses, France
    Cancer Res 69:3642-9. 2009
    ..Our findings support the idea that individuals homozygous for the OGG1-Cys variant could more readily accumulate mutations under conditions of oxidative stress...
  8. ncbi Rapid inactivation and proteasome-mediated degradation of OGG1 contribute to the synergistic effect of hyperthermia on genotoxic treatments
    Damiano Fantini
    CEA, Institute of Molecular and Cellular Radiobiology, 18 route du Panorama, Fontenay aux Roses, F 92265, France
    DNA Repair (Amst) 12:227-37. 2013
    ..Taken together, our results suggest that OGG1 inhibition contributes to heat-induced chemosensitisation of cells and could lay the basis for new anticancer therapeutic protocols that include hyperthermia...
  9. ncbi UVA irradiation induces relocalisation of the DNA repair protein hOGG1 to nuclear speckles
    Anna Campalans
    Departement de Radiobiologie et Radiopathologie, Commissariat a l Energie Atomique, UMR 217 CNRS CEA, 18 route du Panorama, 92265 Fontenay aux Roses, France
    J Cell Sci 120:23-32. 2007
    ..The recruitment of DNA repair proteins to nuclear speckles after oxidative stress implicates these organelles in the cellular stress response...
  10. ncbi Redox regulation of human OGG1 activity in response to cellular oxidative stress
    Anne Bravard
    Departement de Radiobiologie et Radiopathologie, CEA, 18 route du Panorama, F 92265 Fontenay aux Roses, France
    Mol Cell Biol 26:7430-6. 2006
    ..The results presented here unveil a novel redox-dependent mechanism for the regulation of OGG1 activity...