Giacomo Cavalli


Country: France


  1. Cheutin T, Cavalli G. Loss of PRC1 induces higher-order opening of Hox loci independently of transcription during Drosophila embryogenesis. Nat Commun. 2018;9:3898 pubmed publisher
    ..Our data suggest that PRC1 maintains gene silencing by folding chromatin domains and impose architectural layer to gene regulation. ..
  2. Ogiyama Y, Schuettengruber B, Papadopoulos G, Chang J, Cavalli G. Polycomb-Dependent Chromatin Looping Contributes to Gene Silencing during Drosophila Development. Mol Cell. 2018;71:73-88.e5 pubmed publisher
    ..Preventing loop formation without removal of polycomb components also decreases silencing efficiency, suggesting that chromatin architecture can play instructive roles in gene regulation during development. VIDEO ABSTRACT. ..
  3. Ciabrelli F, Cavalli G. Chromatin-driven behavior of topologically associating domains. J Mol Biol. 2015;427:608-25 pubmed publisher
    ..In this review, we will describe the main three-dimensional features of each chromatin type and finally their relationships with TAD organization and epigenetic memory. ..
  4. Sexton T, Cavalli G. The role of chromosome domains in shaping the functional genome. Cell. 2015;160:1049-59 pubmed publisher
  5. Ea V, Sexton T, Gostan T, Herviou L, Baudement M, Zhang Y, et al. Distinct polymer physics principles govern chromatin dynamics in mouse and Drosophila topological domains. BMC Genomics. 2015;16:607 pubmed publisher
    ..However, constraints applied on this dynamics within mammalian TADs have a peculiar impact resulting in a statistical helix organization. ..
  6. request reprint
    Cavalli G. Chromatin as a eukaryotic template of genetic information. Curr Opin Cell Biol. 2002;14:269-78 pubmed
  7. Cavalli G, Misteli T. Functional implications of genome topology. Nat Struct Mol Biol. 2013;20:290-9 pubmed publisher
  8. González I, Mateos Langerak J, Thomas A, Cheutin T, Cavalli G. Identification of regulators of the three-dimensional polycomb organization by a microscopy-based genome-wide RNAi screen. Mol Cell. 2014;54:485-99 pubmed publisher
  9. Schuettengruber B, Oded Elkayam N, Sexton T, Entrevan M, Stern S, Thomas A, et al. Cooperativity, specificity, and evolutionary stability of Polycomb targeting in Drosophila. Cell Rep. 2014;9:219-33 pubmed publisher
    ..These data suggest that cooperative rather than hierarchical interactions among low-affinity sequences, DNA-binding factors, and the Polycomb machinery are giving rise to specific and strongly conserved 3D structures in Drosophila. ..

More Information


  1. Yung P, Stuetzer A, Fischle W, Martinez A, Cavalli G. Histone H3 Serine 28 Is Essential for Efficient Polycomb-Mediated Gene Repression in Drosophila. Cell Rep. 2015;11:1437-45 pubmed publisher
    ..Collectively, our data indicate that the conserved H3S28 residue in metazoans has a role in supporting PRC2 catalysis. ..
  2. Sati S, Cavalli G. Chromosome conformation capture technologies and their impact in understanding genome function. Chromosoma. 2017;126:33-44 pubmed publisher
    ..We also discuss their inherent limitations and caveats in order to provide a critical view of the power and the limits of this technology. ..
  3. Entrevan M, Schuettengruber B, Cavalli G. Regulation of Genome Architecture and Function by Polycomb Proteins. Trends Cell Biol. 2016;26:511-525 pubmed publisher
    ..In this review we discuss recent advances in our understanding of how PcG proteins are recruited to chromatin to induce local and global changes in chromosome conformation and regulate their target genes. ..
  4. Schuettengruber B, Bourbon H, Di Croce L, Cavalli G. Genome Regulation by Polycomb and Trithorax: 70 Years and Counting. Cell. 2017;171:34-57 pubmed publisher
  5. Bonev B, Mendelson Cohen N, Szabo Q, Fritsch L, Papadopoulos G, Lubling Y, et al. Multiscale 3D Genome Rewiring during Mouse Neural Development. Cell. 2017;171:557-572.e24 pubmed publisher
    ..Finally, cell type-specific enhancer-promoter contacts are established concomitant to gene expression. This work shows that multiple factors influence the dynamics of chromatin interactions in development. ..