Jean Christophe Cassel

Summary

Country: France

Publications

  1. doi request reprint Coexisting cholinergic and parahippocampal degeneration: a key to memory loss in dementia and a challenge for transgenic models?
    Jean Christophe Cassel
    LINC UMR 7191, Universite Louis Pasteur, CNRS, Institut Fédératif de Recherche IFR 37, GDR CNRS 2905, Strasbourg, France
    Neurodegener Dis 5:304-17. 2008
  2. ncbi request reprint Attention and executive functions in a rat model of chronic epilepsy
    Jean Baptiste Faure
    Laboratory of Cognitive and Adaptive Neuroscience LNCA, Faculty of Psychology, UMR 7364 University of Strasbourg CNRS, Strasbourg, France Faculty of Medicine, INSERM U 666, Strasbourg, France
    Epilepsia 55:644-53. 2014
  3. pmc Detection of histone acetylation levels in the dorsal hippocampus reveals early tagging on specific residues of H2B and H4 histones in response to learning
    Olivier Bousiges
    Laboratoire de Neurosciences Cognitives et Adaptatives, UMR7364, Universite de Strasbourg CNRS, GDR CNRS 2905, Faculte de Psychologie, Strasbourg, France
    PLoS ONE 8:e57816. 2013
  4. doi request reprint Lesions of the anterior thalamic nuclei and intralaminar thalamic nuclei: place and visual discrimination learning in the water maze
    Pierre Henri Moreau
    Laboratoire d Imagerie et Neurosciences Cognitives, UMR 7237, Universite de Strasbourg, CNRS, IFR 37 Neurosciences, GDR CNRS 2905, 12 rue Goethe, 67000 Strasbourg, France
    Brain Struct Funct 218:657-67. 2013
  5. doi request reprint Spatial memory alterations by activation of septal 5HT 1A receptors: no implication of cholinergic septohippocampal neurons
    Julie Koenig
    Laboratoire d Imagerie et de Neurosciences Cognitives, FRE 3289, Universite de Strasbourg CNRS, Institut Fédérératif de Recherche 37 GDR CNRS 2905, 12 rue Goethe, 67000, Strasbourg, France
    Psychopharmacology (Berl) 214:437-54. 2011
  6. doi request reprint Reduced plasticity and mild cognitive impairment-like deficits after entorhinal lesions in hAPP/APOE4 mice
    Jean Bastien Bott
    Laboratoire de Neurosciences Cognitives et Adaptatives, UMR 7364 CNRS, Universite de Strasbourg, Strasbourg, France
    Neurobiol Aging 34:2683-93. 2013
  7. ncbi request reprint Ethanol-MDMA interactions in rats: the importance of interval between repeated treatments in biobehavioral tolerance and sensitization to the combination
    Sami Ben Hamida
    LINC UMR 7191, Université Louis Pasteur CNRS, Institut Fédérératif de Recherche 37, GDR CNRS 2905, Strasbourg, France
    Psychopharmacology (Berl) 192:555-69. 2007
  8. pmc Lifelong environmental enrichment in rats: impact on emotional behavior, spatial memory vividness, and cholinergic neurons over the lifespan
    Hayat Harati
    Laboratoire d Imagerie et de Neurosciences Cognitives, UMR 7237 CNRS, Universite de Strasbourg, IFR 37 de Neurosciences, GDR 2905 du CNRS, 12 rue Goethe, 67000, Strasbourg, France
    Age (Dordr) 35:1027-43. 2013
  9. ncbi request reprint Activation of septal 5-HT1A receptors alters spatial memory encoding, interferes with consolidation, but does not affect retrieval in rats subjected to a water-maze task
    Julie Koenig
    LINC UMR 7191, CNRS Université Louis Pasteur, Institut Fédérératif de Recherche 37 GDR CNRS 2905, 12 rue Goethe, Strasbourg, France
    Hippocampus 18:99-118. 2008
  10. pmc Interactions between the lateral habenula and the hippocampus: implication for spatial memory processes
    Romain Goutagny
    1 Laboratoire de Neurosciences Cognitives et Adaptatives, UMR7364, Centre National de la Recherche Scientifique CNRS, Strasbourg, France 2 Faculté de Psychologie, Universite de Strasbourg, Strasbourg, France
    Neuropsychopharmacology 38:2418-26. 2013

Collaborators

Detail Information

Publications65

  1. doi request reprint Coexisting cholinergic and parahippocampal degeneration: a key to memory loss in dementia and a challenge for transgenic models?
    Jean Christophe Cassel
    LINC UMR 7191, Universite Louis Pasteur, CNRS, Institut Fédératif de Recherche IFR 37, GDR CNRS 2905, Strasbourg, France
    Neurodegener Dis 5:304-17. 2008
    ....
  2. ncbi request reprint Attention and executive functions in a rat model of chronic epilepsy
    Jean Baptiste Faure
    Laboratory of Cognitive and Adaptive Neuroscience LNCA, Faculty of Psychology, UMR 7364 University of Strasbourg CNRS, Strasbourg, France Faculty of Medicine, INSERM U 666, Strasbourg, France
    Epilepsia 55:644-53. 2014
    ..In the rat lithium-pilocarpine temporal lobe epilepsy model, memory impairment and anxiety disorder are classically reported. Here we evaluated sustained visual attention in this model of epilepsy, a function not frequently explored...
  3. pmc Detection of histone acetylation levels in the dorsal hippocampus reveals early tagging on specific residues of H2B and H4 histones in response to learning
    Olivier Bousiges
    Laboratoire de Neurosciences Cognitives et Adaptatives, UMR7364, Universite de Strasbourg CNRS, GDR CNRS 2905, Faculte de Psychologie, Strasbourg, France
    PLoS ONE 8:e57816. 2013
    ....
  4. doi request reprint Lesions of the anterior thalamic nuclei and intralaminar thalamic nuclei: place and visual discrimination learning in the water maze
    Pierre Henri Moreau
    Laboratoire d Imagerie et Neurosciences Cognitives, UMR 7237, Universite de Strasbourg, CNRS, IFR 37 Neurosciences, GDR CNRS 2905, 12 rue Goethe, 67000 Strasbourg, France
    Brain Struct Funct 218:657-67. 2013
    ..These findings confirmed the influence of ATN lesions on spatial learning, but failed to support the view that ILN/LT lesions disrupt striatal-dependent memory...
  5. doi request reprint Spatial memory alterations by activation of septal 5HT 1A receptors: no implication of cholinergic septohippocampal neurons
    Julie Koenig
    Laboratoire d Imagerie et de Neurosciences Cognitives, FRE 3289, Universite de Strasbourg CNRS, Institut Fédérératif de Recherche 37 GDR CNRS 2905, 12 rue Goethe, 67000, Strasbourg, France
    Psychopharmacology (Berl) 214:437-54. 2011
    ..If so, selective damage of these neurons should mimic the effects of 8-OH-DPAT, or, at least, synergistically interfere with them...
  6. doi request reprint Reduced plasticity and mild cognitive impairment-like deficits after entorhinal lesions in hAPP/APOE4 mice
    Jean Bastien Bott
    Laboratoire de Neurosciences Cognitives et Adaptatives, UMR 7364 CNRS, Universite de Strasbourg, Strasbourg, France
    Neurobiol Aging 34:2683-93. 2013
    ..These findings provide a possible mechanism underlying the aggravating effect of APOE4 on the cognitive outcome of MCI patients. ..
  7. ncbi request reprint Ethanol-MDMA interactions in rats: the importance of interval between repeated treatments in biobehavioral tolerance and sensitization to the combination
    Sami Ben Hamida
    LINC UMR 7191, Université Louis Pasteur CNRS, Institut Fédérératif de Recherche 37, GDR CNRS 2905, Strasbourg, France
    Psychopharmacology (Berl) 192:555-69. 2007
    ..The latter effect was previously thought to reflect tolerance to ethanol or the combination, per se...
  8. pmc Lifelong environmental enrichment in rats: impact on emotional behavior, spatial memory vividness, and cholinergic neurons over the lifespan
    Hayat Harati
    Laboratoire d Imagerie et de Neurosciences Cognitives, UMR 7237 CNRS, Universite de Strasbourg, IFR 37 de Neurosciences, GDR 2905 du CNRS, 12 rue Goethe, 67000, Strasbourg, France
    Age (Dordr) 35:1027-43. 2013
    ..A protected basal forebrain cholinergic system, which could well be one out of several neuronal manifestations of lifelong environmental enrichment, might have contributed to the behavioral benefits of this enrichment...
  9. ncbi request reprint Activation of septal 5-HT1A receptors alters spatial memory encoding, interferes with consolidation, but does not affect retrieval in rats subjected to a water-maze task
    Julie Koenig
    LINC UMR 7191, CNRS Université Louis Pasteur, Institut Fédérératif de Recherche 37 GDR CNRS 2905, 12 rue Goethe, Strasbourg, France
    Hippocampus 18:99-118. 2008
    ..These results might have some relevance to approaches aimed at modifying serotonergic functions in the brain for the treatment of disorders such as depression, anxiety, post-traumatic stress, and amnesia...
  10. pmc Interactions between the lateral habenula and the hippocampus: implication for spatial memory processes
    Romain Goutagny
    1 Laboratoire de Neurosciences Cognitives et Adaptatives, UMR7364, Centre National de la Recherche Scientifique CNRS, Strasbourg, France 2 Faculté de Psychologie, Universite de Strasbourg, Strasbourg, France
    Neuropsychopharmacology 38:2418-26. 2013
    ..Collectively, these results suggest that LHb functionally interacts with the hippocampus and is involved in hippocampus-dependent spatial information processing. ..
  11. ncbi request reprint Whole-body exposure to 2.45 GHz electromagnetic fields does not alter 12-arm radial-maze with reduced access to spatial cues in rats
    Brigitte Cosquer
    LN2C UMR 7521 Université Louis Pasteur CNRS, Institut Fédératif de Recherche 37, GDR CNRS 2905, 12 rue Goethe, 67000 Strasbourg, France
    Behav Brain Res 161:331-4. 2005
    ..Performance of exposed rats was normal. These results show that microwave exposure as used herein does not alter spatial working memory, when access to spatial cues is reduced...
  12. ncbi request reprint Transplantation of neurospheres after granule cell lesions in rats: cognitive improvements despite no long-term immunodetection of grafted cells
    Hélène Jeltsch
    LN2C, UMR 7521, CNRS Université Louis Pasteur, 12 rue Goethe, F 67000, Strasbourg, France
    Behav Brain Res 143:177-91. 2003
    ....
  13. ncbi request reprint MDMA (ecstasy) effects in pubescent rats: Males are more sensitive than females
    Julie Koenig
    Laboratoire de Neurosciences Comportementales et Cognitives, UMR 7521 CNRS Université Louis Pasteur, IFR 37 Neurosciences, GDR CNRS 2905, 12 rue Goethe, F 67000 Strasbourg, France
    Pharmacol Biochem Behav 81:635-44. 2005
    ....
  14. doi request reprint Combined lesions of GABAergic and cholinergic septal neurons increase locomotor activity and potentiate the locomotor response to amphetamine
    Lucas Lecourtier
    Laboratoire d Imagerie et de Neurosciences Cognitives, FRE 3289, Universite de Strasbourg CNRS, 12 rue Goethe, Strasbourg, France
    Behav Brain Res 213:175-82. 2010
    ..Our results further suggest that the septum, through both cholinergic and GABAergic fibers, modulates the functional contribution of the hippocampus/subiculum in the regulation of mesolimbic dopamine transmission...
  15. doi request reprint The ventral hippocampus is necessary for expressing a spatial memory
    Michael Loureiro
    Laboratoire d Imagerie et de Neurosciences Cognitives, UMR 7237, Universite de Strasbourg, CNRS, IFR 37 des Neurosciences, GDR CNRS 2905 Neuromem, 12 rue Goethe, 67000 Strasbourg, France
    Brain Struct Funct 217:93-106. 2012
    ....
  16. ncbi request reprint A comparison of the effects of fimbria-fornix, hippocampal, or entorhinal cortex lesions on spatial reference and working memory in rats: short versus long postsurgical recovery period
    Rodrigue Galani
    Laboratoire de Neurosciences Comportementales et Cognitives, Universite Louis Pasteur, UMR 7521 ULP CNRS, 12 rue Goethe, F 67000 Strasbourg, France
    Neurobiol Learn Mem 77:1-16. 2002
    ..g., on the working memory task) but both hippocampal and fimbria-fornix animals were still impaired compared to controls when training was delayed 6.5 months following the operations...
  17. doi request reprint A comprehensive behavioral evaluation in the lithium-pilocarpine model in rats: effects of carisbamate administration during status epilepticus
    Jean Baptiste Faure
    Faculty of Medicine, INSERM U 666, Strasbourg, France
    Epilepsia 54:1203-13. 2013
    ..To assess whether these carisbamate-induced changes affected comorbidity, we used a large battery of behavioral tests in rats that had developed temporal lobe or absence-like seizures...
  18. doi request reprint ApoE4 confers better spatial memory than apoE3 in young adult hAPP-Yac/apoE-TR mice
    Pierre Henri Moreau
    Laboratoire d Imagerie et de Neurosciences Cognitives, UMR 7237 CNRS, Universite de Strasbourg, IFR 37, GDR CNRS 2905, 12 rue Goethe, F 67000 Strasbourg, France
    Behav Brain Res 243:1-5. 2013
    ..This hAPP-Yac/apoE-TR model may thus provide a useful tool to study the mechanisms involved in the antagonistic pleiotropic effects of APOE-ɛ4 on cognitive functions...
  19. doi request reprint Ethanol increases the distribution of MDMA to the rat brain: possible implications in the ethanol-induced potentiation of the psychostimulant effects of MDMA
    Sami Ben Hamida
    LINC UMR 7191, CNRS Université Louis Pasteur, Institut Fédérératif de Recherche 37, Strasbourg, France
    Int J Neuropsychopharmacol 12:749-59. 2009
    ..Our results present clear evidence that EtOH increases brain and blood concentrations of MDMA and leads to the possibility of both enhanced MDMA-based neurotoxicity and increased liability for abuse...
  20. ncbi request reprint Blood-brain barrier and electromagnetic fields: effects of scopolamine methylbromide on working memory after whole-body exposure to 2.45 GHz microwaves in rats
    Brigitte Cosquer
    LN2C UMR 7521 Université Louis Pasteur, CNRS, Institut Fédérératif de Recherche 37, GDR CNRS 2905, 12 rue Goethe, F67000 Strasbourg, France
    Behav Brain Res 161:229-37. 2005
    ..Thus, EMFs most probably failed to disrupt the BBB. This conclusion was further supported by the absence of Evans blue extravasation into the brain parenchyma of our exposed rats...
  21. ncbi request reprint Intraseptal injection of the 5-HT1A/5-HT7 agonist 8-OH-DPAT and working memory in rats
    Hélène Jeltsch
    LN2C, UMR 7521, CNRS Université Louis Pasteur, IFR 37 de Neurosciences, 12 rue Goethe, F 67000, Strasbourg, France
    Psychopharmacology (Berl) 175:37-46. 2004
    ..In rats, 5-HT(1A) receptors are present in the septal region, e.g. on cholinergic neurons of the medial septum, where they might be a substrate for cognitively relevant interactions between cholinergic and serotonergic systems...
  22. ncbi request reprint Structural and functional recovery elicited by combined putrescine and aminoguanidine treatment after aspirative lesion of the fimbria-fornix and overlying cortex in the adult rat
    Christophe Muller
    Laboratoire de Neurosciences Comportementales et Cognitives, LINC UMR 7191, GDR 2905 CNRS, IFR 37, 67000 Strasbourg, France
    Eur J Neurosci 25:1949-60. 2007
    ..These promising results support the idea that coadministration of putrescine and aminoguanidine might become a potent way to foster structural and functional recovery (or compensation) in the adult mammalian CNS after injury...
  23. pmc Spatial memory consolidation is associated with induction of several lysine-acetyltransferase (histone acetyltransferase) expression levels and H2B/H4 acetylation-dependent transcriptional events in the rat hippocampus
    Olivier Bousiges
    INSERM, U692, Laboratoire de Signalisations Moléculaires et Neurodégénérescence, Strasbourg, France
    Neuropsychopharmacology 35:2521-37. 2010
    ..These findings suggest the use of HAT-activating molecules in new therapeutic strategies of pathological aging, Alzheimer's disease, and other neurodegenerative disorders...
  24. doi request reprint Neuroanatomical and behavioral effects of a novel version of the cholinergic immunotoxin mu p75-saporin in mice
    Pierre Henri Moreau
    Laboratoire d Imagerie et de Neurosciences Cognitives, UMR7191 CNRS, Equipe de Neurobiologie Cognitive et Comportementale, ULP, IFR 37 de Neurosciences, GDR 2905 CNRS, 12 rue Goethe, 67000 Strasbourg, France
    Hippocampus 18:610-22. 2008
    ..These behavioral consequences are comparable, with fewer side effects, to those reported after ICV 192 IgG-saporin in rats. In conclusion, the new version of mu p75-saporin provides a safe and powerful tool for BFCN lesion in mice...
  25. doi request reprint The concept of brain plasticity--Paillard's systemic analysis and emphasis on structure and function (followed by the translation of a seminal paper by Paillard on plasticity)
    Bruno Will
    LINC, UMR 7191, Université Louis Pasteur Centre National de la Recherche Scientifique, IFR des Neurosciences 037, GDR 2905 CNRS, 12 rue Goethe, Strasbourg, France
    Behav Brain Res 192:2-7. 2008
    ..Sadly, Jacques Paillard died in 2006; our comments therefore also include a brief biographical tribute to this outstanding neuroscientist...
  26. ncbi request reprint Interactions between ethanol and cocaine, amphetamine, or MDMA in the rat: thermoregulatory and locomotor effects
    Sami Ben Hamida
    LINC UMR 7191, CNRS Université Louis Pasteur, Institut Fédérératif de Recherche 37 GDR CNRS 2905, 12 rue Goethe, F 67000, Strasbourg, France
    Psychopharmacology (Berl) 197:67-82. 2008
    ..3,4-methylenedioxymethamphetamine (MDMA, ecstasy) is often taken recreationally with ethanol (EtOH). In rats, EtOH may potentiate MDMA-induced hyperactivity, but attenuate hyperthermia...
  27. doi request reprint Modulation of cholinergic functions by serotonin and possible implications in memory: general data and focus on 5-HT(1A) receptors of the medial septum
    Hélène Jeltsch-David
    Laboratoire d Imagerie et de Neurosciences Cognitives, UMR 7191, Université Louis Pasteur CNRS, IFR 27 des Neurosciences et GDR 2905 du CNRS, 12 rue Goethe, F 67000 Strasbourg, France
    Behav Brain Res 195:86-97. 2008
    ..This control, however, does not occur by the way of an exclusive action of serotonin on cholinergic neurons...
  28. ncbi request reprint Environmental cue saliency influences the vividness of a remote spatial memory in rats
    Joëlle Lopez
    LINC, UMR 7191, CNRS Université Louis Pasteur, IFR 37 Neurosciences, GDR CNRS 2905, 12 rue Goethe, F 67000 Strasbourg, France
    Neurobiol Learn Mem 90:285-9. 2008
    ..Thus, the memory trace formed in the cue-enriched context shows better resistance to time, suggesting an implication of cue saliency in the vividness of a spatial memory...
  29. ncbi request reprint Cognitive deficits in aged rats correlate with levels of L-arginine, not with nNOS expression or 3,4-DAP-evoked transmitter release in the frontoparietal cortex
    Jean Christophe Cassel
    Institut für Experimentelle und Klinische Pharmakologie und Toxikologie der Universität Freiburg, Neuropharmakologisches Labor, Hansastrasse 9A, D 79104 Freiburg, Germany
    Eur Neuropsychopharmacol 15:163-75. 2005
    ..NO synthase concentrations were not affected by aging. It is suggested that events related to L-arginine-to-L-citrulline/NO metabolism in the frontoparietal cortex may take part in age-related cognitive deficits...
  30. ncbi request reprint Effects of 192 IgG-saporin on acetylcholinesterase histochemistry in male and female rats
    Rodrigue Galani
    Laboratoire de Neurosciences Comportementales et Cognitives, UMR 7521 ULP CNRS IFR 37, Strasbourg, France
    Brain Res Bull 58:179-86. 2002
    ..These results show that sex or estradiol treatment in male rats does not interfere with the immunotoxic effects of intracerebroventricular injections of 192 IgG-saporin on cholinergic projections from the basal forebrain...
  31. ncbi request reprint Selective immunolesions of CH4 cholinergic neurons do not disrupt spatial memory in rats
    Rodrigue Galani
    Laboratoire de Neurosciences Comportementales et Cognitives, LN2C UMR 7521, Université Louis Pasteur CNRS IFR 37, 12 rue Goethe, F 67000 Strasbourg, France
    Physiol Behav 76:75-90. 2002
    ....
  32. ncbi request reprint Whole-body exposure to 2.45 GHz electromagnetic fields does not alter radial-maze performance in rats
    Jean Christophe Cassel
    Institut Fédérératif de Recherche 37, LN2C UMR 7521 Université Louis Pasteur CNRS, 12 rue Goethe, Strasbourg 67000, France
    Behav Brain Res 155:37-43. 2004
    ..on their testing protocol, our results might suggest that the microwave-induced behavioral alterations measured by these authors might have had more to do with factors liable to performance bias than with spatial working memory per se...
  33. ncbi request reprint Locomotor and pyretic effects of MDMA-ethanol associations in rats
    Jean Christophe Cassel
    Laboratoire de Neurosciences Comportementales et Cognitives, UMR 7521 CNRS Université Louis Pasteur, IFR 37 Neurosciences, 12 rue Goethe, F 67000 Strasbourg, France
    Alcohol 34:285-9. 2004
    ..Results of our study have important implications for understanding the motivation and the health risks of polydrug abusers combining ecstasy and ethanol...
  34. ncbi request reprint Ethanol, 3,4-methylenedioxymethamphetamine (ecstasy) and their combination: long-term behavioral, neurochemical and neuropharmacological effects in the rat
    Jean Christophe Cassel
    Laboratoire de Neurosciences Comportementales et Cognitives, UMR 7521, CNRS Université Louis Pasteur, GDR 2905 CNRS, IFR 37 Neurosciences, 12 rue Goethe, F 67000 Strasbourg, France
    Neuropsychopharmacology 30:1870-82. 2005
    ..Thus, it is likely that the psycho(patho)logical problems reported by ecstasy users drinking alcohol are not solely due to the consumption of MDMA...
  35. doi request reprint Detecting spatial memory deficits beyond blindness in tg2576 Alzheimer mice
    Nour Yassine
    Laboratoire d Imagerie et de Neurosciences Cognitives, UMR 7237 CNRS, Universite de Strasbourg, IFR 37, GDR CNRS 2905, Strasbourg, France
    Neurobiol Aging 34:716-30. 2013
    ..Thus, the latter tasks appear extremely useful to evaluate spatial memory deficits and to test cognitive therapies in tg2576 mice and other mouse models bred on a background susceptible to visual impairment...
  36. ncbi request reprint The behavioral effects of enriched housing are not altered by serotonin depletion but enrichment alters hippocampal neurochemistry
    Rodrigue Galani
    LINC, UMR 7191 CNRS, Universite Louis Pasteur, IFR 37, GDR 2905 du CNRS, Strasbourg, France
    Neurobiol Learn Mem 88:1-10. 2007
    ..The neurochemical changes found in the hippocampus of EC rats, however, show that the monoaminergic innervation of the hippocampus is a target of EC...
  37. ncbi request reprint Spatial reference- (not working- or procedural-) memory performance of aged rats in the water maze predicts the magnitude of sulpiride-induced facilitation of acetylcholine release by striatal slices
    Jean Christophe Cassel
    Laboratoire de Neurosciences Comportementales et Cognitives, FRE 2855, CNRS Université Louis Pasteur, IFR 37 Neurosciences, GDR CNRS 2905, Strasbourg, France
    Neurobiol Aging 28:1270-85. 2007
    ....
  38. ncbi request reprint Polyamine and aminoguanidine treatments to promote structural and functional recovery in the adult mammalian brain after injury: a brief literature review and preliminary data about their combined administration
    Sarah Schimchowitsch
    Laboratoire de Neurosciences Comportementales et Cognitives, UMR 7521 CNRS Université Louis Pasteur, IFR 37 Neurosciences, Strasbourg, France
    J Physiol Paris 99:221-31. 2006
    ....
  39. doi request reprint Differential sensitivity of recent vs. remote memory traces to extinction in a water-maze task in rats
    Joëlle Lopez
    Laboratoire d Imagerie et de Neurosciences Cognitives, UMR 7191, Université Louis Pasteur CNRS, IFR 37 Neurosciences, GDR CNRS 2905, 12 rue Goethe, F 67000 Strasbourg, France
    Neurobiol Learn Mem 90:460-6. 2008
    ....
  40. ncbi request reprint Combined damage to entorhinal cortex and cholinergic basal forebrain neurons, two early neurodegenerative features accompanying Alzheimer's disease: effects on locomotor activity and memory functions in rats
    Natalia Traissard
    Laboratoire de Neurosciences Comportementales et Cognitives, FRE 2855 CNRS, Universite Louis Pasteur, IFR 37 Neurosciences, GDR 2905 CNRS, Strasbourg, France
    Neuropsychopharmacology 32:851-71. 2007
    ....
  41. ncbi request reprint Attenuation of MDMA-induced hyperthermia by ethanol in rats depends on ambient temperature
    Jean Christophe Cassel
    LINC UMR 7191, Université Louis Pasteur CNRS, Institut Fédérératif de Recherche 37 GDR CNRS 2905, 12 rue Goethe, F 67000 Strasbourg, France
    Eur J Pharmacol 571:152-5. 2007
    ..At 23 degrees C, however, there was no lethality and ethanol reduced the hyperthermia. Thus, the effects of ethanol on MDMA-induced hyperthermia are related to ambient temperature...
  42. doi request reprint Reflections on the use of the concept of plasticity in neurobiology. Translation and adaptation by Bruno Will, John Dalrymple-Alford, Mathieu Wolff and Jean-Christophe Cassel from J. Paillard, J Psychol 1976;1:33-47
    Bruno Will
    LINC UMR 7191, Université Louis Pasteur Centre National de la Recherche Scientifique, IFR de Neurosciences 037, GDR CNRS 2905, 12 rue Goethe, Strasbourg, France
    Behav Brain Res 192:7-11. 2008
    ..Therefore, systematic or random variations of performance, functional flexibility or the vicarious(1) processes or strategies that can be found in a rigidly wired system are not justified examples of plasticity...
  43. ncbi request reprint Ethanol and MDMA: a comment on the paper by Izco et al
    Byron C Jones
    Psychopharmacology (Berl) 191:387-8. 2007
  44. ncbi request reprint Modulation of photic resetting in rats by lesions of projections to the suprachiasmatic nuclei expressing p75 neurotrophin receptor
    Christine Erhardt
    Laboratory of Neurobiology of Rhythms, Centre National de la Recherche Scientifique UMR7518, Department of Neuroscience IFR37, University Louis Pasteur, 12 rue de l Université, 67000 Strasbourg, France
    Eur J Neurosci 19:1773-88. 2004
    ....
  45. ncbi request reprint Baseline and 8-OH-DPAT-induced release of acetylcholine in the hippocampus of aged rats with different levels of cognitive dysfunction
    Anelise Lazaris
    Laboratoire de Neurosciences Comportementales et Cognitives, U M R 7521 Université Louis Pasteur Centre National de la Recherche Scientifique, I F R 37 de Neurosciences, 12 rue Goethe, 67000 Strasbourg, France
    Brain Res 967:181-90. 2003
    ....
  46. ncbi request reprint 3,4-DAP-evoked transmitter release in hippocampal slices of aged rats with impaired memory
    Theresa Schweizer
    Institut für Experimentelle und Klinische Pharmakologie und Toxikologie der Universität Freiburg, Neuropharmakologisches Labor, Hansastrasse 9A, D 79104 Freiburg, Germany
    Brain Res Bull 62:129-36. 2003
    ..Excessive excitability of serotonergic terminals, perhaps in addition to cholinergic dysfunction, might be a crucial factor accounting for age-related cognitive deficits in the present population of rats...
  47. ncbi request reprint Morphological alterations in the occipital cortex of aged rats with impaired memory: a Golgi-Cox study
    Jeanne Stemmelin
    Laboratoire de Neurosciences Comportementales et Cognitives, IFR 37 Neurosciences, UMR 7521, ULP CNRS, 12 rue Goethe, 67000 Strasbourg, France
    Exp Brain Res 151:380-6. 2003
    ..Indeed, in a subpopulation of well-performing aged rats, these structural alterations were less marked than in the population of bad performers...
  48. ncbi request reprint Effects of septal grafts on acetylcholine release from rat hippocampus after 192 IgG-saporin lesion
    Michael Hilgert
    Department of Pharmacology, University of Mainz, Obere Zahlbacher Str 67, D 55101 Mainz, Germany
    Neurochem Res 28:467-72. 2003
    ..The graft responded to intrinsic serotonergic regulation...
  49. ncbi request reprint 5,7-Dihydroxytryptamine lesions enhance and serotonergic grafts normalize the evoked overflow of acetylcholine in rat hippocampal slices
    Anja Birthelmer
    Institut für Experimentelle und Klinische Pharmakologie und Toxikologie der Universität Freiburg, Neuropharmakologisches Labor, Hansastrasse 9A, D 79104 Freiburg, Germany
    Eur J Neurosci 16:1839-49. 2002
    ..When related to data in the literature, this facilitation may be of particular interest in terms of transmitter-based strategies developed to tackle cognitive symptoms related to neurodegenerative diseases...
  50. ncbi request reprint Raphé grafts and 3,4-diaminopyridine-evoked overflow of serotonin in the rat hippocampus after 5,7-dihydroxytryptamine lesions: evidence for 5-HT1A autoreceptors
    Theresa Schweizer
    Institut für Experimentelle und Klinische Pharmakologie und Toxikologie der Universität Freiburg, Neuropharmakologisches Labor, Hansastrasse 9A, D 79104 Freiburg, Germany
    Neuroreport 13:1871-4. 2002
    ..Although the graft-induced effects were less marked than in previous studies, they were beneficial and modulated by a mechanism that normally does not operate in the intact hippocampus...
  51. ncbi request reprint 5,7-DHT-induced hippocampal 5-HT depletion attenuates behavioural deficits produced by 192 IgG-saporin lesions of septal cholinergic neurons in the rat
    Olivia Lehmann
    LN2C, UMR 7521 CNRS Université Louis Pasteur, IFR de Neurosciences 37, 12 rue Goethe, F 67000 Strasbourg, France
    Eur J Neurosci 15:1991-2006. 2002
    ..This work has been presented previously [Serotonin Club/Brain Research Bulletin conference, Serotonin: From Molecule to the Clinic (satellite to the Society for Neuroscience Meeting, New Orleans, USA, November 2-3, 2000)]...
  52. ncbi request reprint Combined 192 IgG-saporin and 5,7-dihydroxytryptamine lesions in the male rat brain: a neurochemical and behavioral study
    Olivia Lehmann
    LN2C, UMR 7521 CNRS Université Louis Pasteur, IFR de Neurosciences 37, 12 rue Goethe, F 67000 Strasbourg, France
    Pharmacol Biochem Behav 72:899-912. 2002
    ..The results of the present experiment in male rats are not as clear-cut, although they are not in obvious contradiction with our previous results in females...
  53. ncbi request reprint Whole-body exposure to 2.45 GHz electromagnetic fields does not alter anxiety responses in rats: a plus-maze study including test validation
    Brigitte Cosquer
    LN2C UMR 7521 Université Louis Pasteur CNRS, Institut Fédératif de Recherche 37, 12 rue Goethe, 67000 Strasbourg, France
    Behav Brain Res 156:65-74. 2005
    ..Single vs. repeated microwave exposure: effects on benzodiazepine receptors in the brain of the rat. Bioelectromagnetics 1992;13(1):57-66], does not alter anxiety responses assessed in the elevated plus maze...
  54. ncbi request reprint No facilitation of amphetamine- or cocaine-induced hyperactivity in adult rats after various 192 IgG-saporin lesions in the basal forebrain
    Hélène Jeltsch
    Laboratoire de Neurosciences Comportementales et Cognitives, UMR 7521 Université Louis Pasteur CNRS IFR 37 Neurosciences 12, rue Goethe 67000 Strasbourg, France
    Brain Res 1029:259-71. 2004
    ..c.v. injections of 192 IgG-saporin, but suggest that cocaine-induced locomotion can be increased by such lesions and, to some respect, attenuated by cholinergic damage in the Nbm...
  55. ncbi request reprint Hebb-Williams performance and scopolamine challenge in rats with partial immunotoxic hippocampal cholinergic deafferentation
    Patricia Marques Pereira
    Laboratoire de Neurosciences Comportementales et Cognitives, UMR 7521, CNRS Université Louis Pasteur, IFR 37, 12, rue Goethe, F 67000 Strasbourg, France
    Brain Res Bull 64:381-94. 2005
    ..Finally, the data from the scopolamine challenge are in keeping with clinical results showing higher sensitivity to muscarinic blockade in aged subjects in whom weaker cholinergic functions can be presumed...
  56. ncbi request reprint Anterior but not intralaminar thalamic nuclei support allocentric spatial memory
    Mathieu Wolff
    Van der Veer Institute for Parkinson s and Brain Research, Department of Psychology, University of Canterbury, Private Bag 4800, Christchurch 8020, New Zealand
    Neurobiol Learn Mem 90:71-80. 2008
    ....
  57. ncbi request reprint Immunotoxic cholinergic lesions in the basal forebrain reverse the effects of entorhinal cortex lesions on conditioned odor aversion in the rat
    Barbara Ferry
    Laboratoire de Neurosciences et Systèmes Sensoriels, Comportement et Cognition, UMR 5020 CNRS Université Claude Bernard Lyon 1, GDR 2905 CNRS, Lyon Cedex 07, France
    Neurobiol Learn Mem 88:114-26. 2007
    ..As the injection of 192 IgG-saporin alone did not affect COA with a short ISI, our data also point to a possible role of hippocampal cholinergic neurons in the modulation of memory processes underlying COA...
  58. ncbi request reprint Long-term effects of immunotoxic cholinergic lesions in the septum on acquisition of the cone-field task and noncognitive measures in rats
    F Josef van der Staay
    CNS Research, Bayer, Wuppertal, Germany
    Hippocampus 16:1061-79. 2006
    ..These data support the growing evidence that involvement of the septohippocampal cholinergic system in spatial learning and memory may have been overestimated in studies that used lesions with poor selectivity...
  59. doi request reprint Involvement of the basal cholinergic forebrain in the mediation of general (propofol) anesthesia
    Fatem Zohra Laalou
    Groupe de Recherche Expérimentale sur les Répercussions Cognitivo affectives de l Anesthésie, INSERM U666, France
    Anesthesiology 108:888-96. 2008
    ..In this study, the authors asked whether the basal forebrain cholinergic system is also involved in mediating the effects of general anesthetics such as propofol...
  60. pmc Increased expression of 5-HT(1B) receptors by Herpes simplex virus gene transfer in septal neurons: New in vitro and in vivo models to study 5-HT(1B) receptor function
    Céline Riegert
    Institut für Experimentelle und Klinische Pharmakologie und Toxikologie der Universität Freiburg, Neuropharmakologisches Labor, Hansastrasse 9A, D 79104 Freiburg, Germany
    Brain Res Bull 76:439-53. 2008
    ....
  61. ncbi request reprint Presynaptic serotonergic modulation of 5-HT and acetylcholine release in the hippocampus and the cortex of 5-HT1B-receptor knockout mice
    Susanne Rutz
    Institute of Experimental and Clinical Pharmacology and Toxicology, Laboratory of Neuropharmacology, University of Freiburg, Hansastrasse 9A, D 79104 Freiburg, Germany
    Brain Res Bull 70:81-93. 2006
    ....
  62. ncbi request reprint Ethanol-ecstasy (MDMA) interactions in rats: preserved attenuation of hyperthermia and potentiation of hyperactivity by ethanol despite prior ethanol treatment
    Sami Ben Hamida
    LN2C FRE 2855 Université Louis Pasteur CNRS, Institut Fédérératif de Recherche 37 GDR CNRS 2905, 12 rue Goethe, F 67000 Strasbourg, France
    Pharmacol Biochem Behav 84:162-8. 2006
    ..This indicates that tolerance to ethanol per se does not account for what appears to be tolerance to the ethanol-MDMA combination, thus indicating that ethanol-MDMA combination likely has unique pharmacological effects...
  63. doi request reprint Noradrenergic denervation facilitates the release of acetylcholine and serotonin in the hippocampus: towards a mechanism underlying upregulations described in MCI patients?
    Rolf Jackisch
    Institute of Experimental and Clinical Pharmacology and Toxicology, Laboratory of Neuropharmacology, University of Freiburg, Freiburg, Germany
    Exp Neurol 213:345-53. 2008
    ....
  64. ncbi request reprint Letter to the editor concerning "Radial arm maze performance of rats following repeated low-level microwave radiation exposure" by Cobb et al. [BEMS, 2004, 25:49-57] and "letter to the editor" by Lai [BEMS, 2005, 26:81]
    Jean Christophe Cassel
    Bioelectromagnetics 26:526-7; author reply 528. 2005
  65. ncbi request reprint Septal grafts and evoked acetylcholine release in the rat hippocampus after 192 IgG-saporin lesions
    Anja Birthelmer
    Institut für Experimentelle und Klinische Pharmakologie und Toxikologie der Universität Freiburg, Neuropharmakologisches Labor, Hansastrasse 9A, D 79104 Freiburg, Germany
    Neuroreport 13:973-6. 2002
    ..The increased noradrenaline uptake may account for sympathetic ingrowth. Although the grafts of fetal septal neurons produced modest cholinergic effects, these effects were positive and significant...